The New Generation Planetary Population Synthesis (NGPPS). IV. Planetary systems around low-mass stars

Context. Previous theoretical works on planet formation around low-mass stars have often been limited to large planets and individual systems. As current surveys routinely detect planets down to terrestrial size in these systems, models have shifted toward a more holistic approach that reflects their diverse architectures. Aims. Here, we investigate planet formation around low-mass stars and identify differences in the statistical distribution of modeled planets. We compare the synthetic planet populations to observed exoplanets and we discuss the identified trends. Methods. We used the Generation III Bern global model of planet formation and evolution to calculate synthetic populations, while varying the central star from Solar-like stars to ultra-late M dwarfs. This model includes planetary migration, N-body interactions between embryos, accretion of planetesimals and gas, and the long-term contraction and loss of the gaseous atmospheres. Results. We find that temperate, Earth-sized planets are most frequent around early M dwarfs (0.3 M⊙–0.5 M⊙) and that they are more rare for Solar-type stars and late M dwarfs. The planetary mass distribution does not linearly scale with the disk mass. The reason behind this is attributed to the emergence of giant planets for M⋆ ≥ 0.5 M⊙, which leads to the ejection of smaller planets. Given a linear scaling of the disk mass with stellar mass, the formation of Earth-like planets is limited by the available amount of solids for ultra-late M dwarfs. For M⋆ ≥ 0.3 M⊙, however, there is sufficient mass in the majority of systems, leading to a similar amount of Exo-Earths going from M to G dwarfs. In contrast, the number of super-Earths and larger planets increases monotonically with stellar mass. We further identify a regime of disk parameters that reproduces observed M-dwarf systems such as TRAPPIST-1. However, giant planets around late M dwarfs, such as GJ 3512b, only form when type I migration is substantially reduced. Conclusions. We are able to quantify the stellar mass dependence of multi-planet systems using global simulations of planet formation and evolution. The results fare well in comparison to current observational data and predict trends that can be tested with future observations

The New Generation Planetary Population Synthesis (NGPPS). V. Predetermination of planet types in global core accretion models

Context. State-of-the-art planet formation models are now capable of accounting for the full spectrum of known planet types. This comes at the cost of an increasing complexity of the models, which calls into question whether established links between their initial conditions and the calculated planetary observables are preserved. Aims. In this paper, we take a data-driven approach to investigate the relations between clusters of synthetic planets with similar properties and their formation history. Methods. We trained a Gaussian mixture model on typical exoplanet observables computed by a global model of planet formation to identify clusters of similar planets. We then traced back the formation histories of the planets associated with them and pinpointed their differences. Using the cluster affiliation as labels, we trained a random forest classifier to predict planet species from properties of the originating protoplanetary disk. Results. Without presupposing any planet types, we identified four distinct classes in our synthetic population. They roughly correspond to the observed populations of (sub-)Neptunes, giant planets, and (super-)Earths, plus an additional unobserved class we denote as “icy cores”. These groups emerge already within the first 0.1 Myr of the formation phase and are predicted from disk properties with an overall accuracy of >90%. The most reliable predictors are the initial orbital distance of planetary nuclei and the total planetesimal mass available. Giant planets form only in a particular region of this parameter space that is in agreement with purely analytical predictions. Including N-body interactions between the planets decreases the predictability, especially for sub-Neptunes that frequently undergo giant collisions and turn into super-Earths. Conclusions. The processes covered by current core accretion models of planet formation are largely predictable and reproduce the known demographic features in the exoplanet population. The impact of gravitational interactions highlights the need for N-body integrators for realistic predictions of systems of low-mass planets

Comparing physiological responses to hot and cold stress in a cnidarian–algal holobiont, \u3ci\u3eExaiptasia diaphana\u3c/i\u3e

Coral bleaching—the breakdown of the cnidarian–algal symbiosis—is a major cause of reef decline. The sea anemone Exaiptasia diaphana, commonly known as Aiptasia, is used as a model to study cnidarian-algal symbiosis in laboratory settings. Aiptasia can live with or without symbionts, which allows scientists to study the host combined and separate from the influence of the symbionts. Scientists are able to trigger the breakdown of the symbiosis using heat or cold stress. Cold stress is more commonly used to render aposymbiotic Aiptasia because it seems to be less harmful to the host than bleaching under heat stress. Is cold really less harmful than heat stress? We compared hot and cold stress responses to different stress regiments: a gradual temperature change, a gradual temperature change followed by a sudden temperature change, and a sudden temperature change from ambient conditions. We explored multiple physiological responses of the anemones to determine their level of stress response. We measured mortality and algal density in the host, as well as carbohydrate in the host and symbiont fractions. We also measured peroxide production in algal cultures exposed to the same treatment regimes. After repeating the experiment twice, we found that anemones had different responses, which emphasizes the necessity for repeated experiments in research conducted with live subjects

The CARMENES search for exoplanets around M dwarfs -- Planet occurrence rates from a subsample of 71 stars

