Honor, Shame, and Redemption: Explicating the American Evangelical Right\u27s Moral Worldview Regarding Same-Sex Marriage and Abortion

With the rise of the New Religious Right in American politics, same-sex marriage and abortion emerged as the seminal political issues in a burgeoning culture wars narrative. While previous literature in the sociology of religion and political science fields has examined conservative evangelical political mobilization around these issues, this literature has not adequately considered the primacy of theology in determining these critical political commitments of the evangelical right. This dissertation utilizes aspects of James Wellman\u27s concept of moral worldview, Ann Swidler\u27s ideas on the cultural toolkit, and Christian Smith\u27s subcultural identity theory to explore the formation of conservative evangelical social identity. In contrast to other works, however, this project asserts that theological orthodoxy directly dictates the most salient issues of political mobilization for members of the evangelical right. Key evangelical theological themes distill into three ideological frames that govern the conservative evangelical moral worldview and their political issue priorities. These ideological frames of moral purity/innocence, personal responsibility, and obedience to authority filter and limit the range of cultural tools available to conservative evangelicals in their experience of the world. Using content analysis to show how evangelical right leaders utilize these frames in their rhetoric, this project demonstrates how same-sex marriage and abortion emerge as the pivotal issues in the conservative evangelical mind. It argues that conservative evangelicals do not sort their sense of tribal identity into two categories of us and them, but rather three discrete categories of us, them, and potentially us, bringing the redemptive aspect of evangelical theology into their classification, reclassification and engagement with the Other. Combining the use of ideological frames with factors of threat and taboo, this dissertation demonstrates how evangelical theology directly produces moral claims and explicates how same-sex marriage and abortion have become a new political orthodoxy in an increasingly polarized American political landscape

Assessment of STEM e-Learning in an Immersive Virtual Reality (VR) Environment

This paper shows the early research findings of utilizing a virtual reality environment as an educational tool for the operation of a computerized numerical control (CNC) milling machine. Based off of previous work, the Advanced Virtual Machining Lab (AVML), this project features an environment in which a virtual CNC machine is fully operable, designed to allow STEM students and training professionals to learn the use of the CNC machine without the need to be in a physical lab. Users operate in the virtual environment using an immersive virtual reality headset (i.e. Oculus Rift) and standard input devices (i.e. mouse and keyboard), both of which combined make for easy movement and realistic visuals. On-screen tutorials allow users to learn about what they need to do to operate the machine without the need for outside instruction. While designing and perfecting this environment has been the primary focus of this project thus far, the research goal is to test the ease of use and the pedagogical effectiveness of the immersive technology as it relates to education in STEM fields. Initial usability studies for this environment featured students from a CAD/CAM-Theory and Advanced Applications (ME 54600) course at a Midwestern urban institution. Results from the study were tabulated with a survey using a four-point Likert scale and several open-ended questions. Findings from the survey indicated that the majority of users found the environment realistic and easy to navigate, in addition to finding the immersive technology to be beneficial. Many also indicated that they felt comfortable navigating the environment without the need for additional assistance from the survey proctors. Full details on the usability study, including data and discussion, can be found in this paper. The general consensus from the study was that, while some features needed refinement, the immersive environment helped them learn about the operation of a CNC machine. An additional comparative study will be undertaken to evaluate pedagogical effectiveness

High temperature superconducting infrared imaging satellite

A low earth orbiting platform for an infrared (IR) sensor payload is examined based on the requirements of a Naval Research Laboratory statement of work. The experiment payload is a 1.5-meter square by 0.5-meter high cubic structure equipped with the imaging system, radiators, and spacecraft mounting interface. The orbit is circular at 509 km (275 nmi) altitude and 70 deg. inclination. The spacecraft is three-axis stabilized with pointing accuracy of plus or minus 0.5 deg. in each axis. The experiment payload requires two 15-minute sensing periods over two contiguous orbit periods for 30 minutes of sensing time per day. The spacecraft design is presented for launch via a Delta 2 rocket. Subsystem designs include attitude control, propulsion, electric power, telemetry, tracking and command, thermal design, structure, and cost analysis

