2,029 research outputs found
Yeast artificial chromosomes with 200- to 800-kilobase inserts of human DNA containing HLA, V kappa, 5S, and Xq24-Xq28 sequences.
Carotid beta stiffness association with thyroid function
Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wallâlumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with β stiffness index (β = 0.026, p = 0.041), and had a negative association with strain (β = â0.025, p = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, p = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, p < 0.001) as well as their interaction (β = 0.271, p = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate
Population history from the Neolithic to present on the Mediterranean island of Sardinia: an ancient DNA perspective
Recent ancient DNA studies of western Eurasia have revealed a dynamic history of admixture, with evidence for major migrations during the Neolithic and Bronze Age. The population of the Mediterranean island of Sardinia has been notable in these studies â} Neolithic individuals from mainland Europe cluster more closely with Sardinian individuals than with all other present-day Europeans. The current model to explain this result is that Sardinia received an initial influx of Neolithic ancestry and then remained relatively isolated from expansions in the later Neolithic and Bronze Age that took place in continental Europe. To test this model, we generated genome-wide capture data (approximately 1.2 million variants) for 43 ancient Sardinian individuals spanning the Neolithic through the Bronze Age, including individuals from Sardinia{â}s Nuragic culture, which is known for the construction of numerous large stone towers throughout the island. We analyze these new samples in the context of previously generated genome-wide ancient DNA data from 972 ancient individuals across western Eurasia and whole-genome sequence data from approximately 1,500 modern individuals from Sardinia. The ancient Sardinian individuals show a strong affinity to western Mediterranean Neolithic populations and we infer a high degree of genetic continuity on the island from the Neolithic (around fifth millennium BCE) through the Nuragic period (second millennium BCE). In particular, during the Bronze Age in Sardinia, we do not find significant levels of the {â}Steppe{â ancestry that was spreading in many other parts of Europe at that time. We also characterize subsequent genetic influx between the Nuragic period and the present. We detect novel, modest signals of admixture between 1,000 BCE and present-day, from ancestry sources in the eastern and northern Mediterranean. Within Sardinia, we confirm that populations from the more geographically isolated mountainous provinces have experienced elevated levels of genetic drift and that northern and southwestern regions of the island received more gene flow from outside Sardinia. Overall, our genetic analysis sheds new light on the origin of Neolithic settlement on Sardinia, reinforces models of genetic continuity on the island, and provides enhanced power to detect post-Bronze-Age gene flow. Together, these findings offer a refined demographic model for future medical genetic studies in Sardinia
Signature of strange dibaryon in kaon-induced reaction
We examine how the signature of the strange-dibaryon resonances in the
barKNN-piSigmaN system shows up in the scattering amplitude on the physical
real energy axis within the framework of Alt-Grassberger-Sandhas (AGS)
equations. The so-called point method is applied to handle the three-body
unitarity cut in the amplitudes. We also discuss the possibility that the
strange-dibaryon production reactions can be used for discriminating between
existing models of the two-body barKN-piSigma system with Lambda(1405).Comment: 4 pages, 6 figures, talk given at The Fifth Asia-Pacific Conference
on Few-Body Problems in Physics 2011 (APFB2011), held in Seoul, Korea, August
22-26, 201
Relationship of Insulin Resistance and Related Metabolic Variables to Coronary Artery Disease: A Mathematical Analysis
OBJECTIVEâPeople with diabetes have an increased risk of coronary artery disease (CAD). An unanswered question is what portion of CAD can be attributed to insulin resistance, related metabolic variables, and other known CAD risk factors
Homological Type of Geometric Transitions
The present paper gives an account and quantifies the change in topology
induced by small and type II geometric transitions, by introducing the notion
of the \emph{homological type} of a geometric transition. The obtained results
agree with, and go further than, most results and estimates, given to date by
several authors, both in mathematical and physical literature.Comment: 36 pages. Minor changes: A reference and a related comment in Remark
3.2 were added. This is the final version accepted for publication in the
journal Geometriae Dedicat
IEDB-3D: structural data within the immune epitope database
IEDB-3D is the 3D structural component of the Immune Epitope Database (IEDB) available via the âBrowse by 3D Structureâ page at http://www.iedb.org. IEDB-3D catalogs B- and T-cell epitopes and Major Histocompatibility Complex (MHC) ligands for which 3D structures of complexes with antibodies, T-cell receptors or MHC molecules are available in the Protein Data Bank (PDB). Journal articles that are primary citations of PDB structures and that define immune epitopes are curated within IEDB as any other reference along with accompanying functional assays and immunologically relevant information. For each curated structure, IEDB-3D provides calculated data on intermolecular contacts and interface areas and includes an application, EpitopeViewer, to visualize the structures. IEDB-3D is fully embedded within IEDB, thus allowing structural data, both curated and calculated, and all accompanying information to be queried using multiple search interfaces. These include queries for epitopes recognized in different pathogens, eliciting different functional immune responses, and recognized by different components of the immune system. The query results can be downloaded in Microsoft Excel format, or the entire database, together with structural data both curated and calculated, can be downloaded in either XML or MySQL formats
On nonsupersymmetric \BC^4/\BZ_N, tachyons, terminal singularities and flips
We investigate nonsupersymmetric \BC^4/\BZ_N orbifold singularities using
their description in terms of the string worldsheet conformal field theory and
its close relation with the toric geometry description of these singularities
and their possible resolutions. Analytic and numerical study strongly suggest
the absence of nonsupersymmetric Type II terminal singularities (i.e. with no
marginal or relevant blowup modes) so that there are always moduli or closed
string tachyons that give rise to resolutions of these singularities, although
supersymmetric and Type 0 terminal singularities do exist. Using gauged linear
sigma models, we analyze the phase structure of these singularities, which
often involves 4-dimensional flip transitions, occurring between resolution
endpoints of distinct topology. We then discuss 4-dim analogs of unstable
conifold-like singularities that exhibit flips, in particular their Type II GSO
projection and the phase structure. We also briefly discuss aspects of
M2-branes stacked at such singularities and nonsupersymmetric AdS_4\times
S^7/\BZ_N backgrounds.Comment: Latex, 43pgs incl. appendices, 2 eps figs, v2. minor clarifications
added, to appear in JHE
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Kaiser Permanente-Sandia National Health Care Model: Phase 1 prototype final report. Part 2 -- Domain analysis
This report describes the results of a Cooperative Research and Development Agreement between Sandia National Laboratories and Kaiser Permanente Southern California to develop a prototype computer model of Kaiser Permanente`s health care delivery system. As a discrete event simulation, SimHCO models for each of 100,000 patients the progression of disease, individual resource usage, and patient choices in a competitive environment. SimHCO is implemented in the object-oriented programming language C{sup 2}, stressing reusable knowledge and reusable software components. The versioned implementation of SimHCO showed that the object-oriented framework allows the program to grow in complexity in an incremental way. Furthermore, timing calculations showed that SimHCO runs in a reasonable time on typical workstations, and that a second phase model will scale proportionally and run within the system constraints of contemporary computer technology
Formality theorems for Hochschild complexes and their applications
We give a popular introduction to formality theorems for Hochschild complexes
and their applications. We review some of the recent results and prove that the
truncated Hochschild cochain complex of a polynomial algebra is non-formal.Comment: Submitted to proceedings of Poisson 200
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