1,684 research outputs found
Nonequilibrium phase transition in the coevolution of networks and opinions
Models of the convergence of opinion in social systems have been the subject
of a considerable amount of recent attention in the physics literature. These
models divide into two classes, those in which individuals form their beliefs
based on the opinions of their neighbors in a social network of personal
acquaintances, and those in which, conversely, network connections form between
individuals of similar beliefs. While both of these processes can give rise to
realistic levels of agreement between acquaintances, practical experience
suggests that opinion formation in the real world is not a result of one
process or the other, but a combination of the two. Here we present a simple
model of this combination, with a single parameter controlling the balance of
the two processes. We find that the model undergoes a continuous phase
transition as this parameter is varied, from a regime in which opinions are
arbitrarily diverse to one in which most individuals hold the same opinion. We
characterize the static and dynamical properties of this transition
Canine-Derived Cosmid Probes Containing Microsatellites Can Be Used in Physical Mapping of Arctic Fox (Alopex lagopus) and Chinese Raccoon Dog (Nyctereutes procyonoides procyonoides) Genomes
Rapid development of the canine marker genome map facilitates genome mapping of other Canidae species. In this study we present chromosomal localization of 18 canine-derived cosmid probes containing microsatellites in the arctic fox (Alopex lagopus) and Chinese raccoon dog (Nyctereutes procyonoides procyonoides) genomes by the use of fluorescence in situ hybridization (FISH). The chromosome localizations in the arctic fox are in general agreement with data obtained from comparative genome maps of the dog and the fox. However, our studies showed that the order of the loci on some chromosomes was changed during karyotype evolution. Therefore, we suggest that small intrachromosomal rearrangements took plac
Rise of the centrist: from binary to continuous opinion dynamics
We propose a model that extends the binary ``united we stand, divided we
fall'' opinion dynamics of Sznajd-Weron to handle continuous and multi-state
discrete opinions. Disagreement dynamics are often ignored in continuous
extensions of the binary rules, so we make the most symmetric continuum
extension of the binary model that can treat the consequences of agreement
(debate) and disagreement (confrontation) within a population of agents. We use
the continuum extension as an opportunity to develop rules for persistence of
opinion (memory). Rules governing the propagation of centrist views are also
examined. Monte Carlo simulations are carried out. We find that both memory
effects and the type of centrist significantly modify the variance of average
opinions in the large timescale limits of the models. Finally, we describe the
limit of applicability for Sznajd-Weron's model of binary opinions as the
continuum limit is approached. By comparing Monte Carlo results and long
time-step limits, we find that the opinion dynamics of binary models are
significantly different to those where agents are permitted more than 3
opinions
Analysis of a threshold model of social contagion on degree-correlated networks
We analytically determine when a range of abstract social contagion models
permit global spreading from a single seed on degree-correlated random
networks. We deduce the expected size of the largest vulnerable component, a
network's tinderbox-like critical mass, as well as the probability that
infecting a randomly chosen individual seed will trigger global spreading. In
the appropriate limits, our results naturally reduce to standard ones for
models of disease spreading and to the condition for the existence of a giant
component. Recent advances in the distributed, infinite seed case allow us to
further determine the final size of global spreading events, when they occur.
To provide support for our results, we derive exact expressions for key
spreading quantities for a simple yet rich family of random networks with
bimodal degree distributions.Comment: 7 Pages, 1 figure, submitted to Phys. Rev.
