OC-0441: Genomic amplification of FancA in HNSCC: mechanisms of radioresistance and clinical relevance

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Sun stanshe

Розглянута структура фотоелектричної станції середньої потужності з можливістю передачі енергії в промислову мережу. Запропоновані рішення для спрощення схемотехніки перетворювальної частини сонячної станції, спрямовані на зниження її собівартості. Проведено експериментальні дослідження особливостей функціонування сонячної станції. Розглянуто можливі аварійні режими роботи сонячної станції та надано рекомендації щодо їх усунення. Проведено аналіз експериментальних досліджень і на їх основі запропоновано шляхи підвищення ККД станції.The structure of a small-scale photovoltaic station, which can be used on single structures, is considered. At the same time, it is desirable to have a backup the battery on accumulators for reliable power supply and to be connected to the industrial network. Thus, the structure of the photovoltaic station, which has the ability to accumulate energy in the battery on accumulators and transfer the remnants to the industrial network, using it as a reservoir of infinite capacity, is proposed. The influence on the production of electricity from the photovoltaic station is shown due to the unevenness of the illumination of the surface of the solar panels

UPDATE OF THE EUROTOP MANUAL: NEW INSIGHTS ON WAVE OVERTOPPING

Quite some new insights on wave overtopping were achieved since the first submission of the EurOtop Manual in 2007, which have now resulted in a second edition of this Manual. A major improvement has been made on the understanding of wave by wave overtopping and tolerable wave overtopping that is connected to it. Many videos are available on the overtopping website that show all kind of overtopping discharges and volumes and may give guidance for the user of the Manual. The EurOtop Neural Network and the EurOtop database are improved and extended versions of the earlier NN and CLASH database. New insights and prediction formulae have been developed for very low freeboards; for very steep slopes up to vertical walls; for run-up on steep slopes; for overtopping on storm walls on a promenade; and for overtopping on vertical walls, where overtopping has been divided in situations with and without an influencing foreshore and where the first situation may be divided in non-impulsive and impulsive overtopping

Strengthening resilience in reconstruction after extreme events – Insights from flood affected communities in Germany

Disaster resilience and building back better (BBB) are key concepts in the disaster risk and resilience discourse; however, these concepts often remain vague for many stakeholders involved in recovery. Based on the reconstruction process in Germany after the extreme floods of 2021 that caused more than 180 deaths, we explore challenges and opportunities to strengthen resilient recovery in one of the world's wealthiest and most technologically advanced countries. We examine factors that contributed to severe losses and damages and assess different phases of the reconstruction process. In addition, we identify and discuss measures to support resilience building, focusing particularly on issues of land management, planning and infrastructure. Our findings provide new insights into how funding schemes and planning approaches contribute to or block resilience building and BBB. The results are also highly relevant for other world regions hit by extreme events and for the international discourse on disaster resilience, loss and damage and BBB, for example, how funding arrangements and quality criteria need to be designed to support disaster resilient reconstruction

Overview of converting abandoned coal mines to underground pumped storage systems: Focus on the underground reservoir

The utilization of Underground Pumped Storage Power Systems (UPSP) addresses the growing need for energy storage in the face of increasing intermittent energy sources. Simultaneously, the closure of mining activities has resulted in vast underground spaces potentially becoming available for alternative purposes. This paper explores the potential of repurposing abandoned mines, particularly coal mines, as lower reservoirs for UPSPs. The challenges associated with employing abandoned mines as lower reservoirs are multifaceted. The foremost challenge stems from limited knowledge about the current state of the mines due to post-mining processes, such as weathering, dissolution, hydration, leaching, swelling, slacking, subsidence, creeping along faults, gas migration, and precipitation, along with corrosion and deterioration of the support elements. This study documents and discusses the various processes related to cyclical pumping and discharge within the context of UPSPs, encompassing hydraulic discharge processes, cyclic loading, dry and wet processes, as well as fatigue and thermal stress. These processes significantly impact the safety, productivity, and stability of the lower reservoir. To address these challenges, the paper presents different numerical solutions available to comprehend and mitigate cyclical processes in abandoned mines. Finally, it explores the economic feasibility of repurposing mines as lower reservoirs and the conditions required are examined, including favorable rock mass properties, reduced land acquisition costs, the necessity of permanent water pumping, and the potential income from excavated rock as a revenue source in case of new excavations. This research contributes to the understanding of utilizing abandoned mines for UPSPs, highlighting the challenges associated with the use of coal mines as lower reservoirs and presenting several main processes to prevent safety and productivity issues

