The trophic structure of Spongosorites coralliophaga-coral rubble communities at two northeast Atlantic cold water coral reefs

Funding for the JC073 cruise was provided by the Natural Environment Research Council (NERC) UK Ocean Acidification (UKOA) research programme’s Benthic Consortium project (NE/H017305/1 to J Murray Roberts). Funding for analytical costs and field work was provided by the Marine Alliance for Science and Technology Scotland (MASTS) (Biodiversity Grant to Ursula FM Witte, 140 SF10003-10). Georgios Kazanidis was funded by a MASTS PhD scholarship.Peer reviewedPublisher PD

Electrochemistry of nanozeolite-immobilized cytochrome c in aqueous and nonaqueous solutions

peer-reviewedThe electrochemical properties of cytochrome c (cyt c) immobilized on multilayer nanozeolite-modified electrodes have been examined in aqueous and nonaqueous solutions. Layers of Linde type-L zeolites were assembled on indium tin oxide (ITO) glass electrodes followed by the adsorption of cyt c, primarily via electrostatic interactions, onto modified ITO electrodes. The heme protein displayed a quasi-reversible response in aqueous solution with a redox potential of +324 mV (vs NHE), and the surface coverage (Gamma*) increased linearly for the first four layers and then gave a nearly constant value of 200 pmol cm(-2). On immersion of the modified electrodes in 95% (v/v) nonaqueous solutions, the redox potential decreased significantly, a decrease that originated from changes in both the enthalpy and entropy of reduction. On reimmersion of the modified electrode in buffer, the faradic response immediately returned to its original value. These results demonstrate that nanozeolites are potential stable supports for redox proteins and enzymes.ACCEPTEDpeer-reviewe

Characterization of the Clinical and Immunologic Phenotype and Management of 157 Individuals with 56 Distinct Heterozygous NFKB1 Mutations

Background: An increasing number of NFKB1 variants are being identified in patients with heterogeneous immunologic phenotypes. Objective: To characterize the clinical and cellular phenotype as well as the management of patients with heterozygous NFKB1 mutations. Methods: In a worldwide collaborative effort, we evaluated 231 individuals harboring 105 distinct heterozygous NFKB1 variants. To provide evidence for pathogenicity, each variant was assessed in silico; in addition, 32 variants were assessed by functional in vitro testing of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-κB) signaling. Results: We classified 56 of the 105 distinct NFKB1 variants in 157 individuals from 68 unrelated families as pathogenic. Incomplete clinical penetrance (70%) and age-dependent severity of NFKB1-related phenotypes were observed. The phenotype included hypogammaglobulinemia (88.9%), reduced switched memory B cells (60.3%), and respiratory (83%) and gastrointestinal (28.6%) infections, thus characterizing the disorder as primary immunodeficiency. However, the high frequency of autoimmunity (57.4%), lymphoproliferation (52.4%), noninfectious enteropathy (23.1%), opportunistic infections (15.7%), autoinflammation (29.6%), and malignancy (16.8%) identified NF-κB1-related disease as an inborn error of immunity with immune dysregulation, rather than a mere primary immunodeficiency. Current treatment includes immunoglobulin replacement and immunosuppressive agents. Conclusions: We present a comprehensive clinical overview of the NF-κB1-related phenotype, which includes immunodeficiency, autoimmunity, autoinflammation, and cancer. Because of its multisystem involvement, clinicians from each and every medical discipline need to be made aware of this autosomal-dominant disease. Hematopoietic stem cell transplantation and NF-κB1 pathway-targeted therapeutic strategies should be considered in the future.info:eu-repo/semantics/publishedVersio

Polarized Secretion of Drosophila EGFR Ligand from Photoreceptor Neurons Is Controlled by ER Localization of the Ligand-Processing Machinery

Trafficking within the endoplasmic reticulum and specialized localization of the intra-membrane protease Rhomboid regulate EGF ligand-dependent signaling in Drosophila photoreceptor axon termini

The hermit crab Sympagurus dimorphus (Anomura: Parapaguridae) at the edge of its range in the south-western Atlantic Ocean: population and morphometry features

