606 research outputs found
Benchmark Calculations of Electron Impact Electronic Excitation of the Hydrogen Molecule
We present benchmark integrated and differential cross-sections for electron
collisions with H using two different theoretical approaches, namely, the
R-matrix and molecular convergent close-coupling (MCCC). This is similar to
comparative studies conducted on electron-atom collisions for H, He and Mg.
Electron impact excitation to the , , $B \
^1\Sigma_u^+c \ ^3\Pi_uEF \ ^1\Sigma_g^+C \ ^1\Pi_ue \
^3\Sigma_u^+h \ ^3\Sigma_g^+B' \ ^1\Sigma_u^+d \ ^3\Pi_ub \ ^3\Sigma_u^+$ state. Good agreement is found for all
transitions presented. Where available, we compare with existing experimental
and recommended data.Comment: 21 pages, 25 figure
Synthesis and Cytotoxicity of Cyanoborane Adducts of N 6 -Benzoyladenine and 6-Triphenylphosphonylpurine
N
6
-Benzoyladenine-cyanoborane (2), and 6-triphenylphosphonylpurine-cyanoborane (3) were selected for
investigation of cytotoxicity in murine and human tumor cell lines, effects on human HL-60 leukemic
metabolism and DNA strand scission to determine the feasibility of these compounds as clinical
antineoplastic agents. Compounds 2 and 3 both showed effective cytotoxicity based on ED50 values less than
4 μg/ml for L1210, P388, HL-60, Tmolt3, HUT-78, HeLa-S3 uterine, ileum HCT-8, and liver Hepe-2.
Compound 2 had activity against ovary 1-A9, while compound 3 was only active against prostate PL and
glioma UM. Neither compound was active against the growth of lung 549, breast MCF-7, osteosarcoma
HSO, melanoma SK2, KB nasopharynx, and THP-1 acute monocytic leukemia. In mode of action studies in
human leukemia HL-60 cells, both compounds demonstrated inhibition of DNA and protein syntheses after
60 min at 100 μM. These compounds inhibited RNA synthesis to a lesser extent. The utilization of the DNA
template was suppressed by the compounds as determined by inhibition of the activities of DNA polymerase
α, m-RNA polymerase, r-RNA polymerase and t-RNA polymerase, which would cause adequate inhibition
of the synthesis of both DNA and RNA. Both compounds markedly inhibited dihydrofolate reductase
activity, especially in compound 2. The compounds appeared to have caused cross-linking of the DNA
strands after 24 hr at 100 μM in HL-60 cells, which was consistent with the observed increased in ct-DNA
viscosity after 24 hr at 100 μM. The compounds had no inhibitory effects on DNA topoisomerase I and II
activities or DNA-protein linked breaks. Neither compound interacted with the DNA molecule itself through
alkylation of the nucleotide bases nor caused DNA interculation between base pairs. Overall, these antineoplastic
agents caused reduction of DNA and protein replication, which would lead to killing of cancer
cells
Understanding Young Children's Health Beliefs and Diabetes Regimen Adherence
Previous studies of chronic illness management in children have focused mainly on parents' health beliefs. However, children's health beliefs also can be an important factor in predicting adherence. Indeed, children 6 to 10 years old spend most waking hours away from home, are under less parental supervision, and are becoming more responsible for their own care. The purpose of this study was to develop a pictorial, multi-item instrument to measure dimensions of the Health Belief Model (HBM) and self-efficacy (SE), designed specifically for children with diabetes, thus making it possible to examine both the parent's and child's health beliefs; to explore the relationship between their beliefs; and to examine the extent to which these beliefs are predictors of adherence and metabolic control.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68551/2/10.1177_014572179301900508.pd
Plasma Intercellular Adhesion Molecule-1 and von Willebrand Factor in Primary Graft Dysfunction After Lung Transplantation
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75029/1/j.1600-6143.2007.01981.x.pd
Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma
Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection, whereas the survival of those patients whose tumours had low or no LMO4 expression was not significantly different when resection was compared with operative biopsy alone
Nuclear dependence of the transverse single-spin asymmetry in the production of charged hadrons at forward rapidity in polarized , Al, and Au collisions at GeV
We report on the nuclear dependence of transverse single-spin asymmetries
(TSSAs) in the production of positively-charged hadrons in polarized
, Al and Au collisions at
GeV. The measurements have been performed at forward
rapidity () over the range of GeV and
. We observed a positive asymmetry for
positively-charged hadrons in \polpp collisions, and a significantly reduced
asymmetry in + collisions. These results reveal a nuclear
dependence of charged hadron in a regime where perturbative techniques
are relevant. These results provide new opportunities to use \polpA collisions
as a tool to investigate the rich phenomena behind TSSAs in hadronic collisions
and to use TSSA as a new handle in studying small-system collisions.Comment: 303 authors from 66 institutions, 9 pages, 2 figures, 1 table. v1 is
version accepted for publication in Physical Review Letters. Plain text data
tables for the points plotted in figures for this and previous PHENIX
publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Charting the future of cancer health disparities research: A position statement from the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138314/1/caac21404_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138314/2/caac21404.pd
- …