2,987 research outputs found
Post-conflict aid, real exchange rate adjustment, and catch-up growth
Post-conflict countries receive substantial aid flows after the start of peace. While post-conflict countries'capacity to absorb aid (that is, the quality of their policies and institutions) is built up only gradually after the onset of peace, the evidence suggests that aid tends to peak immediately after peace is attained and decline thereafter. Aid composition broadly reflects post-conflict priorities, with large parts of aid financing social expenditure and infrastructure investment. Aid has significant short-term effects on the real exchange rate (RER), as inferred from the behavior of RER in the world. While moderate RER overvaluation is observed in post-conflicts, it cannot be traced down to the aid flows. The empirical evidence on world growth reveals new findings about the pattern of catch-up growth during post-conflicts and the role of key growth determinants on post-conflict growth. Aid is an important determinant of growth, both generally and more strongly during post-conflict periods. Because RER misalignment reduces growth, RER overvaluation during post-conflicts reduces catch-up growth. Aid and RER overvaluation combined also lower growth. But the negative growth effect of RER overvaluation declines with financial development.Social Conflict and Violence,Economic Theory&Research,Development Economics&Aid Effectiveness,Post Conflict Reintegration,Achieving Shared Growth
Transglutaminase 3 Present in the IgA Aggregates in Dermatitis Herpetiformis Skin Is Enzymatically Active and Binds Soluble Fibrinogen
Cognitive performance in healthy women during induced hypogonadism and ovarian steroid addback
BackgroundâGynecology clinic-based studies have consistently demonstrated that induced hypogonadism is accompanied by a decline in cognitive test performance. However, a recent study in healthy asymptomatic controls observed that neither induced hypogonadism nor estradiol replacement influenced cognitive performance. Thus the effects of induced hypogonadism on cognition might not be uniformly experienced across individual women. Moreover, discrepancies in the effects of hypogonadism on cognition also could suggest the existence of specific risk phenotypes that predict a womanâs symptomatic experience during the menopause. In this study, we examined the effects of induced hypogonadism and ovarian steroid replacement on cognitive performance in healthy premenopausal women. MethodsâOvarian suppression was induced with a GnRH agonist (Lupron) and then physiologic levels of estradiol and progesterone were re-introduced in 23 women. Cognitive tests were administered during each hormone condition. To evaluate possible practice effects arising during repeated testing, an identical battery of tests was administered at the same time intervals in 11 untreated women. ResultsâWith the exception of an improved performance on mental rotation during estradiol, we observed no significant effects of estradiol or progesterone on measures of attention, concentration, or memory compared with hypogonadism. ConclusionsâIn contrast to studies in which a decline in cognitive performance was observed in women receiving ovarian suppression therapy for an underlying gynecologic condition, we confirm a prior report demonstrating that short term changes in gonadal steroids have a limited effect on cognition in young, healthy, women. Differences in the clinical characteristics of the women receiving GnRH agonists could predict a risk for ovarian steroid-related changes in cognitive performance during induced, and possibly, natural menopause
Obesity and Physical Function in Rural Women who enroll in a Lifestyle Modification Intervention for Reducing Blood Pressure
Purpose: Rural women have high prevalence of obesity and prehypertension. Obesity, if associated with poor physical function, may have implications for applying activity guidelines for women volunteering for lifestyle modification. This study examined associations of body mass index (BMI) and percent body fat with measures of 1-mile walk time, post-walk perceived exertion, and 10-repetition chair stands in rural women ages 40-69.
Methods: Cross-sectional baseline data were collected using standardized methods from 289 rural women with prehypertension who volunteered for a lifestyle clinical trial for reducing blood pressure. ANOVAs and linear regression were used for analysis.
Results: With exception of the chair stands measure across categories of BMI, group differences were noted in all measures across categories of BMI and percent body fat, with women in the two highest categories demonstrating the poorest performance. These two body composition measures were significant predictors for 1-mile walk-time and 10-repetition chair stands, after controlling for confounding variables.
