Efficiency of carotine-chlorophyllic complexes use in a-hypovitaminosis of poultry

The principal purpose of this study was to investigate the possibility of using chloroprenol as a vitamin supplement in diets of broiler chickens for the prevention of A-vitamin deficiencies and improve the commercial quality of poultry products. In accordance with desired goal we have estimated the clinical-biochemical status of the broiler chickens under production-line conditions, defined the optimal dosages of chloroprenol for the broiler chicken, determined the effect of the drug on the morphological and biochemical parameters of blood, studied their effect on the natural resistance parameters of the body, accumulation of biological active substances in the liver, viability and productivit

Some Aspects of Mast Cells Carboxypeptidase A3 Participation in the Pathogenesis of COVID-19

Background: This study aimed to determine the involvement of carboxypeptidase A3 (CPA3) in developing lung damage in patients with COVID-19. Methods and Results: The study included samples of autopsy material from the lungs of patients who died as a result of severe COVID-19 (the main group [MG] and persons who died from external causes (the control group [CG]). Immunohistochemical staining for CPA3 was carried out. A quantitative study of CPA3-positive mast cells (MCs) and the degree of their degranulation was carried out using a ×40 objective lens with an analysis of ≥50 fields of view with further conversion to 1 mm². Significant representation of CPA3-positive MCs per 1 mm2 of CPA3-positive MCs, CPA3-positive MCs with signs of degranulation (SD), and co-adjacent MCs was found in the MG compared to the CG (P=0.01 in all cases). In the main group, positive correlations were identified between the total number of CPA3-positive MCs, CPA3-positive MCs with SD and the blood hemoglobin level shortly before death (r=0.491 [P=0.008] and r=0.521 [P=0.004], respectively). Co-adjacent CPA3-positive MCs were negatively correlated with blood eosinophils at the beginning of hospitalization (r=-0.420 [P=0.023]). Also, the number of separately lying, CPA3-positive MCs negatively correlated with the blood monocyte shortly before death (r=-0.384 [P=0.044]). A positive correlation was established between the total number of CPA3-positive MCs, CPA3-positive MCs with SD, and adjacent CPA3-positive MCs with total blood protein in patients at the beginning of hospitalization (r=0.431 [P=0.020], r=0.449 [P=0.015] and r=0.456 [P=0.013], respectively). In addition, the study demonstrated a positive correlation between CPA3-positive MCs with SD and the total number of CPA3-positive MCs with blood aPTT levels (r=0.304 [P=0.045] and r=0.375 [P=0.045], respectively). A negative correlation was also found between the total number of CPA3-positive MCs and the blood INR level (r=-0.812 [P=0.050]). Finally, in patients at the beginning of hospitalization, a negative correlation was found between CPA3-positive MCs with SD, CPA3-positive MCs without SD, separately located CPA3-positive MCs, adjacent CPA3-positive MCs, and the total number of CPA3-positive MCs with blood amylase (r=-0.550 [P=0.002], r=-0.452 [P=0.045], r=-0.485 [P=0.030], r=-0.622 [P=0.008], and r=-0.590 [P=0.006], respectively). Conclusion: Our study identifies the potential involvement of CPA3 in the pathogenesis of severe COVID-19. However, many aspects of its participation remain unclear and require further study

Гемофильтрация и гемодиализ в профилактике и лечении острой почечной недостаточности после операций на сердце с искусственным кровообращением

