972 research outputs found
Asymmetric simple exclusion process in one-dimensional chains with long-range links
We study the boundary-driven asymmetric simple exclusion process (ASEP) in a
one-dimensional chain with long-range links. Shortcuts are added to a chain by
connecting different pairs of sites selected randomly where and
denote the chain length and the shortcut density, respectively. Particles flow
into a chain at one boundary at rate and out of a chain at the other
boundary at rate , while they hop inside a chain via nearest-neighbor
bonds and long-range shortcuts. Without shortcuts, the model reduces to the
boundary-driven ASEP in a one-dimensional chain which displays the low density,
high density, and maximal current phases. Shortcuts lead to a drastic change.
Numerical simulation studies suggest that there emerge three phases; an empty
phase with , a jammed phase with , and a shock phase
with where is the mean particle density. The shock phase is
characterized with a phase separation between an empty region and a jammed
region with a localized shock between them. The mechanism for the shock
formation and the non-equilibrium phase transition is explained by an analytic
theory based on a mean-field approximation and an annealed approximation.Comment: revised version (16 pages and 6 eps figures
Particle interactions and lattice dynamics: Scenarios for efficient bidirectional stochastic transport?
Intracellular transport processes driven by molecular motors can be described
by stochastic lattice models of self-driven particles. Here we focus on
bidirectional transport models excluding the exchange of particles on the same
track. We explore the possibility to have efficient transport in these systems.
One possibility would be to have appropriate interactions between the various
motors' species, so as to form lanes. However, we show that the lane formation
mechanism based on modified attachment/detachment rates as it was proposed
previously is not necessarily connected to an efficient transport state and is
suppressed when the diffusivity of unbound particles is finite. We propose
another interaction mechanism based on obstacle avoidance that allows to have
lane formation for limited diffusion. Besides, we had shown in a separate paper
that the dynamics of the lattice itself could be a key ingredient for the
efficiency of bidirectional transport. Here we show that lattice dynamics and
interactions can both contribute in a cooperative way to the efficiency of
transport. In particular, lattice dynamics can decrease the interaction
threshold beyond which lanes form. Lattice dynamics may also enhance the
transport capacity of the system even when lane formation is suppressed.Comment: 25 pages, 17 figures, 2 table
Upscaling of LATP synthesis: Stoichiometric screening of phase purity and microstructure to ionic conductivity maps
Lithium aluminum titanium phosphate (LATP) is known to have a high Li-ion conductivity and is therefore a potential candidate as a solid electrolyte. Via sol-gel route, it is already possible to prepare the material at laboratory scale in high purity and with a maximum Li-ion conductivity in the order of 1·10 s/cm at room temperature. However, for potential use in a commercial, battery-cell upscaling of the synthesis is required. As a first step towards this goal, we investigated whether the sol-gel route is tolerant against possible deviations in the concentration of the precursors. In order to establish a possible process window for sintering, the temperature interval from 800 °C to 1100 °C and holding times of 10 to 480 min were evaluated. The resulting phase compositions and crystal structures were examined by X-ray diffraction. Impedance spectroscopy was performed to determine the electrical properties. The microstructure of sintered pellets was analyzed by scanning electron microscopy and correlated to both density and ionic conductivity. It is shown that the initial concentration of the precursors strongly influences the formation of secondary phases like AlPO and LiTiOPO, which in turn have an influence on ionic conductivity, densification behavior, and microstructure evolution
The double Ringel-Hall algebra on a hereditary abelian finitary length category
In this paper, we study the category of semi-stable
coherent sheaves of a fixed slope over a weighted projective curve. This
category has nice properties: it is a hereditary abelian finitary length
category. We will define the Ringel-Hall algebra of and
relate it to generalized Kac-Moody Lie algebras. Finally we obtain the Kac type
theorem to describe the indecomposable objects in this category, i.e. the
indecomposable semi-stable sheaves.Comment: 29 page
Correlation of CCV Between In-Cylinder Swirl Ratio and Polar Velocity Profile in Valve Seat Region Using LES Under Motored Engine Condition
An analysis of Transparent Combustion Chamber (TCC3) engine Large-Eddy Simulation (LES) result was carried out to investigate Cycle-to-Cycle Variation (CCV) correlation between in-cylinder swirl ratio and flow in the valve seat region of the intake port to address a challenging question on “What causes CCV of in-cylinder flow”. Polar Velocity (PV) profile, mean velocities normal to a ring-shaped cutting surface in the valve seat region, is calculated to depict intake port flow. A Net Polar Velocity (NPV) can be defined by performing the vector sum of the polar velocity around the intake valve. A standard deviation of PV is also calculated from azimuthal distribution of PV magnitudes relative to its mean value. The analysis of 18 LES cycles of TCC3 engine with a two-valve, pancake-shaped combustion chamber shows that similar CCV of in-cylinder swirl ratio patterns are observed at different crank angles from Intake Valve Opening (IVO) to Exhaust Valve Opening (EVO). Further analysis shows clear correlations of CCV between in-cylinder swirl ratio and NPV magnitude and the standard deviation of PV at selected crank angles from IVO to EVO. The correlations get significantly better with the ring-shaped cutting surface moves from up-stream to downstream of the valve-seat region. This study reveals that the CCV of in-cylinder swirl ratio is built up gradually from upstream to downstream in the intake port and valve-seat region. Further evaluation of the analysis method is planned for a four-valve engine as an evaluation metric for better engine intake port design and combustion chamber optimization
