Late onset of Huntington's disease

Twenty-five patients with late-onset Huntington's disease were studied; motor impairment appeared at age 50 years or later. The average age at onset of chorea was 57.5 years, with an average age at diagnosis of 63.1 years. Approximately 25% of persons affected by Huntington's disease exhibit late onset. A preponderance of maternal transmission was noted in late-onset Huntington's disease. The clinical features resembled those of mid-life onset Huntington's disease but progressed more slowly. Neuropathological evaluation of two cases reveal less severe neuronal atrophy than for mid-life onset disease

Development of an information platform for new grid users in the biomedical field

Bringing new users into grids is a top priority for all grid initiatives and one of the most challenging tasks. Especially in life sciences it is essential to have a certain amount of users to establish a critical mass for a sustainable grid and give feedback back to the technological middleware layer. Based on the presumable lack of grid IT knowledge it is notably more arduous to satisfy user demands although here the requirements are especially demanding. Therefore, the development of an information- and learning platform could support the efforts of grid experts to guide new users. By providing a platform about grid technology and their feasibilities for users of the community of biomedicine potential, users could be supported using the high potential of their discipline

Development of an information platform for new grid users in the biomedical field

Bringing new users into grids is a top priority for all grid initiatives and one of the most challenging tasks. Especially in life sciences it is essential to have a certain amount of users to establish a critical mass for a sustainable grid and give feedback back to the technological middleware layer. Based on the presumable lack of grid IT knowledge it is notably more arduous to satisfy user demands although here the requirements are especially demanding. Therefore, the development of an information- and learning platform could support the efforts of grid experts to guide new users. By providing a platform about grid technology and their feasibilities for users of the community of biomedicine potential, users could be supported using the high potential of their discipline

Single impurity operators at critical wrapping order in the beta-deformed N=4 SYM

We study the spectrum of one single magnon in the superconformal beta-deformed N=4 SYM theory in the planar limit. We compute the anomalous dimensions of one-impurity operators O_{1,L}= tr(phi Z^{L-1}), including wrapping contributions at their critical order L.Comment: LaTeX, feynmf, Metapost, 20 pages, 11 figures, v2: results up to 11 loops completed, appendix on integral calculation extende

The low-energy limit of AdS(3)/CFT2 and its TBA

We investigate low-energy string excitations in AdS3 × S3 × T4. When the worldsheet is decompactified, the theory has gapless modes whose spectrum at low energies is determined by massless relativistic integrable S matrices of the type introduced by Al. B. Zamolodchikov. The S matrices are non-trivial only for excitations with identical worldsheet chirality, indicating that the low-energy theory is a CFT2. We construct a Thermodynamic Bethe Ansatz (TBA) for these excitations and show how the massless modes’ wrapping effects may be incorporated into the AdS3 spectral problem. Using the TBA and its associated Y-system, we determine the central charge of the low-energy CFT2 to be c = 6 from calculating the vacuum energy for antiperiodic fermions — with the vacuum energy being zero for periodic fermions in agreement with a supersymmetric theory — and find the energies of some excited states

High-speed integrated QKD system

Quantum key distribution (QKD) is nowadays a well-established method for generating secret keys at a distance in an information-theoretically secure way, as the secrecy of QKD relies on the laws of quantum physics and not on computational complexity. In order to industrialize QKD, low-cost, mass-manufactured, and practical QKD setups are required. Hence, photonic and electronic integration of the sender's and receiver's respective compo-nents is currently in the spotlight. Here we present a high-speed (2.5 GHz) integrated QKD setup featuring a transmitter chip in silicon photonics allowing for high-speed modulation and accurate state preparation, as well as a polarization-independent low-loss receiver chip in aluminum borosilicate glass fabricated by the femtosecond laser micromachining technique. Our system achieves raw bit error rates, quantum bit error rates, and secret key rates equivalent to a much more complex state-of-the-art setup based on discrete components [A. Boaron et al., Phys. Rev. Lett. 121, 190502 (2018)].& COPY; 2023 Chinese Laser Pres

On the dressing factors, Bethe equations and Yangian symmetry of strings on AdS3 × S3 × T4

Integrability is believed to underlie the AdS3/CFT2 correspondence with sixteen supercharges. We elucidate the role of massless modes within this integrable framework. Firstly, we find the dressing factors that enter the massless and mixed-mass worldsheet S matrix. Secondly, we derive a set of all-loop Bethe Equations for the closed strings, determine their symmetries and weak-coupling limit. Thirdly, we investigate the underlying Yangian symmetry in the massless sector and show that it fits into the general framework of Yangian integrability. In addition, we compare our S matrix in the near-relativistic limit with recent perturbative worldsheet calculations of Sundin and Wulff

Auf dem Weg zur individualisierten Medizin - Grid-basierte Services für die EPA der Zukunft.

Personalized Medicine is of paramount interest for many areas in Medical Informatics. Therefore genotype data as well a phenotype data about patients have to be available. This data will be stored in Electronic Health Records or – patient controlled - in Personal Health Records. As the amount of (raw) data is rising continuously, methods for a secure data administration have to be found. Grid Services offer data storage, can support data retrieval and the presentation of the data. The basic security services could be provided by the German health professional infrastructure, but there are many security challenges to be faced