Determination of equivalent uniform live load "envelopes" for the simplification of methods used in the design of highway bridges

M.S.Boris W. Boguslavsk

A Look at the California Records Act and Its Exemptions

Authors: Edward M. Schaffer, et al

Strategies to Obtain Maximum Usage of Enterprise Resource Planning Systems

Business organizations invest significant resources implementing enterprise resource planning (ERP) systems, yet some organizations utilize less than 75% of the ERP system capabilities. The purpose of this single-site case study was to explore ERP utilization strategies implemented by 4 managers in the information technology (IT) department from 1 organization that uses an ERP system in the Midwest region of the United States. The conceptual framework that grounded this study was the user participation theory. Data were collected through participant interviews and analyzed using traditional text analysis. Member checking was used to strengthen the credibility and trustworthiness of the interpretation of the participants\u27 responses. The emergent themes from the study were user participation, user involvement, user attitude, user system satisfaction, and user preparation. The most prominent utilization strategies identified by the participants related to the user participation theme. The implications for positive social change include the potential optimization of benefits from the ERP system that could allow the organization\u27s leaders to direct their resources to causes that can improve the health and welfare of the geographic population in the operational region

A Look at the California Records Act and Its Exemptions

Authors: Edward M. Schaffer, et al

STATUS OF COMPOUND DRC-1339 REGISTRATIONS

Compound DRC-1339 is a restricted-use, slow-acting avicide that is registered to control a number of avian pests. It is unique because of its selective high toxicity to most pest birds, low-to-moderate toxicity to most mammals and predatory birds, and lack of known secondary hazards when used on baits. The most widely known product containing DRC- 1339 is Purina Mills’ Starlicide Complete®, a pelleted bait used to control blackbirds and starlings in feedlots. Other DRC- 1339 registrations are held by the U.S. Department of Agriculture, Animal and Plant Health Inspection Service (USDA/APHIS), for the use of nonpelletized baits at feedlots and for the control of gulls in or near their nesting colonies. Over 20 State Special Local Need 24(c) registrations have also been issued to APHIS for special DRC-1339 uses. To consolidate these registrations, APHIS has submitted data to amend its feedlot registration for blackbirds and starlings, and applied for three registrations for control of 1) raven and crow depredations on livestock and for wildlife protection, 2) pigeons in and around structures, and 3) blackbirds, starlings, and crows at preroosting staging areas. Because most of the submitted data were collected in the 1960s and 1970s, none of it was produced under the Environmental Protection Agency\u27s (EPA) Good Laboratory Practices (GLP) regulations; therefore, new data will probably be needed to support these registrations. Future data needs and procedures for collecting valid information for DRC-1339 are suggested

Hope Agency and Hope Pathways as Potential Mediators of Trauma Exposure and Psychological Adjustment in Emerging Adults

The present study examined hope as a mediator between trauma exposure and negative affective conditions in 490 college students. Hope agency, but not hope pathways, mediated some of the association. Trauma exposure maintained a significant association with negative affective conditions. Implications for counselors working with trauma-exposed college students are discussed

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

BACKGROUND: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. METHOD: Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON). RESULTS: A 28-gene signature was derived. Patients with high signature scores had poorer biochemical recurrence free survivals in six of eight independent cohorts of prostatectomy-treated patients (Log rank test P \u3c .05), with borderline significances achieved in the other two (P \u3c .1). The signature also predicted biochemical recurrence in patients receiving post-prostatectomy radiotherapy (n = 130, P = .007) or definitive radiotherapy alone (n = 248, P = .035). Lastly, the signature predicted metastasis events in a pooled cohort (n = 631, P = .002). Prognostic significance remained after adjusting for clinic-pathological factors and commercially available prognostic signatures. The signature predicted benefit from hypoxia-modifying therapy in bladder cancer patients (intervention-by-signature interaction test P = .0026), where carbogen and nicotinamide was associated with improved survival only in hypoxic tumours. CONCLUSION: A 28-gene hypoxia signature has strong and independent prognostic value for prostate cancer patients

Risk factors for mesh/suture erosion following sacral colpopexy

To identify risks for mesh/suture erosions following sacrocolpopexy (ASC)

Molecular Characterization of Podoviral Bacteriophages Virulent for Clostridium perfringens and Their Comparison with Members of the Picovirinae

Clostridium perfringens is a Gram-positive, spore-forming anaerobic bacterium responsible for human food-borne disease as well as non-food-borne human, animal and poultry diseases. Because bacteriophages or their gene products could be applied to control bacterial diseases in a species-specific manner, they are potential important alternatives to antibiotics. Consequently, poultry intestinal material, soil, sewage and poultry processing drainage water were screened for virulent bacteriophages that lysed C. perfringens. Two bacteriophages, designated ΦCPV4 and ΦZP2, were isolated in the Moscow Region of the Russian Federation while another closely related virus, named ΦCP7R, was isolated in the southeastern USA. The viruses were identified as members of the order Caudovirales in the family Podoviridae with short, non-contractile tails of the C1 morphotype. The genomes of the three bacteriophages were 17.972, 18.078 and 18.397 kbp respectively; encoding twenty-six to twenty-eight ORF's with inverted terminal repeats and an average GC content of 34.6%. Structural proteins identified by mass spectrometry in the purified ΦCP7R virion included a pre-neck/appendage with putative lyase activity, major head, tail, connector/upper collar, lower collar and a structural protein with putative lysozyme-peptidase activity. All three podoviral bacteriophage genomes encoded a predicted N-acetylmuramoyl-L-alanine amidase and a putative stage V sporulation protein. Each putative amidase contained a predicted bacterial SH3 domain at the C-terminal end of the protein, presumably involved with binding the C. perfringens cell wall. The predicted DNA polymerase type B protein sequences were closely related to other members of the Podoviridae including Bacillus phage Φ29. Whole-genome comparisons supported this relationship, but also indicated that the Russian and USA viruses may be unique members of the sub-family Picovirinae