Perceived fairness of direct-to-consumer genetic testing business models

Although consumers and experts often express concerns regarding the questionable business practices of direct-to-consumer (DTC) genetic testing services (e.g., reselling of consumers’ genetic data), the DTC genetic testing market keeps expanding rapidly. We employ retail fairness as our theoretical lens to address this seeming paradox and conduct a discrete choice experiment with 16 attributes to better understand consumers’ fairness perceptions of DTC genetic testing business models. Our results suggest that, while consumers perceive privacy-preserving DTC genetic testing services fairer, price is the main driver for fairness perception. We contribute to research on consumer perceptions of DTC genetic testing by investigating consumer preferences of DTC genetic testing business models and respective attributes. Further, this research contributes to knowledge about disruptive business models in healthcare and retail fairness by contextualizing the concept of retail fairness in the DTC genetic testing market. We also demonstrate how to utilize discrete choice experiments to elicit perceived fairness

Klima- und Energiepolitik in Deutschland: Dissens und Konsens

Öffentlichkeit und Politik müssen häufig den Eindruck gewinnen, dass Wirtschaftswissenschaftler bei zentralen wirtschaftspolitischen Fragen keine Einigkeit erzielen können. Dies gilt nicht zuletzt für die Umsetzung der Energiewende. Dieser Beitrag nutzt die öff entlich zugänglichen Stellungnahmen einschlägiger Forschungsinstitute, um durch die Identifikation von Bereichen des Konsens und Dissens unter Energieökonomen einen Kontrapunkt zu setzen. Wider Erwarten wird offenbar, dass auf wesentlichen Handlungsfeldern weitgehende Einigkeit besteht und somit klare Handlungsempfehlungen ausgesprochen werden können

Thermodynamic nonextensivity in a closed string gas

Well known results in string thermodynamics show that there is always a negative specific heat phase in the microcanonical description of a gas of closed free strings whenever there are no winding modes present. We will carefully compute the number of strings in the gas to show how this negative specific heat is related to the fact that the system does not have thermodynamic extensivity. We will also discuss the consequences for a system of having a microcanonical negative specific heat versus the exact result that such a thing cannot happen in any canonical (fixed temperature) description.Comment: Title + 13 pages, more typos correcte

Ascending Axonal Degeneration of the Corticospinal Tract in Pure Hereditary Spastic Paraplegia: A Cross-Sectional DTI Study

Objective: To identify structural white matter alterations in patients with pure hereditary spastic paraplegia (HSP) using high angular resolution diffusion tensor imaging (DTI). Methods: We examined 37 individuals with high resolution DTI, 20 patients with pure forms of hereditary spastic paraplegia and 17 age and gender matched healthy controls. DTI was performed using a 3 T clinical scanner with whole brain tract-based spatial statistical (TBSS) analysis of the obtained fractional anisotropy (FA) data as well as a region-of-interest (ROI)-based analysis of affected tracts including the cervical spinal cord. We further conducted correlation analyses between DTI data and clinical characteristics. Results: TBSS analysis in HSP patients showed significantly decreased fractional anisotropy of the corpus callosum and the corticospinal tract compared to healthy controls. ROI-based analysis confirmed significantly lower FA in HSP compared to controls in the internal capsule (0.77 vs. 0.80, p = 0.048), the corpus callosum (0.84 vs. 0.87, p = 0.048) and the cervical spinal cord (0.72 vs. 0.79, p = 0.003). FA values of the cervical spinal cord significantly correlated with disease duration. Conclusion: DTI metrics of the corticospinal tract from the internal capsule to the cervical spine suggest microstructural damage and axonal degeneration of motor neurons. The CST at the level of the cervical spinal cord is thereby more severely affected than the intracranial part of the CST, suggesting an ascending axonal degeneration of the CST. Since there is a significant correlation with disease duration, FA may serve as a future progression marker for assessment of the disease course in HSP

Designing Gamification Concepts for Expert Explainable Artificial Intelligence Evaluation Tasks: A Problem Space Exploration

