Invest as You Go: How Public Health Investment Keeps Pension Systems Healthy

Better health not only boosts longevity in itself, it also postpones the initial onset of disability and chronic inrmity to a later age. In this paper we examine the potential eects of such compression of morbidity' on pensions, and introduce a health-dependent dimension to the standard pay-as-you-go (PAYG) pension scheme. Studying the long-term implications of such a system in a simple overlapping generations framework, we nd that an increase in public health investment can augment capital accumulation in the long run. Because of this, the combination of health investment with a partially health-dependent PAYG scheme may in fact outperform a purely PAYG system in terms of lifetime welfare

Vaccines are necessary, but not sufficient without better healthcare and ventilation

First paragraph: A high vaccination rate is the foundation of any pandemic policy, but further protection is still needed. From an economic perspective, that protection comes from more investment in healthcare and air quality, which now seem essential complements to vaccines and face masks.https://theconversation.com/vaccines-are-necessary-but-not-sufficient-without-better-healthcare-and-ventilation-17343

Voluntary Provision of Public Knowledge Goods: Group-Based Social Preferences and Coalition Formation

In this paper we develop a private-collective model of voluntary public knowledge production, where group-based social preferences have an impact on coalition formation. Our theoretical model builds on the large empirical literature on voluntary production of pooled public knowledge goods, including source code in communities of software developers or data provided to open access data repositories. Our analysis shows under which conditions social preferences such as 'group belonging' or 'peer approval' influence stable coalition size, as such rationalising several stylized facts emerging from large scale surveys of Free/Libre/Open-Source software developers (David and Shapiro, 2008), previously unaccounted for. Furthermore, heterogeneity of social preferences is added to the model to study the formation of stable, but mixed coalitions

Vaccines are necessary, but not sufficient without better healthcare and ventilation

First paragraph: A high vaccination rate is the foundation of any pandemic policy, but further protection is still needed. From an economic perspective, that protection comes from more investment in healthcare and air quality, which now seem essential complements to vaccines and face masks

Networked innovation and coalition formation: the effect of group-based social preferences

In this paper, we study the production and dissemination of public knowledge goods, such as technological knowledge, generated by a network of voluntarily cooperating innovators. We develop a private-collective model of public knowledge production in networked innovation systems, where group-based social preferences have an impact on the coalition formation of developers. Our model builds on the large empirical literature on voluntary production of pooled public knowledge goods, including source code in communities of software developers or data provided to open access data repositories. Our analysis shows under which conditions social preferences, such as ‘group belonging’ or ‘peer approval’, influence the stable coalition size, as such rationalising several stylized facts emerging from large-scale surveys of open-source software developers, previously unaccounted for. Furthermore, heterogeneity of social preferences is added to the model to study the formation of stable but mixed coalitions

How COVID-19 is shaping the way Europeans think about politicians

First paragraph: COVID-19 is an unprecedented doom loop between a severe health crisis and grave economic repercussions. Government interventions to handle the outbreak and its aftermath first stopped public life in its tracks and then entirely reshaped it. This has left us in a kind of “new normal”, in which social interactions and labour conditions will probably never be the same again.https://theconversation.com/how-covid-19-is-shaping-the-way-europeans-think-about-politicians-14689

Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria

Background: Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity and mortality due to drug resistance and cancer metastasis are yet to be eliminated. Recently, doxycycline has been reported to have cytotoxic and anti-proliferating properties in various cancer cells. In this study, whether doxycycline was apoptosis threshold lowering agent in colorectal cancer cells by targeting mitochondria was answered.Results: This study showed dose-dependent cytotoxic effects of cisplatin, oxaliplatin and doxycycline in HT29 colorectal cancer cells. Doxycycline showed inhibition of cytochrome-c-oxidase activity in these cells over a time period. The pre-treatment of doxycycline reported statistically significant increased cytotoxicity of cisplatin and oxaliplatin compared to cisplatin and oxaliplatin alone. The caspase studies revealed significantly less expression and activity of caspase 3 in HT29 cells pre-treated with doxycycline compared to the cells treated with cisplatin and oxaliplatin alone.Conclusions: It was concluded that doxycycline lowered the apoptotic threshold in HT 29 cells by targeting mitochondria. This also raised possible caspase-independent mechanisms of apoptosis in HT29 cells when pre-treated with doxycycline however this needs further research work

Le fédéralisme budgétaire en Belgique : genèse, tensions et défis

editorial reviewe

Pyrethroid resistance in Anopheles gambiae leads to increased susceptibility to the entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana

<p>Abstract</p> <p>Background</p> <p>Entomopathogenic fungi are being investigated as a new mosquito control tool because insecticide resistance is preventing successful mosquito control in many countries, and new methods are required that can target insecticide-resistant malaria vectors. Although laboratory studies have previously examined the effects of entomopathogenic fungi against adult mosquitoes, most application methods used cannot be readily deployed in the field. Because the fungi are biological organisms it is important to test potential field application methods that will not adversely affect them. The two objectives of this study were to investigate any differences in fungal susceptibility between an insecticide-resistant and insecticide-susceptible strain of <it>Anopheles gambiae sensu stricto</it>, and to test a potential field application method with respect to the viability and virulence of two fungal species</p> <p>Methods</p> <p>Pieces of white polyester netting were dipped in <it>Metarhizium anisopliae </it>ICIPE-30 or <it>Beauveria bassiana </it>IMI391510 mineral oil suspensions. These were kept at 27 ± 1°C, 80 ± 10% RH and the viability of the fungal conidia was recorded at different time points. Tube bioassays were used to infect insecticide-resistant (VKPER) and insecticide-susceptible (SKK) strains of <it>An. gambiae s.s</it>., and survival analysis was used to determine effects of mosquito strain, fungus species or time since fungal treatment of the net.</p> <p>Results</p> <p>The resistant VKPER strain was significantly more susceptible to fungal infection than the insecticide-susceptible SKK strain. Furthermore, <it>B. bassiana </it>was significantly more virulent than <it>M. anisopliae </it>for both mosquito strains, although this may be linked to the different viabilities of these fungal species. The viability of both fungal species decreased significantly one day after application onto polyester netting when compared to the viability of conidia remaining in suspension.</p> <p>Conclusions</p> <p>The insecticide-resistant mosquito strain was susceptible to both species of fungus indicating that entomopathogenic fungi can be used in resistance management and integrated vector management programmes to target insecticide-resistant mosquitoes. Although fungal viability significantly decreased when applied to the netting, the effectiveness of the fungal treatment at killing mosquitoes did not significantly deteriorate. Field trials over a longer trial period need to be carried out to verify whether polyester netting is a good candidate for operational use, and to see if wild insecticide-resistant mosquitoes are as susceptible to fungal infection as the VKPER strain.</p