In utero DDT and DDE exposure and obesity status of 7-year-old Mexican-American children in the CHAMACOS cohort.

BackgroundIn utero exposure to endocrine disrupting compounds including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity later in life.ObjectivesThe Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study is a longitudinal birth cohort of low-income Latinas living in a California agricultural community. We examined the relation of in utero DDT and DDE exposure to child obesity at 7 years of age. We also examined the trend with age (2, 3.5, 5, and 7 years) in the exposure-obesity relation.MethodsWe included 270 children with o,p´-DDT, p,p´-DDT, and p,p´-DDE concentrations measured in maternal serum during pregnancy (nanograms per gram lipid) and complete 7-year follow-up data including weight (kilograms) and height (centimeters). Body mass index (BMI; kilograms per meter squared) was calculated and obesity was defined as ≥ 95th percentile on the sex-specific BMI-for-age Centers for Disease Control and Prevention 2000 growth charts.ResultsAt 7 years, 96 (35.6%) children were obese. A 10-fold increase in o,p´-DDT, p,p´-DDT, or p,p´-DDE, was nonsignificantly associated with increased odds (OR) of obesity [o,p´-DDT adjusted (adj-) OR = 1.17, 95% CI: 0.75, 1.82; p,p´-DDT adj-OR = 1.19, 95% CI: 0.81, 1.74; p,p´-DDE adj-OR = 1.22, 95% CI: 0.72, 2.06]. With increasing age at follow-up, we observed a significant trend toward a positive association between DDT and DDE exposure and odds of obesity.ConclusionWe did not find a significant positive relation between in utero DDT and DDE exposure and obesity status of 7-year-old children. However, given the observed trend with age, continued follow-up will be informative

Magnetic coupling in colloidal clusters for hierarchical self-assembly

Manipulating the way in which colloidal particles self-organise is a central challenge in the design of functional soft materials. Meeting this challenge requires the use of building blocks that interact with one another in a highly specific manner. Their fabrication, however, is limited by the complexity of the available synthesis procedures. Here, we demonstrate that, starting from experimentally available magnetic colloids, we can create a variety of complex building blocks suitable for hierarchical self-organisation using a simple scalable process. Using computer simulations, we compress spherical and cubic magnetic colloids in spherical confinement, and investigate their suitability to form small clusters with reproducible structural and magnetic properties. We find that, while the structure of these clusters is highly reproducible, their magnetic character depends on the particle shape. Only spherical particles have the rotational degrees of freedom to produce consistent magnetic configurations, whereas cubic particles frustrate the minimisation of the cluster energy, resulting in various magnetic configurations. To highlight their potential for self-assembly, we demonstrate that already clusters of three magnetic particles form highly nontrivial Archimedean lattices, namely staggered kagome, bounce and honeycomb, when viewing different aspects of the same monolayer structure. The work presented here offers a conceptually different way to design materials by utilizing pre-assembled magnetic building blocks that can readily self-organise into complex structures.Comment: Main text: 13 pages, 6 figures. SI:14 pages, 11 figure

Extended Wertheim theory predicts the anomalous chain length distributions of divalent patchy particles under extreme confinement

Colloidal patchy particles with divalent attractive interaction can self-assemble into linear polymer chains. Their equilibrium properties in 2D and 3D are well described by Wertheim's thermodynamic perturbation theory which predicts a well-defined exponentially decaying equilibrium chain length distribution. In experimental realizations, due to gravity, particles sediment to the bottom of the suspension forming a monolayer of particles with a gravitational height smaller than the particle diameter. In accordance with experiments, an anomalously high monomer concentration is observed in simulations which is not well understood. To account for this observation, we interpret the polymerization as taking place in a highly confined quasi-2D plane and extend the Wertheim thermodynamic perturbation theory by defining addition reactions constants as functions of the chain length. We derive the theory, test it on simple square well potentials, and apply it to the experimental case of synthetic colloidal patchy particles immersed in a binary liquid mixture that are described by an accurate effective critical Casimir patchy particle potential. The important interaction parameters entering the theory are explicitly computed using the integral method in combination with Monte Carlo sampling. Without any adjustable parameter, the predictions of the chain length distribution are in excellent agreement with explicit simulations of self-assembling particles. We discuss generality of the approach, and its application range.Comment: The following article has been submitted to The Journal of Chemical Physic

Shape and Interaction Decoupling for Colloidal Pre-Assembly

Creating materials with a structural hierarchy that is independently controllable at a range of scales requires breaking naturally occurring hierarchies. Breaking natural hierarchies is possible if building block attributes can be decoupled from the structure of pre-assembled, mesoscale building blocks that form the next level in the structural hierarchy. Here, we show that pre-assembled colloidal structures achieving geometric and interaction decoupling can be prepared in emulsions of silica superballs, which are cubic-like particles with rounded edges. We show that, for clusters of up to nine particles, colloidal superballs pack consistently like spheres, despite the presence of shape anisotropy and facets in the cubic-like particles. We compare our results with clusters prepared with magnetic superballs and find good qualitative agreement, suggesting that the cluster geometries are solely determined by the shape of the constituent particles. Our findings demonstrate that highly shape-anisotropic building blocks, under suitable conditions, can be pre-assembled into structures that are not found in bulk, thereby achieving a decoupling that can be further exploited for hierarchical materials development.Comment: 22 pages, 7 figure

Incentivizing High Quality Crowdwork

We study the causal effects of financial incentives on the quality of crowdwork. We focus on performance-based payments (PBPs), bonus payments awarded to workers for producing high quality work. We design and run randomized behavioral experiments on the popular crowdsourcing platform Amazon Mechanical Turk with the goal of understanding when, where, and why PBPs help, identifying properties of the payment, payment structure, and the task itself that make them most effective. We provide examples of tasks for which PBPs do improve quality. For such tasks, the effectiveness of PBPs is not too sensitive to the threshold for quality required to receive the bonus, while the magnitude of the bonus must be large enough to make the reward salient. We also present examples of tasks for which PBPs do not improve quality. Our results suggest that for PBPs to improve quality, the task must be effort-responsive: the task must allow workers to produce higher quality work by exerting more effort. We also give a simple method to determine if a task is effort-responsive a priori. Furthermore, our experiments suggest that all payments on Mechanical Turk are, to some degree, implicitly performance-based in that workers believe their work may be rejected if their performance is sufficiently poor. Finally, we propose a new model of worker behavior that extends the standard principal-agent model from economics to include a worker's subjective beliefs about his likelihood of being paid, and show that the predictions of this model are in line with our experimental findings. This model may be useful as a foundation for theoretical studies of incentives in crowdsourcing markets.Comment: This is a preprint of an Article accepted for publication in WWW \c{opyright} 2015 International World Wide Web Conference Committe

Colloidal aggregation in microgravity by critical Casimir forces

By using the critical Casimir force, we study the attractive strength dependent aggregation of colloids with and without gravity by means of Near Field scattering. Significant differences were seen between microgravity and ground experiments, both in the structure of the formed fractal aggregates as well as the kinetics of growth. Ground measurements are severely affected by sedimentation resulting in reaction limited behavior. In microgravity, a purely diffusive behavior is seen reflected both in the measured fractal dimensions for the aggregates as well as the power law behavior in the rate of growth. Formed aggregates become more open as the attractive strength increases.Comment: 4 pages, 3 figure