Objective: to analyze the efficiency of hemofiltration (HF) in the stage of extracorporeal circulation (EC) during cardiac surgery in order to prevent acute renal function lowering and the development of acute renal failure (ARF). Materials and methods. The risk of postoperative ARF requiring renal replacement therapy (RRT) was preoperatively assessed by the summed Cleveland risk score and percentage (2005). HF during EC was used in patients at high risk for ARF. The procedure was performed, by combining 2 extracorporeal circuits: EC and a Diapact®CRRT apparatus. With evolving ARF, Stage 3 after Risk, Injury, Failure, Loss of Kidney Function, End-stage Renal Disease (RIFLE), 2004, and Acute Kidney Injury Network (AKIN), 2007, continuous venovenous hemofiltration (CVVHF) and continuous high-flow hemodialysis (CHFHD) were done in the dialysate recirculation mode after surgery under EC. The Mann-Whitney non-parametric test was used to estimate the significance of intergroup differences. The results are presented: median (lower quartile; upper quartile), the differences considered to be significant atpResults. HF during EC; 6 patients were aged 65.5 (range 57—70) years with chronic kidney disease, preoperative glomerular filtration rate (GFR) was 50 (range 41.5—65) ml/min/1.73 m2 using the Cockroft-Gault formula. The maximum GFR decrease by 2.9 (range 0.7—7) ml/min/1.73 m2 was seen after EC. A control group comprised 12 patients aged 73 (range 63—75) years. There was a postoperative GFR reduction by 17 (range 13.7—22) ml/min/1.73 m2. One patient from the control group developed ARF and multiple organ dysfunction, which required CVVHF and CHFHD. Conclusion. The use of intraoperative HF in patients at high risk for renal function lowering is likely to prevent a considerable GFR reduction and ARF after surgery under EC.Цель исследования — анализ эффективности гемофильтрации (ГФ) на этапе искусственного кровообращения (ИК) при операциях на сердце, для профилактики острого снижения функции почек и развития острой почечной недостаточности (ОПН). Материал и методы. Риск развития после операции ОПН, требующей применения заместительной почечной терапии (ЗПТ), оценивали до операции согласно сумме баллов и процентов риска по Cleveland score (2005). ГФ на этапе ИК применяли у больных высокого риска развития ОПН. Процедуру проводили посредством совмещения 2-х экстракорпоральных контуров: ИК и аппарата Diapact®CRRT. В случае развития ОПН, 3 стадия по Risk, Injury, Failure, Loss of kidney function, End-stage Renal Disease (RIFLE) 2004 и Acute Kidney Injury Network (AKIN) 2007, после операции с ИК проводили продолжительную вено-венозную гемофильтрацию (ПВВГФ) и продолжительный высокопоточный гемодиализ (ПВГД) в режиме рециркуляции диализата. Для оценки достоверности межгрупповых различий применяли непараметрический метод анализа по Манна—Уитни. Результаты представлены: медиана (нижний квартиль; верхний квартиль), различия считались достоверными приp<0,05. Результаты. ГФ на этапе ИК. Шесть больных, возраст 65,5 (57; 70) лет, с хронической болезнью почек (ХБП), скорость клубочковой фильтрации (СКФ) по Кокрофту-Гаулту до операции 50 (41,5; 65) мл/мин/1,73 м2. Максимальное снижение СКФ после ИК на 2,9 (0,7; 7) мл/мин/1,73 м2. Контрольная группа — 12 больных, возраст 73 (63; 75) лет. Наблюдали снижение СКФ после операции на 17 (13,7; 22) мл/мин/1,73 м2. У одного пациента контрольной группы развилась ОПН и полиорганная недостаточность (ПОН), потребовалось проведение ПВВГФ и ПВГД. Заключение. Использование интраоперационной гемофильтрации у больных с высоким риском снижения функции почек, вероятно, позволит предотвратить значительное снижение СКФ и развитие ОПН после операций с ИК. Ключевые слова: операции на сердце с искусственным кровообращением, острая почечная недостаточность, гемофильтрация, гемодиализ

