Ionic Conductivities of Molten CuI and AgI-CuI Mixtures

Ionic conductivities σ for molten CuI and AgI-CuI mixtures were measured in the temperature ranges of approximately 580-800 and 500-850 °C, respectively. The value of σ for molten CuI in the range is smaller than that for molten CuBr and CuCl. σ for molten AgI-CuI mixtures decreases with increasing CuI-concentration. The activation energies Ea for molten AgI-CuI system were determined from the analysis of temperature dependence of σ by using the by Arrhenius type equation. Ea for molten AgI-CuI gradually increase with increasing CuIconcentration

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for non-protein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology

Middle Ear Carcinoid Tumor : Case Report and Literature Review

We herein report a rare case of a carcinoid tumor observed in the middle ear. The 51-year-old female patient presented to our hospital with an 8-year history of mild deafness and sensation of obstruction within the left ear. Otoscopic examination revealed a pinkish mass in the hypotympanum, which was visible through an intact tympanic membrane. Computed tomography (CT) of the temporal bone showed a well-circumscribed mass of soft tissue density filling the left hypotympanum. The provisional clinical diagnosis was cholesteatoma or another type of tumor (e.g. glomus jugulare tumor or facial nerve neurilemmoma). Transcanal tympanotomy was performed under general anesthesia to explore the lesion. At surgery, a well-delineated, encapsulated pinkish mass was found in the hypotympanum. It was not adherent to the tympanic membrane or ossicles. The mass arose, via a narrow pedicle, from the lining epithelium at the promontory. Complete resection of the mass was performed with careful clearance around the ossicles and epithelium at the promontory. Histological examination showed a carcinoid tumor composed of islands, cords, and nests of tumor cells in a fibrous stroma. Immunohistochemistry revealed granular cytoplasmic positivity for chromogranin A. No general symptoms of carcinoid syndrome were observed in this patient. Endoscopic examination revealed no evidence of other carcinoid tumors in the gastrointestinal and respiratory tracts. Eight years postoperatively, no evidence of recurrence or metastatic disease has been observed

Integrative annotation of 21,037 human genes validated by full-length cDNA clones.

publication en ligne. Article dans revue scientifique avec comité de lecture. nationale.National audienceThe human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for non-protein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology

Spectral profile of atomic emission lines and effects of pulse duration on laser ablation in liquid

The emission spectra of laser-ablated Cu atoms in water were examined, focusing on the irradiation-pulse duration effects. Spectral line profile was observed for the pulse duration of 19, 90, and 150 ns at various delay times. The line width as narrow as instrumental width was obtained by 150-ns pulse at the delay time of 800 ns. Also, long pulses result in high intensity of the emission. The spectral feature obtained by long pulses looks similar to that obtained in a gas phase. The absorption of the later part of the long pulse directly by the plume having been formed by the earlier part of the pulse may be the cause of this gas-phase-like emission. Whether the pulse heats directly the surface or the plume was investigated by the measurements of the removal volume of the ablation pit obtained by laser confocal scanning microscopy and the maximum bubble expansion size observed by shadowgraphy

Ionic Conductivities of Molten CuI and AgI-CuI Mixtures

Ionic conductivities σ for molten CuI and AgI-CuI mixtures were measured in the temperature ranges of approximately 580-800 and 500-850 °C, respectively. The value of σ for molten CuI in the range is smaller than that for molten CuBr and CuCl. σ for molten AgI-CuI mixtures decreases with increasing CuI-concentration. The activation energies Ea for molten AgI-CuI system were determined from the analysis of temperature dependence of σ by using the by Arrhenius type equation. Ea for molten AgI-CuI gradually increase with increasing CuIconcentration

Ionic Conductivities of Molten CuI and AgI-CuI Mixtures

Ionic conductivities σ for molten CuI and AgI-CuI mixtures were measured in the temperature ranges of approximately 580-800 and 500-850 °C, respectively. The value of σ for molten CuI in the range is smaller than that for molten CuBr and CuCl. σ for molten AgI-CuI mixtures decreases with increasing CuI-concentration. The activation energies Ea for molten AgI-CuI system were determined from the analysis of temperature dependence of σ by using the by Arrhenius type equation. Ea for molten AgI-CuI gradually increase with increasing CuIconcentration