Soil–Plant Nutrient Interactions on Manure-Enriched Calcareous Soils

Growers working with manured soils o? en rely on soil test information when developing nutrient management for their crop, especially when manure application information is unavailable. Nutrient-enriched soils, like manured soils, can trigger nutrient de? ciencies and toxicities due to plant–soil nutrient interactions. ? e goal of the study was to determine correlations between soil test and plant tissue nutrient concentrations for irrigated corn silage crops (Zea mays L. subsp. mays) with varying nutrient concentrations unique to dairy manure-enriched calcareous soils. Whole plant and soil samples were collected from 39 cooperator corn silage ? elds at harvest over a 2-yr period throughout the Snake River Plain region of southern Idaho. Soils were sampled to a depth of 30.5 cm and analyzed for plant available forms of P, K, Ca, Mg, Na, S, Zn, Fe, Mn, Cu, and B; whole plant tops were analyzed for total N, P, K, Ca, Mg, Na, S, Zn, Fe, Mn, and Cu. Signi? cant positive correlations were detected between soil test K and tissue K (Spearman’s rho correlation coe? cient = 0.63), soil test K and tissue N (rho = 0.59), and soil test B and tissue N (rho = 0.53). A significant negative correlation was detected between soil test Fe and tissue Mn (rho = –0.59). Controlled studies are needed to corroborate the relationships observed in this survey study

Trends in chlamydia and gonorrhea positivity among heterosexual men and men who have sex with men attending a large urban sexual health service in Australia, 2002-2009

<p>Abstract</p> <p>Background</p> <p>To determine whether chlamydia positivity among heterosexual men (MSW) and chlamydia and gonorrhea positivity among men who have sex with men (MSM), are changing.</p> <p>Methods</p> <p>Computerized records for men attending a large sexual health clinic between 2002 and 2009 were analyzed. Chlamydia and gonorrhea positivity were calculated and logistic regression used to assess changes over time.</p> <p>Results</p> <p>17769 MSW and 8328 MSM tested for chlamydia and 7133 MSM tested for gonorrhea. In MSW, 7.37% (95% CI: 6.99-7.77) were chlamydia positive; the odds of chlamydia positivity increased by 4% per year (OR = 1.04; 95% CI: 1.01-1.07; p = 0.02) after main risk factors were adjusted for. In MSM, 3.70% (95% CI: 3.30-4.14) were urethral chlamydia positive and 5.36% (95% CI: 4.82-5.96) were anal chlamydia positive; positivity could not be shown to have changed over time. In MSM, 3.05% (95% CI: 2.63-3.53) tested anal gonorrhea positive and 1.83% (95% CI: 1.53-2.18) tested pharyngeal gonorrhea positive. Univariate analysis found the odds of anal gonorrhea positivity had decreased (OR = 0.93; 95% CI: 0.87-1.00; p = 0.05), but adjusting for main risk factors resulted in no change. Urethral gonorrhea cases in MSM as a percentage of all MSM tested for gonorrhea also fell (p < 0.001).</p> <p>Conclusions</p> <p>These data suggest that chlamydia prevalence in MSW is rising and chlamydia and gonorrhea prevalence among MSM is stable or declining. High STI testing rates among MSM in Australia may explain differences in STI trends between MSM and MSW.</p

Steroids in kidney transplant patients

Any evaluation of steroids in kidney transplantation is hampered by individual variability in metabolism, the lack of clinically available steroid blood levels, and overall little attention to steroid exposure. Many feel that steroids were an essential part of chronic immunosuppression in past decades but may no longer be necessary in low-risk populations when our newer and more potent drugs are used. Potential differences in long-term outcome will be unapparent in short-term antibody induction studies in low-risk patients, particularly with low on steroid doses, as may have happened in the recent, well-done Astellas trial. In many studies, the evidence for the superiority of mycophenolate (MMF) and tacrolimus (TAC) was not as strong as the evidence for the benefit of steroids in the Canadian cyclosporine study. As the practice of steroid withdrawal has increased, we have not seen the improvement in long-term graft survival that many expected with our newer agents. Steroids have immunosuppressive effects even in doses that are low by historic standards, and side effects may not justify their abandonment

