527 research outputs found
Evaluating a framework of theoretical hypotheses for animation learning
This paper presents a set of theoretical hypotheses suggesting various relationships between didactical setting and learning effects with animations. Particularly, we investigated whether individual flow-control adequately provides didactical means to reduce the cognitive load imposed by animations. We did not find an effect of individual flow control, probably due to the fact that this learning condition was embedded in a setting where not enough verbal information was offered together with the graphical animation. Overall the multimedia effects found in this study are in line with known principles of didactical multimedia design. Further, this study sheds light on theoretical aspects involved in the complex interaction between learning content, presentation, learning and resulting knowledg
The role of soil states in medium-range weather predictability
International audienceCurrent day operational ensemble weather prediction systems generally rely upon perturbed atmospheric initial states, thereby neglecting the eventual effect on the atmospheric evolution that uncertainties in initial soil temperature and moisture fields could bring about during the summer months. The purpose of this study is to examine the role of the soil states in medium-range weather predictability. A limited area weather prediction model is used with the atmosphere/ land-surface system in coupled or uncoupled mode. It covers Europe and part of the north Atlantic, and is driven by prescribed sea-surface temperatures over the sea, and by atmospheric reanalyses at its lateral boundaries. A series of 3 member ensembles of summer simulations are used to assess the predictability of a reference simulation assumed to be perfect. In a first step, two ensembles are simulated: the first with the atmosphere coupled to the land-surface model, the second in the uncoupled mode with perfect soil conditions prescribed every 6 hours. Subsequent experiments are combinations thereof, in which the uncoupled and coupled modes alternate in the course of a simulation. The results show that there are "stable" and "unstable" periods in the weather evolution under consideration. During the stable periods, the predictability (measured in terms of ensemble spread at 500 hPa) of the coupled and uncoupled dynamical systems is almost identical; prescribing the perfect soil conditions has a negligible impact upon the atmospheric predictability. In contrast, the predictability during an unstable phase is found to be remarkably improved in the uncoupled ensembles. This effect results from guiding the atmospheric phase-space trajectory along its perfect evolution. It persists even when switching back from the uncoupled to the coupled mode prior to the onset of the unstable phase, a result that underlines the importance of soil moisture and temperature in data assimilation systems
Are spectroscopic factors from transfer reactions consistent with asymptotic normalisation coefficients?
It is extremely important to devise a reliable method to extract
spectroscopic factors from transfer cross sections. We analyse the standard
DWBA procedure and combine it with the asymptotic normalisation coefficient,
extracted from an independent data set. We find that the single particle
parameters used in the past generate inconsistent asymptotic normalization
coefficients. In order to obtain a consistent spectroscopic factor,
non-standard parameters for the single particle overlap functions can be used
but, as a consequence, often reduced spectroscopic strengths emerge. Different
choices of optical potentials and higher order effects in the reaction model
are also studied. Our test cases consist of: C(d,p)C(g.s.) at
MeV, O(d,p)O(g.s.) at MeV and
Ca(d,p)Ca(g.s.) at MeV. We underline the
importance of performing experiments specifically designed to extract ANCs for
these systems.Comment: 15 pages, 12 figures, Phys. Rev. C (in press
Elevation gradients of European climate change in the regional climate model COSMO-CLM
A transient climate scenario experiment of the regional climate model COSMO-CLM is analyzed to assess the elevation dependency of 21st century European climate change. A focus is put on near-surface conditions. Model evaluation reveals that COSMO-CLM is able to approximately reproduce the observed altitudinal variation of 2m temperature and precipitation in most regions and most seasons. The analysis of climate change signals suggests that 21st century climate change might considerably depend on elevation. Over most parts of Europe and in most seasons, near-surface warming significantly increases with elevation. This is consistent with the simulated changes of the free-tropospheric air temperature, but can only be fully explained by taking into account regional-scale processes involving the land surface. In winter and spring, the anomalous high-elevation warming is typically connected to a decrease in the number of snow days and the snow-albedo feedback. Further factors are changes in cloud cover and soil moisture and the proximity of low-elevation regions to the sea. The amplified warming at high elevations becomes apparent during the first half of the 21st century and results in a general decrease of near-surface lapse rates. It does not imply an early detection potential of large-scale temperature changes. For precipitation, only few consistent signals arise. In many regions precipitation changes show a pronounced elevation dependency but the details strongly depend on the season and the region under consideration. There is a tendency towards a larger relative decrease of summer precipitation at low elevations, but there are exceptions to this as wel
Elevated temperature clears chytrid fungus infections from tadpoles of the midwife toad, Alytes obstetricans
The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd) is sensitive to high temperature. Hence, exposing amphibians to high temperature may be a method to clear Bd infection. However, the effect of exposure to elevated
temperature has never been tested in larval stages or temperate species.We experimentally exposed tadpoles of the toad Alytes obstetricans to low, medium and high temperatures and found that most, but not all, tadpoles lost the infection when exposed to temperatures higher than 26◦C for 5 days. Thus, exposure to elevated temperatures can be used to treat tadpoles against Bd infection
Robust volume-targeted balanced steady-state free-precession coronary magnetic resonance angiography in a breathhold at 3.0 Tesla: a reproducibility study.
BACKGROUND: Transient balanced steady-state free-precession (bSSFP) has shown substantial promise for noninvasive assessment of coronary arteries but its utilization at 3.0 T and above has been hampered by susceptibility to field inhomogeneities that degrade image quality. The purpose of this work was to refine, implement, and test a robust, practical single-breathhold bSSFP coronary MRA sequence at 3.0 T and to test the reproducibility of the technique.