Sympagurus dimorphus is one of the 12 hermit crab species recorded for Argentinean waters. Despite the high abundance registered in some scallop fishing grounds, its biology remains little known. In the present study, we analysed some population features of S. dimorphus living in symbiosis with Epizoanthus paguricola from a series of samples taken in the Argentine Sea, south-western Atlantic Ocean. Our results showed that S. dimorphus was commonly found from 40ºS to lower latitudes, in a patchy distribution along the shelf-break front. The overall sex ratio was 1:1. The smallest ovigerous female measured 6 mm in cephalothoracic shield length and this size was used as parameter to define the size of juveniles. The sex ratio size class pattern corresponded to Type IV or anomalous curve. S. dimorphus is a dimorphic species, as evidenced by the larger size of the males and the positive allometric growth of the right cheliped. The species also showed asymmetry, with the left uropod always larger than the right one. To the best to our knowledge, this is the first report on population features and relative growth for a member of the genus, based on long-term sampling. This species presents a patchy distribution along the shelf-break of Argentina. Its density tended to decrease over the five-year sampling period regarding the recruitment of hermits associated with colonies of zoanthids. In addition, the relatively homogeneous nature of this refuge does not seem to influence the growth of the hermit crab, which presents sexual dimorphism in relation to the sex/size conditions.Fil: Schejter, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencia Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina. Instituto Nacional de Investigaciones y Desarrollo Pesquero; ArgentinaFil: Mantelatto, Fernando L.. Universidade de Sao Paulo; Brasi

Figure 4 in The hermit crab Sympagurus dimorphus (Anomura: Parapaguridae) at the edge of its range in the south-western Atlantic Ocean: population and morphometry features

Figure 4. Relative growth of the major cheliped propodus length (CHL) in relation to cephalothoracic shield length (CL) in males, female and juveniles (≤ 6 mm CL). Regression equations and coefficient of determination for a potential function are shown.Published as part of Schejter, Laura & Mantelatto, Fernando L., 2015, The hermit crab Sympagurus dimorphus (Anomura: Parapaguridae) at the edge of its range in the south-western Atlantic Ocean: population and morphometry features, pp. 2055-2066 in Journal of Natural History 49 (33) on page 2061, DOI: 10.1080/00222933.2015.1009406, http://zenodo.org/record/399983

Figure 1 in The hermit crab Sympagurus dimorphus (Anomura: Parapaguridae) at the edge of its range in the south-western Atlantic Ocean: population and morphometry features

Figure 1. Sympagurus dimorphus. Densities (number of individuals/100 m2) in the sampling areas from 2002 through 2006. Left column shows presence/absence data including all sampling sites, and right column shows densities on a relative scale.Published as part of Schejter, Laura & Mantelatto, Fernando L., 2015, The hermit crab Sympagurus dimorphus (Anomura: Parapaguridae) at the edge of its range in the south-western Atlantic Ocean: population and morphometry features, pp. 2055-2066 in Journal of Natural History 49 (33) on page 2057, DOI: 10.1080/00222933.2015.1009406, http://zenodo.org/record/399983

Shelter association between the hermit crab Sympagurus dimorphus and the zoanthid Epizoanthus paguricola in the southwestern Atlantic Ocean

Schejter, L. and Mantelatto, F.L. 2011. Shelter association between the hermit crab Sympagurus dimorphus and the zoanthid Epizoanthus paguricola in the southwestern Atlantic Ocean. -Acta Zoologica (Stockholm) 92: 141-149. The available literature on zoanthid-hermit crab associations deals only with records of this phenomenon, providing no detailed information. We describe, for the first time, the shell-like colonies of Epizoanthus paguricola associated with the hermit crab Sympagurus dimorphus from benthic samples taken in the Argentine Sea, between 85 and 131 m depth, and provide information about morphometric relationships between the hermits and the zoanthids. In total, 260 specimens (137 males and 123 females) of S. dimorphus were collected, 240 (92.3%) of which were living in symbiosis with E. paguricola. The remaining 20 (7.7%) were living inside gastropod shells. As the initial structure of the pseudoshell, 12 different gastropod species were found (all were almost totally covered with colonies of E. paguricola). The hermit crab lives in the spiral cavity inside the soft colony, which seemed to be slightly different depending on the initial gastropod. Aperture pseudoshell morphology did not seem to be related to the sex of the hermit crab host, although males showed larger apertures for a given colony size. This fact is probably related to a larger size of male`s cheliped (sexual dimorphic character) used like a gastropod operculum and that may serve as a template for the growing of the aperture pseudoshell edge. The number of epizoanthid polyps per colony increased in relation to the weight of the colony and to the size of the hermit crab. A process of selection of the initial shell was evident, because species of Naticidae were not the most common gastropods in this benthic community, but were those most used by hermit crabs (> 60%). The puzzling association between hermit crab, shell and zoanthid presumably occurs during the hermit juvenile phase, when the crab occupies a small shell, and a zoanthid larva settles on it. Given the close relationship between S. dimorphus and E. paguricola found in this region, we support the idea that due to the low availability of adequate gastropod shells for hermit life cycle, this association allows the establishment and the continuity of the hermit crab population in the studied area.CNPq/PROSULPICT[15080]CONICET[PIP 5009]Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)[490122/2006-0