Conclusions: Poorer scores were observed in performance-based measures in women with higher BMI and percent body fat, though mean scores were above thresholds for functional limitation. Physical performance needs to be assessed and addressed by physical therapists when providing lifestyle interventions for overweight and obese women
Failure of hydrogenation in protecting polycyclic aromatic hydrocarbons from fragmentation
A recent study of soft X-ray absorption in native and hydrogenated coronene
cations, CH , led to the conclusion that additional
hydrogen atoms protect (interstellar) Polycyclic Aromatic Hydrocarbon (PAH)
molecules from fragmentation [Reitsma et al., Phys. Rev. Lett. 113, 053002
(2014)]. The present experiment with collisions between fast (30-200 eV) He
atoms and pyrene (CH, , 6, and 16) and simulations
without reference to the excitation method suggests the opposite. We find that
the absolute carbon-backbone fragmentation cross section does not decrease but
increases with the degree of hydrogenation for pyrene molecules.Comment: 10 pages, 5 figure
Sex differences in visuospatial abilities persist during induced hypogonadism
Despite well-established sex differences in the performance on tests of several cognitive domains (e.g., visuospatial ability), few studies in humans have evaluated if these sex differences are evident both in the presence of circulating sex hormones and during sex steroid hormonal suppression. Sex differences identified in the relative absence of circulating levels of estradiol and testosterone suggest that differences in brain structure or function exist independent of current hormonal environment and are more likely a reflection of differing developmental exposures and/or genetic substrates
Effects of morphine on pain-elicited and pain-suppressed behavior in CB1 knockout and wildtype mice
Pharmacological manipulations of the type 1 cannabinoid receptor (CB1) suggest a role for CB1 in morphine-induced antinociception, but studies utilizing CB1 knockout (KO) mice do not support this conclusion. Since studies using CB1 KO mice to study morphineâs antinociceptive effects have only examined thermal nociception, this study examines these interactions in models that employ a chemical stimulus
Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes
OBJECTIVE:
Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory capacity retained the ability to make proinsulin.
RESEARCH DESIGN AND METHODS:
C-peptide and proinsulin were measured in fasting and stimulated sera from 319 subjects with long-standing type 1 diabetes (â„3 years) and 12 control subjects without diabetes. We considered three categories of stimulated C-peptide: 1) C-peptide positive, with high stimulated values â„0.2 nmol/L; 2) C-peptide positive, with low stimulated values â„0.017 but <0.2 nmol/L; and 3) C-peptide <0.017 nmol/L. Longitudinal samples were analyzed from C-peptide-positive subjects with diabetes after 1, 2, and 4 years.
RESULTS:
Of individuals with long-standing type 1 diabetes, 95.9% had detectable serum proinsulin (>3.1 pmol/L), while 89.9% of participants with stimulated C-peptide values below the limit of detection (<0.017 nmol/L; n = 99) had measurable proinsulin. Proinsulin levels remained stable over 4 years of follow-up, while C-peptide decreased slowly during longitudinal analysis. Correlations between proinsulin with C-peptide and mixed-meal stimulation of proinsulin were found only in subjects with high stimulated C-peptide values (â„0.2 nmol/L). Specifically, increases in proinsulin with mixed-meal stimulation were present only in the group with high stimulated C-peptide values, with no increases observed among subjects with low or undetectable (<0.017 nmol/L) residual C-peptide.
CONCLUSIONS:
In individuals with long-duration type 1 diabetes, the ability to secrete proinsulin persists, even in those with undetectable serum C-peptide
Consumersâ willingness to pay for dairy products: what the studies say? A Meta-Analysis.
Willingness to pay (WTP) and consumerâs preferences for dairy products (milk, yogurt, butter and cheese) have attracted attention of researchers. Therefore, several studies have focused on the question of the measure of WTP for these different products. However, these studies found a value of WTP, which is positive or negative between different dairy products, or through the same types of products. We conduct a meta-analysis with the aim to observe the different factors, which can explain the variations of the results of the studies. Therefore, we selected 21 studies (corresponding to 142 observations) which estimates the WTP of consumers for dairy products. A geographical Indication (GI), a Bio label or other signs of quality, differentiates these products. As results, we found that on average, labelâs effect is an important quality signal for surveyed consumers. Indeed, GI and Bio label on average increase the WTP of consumers for dairy products. Then, we highlighted that European consumers have an average of positive WTP for dairy products and this result is quite pronounced for French consumers. On the other hand, consumers seem to have a higher WTP for products derived from cow's milk and goat's milk. Finally, among dairy products, cheese has on average a negative and highly significant WTP. These results remain robust, that we use a sample consumerâs (conjoint analysis, auction, choice experiment, etc.) or a sample prices (hedonic price method), even after withdrawal of outliers. We concluded that the case of the cheese deserves more attention due to the particularity of consumerâs WTP for this type of dairy product
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