Letter to Margarette Dye regarding SEAALL membership, December 30, 1985

A letter from Terri Saye to Margarette Dye requesting information on becoming a SEAALL member

Letter to Claire Engel regarding award of the Lucile Elliott Scholarship, 1988

A letter from Terri O. Saye to Claire Engel accepting the Lucile Elliott Scholarship awarded to Saye. Undated, circa 1988

Settlement of Three Grain Tanks on Alluvial Soils Exhibiting Desiccation Profiles

A desiccated crust of overconsolidated soil commonly forms at the surface of compressible soil deposits. If a depression of the groundwater level occurs, the desiccation zone penetrates into the soil profile. At sites where the groundwater level has subsequently risen, a net overconsolidation will exist in the soil profile below the crust. Settlements of structures may be affected by the overconsolidation and by the ability of the desiccated layer to distribute surface stresses over the lightly overconsolidated soil below the crust. This paper presents the use of profiles of laboratory test results and observation of color changes within the soil profile as independent methods to evaluate the thickness of the desiccated crust and the amount of overconsolidation below the crust. The settlements of steel grain storage tanks founded upon alluvium exhibiting desiccation profiles at two sites in Western Iowa are presented. The net overconsolidation stress was estimated from the yield point of the load-settlement curve using elastic stress distribution methods. Estimates of the stress history of the project sites obtained through settlement observations are compared with estimates based on profiles of laboratory tests and color changes within the profile

Daniel Saye Hollis Papers - Accession 175

Daniel Saye Hollis (1885-1981) was a politician and community leader from Rock Hill, SC. The Daniel Saye Hollis Papers consist of correspondence, speeches, legislative bills, reports, newspaper clippings and other material relating to Hollis’ career, term of office as a member of the South Carolina House of Representatives, York County politics, and the South Carolina Democratic Party. Of particular interest is a memoir entitled, “I Remember, which focuses on his early life, rural attitudes, and growing up in a southern rural community in the early 1900s. There is also some information on St. John’s United Methodist Church, Rotary Club of Rock Hill, and Farm Bureau Insurance Company.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1318/thumbnail.jp

A Connected Component Labeling Algorithm for Implicitly-Defined Domains

A connected component labeling algorithm is developed for implicitly-defined domains specified by multivariate polynomials. The algorithm operates by recursively subdividing the constraint domain into hyperrectangular subcells until the topology thereon is sufficiently simple; in particular, we devise a topology test using properties of Bernstein polynomials. In many cases the algorithm produces a certificate guaranteeing its correctness, i.e., two points yield the same label if and only if they are path-connected. To robustly handle various kinds of edge cases, the algorithm may assign identical labels to distinct components, but only when they are exactly or nearly touching, relative to a user-controlled length scale. A variety of numerical experiments assess the effectiveness of the overall approach, including statistical analyses on randomly generated multi-component geometry in 2D and 3D, as well as specific examples involving cusps, self-intersections, junctions, and other kinds of singularities.Comment: 15 pages, 7 figures, 3 algorithm

The utility of efavirenz-based prophylaxis against HIV infection. A systems pharmacological analysis

