Progenetix: 12 years of oncogenomic data curation

DNA copy number aberrations (CNAs) can be found in the majority of cancer genomes and are crucial for understanding the potential mechanisms underlying tumor initiation and progression. Since the first release in 2001, the Progenetix project (http://www.progenetix.org) has provided a reference resource dedicated to provide the most comprehensive collection of genome-wide CNA profiles. Reflecting the application of comparative genomic hybridization techniques to tens of thousands of cancer genomes, over the past 12 years our data curation efforts have resulted in a more than 60-fold increase in the number of cancer samples presented through Progenetix. In addition, new data exploration tools and visualization options have been added. In particular, the gene-specific CNA frequency analysis should facilitate the assignment of cancer genes to related cancer types. In addition, the new user file processing interface allows users to take advantage of the online tools, including various data representation options for proprietary data pre-publication. In this update article, we report recent improvements of the database in terms of content, user interface and online tool

arrayMap 2014: an updated cancer genome resource

Somatic copy number aberrations (CNA) represent a mutation type encountered in the majority of cancer genomes. Here, we present the 2014 edition of arrayMap (http://www.arraymap.org), a publicly accessible collection of pre-processed oncogenomic array data sets and CNA profiles, representing a vast range of human malignancies. Since the initial release, we have enhanced this resource both in content and especially with regard to data mining support. The 2014 release of arrayMap contains more than 64 000 genomic array data sets, representing about 250 tumor diagnoses. Data sets included in arrayMap have been assembled from public repositories as well as additional resources, and integrated by applying custom processing pipelines. Online tools have been upgraded for a more flexible array data visualization, including options for processing user provided, non-public data sets. Data integration has been improved by mapping to multiple editions of the human reference genome, with the majority of the data now being available for the UCSC hg18 as well as GRCh37 versions. The large amount of tumor CNA data in arrayMap can be freely downloaded by users to promote data mining projects, and to explore special events such as chromothripsis-like genome pattern

A Bridge Between Users and Library Professionals Amid and Post COVID-19 Pandemic: Use of Virtual Reference Services in the Top Five University Libraries of World

The paper discusses the importance of ICT in rendering Virtual Reference Services (VRS) in libraries during and post Covid-19. The application of ICT is not a new phenomenon in libraries. Still, the disclosure of physical buildings is a nudge for adapting technology to make the libraries relevant during and after the pandemic. The study highlights the various ways to render virtual reference services delivery that libraries can provide to their users by harnessing Information and Communication technology. The paper discusses the use of virtual reference services such as email, webform, VoIP, instant messaging, videoconferencing and online chat in libraries to serve their users swiftly in the tough time of Covid-19. The paper investigated the various modes of providing virtual reference services in the top five universities as per the QS World University Rankings 2021, which are Massachusetts Institute of Technology (MIT), Stanford University, Harvard University, California Institute of Technology (Caltech) and the University of Oxford. The content analysis of websites was used to collect data. These libraries were selected deliberately as there are rendering different modes of Virtual reference services. VRS act as a bridge to facilitate users during a pandemic and reshape and enhance the library services after the pandemic. The article is an effort to create awareness among libraries to utilise the virtual reference service and support their users virtually

Complex Traffic Network Modeling & Area-wide Hierarchical Control

This thesis presents a novel methodology to divide a traffic region into subregions such that in each subregion a Macroscopic Fundamental Diagram (MFD) can be used to determine the state of that subregion. The region division is based on the theory of complex networks. We exploit the inherent network characteristics through PageRank centrality algorithm to identify the most significant nodes in the traffic network. We use these significant nodes as the seeds for a Voronoi diagram based partitioning mechanism of the network. A network wide hierarchical control framework is then presented which controls these sub regions individually and the network as a whole. At the subregion level a feedback controller is designed based on MFD concept. At the network level we develop a dynamic toll pricing algorithm to control the inflows into the network. This dynamic toll pricing is coupled with the subregion controller and thus forming a network wide hierarchical control. We use optimal control theory to design the dynamic toll pricing. A cost function is designed and then Hamilton-Jacobi-Bellman equation is used to derive an optimal control law that uses real-time information. The objective of the dynamic toll algorithm is to strike a balance between the toll price and optimal traffic conditions in each of the subregions. A case study is performed for the Manhattan area in New York city and results are provided through simulations

Qualitative study of loneliness in a senior housing community: the importance of wisdom and other coping strategies.

