Modeling highly pathogenic avian influenza transmission in wild birds and poultry in West Bengal, India.

Wild birds are suspected to have played a role in highly pathogenic avian influenza (HPAI) H5N1 outbreaks in West Bengal. Cluster analysis showed that H5N1 was introduced in West Bengal at least 3 times between 2008 and 2010. We simulated the introduction of H5N1 by wild birds and their contact with poultry through a stochastic continuous-time mathematical model. Results showed that reducing contact between wild birds and domestic poultry, and increasing the culling rate of infected domestic poultry communities will reduce the probability of outbreaks. Poultry communities that shared habitat with wild birds or those indistricts with previous outbreaks were more likely to suffer an outbreak. These results indicate that wild birds can introduce HPAI to domestic poultry and that limiting their contact at shared habitats together with swift culling of infected domestic poultry can greatly reduce the likelihood of HPAI outbreaks

Parallel triplet formation pathways in a singlet fission material

Harvesting long-lived free triplets in high yields by utilizing organic singlet fission materials can be the cornerstone for increasing photovoltaic efficiencies potentially. However, except for polyacenes, which are the most studied systems in the singlet fission field, spin-entangled correlated triplet pairs and free triplets born through singlet fission are relatively poorly characterized. By utilizing transient absorption and photoluminescence spectroscopy in supramolecular aggregate thin films consisting of Hamilton-receptor-substituted diketopyrrolopyrrole derivatives, we show that photoexcitation gives rise to the formation of spin-0 correlated triplet pair 1(TT) from the lower Frenkel exciton state. The existence of 1(TT) is proved through faint Herzberg-Teller emission that is enabled by vibronic coupling and correlated with an artifact-free triplet-state photoinduced absorption in the near-infrared. Surprisingly, transient electron paramagnetic resonance reveals that long-lived triplets are produced through classical intersystem crossing instead of 1(TT) dissociation, with the two pathways in competition. Moreover, comparison of the triplet-formation dynamics in J-like and H-like thin films with the same energetics reveals that spin-orbit coupling mediated intersystem crossing persists in both. However, 1(TT) only forms in the J-like film, pinpointing the huge impact of intermolecular coupling geometry on singlet fission dynamics

Relationship of prostate cancer topography and tumour conspicuity on multiparametric magnetic resonance imaging: a protocol for a systematic review and meta-analysis

Abstract Introduction Multiparametric magnetic resonance imaging (mpMRI) has improved the triage of men with suspected prostate cancer, through precision prebiopsy identification of clinically significant disease. While multiple important characteristics, including tumour grade and size have been shown to affect conspicuity on mpMRI, tumour location and association with mpMRI visibility is an underexplored facet of this field. Therefore, the objective of this systematic review and meta-analysis is to collate the extant evidence comparing MRI performance between different locations within the prostate in men with existing or suspected prostate cancer. This review will help clarify mechanisms that underpin whether a tumour is visible, and the prognostic implications of our findings. Methods and analysis The databases MEDLINE, PubMed, Embase and Cochrane will be systematically searched for relevant studies. Eligible studies will be full-text English-language articles that examine the effect of zonal location on mpMRI conspicuity. Two reviewers will perform study selection, data extraction and quality assessment. A third reviewer will be involved if consensus is not achieved. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines will inform the methodology and reporting of the review. Study bias will be assessed using a modified Newcastle-Ottawa scale. A thematic approach will be used to synthesise key location-based factors associated with mpMRI conspicuity. A meta-analysis will be conducted to form a pooled value of the sensitivity and specificity of mpMRI at different tumour locations

Discovery of distinct lithosphere-asthenosphere boundary and the Gutenberg discontinuity in the Atlantic Ocean

The plate tectonic theory requires a rigid lithosphere floating over a weak asthenosphere, separated by the lithosphere-asthenosphere boundary, which has been sometimes interpreted as the Gutenberg discontinuity. Using a deep seismic reflection technique, we report the presence of two continuous reflections covering 27 Ma to 58 Ma oceanic lithosphere in the Atlantic Ocean. We find that the upper reflection deepens with age and follows the similar to 1250 degrees C isotherm, whereas the deeper reflection lies at a constant depth of similar to 75 km. We suggest that the upper reflection represents the thermally controlled lithosphere-asthenosphere boundary, whereas the lower reflection is the Gutenberg discontinuity, a frozen-in dehydration boundary separating the dry mantle melting region above from the hydrated mantle below formed at the ridge axis. We also find that thermal mantle anomalies rejuvenate the lithosphere, uplift the lithosphere-asthenosphere boundary, and destroy the Gutenberg discontinuity

Tick infestation on wild snakes in northern part of western Ghats of India.

In total, 167 individuals of 30 species of snakes belonging to 22 genera and five families were examined for tick infestation from November 2008 to March 2010. Only two species of snakes, Ptyas mucosa (L., 1758) (Indian rat snake) and Naja naja (L., 1758) (spectacled cobra), were found infested by ticks. All ticks collected were identified to be Amblyomma gervaisi [previously Aponomma gervaisi (Lucas, 1847) 1. The average prevalence of these ticks on Indian rat snakes (n=48) was 29.16%, with abundance of 7.02 ticks per individual; on spectacled cobras (n=20), average prevalence was 30.00%, with abundance of 6.9 ticks per individual. The nymphs and males were predominant. All the ticks were found on the dorsal aspect of the body of the snake, and no ticks were recorded on the head, tail, or ventral body. The rate of tick infestation was highest in scrubland and was lowest in evergreen forests. Female Indian rat snakes showed higher tick infestation rates than male Indian rat snakes. Using Mann-Whitney U test, we found that longer snakes of both species had significantly higher rate of tick infestation in both the species of snakes

Tick infestation on wild snakes in northern part of western Ghats of India.

