ASSESSMENT OF CARDIOMETABOLIC RISK FACTORS AMONG LOCAL POPULATION OF NATIONAL CAPITAL REGION

  Objective: In view of marked accentuations in cardiometabolic diseases in developing countries such as India, we aimed to conduct a cross-sectional study analyzing the prevalence of cardiometabolic risk factors in local population of Ghaziabad.Methods: The study is descriptive, random sample survey, and cross-sectional study. The study was carried out at Santosh Medical College, Ghaziabad, on 350 participants between the age group 18-70 years. After taking the informed consent, they were included in the study. The variables recorded were clinical history, all risk factors of cardiovascular disease including blood pressure, body mass index, waist circumference, blood sugar and serum lipid levels, cigarette use, and dietary habit.Result: Our study shows that the high prevalence of multiple risk factors in a general population with as many as 70% of the participants had metabolic syndrome. Among individually studied groups, obesity was the most common followed by dyslipidemia then diabetes and hypertension and the least prevalent was smoking. Females were more commonly affected than males by dyslipidemia and obesity, probably due to physical inactivity coupled with unhealthy diet and lifestyle.Conclusion: There is the higher prevalence of cardiometabolic risk factors among the population making the individuals prone to associated spontaneous coronary artery dissection and their predisposition. Therefore, timely detection of cardiometabolic factors and appropriate interventions may be of prime concern

Methods, potentials, and limitations of gene delivery to regenerate central nervous system cells

This review evaluates methods, success and limitations of transgenes delivery in central nervous system (CNS). Both viral and nonviral (such as liposome mediated) methods, expression and stability of transgenes have been discussed. The controlled expression and delivery techniques of transgene at the injured or diseased sites have also been discussed. Mifepristone (RU486) and tetracycline-based switch system for controlled expression could be a very useful tool for clinical purposes. Here we emphasized the importance and consequences of viral- and nonviral-mediated transgenes transfer and therapeutic ability along with advantages of controlled expressions

VERY HIGH-SPEED STREAMING FLOW CONTROL SYSTEM USING LESS ENERGY CONSUMPTION

Within the conventional system, power consumption is high and costly. The device is within just one condition at any given time, the condition it's in at any time is known as the present condition. It may vary from one condition to a different when initiated with a triggering event or condition, this really is known as transition. Field programmable gate arrays (FPGAs) are extensively utilized in verification of the conceptual design e small quantity. This paper presents design and simulation of the power efficient traffic light controller (PTLC). The primary focus is on simulation and optimization of PTLC design and computing its speed of operation. The style of PTLC is preferable to conventional when it comes to LUT’s (quantity of gates), complexity, size and price. Within this research paper a manuscript PTLC is given the absolute minimum quantity of LEDs which fairly improves its performance and helps make the design efficient when it comes to speed and memory regarding conventional design. The traditional traffic light controller continues to be implemented using microcontroller and FPGA’s. The study paper by Parasmani in 2013 mentioned using FPGA to create a sophisticated traffic light controller which utilizes the sensor to keep the continual traffic flow therefore, the power consumption is simply too high which may be reduced through the design PTLC. The novel style of PTLC is definitely an economical and shares the figures of high integration, low power and versatility. The PTLC continues to be implemented using FPGA. FPGA has numerous advantages because the speed, quantity of input/output ports and gratification. This technique continues to be effective tested and implemented in hardware using Xilinx v 10.1 software programs using High Speed Integrated circuit hardware description language (VHDL), RTL and technology schematic are incorporated to validate simulation results

How accurate are satellite estimates of precipitation over the north Indian Ocean?

Following the launch of the Global Precipitation Measurement (GPM) Core Observatory in early 2014, motivated from the successful Tropical Rainfall Measurement Mission (TRMM) satellite, an advanced and sophisticated global multi-satellite precipitation product – Integrated Multi- satellitE Retrievals for GPM (IMERG) was released at finer spatio-temporal scales. This precipitation product has been upgraded recently after several refinements and supposed to be superior to other existing global or quasi-global multi-satellite precipitation estimates. In the present study, IMERG precipitation is comprehensively evaluated for the first time against moored buoy observations over the north Indian Ocean at hourly scale for the study period of March 2014 to December 2015. IMERG precipitation performs considerably better over the Bay of Bengal than the Arabian Sea in both detection and estimation. The systematic error in IMERG is appreciably lower by about 14%, however, it generally overestimates in-situ precipitation and also exhibits noticeable false alarms. Furthermore, IMERG essentially shows an improvement over the TRMM Multi-satellite Precipitation Analysis (TMPA) at a daily scale over the north Indian Ocean. IMERG precipitation estimates show overall promising error characteristics, but there is still a need of substantial efforts for improvement in the satellite-based precipitation estimation algorithms especially over data sparse regions such as north Indian Ocean

PHYSICO-CHEMICAL AND MICROSCOPIC STUDY OF ARJUNA (TERMINALIA ARJUNA) BARK

In present study plant of Arjuna has been taken for physical and chemical analysis in terms of microtome of bark, powder study, loss on drying, ash values, extractive values, bulk density, Acid insoluble ash, Water-soluble Ash, Water-soluble extractive value, Alcohol-soluble extractive, pH range, TLC, Tapped density, Compressibility index, Hauser ratio, Angle of repose, Ultra violet fluorescence analysis of drug, etc. Physical and chemical analysis an important place in standardization of Ayurvedic drugs in order to make its global acceptability. The plant of Arjuna botanically named as Terminalia arjuna linn.; family Combretaceae, has traditionally been used to treat many diseases especially heart disease for centuries, thats why it is called as “Guardian of the heartâ€. Transverse sections of Arjuna bark shows the calcium oxalate crystal, starch grains and lignified cells respectively shows that Xylem Vessels, Sclerenchymatous Fibers, Cork Cells, Tracheids, Sclereids, LOD value of the sample of Arjuna is 5.63%. According to result the Arjuna has three Rf vaule0.70, 0.42, 0.28 table1.4. Angle of repose of powder sample shows the flow of powder. The extractive value of Arjuna have different solvent like water, ethanol, isopropanol, acetone, chloroform, benzene, toluene, petroleum ether, hexsene are respectively 50.80, 41.07,30.37, 8.95, 0.96, 0.67, 0.52, 0.51, 0.46

