Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis

Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, respiratory system appears to be unique in that PGE2 has beneficial effects. We described that the difference in airway function observed in patients with eosinophilic bronchitis and asthma could be due to differences in PGE2 production. PGE2 present in induced sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity. This protective effect of PGE2 may not only be the result of a direct action exerted on airway smooth-muscle proliferation but may also be attributable to the other anti-inflammatory actions

Valor pronóstico de los volúmenes metabólicos PET/TAC en el cáncer de cérvix avanzado

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Obstetricia y Ginecología. Fecha de lectura: 30-03-2017Esta tesis tiene embargado el acceso al texto completo hasta el 30-09-201

Comparación celular y molecular de la bronquitis eosinofílica y el asma papel de la vía de la prostaglandina E2 en la regulación de la hiperreactividad bronquial

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Fisiología Animal II, leída el 16/03/2010.Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasTRUEProQuestpu

De la teoría a la tecnología. ¿De cómo la concepción de la relación? Forma - Materia, desde un punto de vista neo-materialista repercute en el proceso de diseño de la arquitectura textil.

El estudio y la observación de procesos naturales, y la aplicación de ciertos conceptos y comportamientos dinámicos comprendidos, interiorizados, y planteados como analogías posibles en lo no-viviente, permite concebir la materia como algo vivo, no como acto de fe, sino como posicionamiento metodológico. Desde esta concesión de las teorías neo-materialistas, se plantean cuestiones que inciden en el planteamiento del proceso de diseño. Se concibe la materia como elemento auto-organizado, en vez de como un elemento pasivo. De esta manera, la relación con la materia debe establecer una doble dirección, a través de un ensamblaje más complejo, olvidar el esquema jerárquico desde el que el humano ejerce una imposición sobre lo no-humano. La arquitectura ligera, y en concreto la arquitectura textil, debido a la naturaleza de sus materiales y su funcionamiento estructural, ya parte de la necesidad de un proceso de diseño que disiente radicalmente del conocido en la arquitectura convencional. Para alcanzar el nivel de eficiencia característico de la arquitectura ligera es necesario partir del material, conocerlo y explotar su potencial. Descubrir la forma que emerge de su naturaleza, que adopta. Se plantea un discurso teórico que aplicado a la tecnología utilizada en las tensoestructuras ofrece un punto de partida para un proceso de diseño más coherente con su naturale

Advantages and disadvantages of a interdisciplinary group in the face of European Space for Higher Education. Contributions to the processes of innovation and integration of ICT

La formación universitaria está viviendo uno de esos momentos donde el cambio se institucionaliza y hay que afrontar nuevos retos, básicamente impuestos. En ellos los docentes tendremos que asumir una modificación de nuestras percepciones y estar unidos para trabajar y converger en la universidad del Siglo XXI. Entendemos que es necesario el cambio, siempre y cuando lleve consigo un nuevo modelo de formación en el que el alumnado sea el protagonista de sus aprendizajes y el profesorado se convierta en facilitador de esos procesos. Para ello, deberá introducir nuevas formas de trabajo, tutoría, evaluación y seguimiento en las clases, bien empleando las Tecnologías de la Información y las Comunicaciones (TIC) como apoyo al proceso de enseñanza-aprendizaje, o incorporando nuevos materiales didácticos que favorezcan el aprendizaje autónomo del alumno y el desarrollo de competencias genéricas y específicas para su futuro profesional. En este artículo expondremos desde la perspectiva transversal de los participantes, las principales conclusiones extraídas del proyecto: Análisis y Estudio de Experiencias Colaborativas Apoyadas en E-Learning para el Espacio Europeo de Enseñanza Superior en la Universidad de Valladolid. (Curso 2007-2008). A lo largo del artículo analizaremos los puntos fuertes y débiles, los aciertos, los problemas y las soluciones comunes en relación con el uso de las TIC respecto a las distintas experiencias evaluadas. Todo ello, con la intención de promover sugerencias a un planteamiento común en su integración de cara a mejorar y facilitar el proceso formativo y adaptación a los criterios propuestos desde el EEES.In this moment, European Universities are experiencing one of those moments where change is institutionalized and they must face new challenges which are primarily imposing. Like teachers, we will have to assume a change in our perceptions working together to converge at the new universitary concept. For these reasons, we think change is necessary, but there is to build a new training model in which the students are the principle protagonists of their learning processes and teachers have to define the skills. At the same time, teachers must apply new methodologies, as well as mentoring and monitoring processes in their courses. In order to do this, they could use the Information and Communication Technologies (ICT) resources or other new sources which promote learning autonomous student and the development of generic and specific skills. In this article, we are going to present one of the project parts “Analysis and Study of collaborative experiences supported by E-Learning for the European Higher Education Area (EHEA) at the University of Valladolid”, which has taken place in 2007-2008. In this case, we have analysed some strength and weaknesses, as well as successes, problems and some possible solutions regarding the ICT use. One of our aims is to improve and facilitate these adaptation processes to the EHE