In total, 167 individuals of 30 species of snakes belonging to 22 genera and five families were examined for tick infestation from November 2008 to March 2010. Only two species of snakes, Ptyas mucosa (L., 1758) (Indian rat snake) and Naja naja (L., 1758) (spectacled cobra), were found infested by ticks. All ticks collected were identified to be Amblyomma gervaisi [previously Aponomma gervaisi (Lucas, 1847) 1. The average prevalence of these ticks on Indian rat snakes (n=48) was 29.16%, with abundance of 7.02 ticks per individual; on spectacled cobras (n=20), average prevalence was 30.00%, with abundance of 6.9 ticks per individual. The nymphs and males were predominant. All the ticks were found on the dorsal aspect of the body of the snake, and no ticks were recorded on the head, tail, or ventral body. The rate of tick infestation was highest in scrubland and was lowest in evergreen forests. Female Indian rat snakes showed higher tick infestation rates than male Indian rat snakes. Using Mann-Whitney U test, we found that longer snakes of both species had significantly higher rate of tick infestation in both the species of snakes

Modeling highly pathogenic avian influenza transmission in wild birds and poultry in West Bengal, India.

Wild birds are suspected to have played a role in highly pathogenic avian influenza (HPAI) H5N1 outbreaks in West Bengal. Cluster analysis showed that H5N1 was introduced in West Bengal at least 3 times between 2008 and 2010. We simulated the introduction of H5N1 by wild birds and their contact with poultry through a stochastic continuous-time mathematical model. Results showed that reducing contact between wild birds and domestic poultry, and increasing the culling rate of infected domestic poultry communities will reduce the probability of outbreaks. Poultry communities that shared habitat with wild birds or those indistricts with previous outbreaks were more likely to suffer an outbreak. These results indicate that wild birds can introduce HPAI to domestic poultry and that limiting their contact at shared habitats together with swift culling of infected domestic poultry can greatly reduce the likelihood of HPAI outbreaks

Evolution of the Crustal and upper Mantle seismic structure from 0 – 27 Ma in the equatorial Atlantic Ocean at 2º 43´S

We present seismic tomographic results from a unique seismic refraction and wide-angle survey along a 600-km long flow-line corridor of oceanic lithosphere ranging in age from 0 to 27 Ma in the equatorial Atlantic Ocean at 2º 43´S. The velocities in the crust near the ridge axis rapidly increase in the first 6 Myr and then change gradually with age. The upper crust (Layer 2) thickness varies between 2 – 2.4 km with an average thickness of 2.2 km and the crustal thickness varies from 5.6 – 6 km along the profile with an average crustal thickness of 5.8 km. At some locations, we observe negative velocity anomalies (∼ -0.3 km/s) in the lower crust which could be either due to chemical heterogeneity in gabbroic rocks and/or the effects of fault related deformation zones leading to an increase in porosities up to 1.6% depending on the pore/crack geometry. The existence of a low velocity anomaly beneath the ridge axis suggests the presence of partial melt (∼1.3%) in the lower crust. Upper mantle velocities also remain low (∼7.8 km/s) from ridge axis up to 5 Ma, indicating a high temperature regime associated with mantle melting zone underneath. These results suggest that the evolution of the crust and uppermost mantle at this location occur in the first 10 Ma of its formation and then remains unchanged. Most of the structures in the older crust and upper mantle are fossilized structures and could provide information about past processes at ocean spreading centers

Seismically-derived porosity of deep-sea sediments over the last 74 Ma in the equatorial Atlantic Ocean: Implications for paleo-climate

International audienceDeep-sea sediments record the geological and climate history of the Earth. The seismic properties of these sediments, namely the P- and S-wave velocities, depend on their chemical compositions, grain size, age and depth of burial, which, in turn, influence the porosity. We use multichannel seismic reflection data to estimate the sediment thickness and P-wave velocity over 4-74 Ma old oceanic crust on the African Plate and 3-27 Ma old crust on the South American Plate in the equatorial Atlantic Region. We then use the P-to-S converted waves from the basement-sediment interface recorded by 69 multi-component ocean bottom seismometers to determine the P- and S-wave velocity ratios (VP/VS) over 3 to 74 Ma. We find that the VP/VS decreases from 8.9 ± 2.0 at 3 Ma to 5.0 ± 1.0 at 17 Ma but abruptly increases to 19.5 ± 2.8 at 37.5 Ma. Then, it gradually decreases for crustal ages >37 Ma, reaching 7.0 ± 0.3 at 74 Ma. These variations are almost symmetric across the Mid-Atlantic Ridge over 4-27 Ma, suggesting a relation to climate change rather than regional effects. We estimate the average sediment porosity using the VP/VS and find that the average porosity decreases from 89.2 ± 1.5% at 37.5 Ma to 69.9 ± 1.2% at 74 Ma, possibly associated with accumulation of terrigenous input from Africa. Between 4 and 37 Ma, the porosity fluctuates between 70% and 85%. Such a fluctuation correlates well with the decrease in the global atmospheric CO2 from 800 ppm to 400 ppm during the Oligocene and with carbonate compensation depth, which are possibly related to fauna/flora diversification and calcareous sediment accumulation. The variation in porosity at 23 and 17 Ma also appears to be linked with major climate shifts, suggesting that sediment porosity could be used to shed light on the past climate and fauna/flora characterization