ObjectiveOlder adults are at a high risk for loneliness, which impacts their health, well-being, and longevity. While related to social isolation, loneliness is a distinct, internally experienced, distressing feeling. The present qualitative study sought to identify characteristics of loneliness in older adults living independently within a senior housing community, which is typically designed to reduce social isolation.MethodSemi-structured qualitative interviews regarding the experience of loneliness, risk factors, and ways to combat it were conducted with 30 older adults, ages 65-92 years. The interviews were audiotaped, transcribed, and coded using a grounded theory analytic approach based on coding, consensus, co-occurrence, and comparison.ResultsThree main themes with multiple subthemes are described: (A) Risk and Protective factors for loneliness: age-associated losses, lack of social skills or abilities, and protective personality traits; (B) Experience of loneliness: Sadness and lack of meaning as well as Lack of motivation; and (C) Coping strategies to prevent or overcome loneliness: acceptance of aging, compassion, seeking companionship, and environment enables socialization.DiscussionDespite living within a communal setting designed to reduce social isolation, many older adults described feeling lonely in stark negative terms, attributing it to aging-associated losses or lack of social skills and abilities. However, interviewees also reported positive personal qualities and actions to prevent or cope with loneliness, several of which mirrored specific components of wisdom. The results support the reported inverse relationship between loneliness and wisdom and suggest a potential role for wisdom-enhancing interventions to reduce and prevent loneliness in older populations

Social Media in contemporary marketing: YouTube Advertising for the Guerrillas

The guerrillas of the modern day marketing arena have been eyeing the innovative strategies to promote their products. They aim to grab the maximum attention with least amount the capital spent. This is what guerrilla marketing revolves around. YouTube has evolved as one such platform. It is being used as a powerful medium by the marketing managers to advertise their products on a world-wide stage by less spending. The paper throws light on the effectiveness of YouTube as a guerrilla strategy to know what attributes in a YouTube advertisement attracts the viewers to view and like it. Content analysis of fifty advertisements on YouTube of the consumer electronics segment has been done to know how the audience response to this new form of advertising platform

Práticas sustentáveis através de marketing guerrilla – Verde: uma abordagem inovadora.

Sustainability is the need of the hour. Organizations that align the interests of all their stakeholders – customers, investors and employees are considered to act for sustainable development. But some of the organizations compromise to this fact. They are rather busy exploiting the resources. Bluffing the customers for making quick profits has become a prevalent notion. Amidst all these selfish motives, they tend to forget about the repercussions which we and our planet may endure as a whole in near future. There are many evidences when responsible companies have proved themselves performing better in the long run.Green Guerrilla Marketing is an innovative concept, trying to figure out various ways to successfully market the products and at the same time acting ethically and socially responsible towards the sustainable development. It revolves around being conscious about 3Ps which are People, Profits and Planet. Guerrilla Marketing is an unconventional marketing strategy that focuses on attracting huge customer base with least amount of cost involved. Roots of Guerrilla Marketing can be traced to guerrilla warfare that was off-center warfare technique using unusual tactics by the armed civilians during Vietnam War in the 1960s. Since then this marketing concept has attracted many business houses. So far, Guerrilla Marketing was considered only as a creative tool for promoting ones’ product and services but now it can be seen as a responsible tool as well, which works toward a better society at large under the broad head of Green Guerrilla Marketing. Therefore, the paper is a pioneer attempt in understanding the potential of Green Guerrilla Marketing in the light of both sustainability and innovation at the same time. Also, it discusses various guerrilla techniques to market the products ethically without compromising on the profits. In the end, the paper also evaluates the examples to examine the concept.A Sustentabilidade é a necessidade do momentoa. Organizações que se alinham com os interesses de todos os seus stakeholders - clientes, investidores e funcionários são considerados como agindo para o desenvolvimento sustentável. Mas algumas das organizações não se comprometem como deviam e estão mais ocupadas explorando os recursos. Blefan os clientes para fazer lucros rápidos e isso se tornou comun. Em meio a todos esses motivos egoístas, eles tendem a esquecer das repercussões que nós e nosso planeta podemos suportar como um todo em um futuro próximo. Há muitas evidências quando as empresas responsáveis mostraram melhor desempenho no longo prazo. Green Guerrilla Marketing é um conceito inovador, tentando descobrir várias maneiras de comercializar com sucesso os produtos e, ao mesmo tempo, agir eticamente e socialmente responsável para o desenvolvimento sustentável. Ele gira em torno de ser consciente sobre 3Ps que são Pessoas, Lucros e Planeta. Marketing de Guerrilha é uma estratégia de marketing não convencional que se concentra em atrair uma enorme base de clientes com menos custos envolvidos. As Raízes desta estrategia pode ser rastreada para a guerra de guerrilha que foi a técnica de guerra fora da parte central dos acontecimentos usando táticas incomuns pelos civis armados durante a Guerra do Vietnã na década de 1960. Desde então, este conceito de marketing tem atraído muitas tipos de negócios. Até agora, o Marketingde Guerrilha foi considerado apenas como uma ferramenta criativa para promover produtos e serviços, mas agora ele pode ser visto como uma ferramenta responsável que trabalha para uma sociedade melhor em geral em base ao conceito de Marketing de Guerrilha verde. Portanto, este trablho é uma tentativa de compreender o potencial do Marketing de Guerrilha Verde à luz da sustentabilidade e inovação ao mesmo tempo. Além disso, analisa várias técnicas de guerrilha para comercializar os produtos de forma ética sem comprometer os lucros. No final, o trabalho também avalia exemplos examinndo o conceito