ЛИПОДЕРМАТОСКЛЕРОЗ КАК ВАРИАНТ ЛОБУЛЯРНОГО ПАННИКУЛИТА: ТЕЧЕНИЕ И ИСХОДЫ

Objective: to study the course and outcomes of lipodermatosclerosis (LDS) as a variant of lobular panniculitis.Patients and methods. Examinations were made in 38 patients (37 women and one man) aged 54±13 years who had been diagnosed with LDS lasting 2 weeks to 20 years and followed up at the V.A. Nasonova Research Institute of Rheumatology in 2009–2016. In addition to general clinical examination, the patients underwent immunological studies and lower extremity venous Doppler ultrasonography (DUSG). Outcomes were assessed as a significant improvement (complete regression of indurations), an improvement (regression of indurations was achieved, but there was one recurrence of LDS in the follow-up period), a slight improvement (regression of indurations was achieved, but there was more than one recurrence of LDS, which needed to change treatment policy), no effect of the therapy (no regression of indurations was achieved), and deterioration of health.Results. The 38 patients with LDS were noted to have subcutaneous fat inflammation in the leg (100%) and asymmetric inflammation (55%) on its medial surface (92%). If the body mass index (BMI) was normal, LDS regressed more rapidly (p=0.04). During the entire follow-up period, 16 (42%) patients were observed to have recurrent LDS; the median time to recurrence was 3 [1; 6] months. The development of a recurrence was associated with node merging into conglomerates [odds ratio (OR), 4.33; 95% confidence interval (CI), 1.05–17.8; p=0.037] and with the use of hydroxychloroquine (HCQ) agents at a dose <400 mg/day (OR, 5.25; 95% CI, 1.26–21.96; p=0.019). Regression of indurations was achieved in 39.5% of cases, the likelihood of its development was higher when the duration of LDS was ≤3 months before therapy initiation (OR, 14.67; 95% CI, 1.5–139.8; p=0.006) and in the absence of perforating vein valve incompetence, as evidenced by DUSG (OR, 4.1; 95% CI, 1.0–17.0; p=0.045).Conclusion. In the study group, LDS was more common in middle-aged women with increased BMI and chronic venous insufficiency. The elevated clinical and laboratory parameters of inflammatory activity were not typical of LDS. Higher BMI values contributed to a longer regression of indurations. Recurrences were more frequently observed after stress and due to non-compliance with prescribed therapy. Node merging into conglomerates and use of HCQ< 400 mg/day for ≥6 months after therapy initiation are risk factors of recurrent LDS. The likelihood of regression of indurations was higher in patients, in whom the duration of the underlying disease was ≤3 months before therapy initiation and perforator vein valve incompetence was absent, as evidenced by DUSC. Цель исследования – изучение течения и исходов липодерматосклероза (ЛДС) как одного из видов панникулита.Пациенты и методы. Обследовано 38 пациентов (37 женщин и 1 мужчина) в возрасте 54±13 лет с диагнозом ЛДС и длительностью болезни от 2 нед до 20 лет, наблюдавшихся в ФГБНУ НИИР им. В.А. Насоновой в 2009–2016 гг. Помимо общеклинического обследования проводили иммунологические исследования и ультразвуковую допплерографию (УЗДГ) вен нижних конечностей. Исходы оценивались как значительное улучшение (полный регресс уплотнений), улучшение (регресс уплотнений достигнут, но за период наблюдения отмечен один рецидив ЛДС), незначительное улучшение (регресс уплотнений достигнут, за период наблюдения отмечено более одного рецидива ЛДС, что потребовало изменения тактики лечения), отсутствие эффекта от проводимой терапии (регресс уплотнений не достигнут), ухудшение состояния.Результаты. У 38 больных с ЛДС отмечено воспаление подкожной жировой клетчатки голени (100%), асимметричное (55%), на медиальной ее поверхности (92%). При нормальных значениях индекса массы тела (ИМТ) ЛДС регрессировал быстрее (p=0,04). За весь период наблюдения рецидив ЛДС отмечен у 16 (42%) больных; медиана развития рецидива составила 3 [1; 6] мес. Развитие рецидива ассоциировалось со слиянием узлов в конгломераты [отношение шансов (ОШ) 4,33; 95% доверительный интервал (ДИ) 1,05–17,8; p=0,037] и приемом гидроксихлорохиновых препаратов (ГХ) в дозе < 400 мг/сут (ОШ 5,25; 95% ДИ 1,26–21,96; p=0,019). Регресс уплотнений достигнут в 39,5% случаев, вероятность его развития была выше при длительности ЛДС к моменту начала терапии ≤3 мес (ОШ 14,67; 95% ДИ 1,5–139,8; p=0,006) и отсутствии недостаточности клапанов перфорантных вен по данным УЗДГ (ОШ 4,1; 95% ДИ 1,0–17,0; p=0,045). Выводы. В исследуемой группе ЛДС чаще встречался у женщин среднего возраста с повышенным ИМТ и хронической венозной недостаточностью. Для ЛДС не характерно повышение клинико-лабораторных показателей воспалительной активности. Повышенные значения ИМТ способствовали более длительному регрессу уплотнений. Рецидивы заболевания чаще наблюдались после стресса и нарушения схемы предписанной терапии. Слияние узлов в конгломераты и прием ГХ в дозе < 400 мг/сут на протяжении ≥6 мес от начала терапии являются факторами риска рецидива ЛДС. Вероятность достижения регресса уплотнений выше у пациентов с длительностью основного заболевания к моменту инициации терапии ≤3 мес и отсутствием недостаточности клапанов перфорантных вен по данным УЗДГ