El trabajo interdisciplinar en la enfermedad de Huntington

Se argumenta la importancia del trabajo en equipo en la atención de las personas afectadas por la Enfermedad de Huntington y de sus familias, y se describen las principales funciones de los distintos profesionales que han de cubrir sus necesidades en cada una de las etapas de la enfermedad en función de las alteraciones y secuelas. Siguiendo esta premisa, se presenta el trabajo de intervención basado en la complementariedad de distintos profesionales que atienden y cuidan a las personas afectadas por la Enfermedad de Huntington, desarrollado en la Asociación de Corea de Huntington de Castilla y León

Attitudes of Spanish LGBTI+ Adolescents and Emerging Adults. : Cultural and Political Practices Among 16 to 29-year-old Non-cis-hetero People

Never in Spain’s history have sexual minorities enjoyed the current rights. However, LGBTIphobic rhetoric displayed by extreme-right activism threats the gains made. An online survey among LGBTI+ people between 16 and 29 years was conducted. 152 people answered. Results show that Spanish LGBTI+ youth is mostly prone to activism, they were quite informed about legal initiatives and they mostly think that LGBTI+ people continue to suffer discrimination, the group of friends and peers appears to be the safest context and teachers seem to fail on the duty of help LGBTI+ young people. Additionally, LGBTI+ young people often use inclusive language, especially in casual context, and they seek referents in social media, where they follow influencers who openly declared themselves part of the LGBTI+ collective. The study serves as an example of the changing cultural and political practices of non-cis-hetero youth in a society moving fast towards equality but attending the raising of regressive movements

Suppressors of Cytokine Signaling 3 Expression in Eosinophils: Regulation by PGE2 and Th2 Cytokines

Asthma and nonasthmatic eosinophilic bronchitis (NAEB) are respiratory disorders characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins play an important role in Th2-mediated allergic responses through control of the balance between Th1 and Th2 cells, particularly, SOCS3 and SOCS5. The aim of this study was to analyze SOCS expression in human peripheral blood eosinophils from patients with asthma, NAEB and healthy controls. SOCS expression in eosinophils from subjects was demonstrated by different techniques. Results showed that expression of SOCS3 in eosinophils and CD4 T cells from patients was higher than in healthy subjects. In addition, we demonstrated that prostaglandin E2 (PGE2) and Th2 cytokines are able to upregulate SOCS3 production in eosinophils and attenuate its degranulation. In conclusion, eosinophils are able to transcribe and translate SOCS3 protein and can contribute to the regulation of the Th1/Th2 balance through SOCS3 production

Pathological mandibular fracture: a severe complication of periimplantitis

Nowadays, dental implant treatment is a very common option for patients even in medical compromised conditions. Some complications related to them have been described. Periimplantitis (PI) is one of the biggest concerns of these kind of treatments, probably has a multifactorial aethiology. Usually the consequences of PI are the loss of the implants and prostheses, expenses of money and time for dentists and patients. Very often PI implies the necesity of repeating the treatment . Pathological mandibular fracture due to PI is a severe but infrequent complication after dental implant treatment, especially after PI. In this study we present three cases of mandibular pathologic fractures among patients with different medical and dental records but similar management: two of them had been treated years ago of oral squamous cell carcinoma with surgery and radiotherapy, the other patient received oral bisphosphonates for osteoporosis some years after implantation. We analized the causes, consequences and posible prevention of these fractures as well as the special features of this kind of mandibular fractures and the different existing treatments

Gene Expression Profiling in Lungs of Chronic Asthmatic Mice Treated with Galectin-3: Downregulation of Inflammatory and Regulatory Genes

Background. Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 and Th2 cells. In a previous study, we demonstrated that treatment of chronic asthmatic mice with gene therapy using plasmid encoding galectin-3 (Gal-3) led to an improvement in Th2 allergic inflammation. Methods. Using a microarray approach, this study endeavored to evaluate the changes produced by therapeutic Gal-3 delivered by gene therapy in a well-characterized mouse model of chronic airway inflammation. Results were confirmed by real-time RT-PCR, Western blot and immunohistochemical analysis. Results. We identify a set of genes involved in different pathways whose expression is coordinately decreased/increased in mice treated with Gal-3 gene therapy. We report a correlation between Gal-3 treatment and inhibition of SOCS1 and SOCS3 expression in lungs. Conclusion. These results suggest that negative regulation of SOCS1 and 3 following Gal-3 treatment could be a valuable therapeutic approach in allergic disease