Privacy Protection in Bigdata: A Survey

Bigdata becomes a significant sector and academics research topic. Bigdata is a two-edged sword. The rising volume of information together will increase the likelihood of blundering non-public data privacy. Due to many new technologies and innovations that pervade our everyday lives, like smartphones and social networking apps, and the Internet of Things-based intelligent-world systems, the large amount of data generated in our world has exploded. During this data processing, storage, and the use of the information it can quickly cause personal information exposure and the difficulty of interpreting the information. The aim is to incorporate this range of information into one framework for big data management and to recognize problems regarding privacy. This paper begins with the introduction of bigdata, its process, protection issues, and tools which are used to solve its problem

Content Analysis of Websites of University Libraries in Delhi: A Study

Purpose - This study aims to evaluate the library websites of selected state and deemed universities in Delhi, capital city of India to ascertain how effectively libraries are leveraging their respective websites to provide library related information on their websites. Design/ Methodology - The study adopted the checklist technique to evaluate the content of library’s websites. A comprehensive checklist was designed on the basis of previous studies. It consists of 6 main aspects which are further divided into 66 elements. Findings -The study reveals that library related information such as general library information, about collection, links to e-resources, library services, currency and authority of websites are presented on the university library websites but not to the full extent. Web 2.0 tools are used by least libraries where only 2 libraries have library Facebook page, and only one has a library blog. DTU scored the highest, 45 out of 66 and Indira Gandhi Delhi Technical University for Women (IGDTUW) scored the least 13 out of 66 in overall ranking of websites based on elements presented on their websites. Originality/Value – The study suggested that libraries need to incorporate more information on their websites to promote the use of library resources and services. Libraries need to have a dedicated website and provide all the valuable and relevant information related to the library on their websites. This paper will guide librarians to effectively utilise and improve the quality of library websites. Keywords - Content Analysis, Library Website, University Libraries Paper Type - Research Pape

Generative Modeling of Human Behavior: Social Interaction and Networked Coordination in Shared Facilities

Urbanization is bringing together various modes of transport, and with that, there are challenges to maintaining the safety of all road users, especially vulnerable road users (VRUs). Therefore, there is a need for street designs that encourages cooperation and resource sharing among road users. Shared space is a street design approach that softens the demarcation of vehicles and pedestrian traffic by reducing traffic rules, traffic signals, road markings, and regulations. Understanding the interactions and trajectory formations of various VRUs will facilitate the design of safer shared spaces. It will also lead to many applications, such as implementing reliable ad hoc communication networks. In line with this motivation, this dissertation develops a methodology for generating VRUs\u27 trajectories that accounts for their walking behaviors and social interactions. The performed study leads to three traffic scenarios covering most pedestrian behavior and interactions traffic scenarios - group interactions, fixed obstacle interaction, and moving obstacle interaction. To implement the different scenarios in shared space facilities, we develop a receding horizon optimization-based trajectory planning algorithm capable of modeling pedestrian behavior and interactions. The generated trajectories are validated using two benchmark pedestrian datasets – DUT and TrajNet++. The validation is shown to yield low or near-zero Mean Euclidean Distance and Final Displacement Error values supporting the performance validity of the proposed generative algorithm. We further demonstrate the application of generated trajectories to predict the communication network topology formation, which leads to a stable network formation when integrated within ad hoc protocols. The developed pedestrian trajectory planning algorithm can be expanded as a simulation framework to provide a more realistic demonstration of how pedestrians use traffic facilities and interact with their environment. Moreover, the model\u27s applicability is not limited to road traffic and shared spaces. It can find broader applications such as the emergency evacuation of buildings, large events, airports, and railway stations