Значение легочных функциональных тестов в комплексной оценке риска развития пострезекционных респираторных осложнений у пациентов, перенесших лобэктомию или пневмонэктомию

This study was done to analyze respiratory mechanics and lung diffusing capacity in patients waiting for lobectomy or pneumonectomy in order to predict postoperative risk of cardiorespiratory complications, to choose the surgical treatment strategy and the optimal anesthesiologic approach. Methods. We analyzed parameters of spirometry, body plethysmography and diffusing capacity for carbon monoxide in 30 patients (86.7% were males; mean age, 66.6 ± 10.3 years) before lobectomy or pneumonectomy. Results. Ventilation abnormalities were found in 73.3% of the patients (obstructive abnormalities in 56.7%; restrictive abnormalities in 3.3%, and mixed abnormalities in 13.3%). Lung diffusing capacity (transfer-factor) was reduced in 33.3% of patients; this was accompanied by ventilation defects in 90% of cases. Given the lung tissue volume proposed for resection the expected postoperative forced expiratory volume in 1 second and transfer-factor were calculated. Thereafter, the patients were included in a group of low, moderate or high risk of postoperative complications according to the estimates, and to the ratio of the actual residual volume and the total lung capacity. Conclusion. The results could be used to choose the surgical treatment strategy and the optimal anesthesiologic approach.Риск легочных осложнений и развития сердечной недостаточности у пациентов торакального профиля, большую часть которых составляют лица пожилого и старческого возраста с сопутствующей кардиореспираторной патологией, увеличивается как в периоперационном, так и в раннем послеоперационном периоде после лобэктомии или пневмонэктомии. Важную роль в исходе лечения при этом играет оценка функциональных резервов дыхательной и сердечно-сосудистой систем. Материалы и методы. Проведен анализ показателей наиболее распространенных методов оценки параметров механики дыхания и диффузионной способности легких (ДСЛ) – спирометрии, бодиплетизмографии и диффузионного теста по угарному газу (СО) методом однократного вдоха с задержкой дыхания у пациентов (n = 30: 26 (86,7 %) мужчин, 4 (13,3 %) женщины; средний возраст – 66,6 ± 10,3 года) перед оперативным вмешательством на легких в объеме лобэктомии или пневмонэктомии. Результаты. Нарушения механики дыхания выявлены у 73,3 % пациентов (56,7 % – по обструктивному, 3,3 % – по рестриктивному, 13,3 % – по смешанному типу). У 33,3 % отмечено нарушение ДСЛ (снижение трансфер-фактора СО), которое в 90 % случаев сопровождалось вентиляционными нарушениями. На основании результатов спирометрии, бодиплетизмографии и диффузионного теста в зависимости от объема планируемого удаления функционирующей легочной ткани рассчитывались величины предсказанных послеоперационных объема форсированного выдоха за 1-ю секунду и трансфер-фактора. Заключение. С учетом полученных показателей, а также величины фактического отношения остаточного объема легких к общей емкости легких (%) пациенты были отнесены к одной из трех групп риска пострезекционных кардиореспираторных осложнений, что позволило выбрать оптимальное анестезиологическое пособие и спланировать хирургическую тактику лечения заболевания

