In vitro assessments of cytotoxic and cytostatic effect of two [Cu(dien)(N-N)]Br2 complexes on L6, HCT, PC3 and HepG2 cancer cells

Two new Cu(II) complexes of type [Cu(dien)(N-N)] Br2 (dien is diethlylenetriamine, C1 complex with N-N = diethlylenetriamine and C2 complex with N-N = propyl-1,3-diamine) were made valuable  and in vitro screened for both cytostatic and cytotoxic activities against four cell lines: colon cancer (HCT), liver cancer (HepG2), prostate cancer (PC3) and as control cell (L6) human muscle cell was used via MTT test. The results reflected these complexes as a promising activity antiprolifrative agent against the used cell lines indicating that C1 and C2 complexes have a high anticancer activity at non-toxic concentrations

Synthesis, characterization, E/Z-isomerization, DFT, optical and 1BNA docking of new Schiff base derived from naphthalene-2-sulfonohydrazide

The novel N'-((1H-indol-2-yl)methylene)naphthalene-2-sulfono-hydrazide Schiff base (S.B.) ligand was produced via condensation of 1H-indole-2-carbaldehyde with naphthalene-2-sulfonylhydrazide in a high yield. S.B. was then examined using several physicochemical techniques, and the steric structure was consequently confirmed. The highest B3LYB/DFT level theory was used to optimize the 3D E/Z-isomers structure. The stereoisomers computation demonstrated slightly stable E isomers outperformed by Z-one. The ligand displayed decent photosynthetic mid-bandgap semiconductors optical activate range material, and both the E and Z isomers bound to 1BNA DNA recorded many interactions

Medium effects in K^+ nucleus interaction from consistent analysis of integral and differential cross sections

Self consistency in the analysis of transmission measurements for K^+ on several nuclei in the momentum range of 500-700 MeV/c is achieved with a "t_{eff}(rho)rho" potential and new results are derived for total cross sections. The imaginary part of the t_{eff} amplitude is found to increase linearly with the average nuclear density in excess of a threshold value. This phenomenological density dependence of the K^+ nucleus optical potential also gives rise to good agreement with recent measurements of differential cross sections for elastic scattering of 715 MeV/c K^+ by Li^6 and C.Comment: 11 pages, RevTeX, 2 Postscript figures, submitted Phys. Lett.

The properties of \bar{K} in the nuclear medium

The self-energy of the K^- meson in nuclear matter is calculated in a self-consistent microscopic approach, using a \bar{K}N interaction obtained from the lowest-order meson-baryon chiral Lagrangian. The effective \bar{K}N interaction in the medium is derived by solving the coupled-channel Bethe-Salpeter equation including Pauli blocking on the nucleons, mean-field binding potentials for the baryons and the self-energy of the \pi and \bar{K} mesons. The incorporation of the self-consistent {\bar K} self-energy in the description, in addition to the Pauli blocking effects, yields a weaker attractive in-medium {\bar K}N interaction and a \Lambda(1405) which dissolves faster with increasing matter density, as a result of the {\bar K} spectral function being spread out over a wide range of energies. These effects are further magnified when the intermediate pions are dressed.Comment: 23 pages, 7 figures, ReVTe

Synthesis, optimization, DFT/TD-DFT and COX/LOX docking of new Schiff base N'-((9-ethyl-9H-carbazol-1-yl)methylene)naphthalene-2-sulfonohydrazide

Condensing naphthalene-2-sulfonylhydrazide with 9-ethyl-9H-carbazole-1-carbaldehyde enabled to prepare the N'-((9-ethyl-9H-carbazol-1-yl)methylene)naphthalene-2-sulfonohydrazide as new Schiff base (S.B.)  ligand with a high yield. A wide range of physicochemical measurements, such as CHN-elemental analysis, UV-Vis., NMR, FT-IR, and mass spectrometry (ESI-MS) were used to extensively investigate the structural properties of the prepared S.B. ligand. Moreover, the highest level of B3LYB/DFT also served to optimize the 3D structure of the S.B, the experimental optical UV-Vis absorption measurements was compared to the theoretical DFT/TD-DFT study under identical conditions using the same solvent. Furthermore, the anti-inflammatory possible future capability was evaluated via the LOX/COX molecular docking against the desired S.B. ligand

The K600 Focal Plane Polarimeter

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

The K600 Focal Plane Polarimeter

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440