Context, Community, and Capital

This essay focuses on the language architects use to navigate the intersection of architecture, housing, and neoliberalism. Schindler argues that terminology plays a powerful role in allowing architects to avoid the socio-economic assumptions embedded in their work. Schindler traces the emergence, evolution, and codification of two such terms, ‘context’ and ‘community’, and how they have frequently been conflated. She shows how they were central to New York City’s gradual shift from welfare-state to neoliberal housing policies between the mid-1960s and the present day by connecting them to a third key term, ‘capital’. The vest-pocket housing plan developed for the South Bronx as part of the federal Model Cities programme serves as a case study. In the Bronx, the triangulation of community, context, and capital led to new development models, as well as new housing typologies, including the large-scale rehabilitation of existing tenements and small-scale new construction of row houses. The resulting shift in architectural discourse, and the codification of these practices in zoning and tax laws, have remained in force in New York City to this day

Influence of CEO characteristics on short-term M&A performance

The purpose of this research study is to identify and analyse how different CEO characteristics can influence short-term M&A performance. In particular, personal aspects in regards to M&A decisions are examined within a European setting, covering the time period from 2004 until 2013. The defined hypotheses, based on previous empirical research studies, are tested by conducting multivariate regression analyses. As a result, it can be concluded which CEO characteristics have a crucial influence on short-term M&A performance and what kind of implications can be drawn for corporate governance

Courtship behaviour in the genus Nomada - antennal grabbing and possible transfer of male secretions

Due to low population densities, copulation in the cuckoo bee genus Nomada has not previously been observed, although a seminal paper by Teng8 and Bergstrom (1977) on the chemomimesis between these parasitic bees and their Andrena or Melilla hosts postulated that secretions from male glands might be sprayed onto females during copulation. Our observations on the initiation and insertion phase of copulation in three species of Nomada now indicate antennal grabbing as a mechanism by which chemicals are transferred between the sexes. Histological studies of the antennae of N. fucata and N. lathburiana reveal antennal modifications associated with cell aggregations that represent glandular cells, and SEM studies revealed numerous excretory canals

Sex-specific heterogeneity in fixed morphological traits influences individual fitness in a monogamous bird population

Theoretical work has emphasized the important role of individual traits on population dynamics, but empirical models are often based on average or stage-dependent demographic rates. In this study on a monogamous bird, the Eurasian hoopoe (Upupa epops), we show how the interactions between male and female fixed and dynamic heterogeneity influence demographic rates and population dynamics. We built an integral projection model including individual sex, age, condition (reflecting dynamic heterogeneity) and fixed morphology (reflecting fixed heterogeneity). Fixed morphology was derived from a principal component analysis of six morphological traits. Our results revealed that reproductive success and survival were linked to fixed heterogeneity whereas dynamic heterogeneity influenced mainly the timing of reproduction. Fixed heterogeneity had major consequences for the population growth rate, but interestingly, its effect on population dynamics differed between the sexes. Female fixed morphology was directly linked to annual reproductive success whereas male fixed morphology influenced also annual survival, being twice higher in large than in small males. Even in a monogamous bird with shared parental care, large males can reach 10\% higher fitness than females. Including the dynamics of male and female individual traits in population models refines our understanding of the individual mechanisms that influence demographic rates and population dynamics and can help identifying differences in sex-specific strategies

Modeling adaptive and non-adaptive responses to environmental change

Understanding how the natural world will be impacted by environmental change over the coming decades is one of the most pressing challenges facing humanity. Addressing this challenge is difficult because environmental change can generate both population level plastic and evolutionary responses, with plastic responses being either adaptive or non-adaptive. We develop an approach that links quantitative genetic theory with data-driven structured models to allow prediction of population responses to environmental change via plasticity and adaptive evolution. After introducing general new theory, we construct a number of example models to demonstrate that evolutionary responses to environmental change over the short-term will be considerably slower than plastic responses, and that the rate of adaptive evolution to a new environment depends upon whether plastic responses are adaptive or non-adaptive. Parameterization of the models we develop requires information on genetic and phenotypic variation and demography that will not always be available, meaning that simpler models will often be required to predict responses to environmental change. We consequently develop a method to examine whether the full machinery of the evolutionarily explicit models we develop will be needed to predict responses to environmental change, or whether simpler non-evolutionary models that are now widely constructed may be sufficient

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

The generation of affinity reagents to large numbers of human proteins depends on the ability to express the target proteins as high-quality antigens. The Structural Genomics Consortium (SGC) focuses on the production and structure determination of human proteins. In a 7-year period, the SGC has deposited crystal structures of >800 human protein domains, and has additionally expressed and purified a similar number of protein domains that have not yet been crystallised. The targets include a diversity of protein domains, with an attempt to provide high coverage of protein families. The family approach provides an excellent basis for characterising the selectivity of affinity reagents. We present a summary of the approaches used to generate purified human proteins or protein domains, a test case demonstrating the ability to rapidly generate new proteins, and an optimisation study on the modification of >70 proteins by biotinylation in vivo. These results provide a unique synergy between large-scale structural projects and the recent efforts to produce a wide coverage of affinity reagents to the human proteome