Formulation and Evaluation of Torsemide Granules (Sustained Release)

The aim of study was to design development and optimize a controlled release system of Torsemide. to increase its bioavailability by increasing the residence time in the stomach without contact with the mucosa, and was achieved through the preparation of floating granules by melt granulation techniques. Torsemide; a loop diuretic used in the treatment of congestive heart failure and edema was chosen as the drug candidate to be formulated as gastro retentive multiparticulate system as it is a weakly basic drug with a short half life of 2-3 hrs. Gelucire 43/01 was selected as a lipid carrier in different ratio (1:0.5, 1:1, 1:1.5) along with drug. The formulation F1 to F6 were prepared and evaluated for dependent variable (in vitro floating ability) and formulations F4 to F6 were selected as preliminary optimized formulation. The preliminary optimized formulation F4 to F6 were evaluated for micromeritic properties, drug content and percentage yield, in-vitro drug release,  percentage in-vitro floating ability and formulation F4 was selected as optimized formulation that exhibited good floating ability and zero order drug release (85.95 %) at the end of 8 hours. Aging effect on storage was evaluated using In-vitro drug release. The In-vitro drug release study of the aged sample showed increase in release behaviour, it may be due to phase transformation of Gelucire. In conclusion, hydrophobic lipid, Gelucire 43/01 can be considered as an effective carrier for design of a multi-unit floating drug delivery system of Torsemide. Keywords: Torsemide, Floating granules, Gelucire, In-vitro release study

Reducing the Number of Forward Nodes from 1-Hop Nodes to Cover 2-Hop Nodes with Network Coding

All neighbors of a node can receive a data packet conveyed by a broadcasting node in an ad-hoc wireless network. In this way, the no. of forwarding nodes is utilized as the cost criterion for propagation. Among different estimation approaches, the researcher uses 1-Hop nodes to cover entire 2- Hop nodes utilizing 2-hop region information to decrease repetitive communicates. We dissect a few deficiencies of this approach and propose an improved algorithm along with the network coding concepts in this paper. Our algorithm utilizes 2-hop neighborhood more successfully to lessen excess communicates. The Simulation results of applying this algorithm demonstrate performance improvements. Nowadays the scientists are acquainting the idea of Network coding to neighbour topology aware protocols that beats the excess number of broadcast by victimization the using XOR of data packets. We have made an endeavor to seek out the network coding gain. We’ve shown simulation, implementation and breakdown of result in various circumstances

Multivariate analysis in rice (Oryza sativa L.) germplasms for yield attributing traits

A study was conducted to evaluate the genetic diversity and relationships among sixty rice genotypes by assessing eleven morphological yield traits using principal component analysis (PCA) and cluster analysis at ANDUAT, Ayodhya (Uttar Pradesh), India. The results found significant variation among the genotypes, with some exhibiting higher values for certain traits which confirm genetic diversity. Cluster analysis revealed that Cluster V had the highest number of genotypes, while Cluster IV had the highest intra-cluster distance, suggesting that these genotypes would be useful for rice improvement. Principal component analysis revealed that the first two principal components, along with three other components, accounted for 75.11 percent of the total variability. Days to 50% flowering (DFF) in days was identified as the most accurate predictor of variability, followed by days to maturity (DM) in days, 1000 seed weight (TSW) in gm, and panicle length (PL) in cm. The principal component to be first (PC1) was linked with plant height (PH) and harvest index (HI) in gm, the second principal component (PC2) was linked with DFF and DM, the third (PC3) was linked with TSW and grains/panicle (GP) in number, the fourth (PC4) with panicles bearing per plant (PBP) in number and biological yield per plant (BY) in gramme, and the fifth principal component (PC5) is linked with PL and BY. The study identified several promising genotypes for various traits, including G.35, G.17, G.30, G.45, and G.46 for short plant height and G.60, G.40, G.54, G.55, and G.41 for high yield

Effect of application of some organic amendments on soil properties, extractable micronutrients and their chemical fractions in a sandy loam soil

In a 120-day incubation study, farmyard manure (FYM), mushroom compost (MC), poultry manure (PM), vermi-compost (VC), biogas slurry (BS) and biochar from Lantana sp.; a common weed (BC) each added at 15 t ha-1 significantly increased soil electrical conductivity and organic C content, however, only VC failed to increase soil organic C content significantly but increased soil pH when compared with the control sample. Among organic amendments, FYM, MC, VC and BS increased DTPA-extractable Zn and Mn in soil significantly when compared with the control sample, while BC was significantly effective in regard to increasing both DTPA-extractable Mn and hot water soluble B when compared with the control sample. Application of FYM and MC significantly increased DTPA-extractable Cu and Fe, respectively when compared with the control sample. Simple correlation and path coefficient analysis were performed to identify key chemical fractions of micronutrients in soil having the direct and indirect effects on availability of micronutrients in organically amended soils. Based on soil extractable concentrations of micronutrients in organically amended soils, FYM appeared to be the best source of Zn, Cu and Mn, while MC could serve as the best source of Fe. Biochar from Lantana sp. may serve as a good source of B