METHODS: A 3D, volume-targeted, high-resolution bSSFP sequence was implemented. Localized image-based shimming was performed to minimize inhomogeneities of both the static magnetic field and the radio frequency excitation field. Fifteen healthy volunteers and three patients with coronary artery disease underwent examination with the bSSFP sequence (scan time = 20.5 ± 2.0 seconds), and acquisitions were repeated in nine subjects. The images were quantitatively analyzed using a semi-automated software tool, and the repeatability and reproducibility of measurements were determined using regression analysis and intra-class correlation coefficient (ICC), in a blinded manner.
RESULTS: The 3D bSSFP sequence provided uniform, high-quality depiction of coronary arteries (n = 20). The average visible vessel length of 100.5 ± 6.3 mm and sharpness of 55 ± 2% compared favorably with earlier reported navigator-gated bSSFP and gradient echo sequences at 3.0 T. Length measurements demonstrated a highly statistically significant degree of inter-observer (r = 0.994, ICC = 0.993), intra-observer (r = 0.894, ICC = 0.896), and inter-scan concordance (r = 0.980, ICC = 0.974). Furthermore, ICC values demonstrated excellent intra-observer, inter-observer, and inter-scan agreement for vessel diameter measurements (ICC = 0.987, 0.976, and 0.961, respectively), and vessel sharpness values (ICC = 0.989, 0.938, and 0.904, respectively).
CONCLUSIONS: The 3D bSSFP acquisition, using a state-of-the-art MR scanner equipped with recently available technologies such as multi-transmit, 32-channel cardiac coil, and localized B0 and B1+ shimming, allows accelerated and reproducible multi-segment assessment of the major coronary arteries at 3.0 T in a single breathhold. This rapid sequence may be especially useful for functional imaging of the coronaries where the acquisition time is limited by the stress duration and in cases where low navigator-gating efficiency prohibits acquisition of a free breathing scan in a reasonable time period
Noncontact atomic force microscopy simulator with phase-locked-loop controlled frequency detection and excitation
A simulation of an atomic force microscope operating in the constant
amplitude dynamic mode is described. The implementation mimics the electronics
of a real setup including a digital phase-locked loop (PLL). The PLL is not
only used as a very sensitive frequency detector, but also to generate the
time-dependent phase shifted signal driving the cantilever. The optimum
adjustments of individual functional blocks and their joint performance in
typical experiments are determined in detail. Prior to testing the complete
setup, the performances of the numerical PLL and of the amplitude controller
were ascertained to be satisfactory compared to those of the real components.
Attention is also focused on the issue of apparent dissipation, that is, of
spurious variations in the driving amplitude caused by the nonlinear
interaction occurring between the tip and the surface and by the finite
response times of the various controllers. To do so, an estimate of the minimum
dissipated energy that is detectable by the instrument upon operating
conditions is given. This allows us to discuss the relevance of apparent
dissipation that can be conditionally generated with the simulator in
comparison to values reported experimentally. The analysis emphasizes that
apparent dissipation can contribute to the measured dissipation up to 15% of
the intrinsic dissipated energy of the cantilever interacting with the surface,
but can be made negligible when properly adjusting the controllers, the PLL
gains and the scan speed. It is inferred that the experimental values of
dissipation usually reported in the literature cannot only originate in
apparent dissipation, which favors the hypothesis of "physical" channels of
dissipation
Atomic structure of alkali halide surfaces
The atomic structure of surfaces of alkali halide crystals has been revealed by means of high-resolution dynamic force microscopy. True atomic resolution is demonstrated both on steps surrounding islands or pits, and on a chemically mixed crystal. We have directly observed the enhanced interaction at low-coordinated sites by force microscopy. The growth of NaCl films on metal surfaces and radiation damage in a KBr surface is discussed based on force microscopy results. The damping of the tip oscillation in dynamic force microscopy might provide insight into dissipation processes on the atomic scale. Finally, we present atomically resolved images of wear debris found after scratching a KBr surfac
Spatially selective implementation of the adiabatic T2 prep sequence for magnetic resonance angiography of the coronary arteries.
In coronary magnetic resonance angiography, a magnetization-preparation scheme for T2 -weighting (T2 Prep) is widely used to enhance contrast between the coronary blood-pool and the myocardium. This prepulse is commonly applied without spatial selection to minimize flow sensitivity, but the nonselective implementation results in a reduced magnetization of the in-flowing blood and a related penalty in signal-to-noise ratio. It is hypothesized that a spatially selective T2 Prep would leave the magnetization of blood outside the T2 Prep volume unaffected and thereby lower the signal-to-noise ratio penalty. To test this hypothesis, a spatially selective T2 Prep was implemented where the user could freely adjust angulation and position of the T2 Prep slab to avoid covering the ventricular blood-pool and saturating the in-flowing spins. A time gap of 150 ms was further added between the T2 Prep and other prepulses to allow for in-flow of a larger volume of unsaturated spins. Consistent with numerical simulation, the spatially selective T2 Prep increased in vivo human coronary artery signal-to-noise ratio (42.3 ± 2.9 vs. 31.4 ± 2.2, n = 22, P < 0.0001) and contrast-to-noise-ratio (18.6 ± 1.5 vs. 13.9 ± 1.2, P = 0.009) as compared to those of the nonselective T2 Prep. Additionally, a segmental analysis demonstrated that the spatially selective T2 Prep was most beneficial in proximal and mid segments where the in-flowing blood volume was largest compared to the distal segments. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc
Skeletal muscle high energy phosphate metabolism in patients with obesity and impaired fasting blood glucose
- …