A Prospective Pilot Study to Identify a Myocarditis Cohort who may Safely Resume Sports Activities 3 Months after Diagnosis

International cardiovascular society recommendations to return to sports activities following acute myocarditis are based on expert consensus in the absence of prospective studies. We prospectively enrolled 30 patients with newly diagnosed myocarditis based on clinical parameters, laboratory measurements and cardiac magnetic resonance imaging with mildly reduced or pre served left ventricular ejection fraction (LVEF) with a follow-up of 12 months. Cessation of physical activity was recommended for 3 months. The average age was 35 (19–80) years with 73% male patients. One case of non-sustained ventricular tachycardia was recorded during 48-h-Holter electrocardiogram. Except for this case, all patients were allowed to resume physical exercise after 3 months. At 6- (n = 26) and 12-month (n = 19) follow-up neither cardiac events nor worsening LVEF were recorded. The risk of cardiac events at 1 year after diagnosis of myocarditis appears to be low after resumption of exercise after 3 months among patients who recover from acute myocarditis

Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Cardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights regarding neurological disease entities triggering TTS and to investigate the clinical profile and outcomes of TTS patients after primary neurological disorders. The International Takotsubo Registry is an observational multicenter collaborative effort of 45 centers in 14 countries (ClinicalTrials.gov, identifier NCT01947621). All patients in the registry fulfilled International Takotsubo Diagnostic Criteria. For the present study, patients were included if complete information on acute neurological disorders were available. 2402 patients in whom complete information on acute neurological status were available were analyzed. In 161 patients (6.7%) an acute neurological disorder was identified as the preceding triggering factor. The most common neurological disorders were seizures, intracranial hemorrhage, and ischemic stroke. Time from neurological symptoms to TTS diagnosis was ≤ 2 days in 87.3% of cases. TTS patients with neurological disorders were younger, had a lower female predominance, fewer cardiac symptoms, lower left ventricular ejection fraction, and higher levels of cardiac biomarkers. TTS patients with neurological disorders had a 3.2-fold increased odds of in-hospital mortality compared to TTS patients without neurological disorders. In this large-scale study, 1 out of 15 TTS patients had an acute neurological condition as the underlying triggering factor. Our data emphasize that a wide spectrum of neurological diseases ranging from benign to life-threatening encompass TTS. The high rates of adverse events highlight the need for clinical awareness.The International Takotsubo Registry was supported by the Biss Davies Charitable Trust. Dr. Scheitz has been supported by the Corona Foundation. Dr. Templin has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation.info:eu-repo/semantics/publishedVersio

A Prospective Pilot Study to Identify a Myocarditis Cohort who may Safely Resume Sports Activities 3 Months after Diagnosis

International cardiovascular society recommendations to return to sports activities following acute myocarditis are based on expert consensus in the absence of prospective studies. We prospectively enrolled 30 patients with newly diagnosed myocarditis based on clinical parameters, laboratory measurements and cardiac magnetic resonance imaging with mildly reduced or preserved left ventricular ejection fraction (LVEF) with a follow-up of 12 months. Cessation of physical activity was recommended for 3 months. The average age was 35 (19-80) years with 73% male patients. One case of non-sustained ventricular tachycardia was recorded during 48-h-Holter electrocardiogram. Except for this case, all patients were allowed to resume physical exercise after 3 months. At 6- (n = 26) and 12-month (n = 19) follow-up neither cardiac events nor worsening LVEF were recorded. The risk of cardiac events at 1 year after diagnosis of myocarditis appears to be low after resumption of exercise after 3 months among patients who recover from acute myocarditis

Atmospheric noble gas isotope and bulk K/U ratios as a constraint on the origin and early evolution of Venus and Earth

International audienceWhile Venus and Earth were accumulating mass within the solar nebular these protoplanets also captured significant hydrogen dominated atmospheres by picking up gas from the circumstellar disk during the formation of the Solar System (e.g. Stökl et al. 2016). These primordial atmospheres were then quickly lost by hydrodynamic escape after the disk dissipated. After a short but efficient boil-off phase the EUV-driven hydrodynamic flow of H atoms dragged heavier elements with it at different rates, leading to changes in their isotopic and elemental ratios (Zahnle and Kasting 1986, Hunten et al. 1987, Odert et al. 2018), which is reflected in the present-day atmospheric noble gas isotope and elemental ratios of Venus and Earth. Depending on the disk lifetime and the initial composition of the protoplanets, we find that the atmospheric 36Ar/38Ar, 20Ne/22Ne, and bulk K/U ratios observed for both planets can be best explained if the Sun was born between a weakly and moderately active star and if Venus and Earth had grown to 85-100% and 53-58% respectively of their current masses by the time the nebula gas dissipated approximately 3.5 Myr after formation of the Sun. If proto-Earth accreted its mass from 60% volatile poor ureilite-like and 40% carbonatious chondritic-like material (Schiller et al. 2018) then the planet must have been grown to about 80% of its final mass as long as it was surrounded by the escaping primordial atmosphere ( 7 Myr). Our results are therefore in agreement with a fast accretion of thermally-processed disk material into asteroidal bodies and/or planetary embryos, as well as Hafnium-Tungsten chronometric fast accretion scenarios of the proto-Earth (e.g. Yu & Jacobsen 2011), as well as a noble gas origin based on a mixture of primitive meteoroids and a small remnant of the proto-solar nebula (Marty 2012). This also indicates that a significant amount of the terrestrial building blocks were delivered from behind the so-called snow line early-on

Atmospheric noble gas isotope and bulk K/U ratios as aconstraint on the early evolution of Venus and Earth

International audienc