Tools for the Improvement of the Efficiency and Sustainability of Shore Nourishments – Results of the research project STENCIL

Online First, geplanter Druck 202

Sicherung von Dämmen, Deichen und Stauanlagen : Handbuch für Theorie und Praxis ; Vol. V - 2015

Die Universität Siegen beschäftigt sich seit über 15 Jahren wissenschaftlich und im Bereich der anwendungsorientierten Forschung mit diesem Thema und hat dazu mittlerweile fünf Symposien durchgeführt. Mit der Veröffentlichung soll die langjährige Tradition als etablierte wissenschaftliche Plattform mit einem Wissensaustausch auf europäischer Ebene fortgesetzt werden. Die Bearbeitung dieser Thematik erfolgt auf der Basis der bewährten Kooperation zwischen Geotechnik und Wasserbau an der Universität Siegen. Aktuelle Ereignisse, wie z.B. die aus England oder Australien im Februar des Jahres 2014, machen uns aber auch deutlich, dass ein absoluter Schutz gegen Extremereignisse nicht möglich ist. Sie zeigen aber auch, dass dort wo technischer Hochwasserschutz konsequent umgesetzt wurde Schäden vermieden werden konnten. Wir sind nach den Ereignissen in den vergangenen Jahren aufgefordert wissenschaftlich noch leistungsfähigere und duktilere Systeme zu entwickeln. Weiter ist die Wissenschaft in der Pflicht, die Zivile Sicherheit im Hochwasser-schutz permanent zu bewerten, zu bearbeiten und ganzheitliche-interdisziplinäre und länderübergreifende Lösungen für die Zivilgesellschaft einzufordern

Adeno-Associated Viral Vector-Mediated Transgene Expression Is Independent of DNA Methylation in Primate Liver and Skeletal Muscle

Recombinant adeno-associated viral (rAAV) vectors can support long-term transgene expression in quiescent tissues. Intramuscular (IM) administration of a single-stranded AAV vector (ssAAV) in the nonhuman primate (NHP) results in a peak protein level at 2–3 months, followed by a decrease over several months before reaching a steady-state. To investigate transgene expression and vector genome persistence, we previously demonstrated that rAAV vector genomes associate with histones and form a chromatin structure in NHP skeletal muscle more than one year after injection. In the mammalian nucleus, chromatin remodeling via epigenetic modifications plays key role in transcriptional regulation. Among those, CpG hyper-methylation of promoters is a known hallmark of gene silencing. To assess the involvement of DNA methylation on the transgene expression, we injected NHP via the IM or the intravenous (IV) route with a recombinant ssAAV2/1 vector. The expression cassette contains the transgene under the transcriptional control of the constitutive Rous Sarcoma Virus promoter (RSVp). Total DNA isolated from NHP muscle and liver biopsies from 1 to 37 months post-injection was treated with sodium bisulfite and subsequently analyzed by pyrosequencing. No significant CpG methylation of the RSVp was found in rAAV virions or in vector DNA isolated from NHP transduced tissues. Direct de novo DNA methylation appears not to be involved in repressing transgene expression in NHP after gene transfer mediated by ssAAV vectors. The study presented here examines host/vector interactions and the impact on transgene expression in a clinically relevant model