Роль тучных клеток и их протеаз в поражении легких у пациентов с COVID-19

The new coronavirus infection COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2, has posed scientific and public health challenges. The problem of treating COVID-19 still remains, and the pathogenesis of COVID-19 needs to be studied in detail, including the involvement of mast cells (MCs) and their specific proteases.The aim of this study was to characterize the role of mast cell proteases chymase, tryptase, and carboxypeptidase A3 (CPA3) in the lung damage associated with COVID-19.Methods. The study included postmortem lung biopsies from 30 patients who died of severe COVID-19, and biopsies from 9 control group patients. Histological preparations were made and protease profile and degranulation activity of MCs were analyzed. In addition, some demographic, clinical, and laboratory parameters were analyzed.Results. The average number of tryptase-positive MCs without evidence of degranulation and the total number of CPA3-positive MCs were statistically significantly higher in patients with COVID-19, and the number of tryptase-positive and CPA3-positive MCs fragments was lower compared with controls. Negative correlations were established between the numbers of tryptase-positive MCs and red blood cell count. Negative correlations were found between non-granulating tryptase-positive MCs and hemoglobin levels. Positive correlations were noted between tryptase-positive MCs and the leukocytes and eosinophils counts, and negative correlations were noted between the number of CPA3-positive cells and the platelet count. A positive correlation was found between the number of adjoining MCs, as well as fragments of tryptase-positive MCs, and the erythrocyte sedimentation rate (ESR). A negative correlation was also observed between the number of non-degranulated CPA3-positive MCs and the blood level of C-reactive protein. In patients with COVID-19, reduced degranulation activity of tryptase-positive MCs was found along with increased representation of CPA3positive MCs. Several trends and associations with laboratory test results were noted. The potential involvement of MCs in the development of anemia and thrombocytopenia is considered. Associations were established between tryptase-positive MCs and the peripheral blood counts of leukocytes and eosinophils, as well as ESR.Conclusion. The results obtained are highly contradictory. Since many aspects of the involvement of MCs and their proteases in COVID-19 pathogenesis are still unknown, studies with larger cohorts of patients are needed.          В период пандемии новой коронавирусной инфекции (НКИ) COVID-19 (COronaVIrus Disease 2019), вызванной вирусом SARS-CoV-2 (Severe Acute Respiratory Syndrome-related CoronaVirus 2), перед наукой и общественным здравоохранением поставлены сложные задачи. Проблема лечения COVID-19 по-прежнему актуальна, в связи с этим необходимо детально изучать патогенез COVID-19, в т. ч. участие в нем тучных клеток (ТК) и их специфических протеаз.Целью исследования явилось уточнение роли протеаз ТК – химазы, триптазы и карбоксипептидазы А3 (CPA3) – в развитии поражения легких у пациентов с COVID-19.Материалы и методы. В исследование включены образцы аутопсийного материала легких, полученные от пациентов (n = 30), умерших после COVID-19 тяжелого течения, и пациентов (n = 9) контрольной группы с последующей подготовкой гистологических препаратов, анализом протеазного профиля и дегрануляционной активности ТК. Также проводился анализ некоторых демографических и клинико-лабораторных показателей.Результаты. У пациентов с COVID-19 среднее количество триптаза-позитивных ТК без признаков дегрануляции и общее количество CPA3позитивных ТК было статистически значимо выше, а фрагментов триптаза- и CPA3-позитивных ТК – ниже. Установлены отрицательные корреляционные связи между количеством триптаза-позитивных ТК и содержанием эритроцитов крови в общем анализе крови (ОАК). Установлена отрицательная корреляция количества недегранулирующих триптаза-позитивных ТК с содержанием гемоглобина по результатам ОАК. Установлены положительные корреляции триптаза-позитивных ТК с содержанием лейкоцитов и эозинофилов в ОАК и отрицательные – между количеством CPA3-позитивных клеток и содержанием тромбоцитов. Установлена прямая корреляция между количеством совместно прилежащих, а также фрагментов триптаза-позитивных ТК с показателем скорости оседания эритроцитов (СОЭ). Обнаружена отрицательная корреляция между количеством CPA3-позитивных ТК без признаков дегрануляции и уровнем С-реактивного белка крови. У пациентов с COVID-19 обнаружена сниженная дегрануляционная активность триптаза-позитивных ТК наряду с повышенным представительством CPA3-позитивных. Отмечены некоторые возрастные тенденции и связи с лабораторными показателями. Рассматривается потенциальное участие ТК в развитии анемии и тромбоцитопении, установлены связи триптаза-позитивных ТК с уровнем лейкоцитов и эозинофилов периферической крови, а также СОЭ.Заключение. Полученные результаты весьма противоречивы. Многие аспекты участия ТК и их протеаз в патогенезе COVID-19 остаются неясными, что обусловливает необходимость проведения исследований на более крупных когортах пациентов

Efficiency of carotine-chlorophyllic complexes use in a-hypovitaminosis of poultry

The principal purpose of this study was to investigate the possibility of using chloroprenol as a vitamin supplement in diets of broiler chickens for the prevention of A-vitamin deficiencies and improve the commercial quality of poultry products. In accordance with desired goal we have estimated the clinical-biochemical status of the broiler chickens under production-line conditions, defined the optimal dosages of chloroprenol for the broiler chicken, determined the effect of the drug on the morphological and biochemical parameters of blood, studied their effect on the natural resistance parameters of the body, accumulation of biological active substances in the liver, viability and productivit

