A communal catalogue reveals Earth’s multiscale microbial diversity

Our growing awareness of the microbial world\u27s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth\u27s microbial diversity

Rapid Pole Climbing with a Quadrupedal Robot

This paper describes the development of a legged robot designed for general locomotion of complex terrain but specialized for dynamical, high-speed climbing of a uniformly convex cylindrical structure, such as an outdoor telephone pole. This robot, the RiSE V3 climbing machine—mass 5.4 kg, length 70 cm, excluding a 28 cm tail appendage—includes several novel mechanical features, including novel linkage designs for its legs and a non-backdrivable, energy-dense power transmission to enable high-speed climbing. We summarize the robot’s design and document a climbing behavior that achieves rapid ascent of a wooden telephone pole at 21 cm/s, a speed previously unachieved—and, we believe, heretofore impossible—with a robot of this scale. The behavioral gait of the robot employs the mechanical design to propel the body forward while passively maintaining yaw, pitch, and roll stability during climbing locomotion. The robot’s general-purpose legged design coupled with its specialized ability to quickly gain elevation and park at a vertical station silently with minimal energy consumption suggest potential applications including search and surveillance operations as well as ad hoc networking

Polyurethane Elastomers as Maxillofacial Prosthetic Materials

A series of polyurethane elastomers based on an aliphatic diisocyanate and a polyether macroglycol was polymerized with various crosslink densities and OH/NCO ratios. Stoichiometries yielding between 8,600 and 12,900 gm/ mole/crosslink and an OH/NCO ratio of 1.1 resulted in polymers with the low modulus, yet high strength and elongation necessary for maxillofacial applications.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68299/2/10.1177_00220345780570040501.pd

Machine-learning derived acetabular dysplasia and cam morphology are features of severe hip osteoarthritis : findings from UK Biobank

Acknowledgements and disclosures The authors would like to thank Dr Martin Williams, Consultant Musculoskeletal Radiologist North Bristol NHS Trust, who provided substantial training and expertise in osteophyte assessment on DXA images. This research has been conducted using the UK Biobank Resource (application number 17295). Financial Support: RE, MF, FS are supported, and this work is funded by a Wellcome Trust collaborative award (reference number 209233). BGF is supported by a Medical Research Council (MRC) clinical research training fellowship (MR/S021280/1). CL was funded by the MRC, UK (MR/S00405X/1) as well as a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (223267/Z/21/Z). NCH acknowledges support from the MRC and NIHR Southampton Biomedical Research Centre, University of Southampton, and University Hospital Southampton. This research was funded in whole, or in part, by the Wellcome Trust [Grant number 223267/Z/21/Z]. NCH has received consultancy, lecture fees and honoraria from Alliance for Better Bone Health, AMGEN, MSD, Eli Lilly, Servier, UCB, Shire, Consilient Healthcare, Kyowa Kirin and Internis Pharma. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.Peer reviewedPublisher PD

Photometry of Variable Stars from Dome A, Antarctica

Dome A on the Antarctic plateau is likely one of the best observing sites on Earth thanks to the excellent atmospheric conditions present at the site during the long polar winter night. We present high-cadence time-series aperture photometry of 10,000 stars with i<14.5 mag located in a 23 square-degree region centered on the south celestial pole. The photometry was obtained with one of the CSTAR telescopes during 128 days of the 2008 Antarctic winter. We used this photometric data set to derive site statistics for Dome A and to search for variable stars. Thanks to the nearly-uninterrupted synoptic coverage, we find 6 times as many variables as previous surveys with similar magnitude limits. We detected 157 variable stars, of which 55% are unclassified, 27% are likely binaries and 17% are likely pulsating stars. The latter category includes delta Scuti, gamma Doradus and RR Lyrae variables. One variable may be a transiting exoplanet.Comment: Accepted for publication in the Astronomical Journal. PDF version with high-resolution figures available at http://faculty.physics.tamu.edu/lmacri/papers/wang11.pd

The Intermediate-Scale Clustering of Luminous Red Galaxies

We report the intermediate-scale (0.3 to 40 Mpc/h) clustering of 35,000 luminous early-type galaxies at redshifts 0.16 to 0.44 from the Sloan Digital Sky Survey. We present the redshift-space two-point correlation function \xi(s), the projected correlation function w_p(r_p), and the deprojected real-space correlation function \xi(r), for approximately volume-limited samples. As expected, the galaxies are highly clustered, with the correlation length varying from 9.8 +/- 0.2 Mpc/h to 11.2 +/- 0.2 Mpc/h, dependent on the specific luminosity range. For the -23.2 < Mg < -21.2 sample, the inferred bias relative to that of L* galaxies is 1.84 +/- 0.11 for 1 Mpc/h < r_p < 10 Mpc/h, with yet stronger clustering on smaller scales. We detect luminosity-dependent bias within the sample but see no evidence for redshift evolution between z=0.2 and z=0.4. We find a clear indication for deviations from a power-law in the real-space correlation function, with a dip at ~ 2 Mpc/h scales and an upturn on smaller scales. The precision measurements of these clustering trends offer new avenues for the study of the formation and evolution of these massive galaxies.Comment: 11 pages, 14 figures. Accepted to the Astrophysical Journa

