Self-directed passive-aggressive behaviour as an essential component of depression: findings from two cross-sectional observational studies

Background: The self-control model of depression suggests depressive symptoms to derive from distorted self-monitoring, dysfunctional self-evaluation and reduced self-reward as well as increased self-punishment. Building on this model a relationship between self-directed passive-aggressive behaviour, that is, harmful inactivity, and depression has been assumed. This association has been supported by a recent study in an inpatient sample. However, it remains unclear if patients with depressive disorders report more self-directed passive-aggressive behaviour than patients without depressive disorders and if self-directed passive aggression mediates the associations between distorted selfmonitoring and dysfunctional self-evaluation with depressive symptoms. Methods: Study 1 compared self-directed passive-aggressive behaviour levels between 220 psychotherapy outpatients with (n=140; 67.9% female; Mage=40.0) and without (n=80; 65.0% female; Mage=36.2) depressive disorders. Diagnoses were made based on the Structured Clinical Interview for DSM-IV. Study 2 examined self-directed passiveaggressive behaviour as a mediator of the relationship between distorted self-monitoring and dysfunctional selfevaluation and self-reported depressive symptoms in 200 undergraduate Psychology students. Results: Compared to outpatients without depressive disorders, outpatients with depressive disorder reported signifcantly more self-directed passive aggression (d=0.51). Furthermore, Study 2 verifed self-directed passiveaggressive behaviour as a partial mediator of the relationship between dysfunctional attitudes (abcs=.22, 95%-CI: .14, .31), attributional style (abcs=.20, 95%-CI: .13, .27), ruminative response style (abcs=.15, 95%-CI: .09, .21) and depressive symptoms. Conclusion: Self-directed passive-aggressive behaviour partially mediates the association between distorted selfmonitoring and dysfunctional self-evaluation with depressive symptoms. Future longitudinal studies need to examine a potential causal relationship that would form a base to include interventions targeting self-directed passive-aggressive behaviour in prevention and treatment of depression. Trial registration: Both studies were preregistered at the German Clinical Trials Register (DRKS00014005 and DRKS00019020)

Can One Hear the Shape of a Graph?

We show that the spectrum of the Schrodinger operator on a finite, metric graph determines uniquely the connectivity matrix and the bond lengths, provided that the lengths are non-commensurate and the connectivity is simple (no parallel bonds between vertices and no loops connecting a vertex to itself). That is, one can hear the shape of the graph! We also consider a related inversion problem: A compact graph can be converted into a scattering system by attaching to its vertices leads to infinity. We show that the scattering phase determines uniquely the compact part of the graph, under similar conditions as above.Comment: 9 pages, 1 figur

Scars on quantum networks ignore the Lyapunov exponent

We show that enhanced wavefunction localization due to the presence of short unstable orbits and strong scarring can rely on completely different mechanisms. Specifically we find that in quantum networks the shortest and most stable orbits do not support visible scars, although they are responsible for enhanced localization in the majority of the eigenstates. Scarring orbits are selected by a criterion which does not involve the classical Lyapunov exponent. We obtain predictions for the energies of visible scars and the distributions of scarring strengths and inverse participation ratios.Comment: 5 pages, 2 figure

Form factor for large quantum graphs: evaluating orbits with time-reversal

It has been shown that for a certain special type of quantum graphs the random-matrix form factor can be recovered to at least third order in the scaled time \tau using periodic-orbit theory. Two types of contributing pairs of orbits were identified, those which require time-reversal symmetry and those which do not. We present a new technique of dealing with contribution from the former type of orbits. The technique allows us to derive the third order term of the expansion for general graphs. Although the derivation is rather technical, the advantages of the technique are obvious: it makes the derivation tractable, it identifies explicitly the orbit configurations which give the correct contribution, it is more algorithmical and more system-independent, making possible future applications of the technique to systems other than quantum graphs.Comment: 25 pages, 14 figures, accepted to Waves in Random Media (special issue on Quantum Graphs and their Applications). Fixed typos, removed an overly restrictive condition (appendix), shortened introductory section

Real-world outcomes in elderly ALL patients with and without allogeneic hematopoietic stem cell transplantation: a single-center evaluation over 10 years

Elderly patients (EP) of 60 years and above with acute lymphoblastic leukemia (ALL) have a dismal prognosis, but pediatric-inspired chemotherapy and allogeneic stem cell transplantation (allo HCT) are used reluctantly due to limited data and historical reports of high treatment-related mortality in EP. We analyzed 130 adult ALL patients treated at our center between 2009 and 2019, of which 26 were EP (range 60-76 years). Induction with pediatric-inspired protocols was feasible in 65.2% of EP and resulted in complete remission in 86.7% compared to 88.0% in younger patients (YP) of less than 60 years. Early death occurred in 6.7% of EP. Three-year overall survival (OS) for Ph - B-ALL was significantly worse for EP (n = 16) than YP (n = 64) with 30.0% vs 78.1% (p ≤ 0.001). Forty-nine patients received allo HCT including 8 EP, for which improved 3-year OS of 87.5% was observed, whereas EP without allo HCT died after a median of 9.5 months. In Ph + B-ALL, 3-year OS did not differ between EP (60.0%, n = 7) and YP (70.8%, n = 19). Non-relapse mortality and infection rate were low in EP (14.3% and 12.5%, respectively). Our data indicate that selected EP can be treated effectively and safely with pediatric regimens and might benefit from intensified therapy including allo HCT. Keywords: Acute lymphoblastic leukemia; Allogeneic hematopoietic stem cell transplantation; Elderly; Treatmen

FlashCam: A fully digital camera for CTA telescopes

The future Cherenkov Telescope Array (CTA) will consist of several tens of telescopes of different mirror sizes. CTA will provide next generation sensitivity to very high energy photons from few tens of GeV to >100 TeV. Several focal plane instrumentation options are currently being evaluated inside the CTA consortium. In this paper, the current status of the FlashCam prototyping project is described. FlashCam is based on a fully digital camera readout concept and features a clean separation between photon detector plane and signal digitization/triggering electronics.Comment: In Proceedings of the 2012 Heidelberg Symposium on High Energy Gamma-Ray Astronomy. All CTA contributions at arXiv:1211.184