Machine Learning Assisted Design of Experiments for Solid State Electrolyte Lithium Aluminum Titanium Phosphate
Lithium-ion batteries with solid electrolytes offer safety, higher energy density and higher long-term performance, which are promising alternatives to conventional liquid electrolyte batteries. Lithium aluminum titanium phosphate (LATP) is one potential solid electrolyte candidate due to its high Li-ion conductivity. To evaluate its performance, influences of the experimental factors on the materials design need to be investigated systematically. In this work, a materials design strategy based on machine learning (ML) is employed to design experimental conditions for the synthesis of LATP. In the variation of parameters, we focus on the tolerance against the possible deviations in the concentration of the precursors, as well as the influence of sintering temperature and holding time. Specifically, models built with different design selection strategies are compared based on the training data assembled from previous laboratory experiments. The best one is then chosen to design new experiment parameters, followed by measuring the corresponding properties of the newly synthesized samples. A previously unknown sample with ionic conductivity of 1.09 × 10 S cm is discovered within several iterations. In order to further understand the mechanisms governing the high ionic conductivity of these samples, the resulting phase compositions and crystal structures are studied with X-ray diffraction, while the microstructures of sintered pellets are investigated by scanning electron microscopy. Our studies demonstrate the advantages of applying machine learning in designing experimental conditions by the synthesis of desired materials, which can effectively help researchers to reduce the number of required experiments
Variants Cause Spastic Paraplegia Associated with Cerebral Hypomyelination
Oculodentodigital dysplasia is an autosomal dominant disorder due to variants characterized by dysmorphic features. Neurologic symptoms have been described in some patients but without a clear neuroimaging pattern. To understand the pathophysiology underlying neurologic deficits in oculodentodigital dysplasia, we studied 8 consecutive patients presenting with hereditary spastic paraplegia due to variants. Clinical disease severity was highly variable. Cerebral MR imaging revealed variable white matter abnormalities, consistent with a hypomyelination pattern, and bilateral hypointense signal of the basal ganglia on T2-weighted images and/or magnetic susceptibility sequences, as seen in neurodegeneration with brain iron accumulation diseases. Patients with the more prominent basal ganglia abnormalities were the most disabled ones. This study suggests that -related hereditary spastic paraplegia is a complex neurodegenerative disease affecting both the myelin and the basal ganglia. variants should be considered in patients with hereditary spastic paraplegia presenting with brain hypomyelination, especially if associated with neurodegeneration and a brain iron accumulation pattern
Treatment of Fabry Disease: Outcome of a Comparative Trial with Agalsidase Alfa or Beta at a Dose of 0.2 mg/kg
Two different enzyme preparations, agalsidase alfa (Replagal(TM), Shire) and beta (Fabrazyme(TM), Genzyme), are registered for treatment of Fabry disease. We compared the efficacy of and tolerability towards the two agalsidase preparations administered at identical protein dose in a randomized controlled open label trial.Thirty-four Fabry disease patients were treated with either agalsidase alfa or agalsidase beta at equal dose of 0.2 mg/kg biweekly. Primary endpoint was reduction in left ventricular mass after 12 and 24 months of treatment. Other endpoints included occurrence of treatment failure (defined as progression of cardiac, renal or cerebral disease), glomerular filtration rate, pain, anti-agalsidase antibodies, and globotriaosylceramide levels in plasma and urine. After 12 and 24 months of treatment no reduction in left ventricular mass was seen, which was not different between the two treatment groups. Also, no differences in glomerular filtration rate, pain and decline in globotriaosylceramide levels were found. Antibodies developed only in males (4/8 in the agalsidase alfa group and 6/8 in the agalsidase beta group). Treatment failure within 24 months of therapy was seen in 8/34 patients: 6 male patients (3 in each treatment group) and 2 female patients (both agalsidase alfa). The occurrence of treatment failures did not differ between the two treatment groups; chi(2) = 0.38 p = 0.54.Our study revealed no difference in reduction of left ventricular mass or other disease parameters after 12 and 24 months of treatment with either agalsidase alfa or beta at a dose of 0.2 mg/kg biweekly. Treatment failure occurred frequently in both groups and seems related to age and severe pre-treatment disease.International Standard Randomized Clinical Trial ISRCTN45178534 [http://www.controlled-trials.com/ISRCTN45178534]
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