An analysis of integrative outcomes in the Dayton peace negotiations
The nature of the negotiated outcomes of the eight issues of the Dayton Peace Agreement was studied in terms of their integrative and distributive aspects. in cases where integrative elements were Sound, further analysis was conducted by concentrating on Pruitt's five types of integrative solutions: expanding the pie, cost cutting, non-specific compensation, logrolling, and bridging. The results showed that real world international negotiations can arrive at integrative agreements even when they involve redistribution of resources tin this case the redistribution of former Yugoslavia). Another conclusion was that an agreement can consist of several distributive outcomes and several integrative outcomes produced by different kinds of mechanisms. Similarly, in single issues more than one mechanism can be used simultaneously. Some distributive bargaining was needed in order to determine how much compensation was required. Finally, each integrative formula had some distributive aspects as well
Entanglement between Demand and Supply in Markets with Bandwagon Goods
Whenever customers' choices (e.g. to buy or not a given good) depend on
others choices (cases coined 'positive externalities' or 'bandwagon effect' in
the economic literature), the demand may be multiply valued: for a same posted
price, there is either a small number of buyers, or a large one -- in which
case one says that the customers coordinate. This leads to a dilemma for the
seller: should he sell at a high price, targeting a small number of buyers, or
at low price targeting a large number of buyers? In this paper we show that the
interaction between demand and supply is even more complex than expected,
leading to what we call the curse of coordination: the pricing strategy for the
seller which aimed at maximizing his profit corresponds to posting a price
which, not only assumes that the customers will coordinate, but also lies very
near the critical price value at which such high demand no more exists. This is
obtained by the detailed mathematical analysis of a particular model formally
related to the Random Field Ising Model and to a model introduced in social
sciences by T C Schelling in the 70's.Comment: Updated version, accepted for publication, Journal of Statistical
Physics, online Dec 201
Ergebnis der selektiven Verpaarung beim Entlebucher Sennenhund zur Reduktion der ureteralen Ektopie
Outcome of selective mating in the Entlebucher Mountain Dog for reduction of ureteral ectopia
The Entlebucher Mountain Dog is predisposed to ureteral ectopia and associated diseases of the urinary tract as well as the kidneys, which can have severe to lethal consequences. Due to the clustered occurrence of clinical signs in 11â% of Entlebucher Mountain dogs in the absence of a genetic test for ureteral ectopia, screening was introduced in 2008 to allow phenotype-based breeding selection. The ureteral orifices of the dogs are visualized by ultrasound and existing urinary retention or urinary incontinence is documented. The diagnostic findings were evaluated centrally with assignment to one of five phenotypes depending on the localization of the ureteral orifices and the renal and ureteral shape. Breeding approval and mating restrictions are the responsibility of the respective breeding associations and predominantly Entlebucher Mountain Dogs with extravesical ectopic ureters and/or clinical signs were excluded from breeding. The effect of phenotype-based selective mating on the incidence of ureteral ectopia and its clinical signs, as well as possible factors influencing the expression of the phenotype, were determined in the birth cohorts after the introduction of screening. Analysis of the data set of 1456 phenotyped Entlebucher Mountain Dogs showed, that at 11â% versus 5â%, males were more frequently assigned to the extravesical phenotype than females. The effect of phenotype-based breeding selection was examined in a subpopulation consisting of phenotyped parents and their offspring (n = 876). The prevalence of the extravesical phenotype decreased from 24â% in the 2005 to 2007 birth cohorts to 1,4â% in the 2015 to 2017 birth cohorts. Since 2015 almost no Entlebucher Mountain Dogs with incontinence, hydroureter or hydronephrosis have been recorded. It was feared that the additional selection measures to control ureteral ectopia in the small Entlebucher Mountain Dog population would intensify the inbreeding increase. However, this has so far remained absent. Therefore, as long as no genetic test is available, it is recommended to continue phenotype-based breeding selection with exclusion of dogs with extravesical ureteral ectopia and/or hydroureter/hydronephrosis/urinary incontinence, while keeping an eye on the development of the inbreeding coefficient.