Artificial intelligence (AI) models are often complex and require additional explanations for use in high-stakes decision-making contexts like healthcare. To this end, explainable AI (XAI) developers must evaluate their explanations with domain experts to ensure understandability. As these evaluations are tedious and repetitive, we look at gamification as a means to motivate and engage experts in XAI evaluation tasks. We explore the problem space associated with gamified expert XAI evaluation. Based on a literature review of 22 relevant studies and seven interviews with experts in XAI evaluation, we elicit knowledge about affected stakeholders, eight needs, eight goals, and seven requirements. Our results help us understand better the problems associated with expert XAI evaluation and paint a broad application potential for gamification to improve XAI expert evaluations. In doing so, we lay the foundation for the design of successful gamification concepts for expert XAI evaluation

1/T_1 nuclear relaxation time of \kappa-(BEDT-TTF)_ 2 Cu [N(CN)_2] Cl : effects of magnetic frustration

We study the role played by the magnetic frustration in the antiferromagnetic phase of the organic salt \kappa-(BEDT-TTF)_ 2 Cu [N(CN)_2] Cl. Using the spatially anisotropic triangular Heisenberg model we analyze previous and new performed NMR experiments. We compute the 1/T_1 relaxation time by means of the modified spin wave theory. The strong suppression of the nuclear relaxation time observed experimentally under varying pressure and magnetic field is qualitatively well reproduced by the model. Our results suggest the existence of a close relation between the effects of pressure and magnetic frustration.Comment: 10 pages, 9 figures, to appear in Journal of Phys.: Condens Matte

Differentiating Urgent from Elective Cases Matters in Minority Populations: Developing an Ordinal Desirability of Outcome Ranking to Increase Granularity and Sensitivity of Surgical Outcomes Assessment

BACKGROUND: Surgical analyses often focus on single or binary outcomes; we developed an ordinal Desirability of Outcome Ranking (DOOR) for surgery to increase granularity and sensitivity of surgical outcome assessments. Many studies also combine elective and urgent procedures for risk adjustment. We used DOOR to examine complex associations of race/ethnicity and presentation acuity. STUDY DESIGN: NSQIP (2013 to 2019) cohort study assessing DOOR outcomes across race/ethnicity groups risk-adjusted for frailty, operative stress, preoperative acute serious conditions, and elective, urgent, and emergent cases. RESULTS: The cohort included 1,597,199 elective, 340,350 urgent, and 185,073 emergent cases with patient mean age of 60.0 ± 15.8, and 56.4% of the surgeries were performed on female patients. Minority race/ethnicity groups had increased odds of presenting with preoperative acute serious conditions (adjusted odds ratio [aORs] range 1.22 to 1.74), urgent (aOR range 1.04 to 2.21), and emergent (aOR range 1.15 to 2.18) surgeries vs the White group. Black (aOR range 1.23 to 1.34) and Native (aOR range 1.07 to 1.17) groups had increased odds of higher/worse DOOR outcomes; however, the Hispanic group had increased odds of higher/worse DOOR (aOR 1.11, CI 1.10 to 1.13), but decreased odds (aORs range 0.94 to 0.96) after adjusting for case status; the Asian group had better outcomes vs the White group. DOOR outcomes improved in minority groups when using elective vs elective/urgent cases as the reference group. CONCLUSIONS: NSQIP surgical DOOR is a new method to assess outcomes and reveals a complex interplay between race/ethnicity and presentation acuity. Combining elective and urgent cases in risk adjustment may penalize hospitals serving a higher proportion of minority populations. DOOR can be used to improve detection of health disparities and serves as a roadmap for the development of other ordinal surgical outcomes measures. Improving surgical outcomes should focus on decreasing preoperative acute serious conditions and urgent and emergent surgeries, possibly by improving access to care, especially for minority populations

Hypertriglyceridemia and Recurrent Pancreatitis following Splenectomy

Hyperlipoproteinemia represents a constellation of clinical syndromes that frequently includes hypertriglyceridemia. Because of the degree of elevation in the triglyceride levels frequently seen in these syndromes, they are associated with complications not generally observed among those patients with essential hypertriglyceridemia, including as in this case report, recurrent pancreatitis. Here, we present a case of a patient with hyperlipoproteinemia who developed acute worsening of his hypertriglyceridemia and onset of acute panceatitis that became recurrent following elective splenectomy for suspected lymphoma. In particular, we discuss the dietary management of hypertriglyceridemia which significantly reduced the number of episodes of acute pancreatitis in this patient