Proceedings of the Third Caldwell Conference, St. Catherines Island, Georgia, May 9-11, 2008

341 p. : ill. (some col.), maps (some col.) ; 26 cm. "Issued June 23, 2010." Includes bibliographical references (p. 303-341).The late Archaic of the American Southeast is typically described as a time of population growth, innovative developments in subsistence strategies, and increased social complexity. Although it is difficult to generalize, many early Woodland communities are characterized as relatively small scale, fairly mobile foragers organized into unranked or minimally ranked lineages and clans. Early Woodland groups also seem to be more socially isolated than their late Archaic predecessors, with a decline in regional exchange networks. The papers in this volume were presented at a conference entitled "What Happened in the Late Archaic?" which was co-sponsored by the American Museum of Natural History and the St. Catherines Island Foundation and held on St. Catherines Island (Georgia), May 9-11, 2008. The Third Caldwell Conference invited the participants to engage the appropriate archaeological data from the American Southeast, specifically addressing the nature of change during the late Archaic-early Woodland transition. This volume consists of a dozen substantive papers, followed by three discussant contributions. TABLE OF CONTENTS: Trend, tradition, and transition at the end of the Archaic / Tristram R. Kidder -- "Nothing but the river's flood" : late Archaic diaspora or disengagement in the lower Mississippi Valley and southeastern North America / Jon L. Gibson -- The two rings of St. Catherines Island : some preliminary results from the St. Catherines and McQueen shell rings / Matthew C. Sanger and David Hurst Thomas -- Two late Archaic period shell rings, St. Simon's Island, Georgia / Rochelle A. Marrinan -- The Archaic above Choctawhatchee Bay : hydrodynamics, adaptation, and abandonment / Rebecca Saunders -- Prehistoric landscapes of complexity : Archaic and Woodland period shell works, shell rings, and tree islands of the Everglades, South Florida / Margo Schwadron -- Shell rings and other settlement features as indicators of cultural continuity between the late Archaic and Woodland periods of coastal Florida / Michael Russo -- "What happened to the southeastern Archaic?" : a perspective from St. Catherines Island / David Hurst Thomas -- Leaving the rings : shell ring abandonment and the end of the late Archaic / Matthew C. Sanger -- The rhythms of space-time and the making of monuments and places during the Archaic / Victor D. Thompson -- Getting from the late Archaic to early Woodland in three middle valleys (those being the Savannah, St. Johns, and Tennessee) / Kenneth E. Sassaman -- Late Archaic? : what the hell happened to the middle Archaic? / Joe Saunders -- Thoughts on the late Archaic-early Woodland transition on the Georgia and South Carolina coasts / Chester B. DePratter -- Mounds, middens, and rapid climate change during the Archaic-Woodland transition in the southeastern United States / William H. Marquardt -- The end of the southeastern Archaic : regional interaction and archaeological interpretation / David G. Anderson

Nonmotor Symptoms in LRRK2 G2019S Associated Parkinson's Disease

BACKGROUND: Idiopathic Parkinson's disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expected to differ clinically since the neuropathological substrate of LRRK2-PD is heterogeneous. The range and severity of extra-nigral nonmotor features associated with LRRK2 mutations is also not well-defined. OBJECTIVE: To evaluate the prevalence and time of onset of nonmotor symptoms (NMS) in LRRK2-PD patients. METHODS: The presence of hyposmia and of neuropsychiatric, dysautonomic and sleep disturbances was assessed in 33 LRRK2-G2019S-PD patients by standardized questionnaires and validated scales. Thirty-three IPD patients, matched for age, gender, duration of parkinsonism and disease severity and 33 healthy subjects were also evaluated. RESULTS: University of Pennsylvania Smell Identification Test (UPSIT) scores in LRRK2-G2019S-PD were higher than those in IPD (23.5±6.8 vs 18.4±6.0; p = 0.002), and hyposmia was less frequent in G2019S carriers than in IPD (39.4% vs 75.8%; p = 0.01). UPSIT scores were significantly higher in females than in males in LRRK2-PD patients (26.9±4.7 vs 19.4±6.8; p<0.01). The frequency of sleep and neuropsychiatric disturbances and of dysautonomic symptoms in LRRK2-G2019S-PD was not significantly different from that in IPD. Hyposmia, depression, constipation and excessive daytime sleepiness, were reported to occur before the onset of classical motor symptoms in more than 40% of LRRK2-PD patients in whom these symptoms were present at the time of examination. CONCLUSION: Neuropsychiatric, dysautonomic and sleep disturbances occur as frequently in patients with LRRK2-G2019S-PD as in IPD but smell loss was less frequent in LRRK2-PD. Like in IPD, disturbances such as hyposmia, depression, constipation and excessive daytime sleepiness may antedate the onset of classical motor symptoms in LRRK2-G2019S-PD