Keywords: Ectopic ureter, Dog, Inbreeding, Phenotype, Breeding selection
Deutsch
Ergebnis der selektiven Verpaarung beim Entlebucher Sennenhund zur Reduktion der ureteralen Ektopie
Der Entlebucher Sennenhund ist prĂ€disponiert fĂŒr die ureterale Ektopie und damit fĂŒr assoziierte Erkrankungen der Harnwege sowie der Nieren, was schwerwiegende bis letale Folgen haben kann. Aufgrund des gehĂ€uften Auftretens klinischer Symptome bei 11â% der Entlebucher Sennenhunde wurde in Ermangelung eines Gentests auf ureterale Ektopie 2008 ein Screening eingefĂŒhrt, um eine PhĂ€notyp-basierte Zuchtselektion zu ermöglichen. Die UretermĂŒndungen der Hunde werden in der Regel mittels Ultraschall lokalisiert und bestehender HarnrĂŒckstau oder Harninkontinenz wird dokumentiert. Die Befundung erfolgte zentral mit einer Zuordnung zu einem von fĂŒnf PhĂ€notypen in AbhĂ€ngigkeit von der Lokalisation der UretermĂŒndungen sowie der Nieren â und Ureterengestalt. Die Zuchtzulassung und VerpaarungsbeschrĂ€nkungen obliegen den jeweiligen ZuchtverbĂ€nden, wobei ĂŒberwiegend Entlebucher Sennenhunde mit extravesikal ektopischen Ureteren und/oder klinischen Symptomen von der Zucht ausgeschlossen wurden. Die Auswirkung der PhĂ€notyp-basierten selektiven Verpaarung auf das Auftreten der ureteralen Ektopie und deren klinischen Symptome sowie mögliche Einflussfaktoren auf die AusprĂ€gung des PhĂ€notyps wurden in den Geburtsjahren nach EinfĂŒhrung des Screenings ermittelt. Die Analyse des Datensatzes mit 1456 phĂ€notypisierten Entlebucher Sennenhunden zeigte, dass mit 11â% versus 5â% RĂŒden hĂ€ufiger als HĂŒndinnen dem extravesikalen PhĂ€notyp zugeteilt wurden. Die Auswirkung der PhĂ€notyp-basierten Zuchtselektion wurde an einer Teilpopulation, bestehend aus phĂ€notypisierten Elterntieren und ihren Nachkommen (n = 876), untersucht. Die PrĂ€valenz des extravesikalen PhĂ€notyps nahm von 24â% bei den Geburtsjahren 2005 bis 2007 auf 1,4â% bei den Geburtsjahren 2015 bis 2017 ab. Seit 2015 wurden nahezu keine Entlebucher Sennenhunde mehr mit Inkontinenz, Hydroureter oder Hydronephrose erfasst. BefĂŒrchtet wurde, dass die zusĂ€tzlichen Selektionsmassnahmen zur BekĂ€mpfung der ureteralen Ektopie in der kleinen Entlebucher Sennenhundepopulation den Inzuchtanstieg verstĂ€rken wĂŒrde. Dies blieb bisher jedoch aus. Daher wird, solange kein genetischer Test zur VerfĂŒgung steht, empfohlen, die PhĂ€notyp-basierte Zuchtselektion mit Ausschluss von Hunden mit extravesikaler ureteraler Ektopie und/oder Hydroureter/Hydronephrose/Harninkontinenz vorerst weiterzufĂŒhren und gleichzeitig die Entwicklung des Inzuchtkoeffizienten im Auge zu behalten.
SchlĂŒsselwörter: Ektopischer Ureter, Hund, Inzucht, PhĂ€notyp, Zuchtselektion
Français
RĂ©sultat de lâaccouplement sĂ©lectif chez le bouvier de lâEntlebuch pour rĂ©duire lâectopie urĂ©tĂ©rale
Le Bouvier de lâEntlebuch est prĂ©disposĂ© Ă lâectopie urĂ©tĂ©rale et aux maladies associĂ©es des voies urinaires ainsi que des reins, ce qui peut entraĂźner des consĂ©quences fatales. En raison de lâapparition de signes cliniques chez 11â% des chiens et en lâabsence dâun test gĂ©nĂ©tique pour lâectopie urĂ©tĂ©rale, un dĂ©pistage a Ă©tĂ© introduit en 2008 pour permettre une sĂ©lection dâĂ©levage basĂ©e sur le phĂ©notype. Les orifices urĂ©traux des chiens ont Ă©tĂ© visualisĂ©s par Ă©chographie et la rĂ©tention ou lâincontinence urinaire existante documentĂ©e. Les rĂ©sultats du diagnostic ont Ă©tĂ© Ă©valuĂ©s de maniĂšre centralisĂ©e avec attribution Ă lâun des cinq phĂ©notypes en fonction de la localisation des orifices urĂ©tĂ©raux ainsi que de la forme des reins et des uretĂšres. Lâapprobation pour la reproduction et les restrictions dâaccouplement relĂšvent de la responsabilitĂ© des associations dâĂ©levage respectives et les bouviers de lâEntlebuch prĂ©sentant des uretĂšres ectopiques extravĂ©sicaux et/ou des signes cliniques ont