Genotoxicity Evaluation of Commercially Available Acid Red Dye by Comet Assay in Fish (Cyprinus Carpio)

Genotoxicity of commercially available acid red dye on fish was evaluated. Fish were exposed to various concentrations of the dye and gill processed for comet assay. Nucleoids were visually scored and categorized into various damage degrees. Significant increase (p < 0.05) in the percentage and distribution of damaged nucleoids was recorded in all dye-treated groups over control. DNA damage scores (AU) increased with exposure concentrations and dose-response was observed at higher doses. From the results it is concluded that commercially available acid red dye is potentially genotoxic to fish. The results are preliminary and further studies are warranted to acknowledge this effect. Keywords: acid red, commercial dyes, genotoxicity, comet assay

Synthesis of indole based novel symmetrical nitroolefinic dendritic core through n-arylation route

Synthesis of indole based novel symmetrical nitroolefinic dendritic core has been succeeded using N-arylation route followed by Henry reaction. Synthesized symmetrical 1,3,5-triindolyl benzene has been successfully synthesis of by N-arylation of indole, symmetrical 1,3,5-tri(3-formyl indolyl)benzene and 1,3,5-tris(3-((E)-2-nitrovinyl)-1H-indol-1yl)benzene followed by Hendry reaction. These nitroolefinic cores have potential application in theoretical and medicinal chemistry and also used to prepare many new organic compounds of indole derivatives

Synthesis of indole based novel symmetrical nitroolefinic dendritic core through n-arylation route

649-652Synthesis of indole based novel symmetrical nitroolefinic dendritic core has been succeeded using N-arylation route followed by Henry reaction. Synthesized symmetrical 1,3,5-triindolyl benzene has been successfully synthesis of by N-arylation of indole, symmetrical 1,3,5-tri(3-formyl indolyl)benzene and 1,3,5-tris(3-((E)-2-nitrovinyl)-1H-indol-1yl)benzene followed by Hendry reaction. These nitroolefinic cores have potential application in theoretical and medicinal chemistry and also used to prepare many new organic compounds of indole derivatives

Bitcoin Heist Ransomware Attack Prediction Using Data Science Process

In recent years, ransomware attacks have become a more significant source of computer penetration. Only general-purpose computing systems with sufficient resources have been harmed by ransomware so far. Numerous ransomware prediction strategies have been published, but more practical machine learning ransomware prediction techniques still need to be developed. In order to anticipate ransomware assaults, this study provides a method for obtaining data from artificial intelligence and machine learning systems. A more accurate model for outcome prediction is produced by using the data science methodology. Understanding the data and identifying the variables are essential elements of a successful model. A variety of machine learning algorithms are applied to the pre-processed data, and the accuracy of each technique is compared to determine which approach performed better. Additional performance indicators including recall, accuracy, and f1-score are also taken into account while evaluating the model. It uses machine learning to predict how the ransomware attack would pan out

Phytochemical screening and antimicrobial activity of plant leaf extract against enteric bacterial pathogens

Punica granatum, a fruit-bearing shrub belonging to the Lythraceae family, offers various benefits to humans, with both its fibers and seeds being valuable. The seeds contain important oil acids such as palmitic, punica, stearic, and oleic acids. In India, P. granatum (pomegranate) leaves have been investigated for their potential antibacterial activity against enteric pathogens. These pathogens are responsible for causing gastrointestinal infections and are often associated with antibiotic resistance. The study aims to explore whether pomegranate leaves possess properties that can combat these enteric pathogens effectively. This research holds promise in identifying a natural and alternative approach to address antibacterial challenges, potentially contributing to the development of novel antimicrobial agents pomegranate is commonly used as a traditional remedy for treating enteric bacterial pathogens. To investigate its antibacterial properties, researchers studied the aqueous extract of P. granatum leaf against enteric pathogens, conducting tests like biochemical examinations and microscopy on the isolates. The phytochemical analysis of P. granatum (pomegranate) leaf aqueous extract revealed the presence of various bioactive compounds. These compounds include amino acids, carbohydrates, alkaloids, steroids, flavonoids, terpenoids, saponins, tannins, and phenols. To evaluate its antimicrobial activity, the researchers used antibiotic discs, including chloramphenicol, vancomycin, and gentamicin, employing the standard Kirby Bauer method. Results showed that vancomycin had the highest zone of inhibition, followed by chloramphenicol and gentamicin, with respective measurements of 20 mm and 19 mm. Chloramphenicol exhibited sensitivity against Escherichia coli (19 mm), while gentamicin showed sensitivity against Salmonella typhi (20 mm), Staphylococcus aureus (19 mm), and E. coli (18 mm). Vancomycin demonstrated sensitivity against S. aureus (21 mm). The aqueous leaf extract displayed significant antibacterial activity at concentrations of 20, 40 mcg, and 60 μg, showing effective zones of inhibition ranging from 15 mm to 22 mm against Pseudomonas aeruginosa, E. coli, S. aureus, Shigella dysentriae, Proteus vulgaris, and S. typhi. In conclusion, the study established that P. granatum leaf extracts possess remarkable antibacterial properties and contain valuable pharmaceutical bioactive compounds. Due to its efficacy in treating gastrointestinal disorders, it is utilized as a natural remedy in traditional medicine

K-matrices for non-abelian quantum Hall states

Two fundamental aspects of so-called non-abelian quantum Hall states (the q-pfaffian states and more general) are a (generalized) pairing of the participating electrons and the non-abelian statistics of the quasi-hole excitations. In this paper, we show that these two aspects are linked by a duality relation, which can be made manifest by considering the K-matrices that describe the exclusion statistics of the fundamental excitations in these systems.Comment: LaTeX, 12 page

Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

Background and purpose: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. Methods: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). Results: There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P&lt;0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P&lt;0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. Conclusions: During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT

Plant growth-promoting actinobacteria: a new strategy for enhancing sustainable production and protection of grain legumes

Grain legumes are a cost-effective alternative for the animal protein in improving the diets of the poor in South-East Asia and Africa. Legumes, through symbiotic nitrogen fixation, meet a major part of their own N demand and partially benefit the following crops of the system by enriching soil. In realization of this sustainability advantage and to promote pulse production, United Nations had declared 2016 as the “International Year of pulses”. Grain legumes are frequently subjected to both abiotic and biotic stresses resulting in severe yield losses. Global yields of legumes have been stagnant for the past five decades in spite of adopting various conventional and molecular breeding approaches. Furthermore, the increasing costs and negative effects of pesticides and fertilizers for crop production necessitate the use of biological options of crop production and protection. The use of plant growth-promoting (PGP) bacteria for improving soil and plant health has become one of the attractive strategies for developing sustainable agricultural systems due to their eco-friendliness, low production cost and minimizing consumption of non-renewable resources. This review emphasizes on how the PGP actinobacteria and their metabolites can be used effectively in enhancing the yield and controlling the pests and pathogens of grain legumes

Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality.

BACKGROUND AND PURPOSE: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. METHODS: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). RESULTS: There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. CONCLUSIONS: During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT