Molecular cross talk between misfolded proteins in animal models of Alzheimer\u27s and prion diseases.

The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded form of a naturally expressed protein. Despite the diversity of clinical symptoms associated with different PMDs, many similarities in their mechanism suggest that distinct pathologies may cross talk at the molecular level. The main goal of this study was to analyze the interaction of the protein misfolding processes implicated in Alzheimer\u27s and prion diseases. For this purpose, we inoculated prions in an Alzheimer\u27s transgenic mouse model that develop typical amyloid plaques and followed the progression of pathological changes over time. Our findings show a dramatic acceleration and exacerbation of both pathologies. The onset of prion disease symptoms in transgenic mice appeared significantly faster with a concomitant increase on the level of misfolded prion protein in the brain. A striking increase in amyloid plaque deposition was observed in prion-infected mice compared with their noninoculated counterparts. Histological and biochemical studies showed the association of the two misfolded proteins in the brain and in vitro experiments showed that protein misfolding can be enhanced by a cross-seeding mechanism. These results suggest a profound interaction between Alzheimer\u27s and prion pathologies, indicating that one protein misfolding process may be an important risk factor for the development of a second one. Our findings may have important implications to understand the origin and progression of PMDs

Evidence for coal forest refugia in the seasonally dry Pennsylvanian tropical lowlands of the Illinois Basin, USA

The Moscovian plant macroflora at Cottage Grove southeastern Illinois, USA, is a key example of Pennsylvanian (323–299 Million years ago) dryland vegetation. There is currently no palynological data from the same stratigraphic horizons as the plant macrofossils, leaves and other vegetative and reproductive structures, at this locality. Consequently, reconstructions of the standing vegetation at Cottage Grove from these sediments lack the complementary information and a more regional perspective that can be provided by sporomorphs (prepollen, pollen, megaspores and spores). In order to provide this, we have analysed the composition of fossil sporomorph assemblages in two rock samples taken from macrofossil-bearing inter-coal shale at Cottage Grove. Our palynological data differ considerably in composition and in the dominance-diversity profile from the macrofossil vegetation at this locality. Walchian conifers and pteridosperms are common elements in the macroflora, but are absent in the sporomorph assemblages. Reversely, the sporomorph assemblages at Cottage Grove comprise 17 spore taxa (∼16% and ∼63% of the total assemblages) that are known from the lycopsid orders Isoetales, Lepidodendrales and Selaginallales, while Cottage Grove’s macrofloral record fails to capture evidence of a considerable population of coal forest lycopsids. We interpret our results as evidence that the Pennsylvanian dryland glacial landscape at Cottage Grove included fragmented populations of wetland plants living in refugia

Recent Developments in Quarkonium as an Open Quantum System in Quark-Gluon Plasma

We review recent progress in understanding quarkonium dynamics inside the quark-gluon plasma as an open quantum system with a focus on the definition and nonperturbative calculations of relevant transport coefficients and generalized gluon distributions.Comment: 4 pages, contribution to the proceedings of the 9th Workshop for Young Scientists on the Physics of Ultra-relativistic Nucleus-Nucleus Collisions (Hot Quarks 2022

The scattering of phonons by infinitely long quantum dislocations segments and the generation of thermal transport anisotropy in a solid threaded by many parallel dislocations

A canonical quantization procedure is applied to the interaction of elastic waves --phonons-- with infinitely long dislocations that can oscillate about an equilibrium, straight line, configuration. The interaction is implemented through the well-known Peach-Koehler force. For small dislocation excursions away from the equilibrium position, the quantum theory can be solved to all orders in the coupling constant. We study in detail the quantum excitations of the dislocation line, and its interactions with phonons. The consequences for the drag on a dislocation caused by the phonon wind are pointed out. We compute the cross-section for phonons incident on the dislocation lines for an arbitrary angle of incidence. The consequences for thermal transport are explored, and we compare our results, involving a dynamic dislocation, with those of Klemens and Carruthers, involving a static dislocation. In our case, the relaxation time is inversely proportional to frequency, rather than directly proportional to frequency. As a consequence, the thermal transport anisotropy generated on a material by the presence of a highly-oriented array of dislocations is considerably more sensitive to the frequency of each propagating mode, and therefore, to the temperature of the material.Comment: 21 pages, 8 figure

An Overview of Prisoners\u27 Rights: Part II, Conditions of Confinement under the First and Eighth Amendments Symposium - Selected Topics on Constitutional Law - Comment.

Abstract Forthcoming

Adiabatic Hydrodynamization and the Emergence of Attractors: a Unified Description of Hydrodynamization in Kinetic Theory

"Attractor" solutions for the pre-hydrodynamic, far-from-equilibrium, evolution of the matter produced in relativistic heavy ion collisions have emerged as crucial descriptors of the rapid hydrodynamization of quark-gluon plasma (QGP). Adiabatic Hydrodynamization (AH) has been proposed as a framework with which to describe, explain, and predict attractor behavior that draws upon an analogy to the adiabatic approximation in quantum mechanics. In this work, we systematize the description of pre-hydrodynamic attractors in kinetic theory by showing how to use the AH framework to identify these long-lived solutions to which varied initial conditions rapidly evolve, demonstrating the robustness of this framework. In a simplified QCD kinetic theory in the small-angle scattering limit, we use AH to explain both the early- and late-time scaling behavior of a longitudinally expanding gluon gas in a unified framework. In this context, we show that AH provides a unified description of, and intuition for, all the stages of what in QCD would be bottom-up thermalization, starting from a pre-hydrodynamic attractor and ending with hydrodynamization. We additionally discuss the connection between the notions of scaling behavior and adiabaticity and the crucial role of time-dependent coordinate redefinitions in identifying the degrees of freedom of kinetic theories that give rise to attractor solutions. The tools we present open a path to the intuitive explanation of how attractor behavior arises and how the attractor evolves in all stages of the hydrodynamization of QGP in heavy ion collisions.Comment: 63 pages, 20 figure

Critical thinking of young citizens towards news headlines in Chile

Strengthening critical thinking abilities of citizens in the face of news published on the web represents a key challenge for education. Young citizens appear to be vulnerable in the face of poor quality news or those containing nonexplicit ideologies. In the field of data science, computational and statistical techniques have been developed to automatically collect and characterize online news media in real time. Nevertheless, there is still not a lot of interdisciplinary research on how to design data exploration platforms supporting an educational process of critical citizenship. This article explores this opportunity through a case study analyzing critical thinking ability of students when facing news dealing with the social mobilization “No+APF”. From data collected through 4 online exercises conducted by 75 secondary school students, 55 university students and 25 communication specialists, we investigate to what extent young citizens are able to classify news headlines and ideological orientation of news media outlets. We also question the influence of the media’s brand name and the subjectivity of each participant in regards to the social mobilization “No+APF”. The results underline the importance of group work, the influence of the brand name and the correlation between criticalthinking abilities and having a defined opinion