Materials characterization on efforts for ablative materials

Experimental efforts to develop a new procedure to measure char depth in carbon phenolic nozzle material are described. Using a Shor Type D Durometer, hardness profiles were mapped across post fired sample blocks and specimens from a fired rocket nozzle. Linear regression was used to estimate the char depth. Results are compared to those obtained from computed tomography in a comparative experiment. There was no significant difference in the depth estimates obtained by the two methods

Neural Mechanism of a Sex-Specific Risk Variant for Posttraumatic Stress Disorder in the Type I Receptor of the Pituitary Adenylate Cyclase Activating Polypeptide

AbstractBackgroundPosttraumatic stress disorder (PTSD) is a frequent anxiety disorder with higher prevalence rates in female patients than in male patients (2.5:1). Association with a single nucleotide polymorphism (rs2267735) in the gene ADCYAP1R1 encoding the type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been reported with PTSD in female patients. We sought to identify the neural correlates of the described PAC1-R effects on associative learning.MethodsIn a reverse genetic approach, we examined two independent healthy samples (N1 = 112, N2 = 73) using functional magnetic resonance imaging during cued and contextual fear conditioning. Skin conductance responses and verbal self-reports of arousal, valence, and contingency were recorded.ResultsWe found that PAC1-R modulates the blood oxygenation level–dependent response of the hippocampus. Specifically, we observed decreased hippocampal activity during contextual, but not during cued, fear conditioning in female participants carrying the PAC1-R risk allele. We observed no significant differences in conditionability for skin conductance responses, verbal reports, or activation in other brain regions between the genotype groups in female participants.ConclusionsOur results suggest that impaired contextual conditioning in the hippocampal formation may mediate the association between PAC1-R and PTSD symptoms. Our findings potentially identify a missing link between the involvement of PAC1-R in PTSD and the well-established structural and functional hippocampal deficits in these patients

Use of gene expression profiling to identify candidate genes for pretherapeutic patient classification in acute appendicitis

Background: Phlegmonous and gangrenous appendicitis represent independent pathophysiological entities with different clinical courses ranging from spontaneous resolution to septic disease. However, reliable predictive methods for these clinical phenotypes have not yet been established. In an attempt to provide pathophysiological insights into the matter, a genomewide gene expression analysis was undertaken in patients with acute appendicitis. Methods: Peripheral blood mononuclear cells were isolated and, after histological confirmation of PA or GA, analysed for genomewide gene expression profiling using RNA microarray technology and subsequent pathway analysis. Results: Samples from 29 patients aged 7–17 years were included. Genomewide gene expression analysis was performed on 13 samples of phlegmonous and 16 of gangrenous appendicitis. From a total of 56 666 genes, 3594 were significantly differently expressed. Distinct interaction between T and B cells in the phlegmonous appendicitis group was suggested by overexpression of T cell receptor α and β subunits, CD2, CD3, MHC II, CD40L, and the B cell markers CD72 and CD79, indicating an antiviral mechanism. In the gangrenous appendicitis group, expression of genes delineating antibacterial mechanisms was found. Conclusion: These results provide evidence for different and independent gene expression in phlegmonous and gangrenous appendicitis in general, but also suggest distinct immunological patterns for the respective entities. In particular, the findings are compatible with previous evidence of spontaneous resolution in phlegmonous and progressive disease in gangrenous appendicitis

Magnetic fields in solar plage regions: insights from high-sensitivity spectropolarimetry

Plage regions are patches of concentrated magnetic field in the Sun's atmosphere where hot coronal loops are rooted. While previous studies have shed light on the properties of plage magnetic fields in the photosphere, there are still challenges in measuring the overlying chromospheric magnetic fields, which are crucial to understanding the overall heating and dynamics. Here, we utilize high-sensitivity, spectropolarimetric data obtained by the four-meter Daniel K. Inouye Solar Telescope (DKIST) to investigate the dynamic environment and magnetic field stratification of an extended, decaying plage region. The data show strong circular polarization signals in both plage cores and surrounding fibrils. Notably, weak linear polarization signals clearly differentiate between plage patches and the fibril canopy, where they are relatively stronger. Inversions of the Ca II 8542 $\mathring{A}$ spectra show an imprint of the fibrils in the chromospheric magnetic field, with typical field strength values ranging from $\sim$ 200-300 G in fibrils. We confirm the weak correlation between field strength and cooling rates in the lower chromosphere. Additionally, we observe supersonic downflows and strong velocity gradients in the plage periphery, indicating dynamical processes occurring in the chromosphere. These findings contribute to our understanding of the magnetic field and dynamics within plages, emphasizing the need for further research to explore the expansion of magnetic fields with height and the three-dimensional distribution of heating rates in the lower chromosphere.Comment: 17 pages, 8 figures, accepted for publication in ApJ

Das NDICEA-Modell zur Abbildung der Stickstoffdynamik im ökologischen Gemüsebau

Der NDICEA-Ansatz zur Stickstoffmodellierung kombiniert Bewirtschaftungs- und Wetterdaten, um den Umsatz organischer Substanzen zu berechnen. Die Ergebnisse der Modellierung des ökologischen Gartenbaus unterstreichen den Einfluss der Bodenbearbeitung auf die Stickstoffmineralisierung

Word frequency in fast priming: Evidence for immediate cognitive control of eye movements during reading

Numerous studies have demonstrated effects of word frequency on eye movements during reading, but the precise timing of this influence has remained unclear. The fast priming paradigm (Sereno & Rayner, 1992) was previously used to study influences of related versus unrelated primes on the target word. Here, we used this procedure to investigate whether the frequency of the prime word has a direct influence on eye movements during reading when the prime-target relation is not manipulated. We found that with average prime intervals of 32 ms readers made longer single fixation durations on the target word in the low than in the high frequency prime condition. Distributional analyses demonstrated that the effect of prime frequency on single fixation durations occurred very early, supporting theories of immediate cognitive control of eye movements. Finding prime frequency effects only 207 ms after visibility of the prime and for prime durations of 32 ms yields new time constraints for cognitive processes controlling eye movements during reading. Our variant of the fast priming paradigm provides a new approach to test early influences of word processing on eye movement control during reading