Physico- chemical and Pharmacological Characteristics of mixed ligand complex of Cu (II) with Famotidine and Methionine

Mixed ligand complex of Cu (II) with Famotidine as one ligand and Methionine as second ligand was prepared. The complex was characterized on the basis of elemental analysis, electronic and I.R. Spectral and particle size measurements. Pharmacological effects of the complex on gastric secretion in pylorous ligated rats and gastric emptying rate in albino rates were also studies. It was found that the complex in dose range 200-500 mg/kg produced significant reduction in total and free acid and it had no effect on gastric emptying rate

PREVENTION OF MADHUMEH AND ITS COMPLICATIONS THROUGH AYURVEDA

Faulty dietary habits, sedentary life style and stressful conditions may lead to various metabolic disorders and diabetes is one of them. In Ayurveda, Madhumeh one of the types of Vataj prameh is compared to diabetes mellitus because of having similarities of diseases in respect to Etiopathogenesis, clinical features and prognosis. Prevalence of diabetes is increasing day by day throughout the world where India leads the highest numbers. Diabetes is the fourth leading cause of global death by disease. Type-2 DM is    responsible for approximately 90% of cases. The main causes of Madhumeha are lack of exercise, improper food habits, excessive intake of food having Snigdha and Guru guna and food which causes vitiation of Kapha dosha are the primal causes of disease Microvascular complications of diabetes like retinopathy and nephropathy are comparatively lower in Indians. The prevalence of premature coronary artery disease is much higher in Indians compared to other ethnic groups. Diabetic retinopathy is the leading cause of vision loss in adults of working age (20-65yrs) in industrialized countries..Modern therapeutics has many limitations but Ayurvedic principles of management can help the patient to control blood glucose level and have better routine life. Ayurveda plays an important role in prevention of Type-2 DM. Up to 80% of type 2 diabetes is preventable by adopting a healthy diet and increasing physical activity. To prevent this disease and its complications it is necessary to follow principles of Ayurveda i.e. Nidanaparivarjan, Ashtahar Vidhivisheshayatan, Dincharya, Rutucharya, Sadavritta and practicing particular Asana and Yoga postures

A CRITICAL REVIEW ON CONCEPT OF AGNI IN AYURVEDA AND ITS CLINICAL SIGNIFICANCE

Health is the state of mentally and physically well being. According to Ayurveda, when Dosha, Dhatu and Mala are in Sama awastha and Indriya, Aatma, Mann all are working properly then the person is considered as Swastha. For Dosha, Dhatu and Mala to be in the state of proportionality Agni should be normal (Samagni). Agni consist digestive (Pak) and different kinds of hormones, enzyme and co enzymes activities etc. which participate in digestive & metabolic functions. It is believed to be the agency for various types of metabolic transformations. During each and every second various procedure of transformations take place inside the human body. Enumeration of Agni varies in various classical Ayurvedic texts. According to various functions and site of action, Agni has been divided into 13 types, i.e. one Jatharagni, five Bhutagni and seven Dhatvagni. Jatharagni is the most important one, which digests four types of food and transforms it into Rasa and Mala. Ayurveda consider that no disease ever be develop without the derangement of Agni. Therefore in the management of each and every disease, Agni gets primary focus. Though in Ayurvedic literature, a detailed explanation of Agni is available but there is lack of its practical utility. So, this paper is a sincere effort to elaborate the practical utility of Agni

Extreme Value Analysis for Record Loss Prediction during Volatile Market

Year after year stock markets of the world kept on breaking records. They reached new heights and plunged to new depths. During financial crisis of 2008 many markets shed as many points as they never did in their history. It is extremely difficult to predict future index value due to their high randomness but is it possible to know if markets are going to achieve a record fall in near future or not. Daily changes in stock market index are not normally distributed, analysis showed they exhibit fatter tails that normal distribution, while extreme fall and rise generally follow generalized extreme value distribution explained by Extreme Value theory. The study models worst losses suffered in a day by National Stock Exchange index CNX-Nifty by fitting GEV distribution on yearly and quarterly maximum losses. GEV distribution function hence obtained is used for predicting probability of obtaining a record maximum loss next year / quarter of 2008. As Indian markets shed maximum point in a day during financial crisis of 2008, study verifies if model gives indication about such extreme event. Key words: GEV distribution; Extreme Value Theory; Record Loss; Frechet Density Function; Block Maxim

Assessment of Possible Impacts of Climate Change in Water Reservoir of Bhopal with Special Reference to Heavy Metals, Central Region - India

