245 research outputs found
Population polygons of tektite specific gravity for various localities in australasia
Comparison of specific gravity of tektites from australia, asia, texas, and czechoslovaki
Customization, extension and reuse of outdated hydrogeological software
Each scientist is specialized in his or her field of research and in the tools that he or she uses during the research in a specified site. Thus, he or she is the most suitable person for improving the tools by overcoming their limitations to realize faster and higher quality analysis. However, most scientists are not software developers. Hence, it is necessary to provide them with an easy approach that enables non-software developers to improve and customize their tools. This paper presents an approach for easily improving and customizing any hydrogeological software. It is the result of experiences with updating several interdisciplinary case studies. The main insights of this approachhave been demonstrated using four examples: MIX (FORTRAN-based), BrineMIX (C++-based), EasyQuim and EasyBal (both spreadsheet-based). The improved software has been proven to be a better tool for enhanced analysis by substantially reducing the computation time and the tedious processing of the input and output data files
The potential of open-access data for flood estimations: uncovering inundation hotspots in Ho Chi Minh City, Vietnam, through a normalized flood severity index
Hydro-numerical models are increasingly important to
determine the adequacy and evaluate the effectiveness of potential flood
protection measures. However, a significant obstacle in setting up
hydro-numerical and associated flood damage models is the tedious and
oftentimes prohibitively costly process of acquiring reliable input data,
which particularly applies to coastal megacities in developing countries and
emerging economies. To help alleviate this problem, this paper explores the
usability and reliability of flood models built on open-access data in
regions where highly resolved (geo)data are either unavailable or difficult
to access yet where knowledge about elements at risk is crucial for
mitigation planning. The example of Ho Chi Minh City, Vietnam, is taken to
describe a comprehensive but generic methodology for obtaining, processing
and applying the required open-access data. The overarching goal of this
study is to produce preliminary flood hazard maps that provide first insights
into potential flooding hotspots demanding closer attention in subsequent,
more detailed risk analyses. As a key novelty, a normalized flood severity
index (INFS), which combines flood depth and duration, is proposed to
deliver key information in a preliminary flood hazard assessment. This index
serves as an indicator that further narrows down the focus to areas where
flood hazard is significant. Our approach is validated by a comparison with
more than 300 flood samples locally observed during three heavy-rain events
in 2010 and 2012 which correspond to INFS-based inundation hotspots in
over 73 % of all cases. These findings corroborate the high potential of
open-access data in hydro-numerical modeling and the robustness of the newly
introduced flood severity index, which may significantly enhance the
interpretation and trustworthiness of risk assessments in the future. The
proposed approach and developed indicators are generic and may be replicated
and adopted in other coastal megacities around the globe.</p
Pressure Dependence of Born Effective Charges, Dielectric Constant and Lattice Dynamics in SiC
The pressure dependence of the Born effective charge, dielectric constant and
zone-center LO and TO phonons have been determined for -SiC by a linear
response method based on the linearized augmented plane wave calculations
within the local density approximation. The Born effective charges are found to
increase nearly linearly with decreasing volume down to the smallest volume
studied, , corresponding to a pressure of about 0.8 Mbar. This
seems to be in contradiction with the conclusion of the turnover behavior
recently reported by Liu and Vohra [Phys.\ Rev.\ Lett.\ {\bf 72}, 4105 (1994)]
for -SiC. Reanalyzing their procedure to extract the pressure dependence of
the Born effective charges, we suggest that the turnover behavior they obtained
is due to approximations in the assumed pressure dependence of the dielectric
constant , the use of a singular set of experimental data
for the equation of state, and the uncertainty in measured phonon frequencies,
especially at high pressure.Comment: 25 pages, revtex, 5 postscript figures appended, to be published in
Phys. Rev.
Low-regret climate change adaptation in coastal megacities – evaluating large-scale flood protection and small-scale rainwater detention measures for Ho Chi Minh City, Vietnam
Urban flooding is a major challenge for many megacities
in low-elevation coastal zones (LECZs), especially in Southeast Asia. In
these regions, the effects of environmental stressors overlap with rapid
urbanization, which significantly aggravates the hazard potential. Ho Chi
Minh City (HCMC) in southern Vietnam is a prime example of this set of
problems and therefore a suitable case study to apply the concept of
low-regret disaster risk adaptation as defined by the Intergovernmental
Panel on Climate Change (IPCC). In order to explore and evaluate potential
options of hazard mitigation, a hydro-numerical model was employed to
scrutinize the effectiveness of two adaptation strategies: (1) a classic
flood protection scheme including a large-scale ring dike as currently
constructed in HCMC and (2) the widespread installation of small-scale
rainwater detention as envisioned in the framework of the Chinese Sponge
City Program (SCP). A third adaptation scenario (3) assesses the combination of both approaches (1) and (2).