CTIP2 Expression in Human Head and Neck Squamous Cell Carcinoma Is Linked to Poorly Differentiated Tumor Status

We have demonstrated earlier that CTIP2 is highly expressed in mouse skin during embryogenesis and in adulthood. CTIP2 mutant mice die at birth with epidermal differentiation defects and a compromised epidermal permeability barrier suggesting its role in skin development and/or homeostasis. CTIP2 has also been suggested to function as tumor suppressor in cells, and several reports have described a link between chromosomal rearrangements of CTIP2 and human T cell acute lymphoblast leukemia (T-ALL). The aim of the present study was to look into the pattern of CTIP2 expression in Head and Neck Squamous Cell Carcinoma (HNSCC).In the present study, we analyzed CTIP2 expression in human HNSCC cell lines by western blotting, in paraffin embedded archival specimens by immunohistochemistry (IHC), and in cDNA samples of human HNSCC by qRT-PCR. Elevated levels of CTIP2 protein was detected in several HNSCC cell lines. CTIP2 staining was mainly detected in the basal layer of the head and neck normal epithelium. CTIP2 expression was found to be significantly elevated in HNSCC (p<0.01), and increase in CTIP2 expression was associated with poorly differentiated tumor status. Nuclear co-localization of CTIP2 protein and cancer stem cell (CSC) marker BMI1 was observed in most, if not all of the cells expressing BMI1 in moderately and poorly differentiated tumors.We report for the first time expression of transcriptional regulator CTIP2 in normal human head and neck epithelia. A statistically significant increase in the expression of CTIP2 was detected in the poorly differentiated samples of the human head and neck tumors. Actual CTIP2, rather than the long form of CTIP2 (CTIP2(L)) was found to be more relevant to the differentiation state of the tumors. Results demonstrated existence of distinct subsets of cancer cells, which express CTIP2 and underscores the use of CTIP2 and BMI1 co-labeling to distinguish tumor initiating cells or cancer stem cells (CSCs) from surrounding cancer cells

Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells

Expansion of the vasa vasorum network has been observed in a variety of systemic and pulmonary vascular diseases. We recently reported that a marked expansion of the vasa vasorum network occurs in the pulmonary artery adventitia of chronically hypoxic calves. Since hypoxia has been shown to stimulate ATP release from both vascular resident as well as circulatory blood cells, these studies were undertaken to determine if extracellular ATP exerts angiogenic effects on isolated vasa vasorum endothelial cells (VVEC) and/or if it augments the effects of other angiogenic factors (VEGF and basic FGF) known to be present in the hypoxic microenvironment. We found that extracellular ATP dramatically increases DNA synthesis, migration, and rearrangement into tube-like networks on Matrigel in VVEC, but not in pulmonary artery (MPAEC) or aortic (AOEC) endothelial cells obtained from the same animals. Extracellular ATP potentiated the effects of both VEGF and bFGF to stimulate DNA synthesis in VVEC but not in MPAEC and AOEC. Analysis of purine and pyrimidine nucleotides revealed that ATP, ADP and MeSADP were the most potent in stimulating mitogenic responses in VVEC, indicating the involvement of the family of P2Y1-like purinergic receptors. Using pharmacological inhibitors, Western blot analysis, and Phosphatidylinositol-3 kinase (PI3K) in vitro kinase assays, we found that PI3K/Akt/mTOR and ERK1/2 play a critical role in mediating the extracellular ATP-induced mitogenic and migratory responses in VVEC. However, PI3K/Akt and mTOR/p70S6K do not significantly contribute to extracellular ATP-induced tube formation on Matrigel. Our studies indicate that VVEC, isolated from the sites of active angiogenesis, exhibit distinct functional responses to ATP, compared to endothelial cells derived from large pulmonary or systemic vessels. Collectively, our data support the idea that extracellular ATP participates in the expansion of the vasa vasorum that can be observed in hypoxic conditions