The CARMENES exoplanet survey of M dwarfs has obtained more than 18 000 spectra of 329 nearby M dwarfs over the past five years as part of its guaranteed time observations (GTO) program. We determine planet occurrence rates with the 71 stars from the GTO program for which we have more than 50 observations. We use injection-and-retrieval experiments on the radial-velocity (RV) time series to measure detection probabilities. We include 27 planets in 21 planetary systems in our analysis. We find 0.06+0.04-0.03 giant planets (100 M_Earth < M_pl sin i < 1000 M_Earth) per star in periods of up to 1000 d, but due to a selection bias this number could be up to a factor of five lower in the whole 329-star sample. The upper limit for hot Jupiters (orbital period of less than 10 d) is 0.03 planets per star, while the occurrence rate of planets with intermediate masses (10 M_Earth < M_pl sin i < 100 M_Earth) is 0.18+0.07-0.05 planets per star. Less massive planets with 1 M_Earth < M_pl sin i < 10 M_Earth are very abundant, with an estimated rate of 1.32+0.33-0.31 planets per star for periods of up to 100 d. When considering only late M dwarfs with masses M_star < 0.34 M_sol, planets more massive than 10 M_Earth become rare. Instead, low-mass planets with periods shorter than 10 d are significantly overabundant. For orbital periods shorter than 100 d, our results confirm the known stellar mass dependences from the Kepler survey: M dwarfs host fewer giant planets and at least two times more planets with M_pl sin i < 10 M_Earth than G-type stars. In contrast to previous results, planets around our sample of very low-mass stars have a higher occurrence rate in short-period orbits of less than 10 d. Our results demonstrate the need to take into account host star masses in planet formation models.Comment: 15 pages, 12 figures. Accepted for publication in Astronomy & Astrophysic

Salinomycin induces calpain and cytochrome c-mediated neuronal cell death

Salinomycin is a polyether antibiotic with properties of an ionophore, which is commonly used as cocciodiostatic drug and has been shown to be highly effective in the elimination of cancer stem cells (CSCs) both in vitro and in vivo. One important caveat for the potential clinical application of salinomycin is its marked neural and muscular toxicity. In the present study we show that salinomycin in concentrations effective against CSCs exerts profound toxicity towards both dorsal root ganglia as well as Schwann cells. This toxic effect is mediated by elevated cytosolic Na+ concentrations, which in turn cause an increase of cytosolic Ca2+ by means of Na+/Ca2+ exchangers (NCXs) in the plasma membrane as well as the mitochondria. Elevated Ca2+ then leads to calpain activation, which triggers caspase-dependent apoptosis involving caspases 12, 9 and 3. In addition, cytochrome c released from depolarized mitochondria directly activates caspase 9. Combined inhibition of calpain and the mitochondrial NCXs resulted in significantly decreased cytotoxicity and was comparable to caspase 3 inhibition. These findings improve our understanding of mechanisms involved in the pathogenesis of peripheral neuropathy and are important to devise strategies for the prevention of neurotoxic side effects induced by salinomycin

Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).

Current drug therapies against Trypanosoma cruzi, the causative agent of Chagas disease, have limited effectiveness and are highly toxic. T. cruzi-specific metabolic pathways that utilize trypanothione for the reduction of peroxides are being explored as potential novel therapeutic targets. In the present study we solved the X-ray crystal structure of one of the T. cruzi enzymes involved in peroxide reduction, the glutathione peroxidase-like enzyme TcGPXI (T. cruzi glutathione peroxidase-like enzyme I). We also characterized the wild-type, C48G and C96G variants of TcGPXI by NMR spectroscopy and biochemical assays. Our results show that residues Cys48 and Cys96 are required for catalytic activity. In solution, the TcGPXI molecule readily forms a Cys48-Cys96 disulfide bridge and the polypeptide segment containing Cys96 lacks regular secondary structure. NMR spectra of the reduced TcGPXI are indicative of a protein that undergoes widespread conformational exchange on an intermediate time scale. Despite the absence of the disulfide bond, the active site mutant proteins acquired an oxidized-like conformation as judged from their NMR spectra. The protein that was used for crystallization was pre-oxidized by t-butyl hydroperoxide; however, the electron density maps clearly showed that the active site cysteine residues are in the reduced thiol form, indicative of X-ray-induced reduction. Our crystallographic and solution studies suggest a level of structural plasticity in TcGPXI consistent with the requirement of the atypical two-cysteine (2-Cys) peroxiredoxin-like mechanism implied by the behaviour of the Cys48 and Cys96 mutant proteins

The CARMENES search for exoplanets around M dwarfs, Wolf 1069 b: Earth-mass planet in the habitable zone of a nearby, very low-mass star