LIPODERMATOSCLEROSIS AS A VARIANT OF LOBULAR PANNICULITIS: COURSE AND OUTCOMES

Objective: to study the course and outcomes of lipodermatosclerosis (LDS) as a variant of lobular panniculitis.Patients and methods. Examinations were made in 38 patients (37 women and one man) aged 54±13 years who had been diagnosed with LDS lasting 2 weeks to 20 years and followed up at the V.A. Nasonova Research Institute of Rheumatology in 2009–2016. In addition to general clinical examination, the patients underwent immunological studies and lower extremity venous Doppler ultrasonography (DUSG). Outcomes were assessed as a significant improvement (complete regression of indurations), an improvement (regression of indurations was achieved, but there was one recurrence of LDS in the follow-up period), a slight improvement (regression of indurations was achieved, but there was more than one recurrence of LDS, which needed to change treatment policy), no effect of the therapy (no regression of indurations was achieved), and deterioration of health.Results. The 38 patients with LDS were noted to have subcutaneous fat inflammation in the leg (100%) and asymmetric inflammation (55%) on its medial surface (92%). If the body mass index (BMI) was normal, LDS regressed more rapidly (p=0.04). During the entire follow-up period, 16 (42%) patients were observed to have recurrent LDS; the median time to recurrence was 3 [1; 6] months. The development of a recurrence was associated with node merging into conglomerates [odds ratio (OR), 4.33; 95% confidence interval (CI), 1.05–17.8; p=0.037] and with the use of hydroxychloroquine (HCQ) agents at a dose <400 mg/day (OR, 5.25; 95% CI, 1.26–21.96; p=0.019). Regression of indurations was achieved in 39.5% of cases, the likelihood of its development was higher when the duration of LDS was ≤3 months before therapy initiation (OR, 14.67; 95% CI, 1.5–139.8; p=0.006) and in the absence of perforating vein valve incompetence, as evidenced by DUSG (OR, 4.1; 95% CI, 1.0–17.0; p=0.045).Conclusion. In the study group, LDS was more common in middle-aged women with increased BMI and chronic venous insufficiency. The elevated clinical and laboratory parameters of inflammatory activity were not typical of LDS. Higher BMI values contributed to a longer regression of indurations. Recurrences were more frequently observed after stress and due to non-compliance with prescribed therapy. Node merging into conglomerates and use of HCQ< 400 mg/day for ≥6 months after therapy initiation are risk factors of recurrent LDS. The likelihood of regression of indurations was higher in patients, in whom the duration of the underlying disease was ≤3 months before therapy initiation and perforator vein valve incompetence was absent, as evidenced by DUSC

ERYTHEMA NODOSUM IN LÖFGREN’S SYNDROME

Objective: to study the clinical, laboratory, and radiographic characteristics of early-stage sarcoidosis in a cohort of patients referred to a rheumatology center. Materials and methods. The investigation enrolled 125 patients (104 women and 21 men; mean age 42 ± 12 years) with the clinical and X-ray signs of Löfgren’s syndrome. All the patients were referred to a rheumatology center with diagnosed erythema nodosum (EN). The median disease duration was 1 (0.5–2.0) month. All the patients underwent comprehensive clinical examination and laboratory and instrumental studies of biochemical and immunological parameters, chest X-ray or computed tomography (CT), as well as postmortem examinations of skin and subcutaneous fat biopsy specimens were done in 15 cases. Results. EN was located on the lower leg mostly on its anterior surface (97 %), hip (35 %), upper limbs (25 %), and trunk (3 %). There was a symmetric pattern of eruptions in 50 % of the patients. Nodules fused into a conglomerate in 48 %. More than 50 % injury of the shin surface (68 %) was directly related to the number of nodules (p < 0.001; r = 0.60) and the level of C-reactive protein (p = 0.006; r = 0.38). There was a direct relationship of the number of nodules to the duration of EN (p = 0.04; r = 0.20) and their trend of fusion (p < 0.001; r = 0.39). The signs of joint injury were found in 106 (85 %) patients. The predictors of the CT frosted glass phenomenon were male sex (odds ratio (OR) 6.5; confidence interval (CI) 1.2–35.0; p = 0.026) and the presence of nodular conglomerates (OR 4.8; CI 1.4–16.1; p = 0.01). EN did not recur and articular syndrome virtually completely regressed in 90% of the patients during one-year follow-up. Conclusion. Patients with acute sarcoidosis require that physicians of different specialties, including rheumatologists, should coordinate their actions to determine the volume of further examination and to use adequate treatment