Water is a unique substance. Its liquid face predominates on the Earth. Water of Kolar reservoir was investigated to assess its water quality status. Study reveals that physico \u2013 chemical characteristics of the reservoir water largely varied through change of season, degree of anthropogenic activities in and around ,the composition of runoff in the catchment area. Water samples were collected during winter and summer and analysed for various quality parameters with special reference to heavy metals e.g. Iron and Manganese. A perusual of chemical analysis revealed that Iron and Manganese content are more at station S4 which is a channel water outlet of dam

Heterogeneous catalyst Mn(salicylaldimine) complex covalently bonded to α-titanium phosphate: Synthesis, characterization and catalytic activity for oxidation of cyclohexane

A new heterogeneous catalyst, Mn(salicylaldimine) complex covalently bonded to α-titanium phosphate has been synthesized by in situ method and characterized by BET surface area, X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, Fourier transform infrared spectra, X-ray photoelectron spectroscopy and inductively coupled plasma atomic emission spectroscopy. The catalytic activity of α-TiP.Mn(salicylaldimine) is studied for the liquid phase oxidation of cyclohexane using tert-butylhydroperoxide as an oxidant under solvent-free condition. In the oxidation reaction, cyclohexane is oxidized to cyclohexanol, cyclohexanone and some unidentified products. A maximum conversion (14.75%) of cyclohexane with 91.70% selectivity of KA-oil is obtained at 353 K after 6 h of reaction time. The catalyst can be reused for four cycles without significant loss of catalytic activity

DrugBank: a comprehensive resource for in silico drug discovery and exploration

DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive drug target (i.e. protein) information. The database contains >4100 drug entries including >800 FDA approved small molecule and biotech drugs as well as >3200 experimental drugs. Additionally, >14 000 protein or drug target sequences are linked to these drug entries. Each DrugCard entry contains >80 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data. Many data fields are hyperlinked to other databases (KEGG, PubChem, ChEBI, PDB, Swiss-Prot and GenBank) and a variety of structure viewing applets. The database is fully searchable supporting extensive text, sequence, chemical structure and relational query searches. Potential applications of DrugBank include in silico drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction and general pharmaceutical education. DrugBank is available at

BacMap: an interactive picture atlas of annotated bacterial genomes

BacMap is an interactive visual database containing fully labeled, zoomable and searchable chromosome maps from more than 170 bacterial (archaebacterial and eubacterial) species. It uses a recently developed visualization tool (CGView) to generate high-resolution circular genome maps from sequence feature information. Each map includes an interface that allows the image to be expanded and rotated. In the default view, identified genes are drawn to scale and colored according to coding directions. When a region of interest is expanded, gene labels are displayed. Each label is hyperlinked to a custom ‘gene card’ which provides several fields of information concerning the corresponding DNA and protein sequences. Each genome map is searchable via a local BLAST search and a gene name/synonym search. BacMap is freely available at http://wishart.biology.ualberta.ca/BacMap/

Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complex

<p>Abstract</p> <p>Background</p> <p>The <it>Burkholderia cepacia </it>complex (BCC) is a versatile group of Gram negative organisms that can be found throughout the environment in sources such as soil, water, and plants. While BCC bacteria can be involved in beneficial interactions with plants, they are also considered opportunistic pathogens, specifically in patients with cystic fibrosis and chronic granulomatous disease. These organisms also exhibit resistance to many antibiotics, making conventional treatment often unsuccessful. KS10 was isolated as a prophage of <it>B. cenocepacia </it>K56-2, a clinically relevant strain of the BCC. Our objective was to sequence the genome of this phage and also determine if this prophage encoded any virulence determinants.</p> <p>Results</p> <p>KS10 is a 37,635 base pairs (bp) transposable phage of the opportunistic pathogen <it>Burkholderia cenocepacia</it>. Genome sequence analysis and annotation of this phage reveals that KS10 shows the closest sequence homology to Mu and BcepMu. KS10 was found to be a prophage in three different strains of <it>B. cenocepacia</it>, including strains K56-2, J2315, and C5424, and seven tested clinical isolates of <it>B. cenocepacia</it>, but no other BCC species. A survey of 23 strains and 20 clinical isolates of the BCC revealed that KS10 is able to form plaques on lawns of <it>B. ambifaria </it>LMG 19467, <it>B. cenocepacia </it>PC184, and <it>B. stabilis </it>LMG 18870.</p> <p>Conclusion</p> <p>KS10 is a novel phage with a genomic organization that differs from most phages in that its capsid genes are not aligned into one module but rather separated by approximately 11 kb, giving evidence of one or more prior genetic rearrangements. There were no potential virulence factors identified in KS10, though many hypothetical proteins were identified with no known function.</p