majoritairement Ă©tĂ© exclus de la reproduction. Lâeffet de cet accouplement sĂ©lectif basĂ© sur le phĂ©notype sur lâincidence de lâectopie urĂ©tĂ©rale et de ses signes cliniques ainsi que les facteurs possibles influençant lâexpression du phĂ©notype ont Ă©tĂ© dĂ©terminĂ©s dans les cohortes de naissance aprĂšs lâintroduction du dĂ©pistage. Lâanalyse de lâensemble des donnĂ©es de 1456 Bouviers de lâEntlebuch phĂ©notypĂ©s a montrĂ© que, Ă 11â% contre 5â%, les mĂąles Ă©taient plus frĂ©quemment affectĂ©s au phĂ©notype extravĂ©sical que les femelles. Lâeffet de la sĂ©lection dâĂ©levage basĂ©e sur le phĂ©notype a Ă©tĂ© examinĂ© dans une sous-population composĂ©e de parents phĂ©notypĂ©s et de leur progĂ©niture (n = 876). La prĂ©valence du phĂ©notype extravĂ©sical est passĂ©e de 24â% dans les cohortes de naissance de 2005 Ă 2007 Ă 1,4â% dans les cohortes de naissance de 2015 Ă 2017. Depuis 2015, presque aucun bouvier dâEntlebuch prĂ©sentant une incontinence, un hydrouretĂšre ou une hydronĂ©phrose nâa Ă©tĂ© enregistrĂ©. Une possible augmentation de la consanguinitĂ© due aux mesures de sĂ©lection supplĂ©mentaires visant Ă contrĂŽler lâectopie urĂ©tĂ©rale ne sâest pas produite. Par consĂ©quent, tant quâaucun test gĂ©nĂ©tique nâest disponible, il est recommandĂ© de poursuivre la sĂ©lection dâĂ©levage basĂ©e sur le phĂ©notype avec exclusion des chiens prĂ©sentant une ectopie urĂ©tĂ©rale extravĂ©sicale et/ou une hydrouretĂšre/hydronĂ©phrose/incontinence urinaire, tout en surveillant lâĂ©volution du coefficient de consanguinitĂ©.
Mots-clĂ©s: auretĂšre ectopique, chien, consanguinitĂ©, phĂ©notype, sĂ©lection dâĂ©levage
Italiano
Risultato dell'accoppiamento selettivo nel cane da montagna Entlebuch per ridurre l'ectopia ureterale
Il bovaro dellâEntlebuch Ăš predisposto allâectopia ureterale e quindi alle malattie che sono correlate al tratto urinario e renale con possibili conseguenze letali. A causa della frequente comparsa di segni clinici nellâ11â% dei cani e in assenza di un test genetico per lâectopia ureterale, nel 2008 Ăš stato introdotto uno screening per consentire la selezione fenotipica dei riproduttori. Gli orifizi ureterali dei cani sono solitamente localizzato tramite ecografia e viene documentata la presenza di ritenzione o incontinenza urinaria. I risultati sono stati valutati in modo centralizzato e si Ăš assegnato il risultato a uno dei cinque fenotipi a seconda della localizzazione degli orifizi ureterali e della forma dei reni e degli ureteri. Lâautorizzazione allâallevamento e le restrizioni allâaccoppiamento sono di competenza delle rispettive associazioni di allevatori e i bovari dellâEntlebuch con ureteri ectopici extravescicali e/o con segni clinici sono stati prevalentemente esclusi dalla riproduzione. Lâeffetto dellâaccoppiamento selettivo, basato sul fenotipo per rapporto allâincidenza dellâectopia ureterale e dei suoi segni clinici, nonchĂ© dei possibili fattori che influenzano lâespressione del fenotipo, Ăš stato determinato nelle coorti di nascita dopo lâintroduzione dello screening. Lâanalisi del set di dati di 1456 bovari dellâEntlebuch fenotipizzati ha dimostrato che, con una percentuale dellâ11â% rispetto al 5â%, i maschi erano piĂč frequentemente assegnati al fenotipo extravescicale rispetto alle femmine. Lâeffetto della selezione riproduttiva basata sul fenotipo Ăš stato esaminato in una subpopolazione composta da genitori fenotipizzati e dalla loro discendenza (n = 876). La prevalenza del fenotipo extravescicale Ăš diminuita dal 24â% nelle coorti di nascita dal 2005 al 2007 allâ1,4â% nelle coorti di nascita dal 2015 al 2017. Dal 2015 non sono stati registrati quasi piĂč bovari dellâEntlebuch con incontinenza, idrouretere o idronefrosi. Non si Ăš riscontrato un possibile aumento della consanguineitĂ dovuto alle misure di selezione aggiuntive per controllare lâectopia ureterale. Pertanto, finchĂ© non Ăš disponibile un test genetico, si raccomanda di continuare la selezione fenotipica con lâesclusione dei cani con ectopia ureterale extravescicale e/o idrouretere/idronefrosi/incontinenza urinaria, facendo particolare attenzione allâandamento del coefficiente di consanguineitĂ .
Parole chiavi: Uretere ectopico, cane, consanguineitĂ , fenotipo, selezione riproduttiv
The Critical Project in Schelling, Tillich and Goodchild
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