Pre-exposure prophylaxis (PrEP) is considered one of the five “pillars” by UNAIDS to reduce HIV transmission. Moreover, it is a tool for female self-protection against HIV, making it highly relevant to sub-Saharan regions, where women have the highest infection burden. To date, Truvada is the only medication for PrEP. However, the cost of Truvada limits its uptake in resource-constrained countries. Similarly, several currently investigated, patent-protected compounds may be unaffordable in these regions. We set out to explore the potential of the patent-expired antiviral efavirenz (EFV) as a cost-efficient PrEP alternative. A population pharmacokinetic model utilizing data from the ENCORE1 study was developed. The model was refined for metabolic autoinduction. We then explored EFV cellular uptake mechanisms, finding that it is largely determined by plasma protein binding. Next, we predicted the prophylactic efficacy of various EFV dosing schemes after exposure to HIV using a stochastic simulation framework. We predicted that plasma concentrations of 11, 36, 1287 and 1486ng/mL prevent 90% sexual transmissions with wild type and Y181C, K103N and G190S mutants, respectively. Trough concentrations achieved after 600 mg once daily dosing (median: 2017 ng/mL, 95% CI:445–9830) and after reduced dose (400 mg) efavirenz (median: 1349ng/mL, 95% CI: 297–6553) provided complete protection against wild-type virus and the Y181C mutant, and median trough concentrations provided about 90% protection against the K103N and G190S mutants. As reduced dose EFV has a lower toxicity profile, we predicted the reduction in HIV infection when 400 mg EFV-PrEP was poorly adhered to, when it was taken “on demand” and as post-exposure prophylaxis (PEP). Once daily EFV-PrEP provided 99% protection against wild-type virus, if ≥50% of doses were taken. PrEP “on demand” provided complete protection against wild-type virus and prevented ≥81% infections in the mutants. PEP could prevent >98% infection with susceptible virus when initiated within 24 h after virus exposure and continued for at least 9 days. We predict that 400 mg oral EFV may provide superior protection against wild-type HIV. However, further studies are warranted to evaluate EFV as a cost-efficient alternative to Truvada. Predicted prophylactic concentrations may guide release kinetics of EFV long-acting formulations for clinical trial design

Subject determination during the cataloging process: An intensive study of five catalogers

Subject headings and call numbers for the subject description of documents in library catalogs are provided by catalogers, who bridge the gap between producers (e.g., authors) and users of documents by developing representations to support information retrieval. While catalogers prepare document representations according to a set of standards and requirements and using subject heading lists and classification schedules, they also are in a position to select headings and classes that bring together authors' and readers' interests. In spite of the long tradition of subject cataloging, it is still not completely understood how this process works. The question that the research reported here investigates is how do catalogers decide about the topic of the document and appropriate subject description? Five experienced catalogers were observed and interviewed about their work and experience with subject cataloging in libraries. The think-aloud method was used for the observations, and unstructured interview was used for the follow-up discussion. A follow-up discussion clarified any uncertainties and explored some issues in more detail. The results were compared to the results of other similar research. The observed catalogers consistently performed subject cataloging in five stages: (1) identification of the topic of the book; (2) identification ofthe authors' intent; (3) inference of the possible uses; (4) relation of the topic to the existing collection; and (5) relation of the topic to the classification scheme and subject headings list. The sequence of stages was not necessarily linear, but was flexible in such a way that the catalogers returned to any of the previous stages whenever they realized they were on the wrong track. Their common strategy was searching for existing patterns in sets of call numbers and subject headings that had been assigned to the items in the existing collection. This study, limited in sample of five catalogers and thirteen books, does not allow for generalization over all catalogers. It is, however, useful in comparison with other studies and valuable in presenting different research questions that are still open in subject cataloging

Efficient operator-coarsening multigrid schemes for local discontinuous Galerkin methods

An efficient $hp$-multigrid scheme is presented for local discontinuous Galerkin (LDG) discretizations of elliptic problems, formulated around the idea of separately coarsening the underlying discrete gradient and divergence operators. We show that traditional multigrid coarsening of the primal formulation leads to poor and suboptimal multigrid performance, whereas coarsening of the flux formulation leads to optimal convergence and is equivalent to a purely geometric multigrid method. The resulting operator-coarsening schemes do not require the entire mesh hierarchy to be explicitly built, thereby obviating the need to compute quadrature rules, lifting operators, and other mesh-related quantities on coarse meshes. We show that good multigrid convergence rates are achieved in a variety of numerical tests on 2D and 3D uniform and adaptive Cartesian grids, as well as for curved domains using implicitly defined meshes and for multi-phase elliptic interface problems with complex geometry. Extension to non-LDG discretizations is briefly discussed