We present the discovery of an Earth-mass planet ($M_b\sin i = 1.26\pm0.21M_\oplus$) on a 15.6d orbit of a relatively nearby ($d\sim$9.6pc) and low-mass ($0.167\pm0.011 M_\odot$) M5.0V star, Wolf 1069. Sitting at a separation of $0.0672\pm0.0014$au away from the host star puts Wolf 1069b in the habitable zone (HZ), receiving an incident flux of $S=0.652\pm0.029S_\oplus$. The planetary signal was detected using telluric-corrected radial-velocity (RV) data from the CARMENES spectrograph, amounting to a total of 262 spectroscopic observations covering almost four years. There are additional long-period signals in the RVs, one of which we attribute to the stellar rotation period. This is possible thanks to our photometric analysis including new, well-sampled monitoring campaigns undergone with the OSN and TJO facilities that supplement archival photometry (i.e., from MEarth and SuperWASP), and this yielded an updated rotational period range of $P_{rot}=150-170$d, with a likely value at $169.3^{+3.7}_{-3.6}$d. The stellar activity indicators provided by the CARMENES spectra likewise demonstrate evidence for the slow rotation period, though not as accurately due to possible factors such as signal aliasing or spot evolution. Our detectability limits indicate that additional planets more massive than one Earth mass with orbital periods of less than 10 days can be ruled out, suggesting that perhaps Wolf 1069 b had a violent formation history. This planet is also the 6th closest Earth-mass planet situated in the conservative HZ, after Proxima Centauri b, GJ 1061d, Teegarden's Star c, and GJ 1002 b and c. Despite not transiting, Wolf 1069b is nonetheless a very promising target for future three-dimensional climate models to investigate various habitability cases as well as for sub-ms$^{-1}$ RV campaigns to search for potential inner sub-Earth-mass planets in order to test planet formation theories.Comment: 26 pages, 15 figure

Two long-period transiting exoplanets on eccentric orbits: NGTS-20 b (TOI-5152 b) and TOI-5153 b

Long-period transiting planets provide the opportunity to better understand the formation and evolution of planetary systems. Their atmospheric properties remain largely unaltered by tidal or radiative effects of the host star, and their orbital arrangement reflects a different, and less extreme, migrational history compared to close-in objects. The sample of long-period exoplanets with well determined masses and radii is still limited, but a growing number of long-period objects reveal themselves in the TESS data. Our goal is to vet and confirm single transit planet candidates detected in the TESS space-based photometric data through spectroscopic and photometric follow up observations with ground-based instruments. We use the Next Generation Transit Survey (NGTS) to photometrically monitor the candidates in order to observe additional transits. We report the discovery of two massive, warm Jupiter-size planets, one orbiting the F8-type star TOI-5153 and the other orbiting the G1-type star NGTS-20 (=TOI-5152). From our spectroscopic analysis, both stars are metal-rich with a metallicity of 0.12 and 0.15, respectively. Follow-up radial velocity observations were carried out with CORALIE, CHIRON, FEROS, and HARPS. TOI-5153 hosts a 20.33 day period planet with a planetary mass of 3.26 (+-0.18) Mj, a radius of 1.06 (+-0.04) Rj , and an orbital eccentricity of 0.091 (+-0.026). NGTS-20 b is a 2.98 (+-0.16) Mj planet with a radius of 1.07 (+-0.04) Rj on an eccentric (0.432 +- 0.023) orbit with an orbital period of 54.19 days. Both planets are metal-enriched and their heavy element content is in line with the previously reported mass-metallicity relation for gas giants. Both warm Jupiters orbit moderately bright host stars making these objects valuable targets for follow-up studies of the planetary atmosphere and measurement of the spin-orbit angle of the system.Comment: 17 pages, 13 figures, accepted to A&

HD 213885b: a transiting 1-d-period super-Earth with an Earth-like composition around a bright (V = 7.9) star unveiled by TESS

We report the discovery of the 1.008-d, ultrashort period (USP) super-Earth HD 213885b (TOI-141b) orbiting the bright (V = 7.9) star HD 213885 (TOI-141, TIC 403224672), detected using photometry from the recently launched TESS mission. Using FEROS, HARPS, and CORALIE radial velocities, we measure a precise mass of 8.8 ± 0.6 M⊕ for this 1.74 ± 0.05 R⊕ exoplanet, which provides enough information to constrain its bulk composition – similar to Earth’s but enriched in iron. The radius, mass, and stellar irradiation of HD 213885b are, given our data, very similar to 55 Cancri e, making this exoplanet a good target to perform comparative exoplanetology of short period, highly irradiated super-Earths. Our precise radial velocities reveal an additional 4.78-d signal which we interpret as arising from a second, non-transiting planet in the system, HD 213885c, whose minimum mass of 19.9 ± 1.4 M⊕ makes it consistent with being a Neptune-mass exoplanet. The HD 213885 system is very interesting from the perspective of future atmospheric characterization, being the second brightest star to host an USP transiting super-Earth (with the brightest star being, in fact, 55 Cancri). Prospects for characterization with present and future observatories are discussed