Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study

Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment. Current treatments for DED aim at lubricating and controlling inflammation of the ocular surface. Development of novel therapies targeting different pathogenic mechanisms is sought-after. The aim of this study is to evaluate safety and efficacy of recombinant human nerve growth factor (rhNGF) eye drops in patients with DED. Methods: Forty consecutive patients with moderate to severe DED were included in a phase IIa, prospective, open label, multiple-dose, clinical trial to receive rhNGF eye drops at 20 μg/mL (Group 1: G1) or at 4 μg/mL (Group 2: G2) concentrations, two times a day in both eyes for 28 days (NCT02101281). The primary outcomes measures were treatment-emerged adverse events (AE), Symptoms Assessment in Dry Eye (SANDE) scale, ocular surface staining and Schirmer test. Results: Of 40 included patients, 39 completed the trial. Both tested rhNGF eye drop concentrations were safe and well tolerated. Twenty-nine patients experienced at least one AE (14 in G1 and 15 in G2), of which 11 had at least 1 related AE (8 in G1 and 3 in G2). Both frequency and severity of DED symptoms and ocular surface damage showed significant improvement in both groups, while tear function improved only in G1. Conclusions: The data of this study indicate that rhNGF eye drops in both doses is safe and effective in improving symptoms and signs of DED. Randomised clinical trials are ongoing to confirm the therapeutic benefit of rhNGF in DED. Trial registration number: NCT02101281

Another short-burst host galaxy with an optically obscured high star formation rate: The case of GRB 071227

We report on radio continuum observations of the host galaxy of the short gamma-ray burst 071227 (z=0.381) with the Australia Telescope Compact Array (ATCA). We detect the galaxy in the 5.5 GHz band with an integrated flux density of Fnu = 43 +/- 11 microJy, corresponding to an unobscured star-formation rate (SFR) of about 24 Msun/yr, forty times higher than what was found from optical emission lines. Among the ~30 well-identified and studied host galaxies of short bursts this is the third case where the host is found to undergo an episode of intense star formation. This suggests that a fraction of all short-burst progenitors hosted in star-forming galaxies could be physically related to recent star formation activity, implying a relatively short merger time scale.Comment: 6 pages, ApJ, accepted for publicatio

Multiwavelength analysis of three SNe associated with GRBs observed by GROND

After the discovery of the first connection between GRBs and SNe almost two decades ago, tens of SN-like rebrightenings have been discovered and about seven solid associations have been spectroscopically confirmed to date. Using GROND optical/NIR data and Swift X-ray/UV data, we estimate the intrinsic extinction, luminosity, and evolution of three SN rebrightenings in GRB afterglow light curves at z~0.5. The SNe 2008hw, 2009nz, and 2010ma exhibit 0.80, 1.15, and 1.78 times the optical (r band) luminosity of SN 1998bw, respectively. While SN 2009nz evolves similarly to SN 1998bw, SNe 2008hw and 2010ma show earlier peak times. The quasi-bolometric light curves were corrected for the contribution of the NIR bands using data available in the literature and blackbody fits. The large luminosity of SN 2010ma (1.4x10^43 erg/s) is confirmed, while SNe 2008hw and 2009nz reached a peak luminosity closer to SN 1998bw. Physical parameters of the SN explosions, such as synthesised nickel mass, ejecta mass, and kinetic energy, are estimated using Arnett's analytic approach, which resulted in nickel masses of around 0.4-0.5 Msun. By means of the a very comprehensive data set, we found that the luminosity and the nickel mass of SNe 2008hw, 2009nz, and 2010ma resembles those of other known GRB-associated SNe. This findings strengthens previous claims of GRB-SNe being brighter than type-Ic SNe unaccompanied by GRBs.Comment: 11 pages, 9 figures, accepted for publication in Astronomy & Astrophysics, abstract abridge

Afterglow rebrightenings as a signature of a long-lasting central engine activity? The emblematic case of GRB 100814A

In the past few years the number of well-sampled optical to NIR light curves of long Gamma-Ray Bursts (GRBs) has greatly increased particularly due to simultaneous multi-band imagers such as GROND. Combining these densely sampled ground-based data sets with the Swift UVOT and XRT space observations unveils a much more complex afterglow evolution than what was predicted by the most commonly invoked theoretical models. GRB 100814A represents a remarkable example of these interesting well-sampled events, showing a prominent late-time rebrightening in the optical to NIR bands and a complex spectral evolution. This represents a unique laboratory to test the different afterglow emission models. Here we study the nature of the complex afterglow emission of GRB 100814A in the framework of different theoretical models. Moreover, we compare the late-time chromatic rebrightening with those observed in other well-sampled long GRBs. We analysed the optical and NIR observations obtained with the seven-channel Gamma-Ray burst Optical and Near-infrared Detector at the 2.2 m MPG/ESO telescope together with the X-ray and UV data detected by the instruments onboard the Swift observatory. The broad-band afterglow evolution, achieved by constructing multi-instrument light curves and spectral energy distributions, will be discussed in the framework of different theoretical models. We find that the standard models that describe the broad-band afterglow emission within the external shock scenario fail to describe the complex evolution of GRB 100814A, and therefore more complex scenarios must be invoked. [abridged]Comment: 11 pages, 7 figures, 2 tables; Astronomy & Astrophysics, in pres

Submicron-sized MoRe-doped Si-MoRe Josephson junctions with a low specific capacitance

Abstract We start with a short look at the problem of low-capacitance Josephson junctions, its history, and actual state-of-the-art. It is argued that such devices are important for applications requiring nonhysteretic current-voltage characteristics since reduction of capacitance by several times makes it possible to increase the device resistance by the same amount while keeping the McCumber-Stewart damping parameter unaltered. Moreover, at very high frequencies the capacitance in the RCSJ circuit with a parallel connection starts to shunt the superconducting current component due to reduction of the corresponding reactance inversely proportional to C. Hence, to extend the operating frequency range of a Josephson junction its capacitance should be as small as possible. As a solution of a new type of the Josephson device, less resistive and with smaller capacitance, we propose and realize a submicron-sized trilayer with tens nm-thick Si interlayer doped by metallic ultra-small inclusions and superconducting Mo-Re alloy electrodes

The late-time afterglow of the extremely energetic short burst GRB 090510 revisited

The discovery of the short GRB 090510 has raised considerable attention mainly because it had a bright optical afterglow and it is among the most energetic events detected so far within the entire GRB population. The afterglow was observed with swift/UVOT and swift/XRT and evidence of a jet break around 1.5 ks after the burst has been reported in the literature, implying that after this break the optical and X-ray light curve should fade with the same decay slope. As noted by several authors, the post-break decay slope seen in the UVOT data is much shallower than the steep decay in the X-ray band, pointing to an excess of optical flux at late times. We reduced and analyzed new afterglow light-curve data obtained with the multichannel imager GROND. Based on the densely sampled data set obtained with GROND, we find that the optical afterglow of GRB 090510 did indeed enter a steep decay phase starting around 22 ks after the burst. During this time the GROND optical light curve is achromatic, and its slope is identical to the slope of the X-ray data. In combination with the UVOT data this implies that a second break must have occurred in the optical light curve around 22 ks post burst, which, however, has no obvious counterpart in the X-ray band, contradicting the interpretation that this could be another jet break. The GROND data provide the missing piece of evidence that the optical afterglow of GRB 090510 did follow a post-jet break evolution at late times.Comment: submitted to Astronomy & Astrophysics, accepted for publication on Dec 24, 201