From a hydrological point of view, the reduction in various flood intensity
proxies that were computed within this study suggests that large-scale flood protection is comparable but slightly more effective than small-scale
rainwater storage: for instance, the two adaptation options could reduce the normalized flood severity index (INFS), which is a measure combining flood depth and duration, by 17.9 % and 17.7 %, respectively. The
number of flood-prone manufacturing firms that would be protected after
adaptation, in turn, is nearly 2 times higher for the ring dike than for
the Sponge City approach. However, the numerical results also reveal that
both response options can be implemented in parallel, not only without
reducing their individual effectiveness but also complementarily with
considerable added value. Additionally, from a governance perspective,
decentralized rainwater storage conforms ideally to the low-regret paradigm:
while the existing large-scale ring dike depends on a binary commitment (to
build or not to build), decentralized small- and micro-scale solutions can
be implemented gradually (for example through targeted subsidies) and add
technical redundancy to the overall system. In the end, both strategies are
highly complementary in their spatial and temporal reduction in flood
intensity. Local decision-makers may hence specifically seek combined
strategies, adding to singular approaches, and design multi-faceted
adaptation pathways in order to successfully prepare for a deeply uncertain
future.</p
Seasonal differences of corticosterone metabolite concentrations and parasite burden in northern bald ibis (Geronticus eremita): The role of affiliative interactions
The reproductive season is energetically costly as revealed by elevated glucocorticoid concentrations, constrained immune functions and an increased risk of infections. Social allies and affiliative interactions may buffer physiological stress responses and thereby alleviate associated effects. In the present study, we investigated the seasonal differences of immune reactive corticosterone metabolite concentrations, endoparasite burden (nematode eggs and coccidian oocysts) and affiliative interactions in northern bald ibis (Geronticus eremita), a critically endangered bird. In total, 43 individually marked focal animals from a freeranging colony were investigated. The analyses included a description of initiated and received affiliative interactions, pair bond status as well as seasonal patterns of hormone and endoparasite levels. During the reproductive season, droppings contained parasite eggs more often and corticosterone metabolite levels were higher as compared to the period after reproduction. The excretion rate of endoparasite products was lower in paired individuals than in unpaired ones, but paired animals exhibited higher corticosterone metabolite concentrations than unpaired individuals. Furthermore, paired individuals initiated affiliative behaviour more frequently than unpaired ones. This suggests that the reproductive season influences the excretion patterns of endoparasite products and corticosterone metabolites and that affiliative interactions between pair partners may positively affect endoparasite burden during periods of elevated glucocorticoid levels. Being embedded in a pair bond may have a positive impact on individual immune system and parasite resistance
Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds
<p>Abstract</p> <p>Background</p> <p>Since the classic Hopkins and Groom druggable genome review in 2002, there have been a number of publications updating both the hypothetical and successful human drug target statistics. However, listings of research targets that define the area between these two extremes are sparse because of the challenges of collating published information at the necessary scale. We have addressed this by interrogating databases, populated by expert curation, of bioactivity data extracted from patents and journal papers over the last 30 years.</p> <p>Results</p> <p>From a subset of just over 27,000 documents we have extracted a set of compound-to-target relationships for biochemical <it>in vitro </it>binding-type assay data for 1,736 human proteins and 1,654 gene identifiers. These are linked to 1,671,951 compound records derived from 823,179 unique chemical structures. The distribution showed a compounds-per-target average of 964 with a maximum of 42,869 (Factor Xa). The list includes non-targets, failed targets and cross-screening targets. The top-278 most actively pursued targets cover 90% of the compounds. We further investigated target ranking by determining the number of molecular frameworks and scaffolds. These were compared to the compound counts as alternative measures of chemical diversity on a per-target basis.</p> <p>Conclusions</p> <p>The compounds-per-protein listing generated in this work (provided as a supplementary file) represents the major proportion of the human drug target landscape defined by published data. We supplemented the simple ranking by the number of compounds assayed with additional rankings by molecular topology. These showed significant differences and provide complementary assessments of chemical tractability.</p
Law, Environment, and the “Nondismal” Social Sciences
Over the past 30 years, the influence of economics over the study of environmental law and policy has expanded considerably, becoming in the process the predominant framework for analyzing regulations that address pollution, natural resource use, and other environmental issues. This review seeks to complement the expansion of economic reasoning and methodology within the field of environmental law and policy by identifying insights to be gleaned from various “nondismal” social sciences. In particular, three areas of inquiry are highlighted as illustrative of interdisciplinary work that might help to complement law and economics and, in some cases, compensate for it: the study of how human individuals perceive, judge, and decide; the observation and interpretation of how knowledge schemes are created, used, and regulated; and the analysis of how states and other actors coordinate through international and global regulatory regimes. The hope is to provide some examples of how environmental law and policy research can be improved by deeper and more diverse engagement with social science
Influence of surface atomic structure demonstrated on oxygen incorporation mechanism at a model perovskite oxide
Perovskite oxide surfaces catalyze oxygen exchange reactions that are crucial for fuel cells, electrolyzers, and thermochemical fuel synthesis. Here, by bridging the gap between surface analysis with atomic resolution and oxygen exchange kinetics measurements, we demonstrate how the exact surface atomic structure can determine the reactivity for oxygen exchange reactions on a model perovskite oxide. Two precisely controlled surface reconstructions with (4 × 1) and (2 × 5) symmetry on 0.5 wt.% Nb-doped SrTiO3(110) were subjected to isotopically labeled oxygen exchange at 450 °C. The oxygen incorporation rate is three times higher on the (4 × 1) surface phase compared to the (2 × 5). Common models of surface reactivity based on the availability of oxygen vacancies or on the ease of electron transfer cannot account for this difference. We propose a structure-driven oxygen exchange mechanism, relying on the flexibility of the surface coordination polyhedra that transform upon dissociation of oxygen molecules.Austrian Science Fund (SFB “ Functional Oxide Surfaces and Interfaces ” - FOXSI, Project F 45)European Research Council Advanced Grant (“OxideSurfaces” (Project ERC-2011-ADG_20110209))National Science Foundation (U.S.). Division of Materials Research (CAREER Award Grant No. 1055583
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