Rapidity-dependence of jet shape broadening and quenching

The jet shape modification due to partonic energy loss in the dense QCD matter is investigated by the help of the special transverse energy-energy correlator in the vicinity of maximum energy deposition of every event. In the accepted scenario with scattering of jet hard partons off comoving medium constituents this correlator is independent of the pseudorapidity position of a jet axis and becomes considerably broader (symmetrically over the pseudorapidity and the azimuthal angle) in comparison with $pp$-collisions. At scattering off "slow" medium constituents the broadening of correlation functions is dependent on the pseudorapidity position of a jet axis and increases noticeably in comparison with the previous scenario for jets with large enough pseudorapidities. These two considered scenarios result also in the different dependence of jet quenching on the pseudorapidity.Comment: 9 pages, 7 figures, 1 table, RevTex4, typos corrected, accepted for publication in Phys. Rev.

Pharmacological modulation of cell functional activity with valproic acid and erythropoietin

Valproic acid (VA) is carboxylic acid with a branched chain, which is used as an antiepileptic drug. VA, which is an antiepileptic drug, is also a teratogen, which causes defects of a neural tube and an axial skeleton, although the mechanisms are not yet fully clear. It is shown that valproic acid reduces the intracellular level of oxygen active form

Stimulation of reparation in a linear wound model in rats by Bischofit gel

The article is to evaluate Bischofit gel reparative activity in a linear wound model in rat

The system of EAS time analysis

The extensive air showers' (EAS) front shape, angle of incidence, disk thickness, particle distribution along the shower, on the delayed and EAS front advancing particles were determined. The suggested system of the EAS time analysis allows determination of the whole EAS longitudinal structure at the observation points. The information from the detectors is continuously recorded in the memory with the memory cell switching in 5 ns, this enables fixation of the moment of pulse input from the detector with an accuracy to + or - 2.5 ns. Along with the fast memory, a slow memory with the cell switching in 1 micron s is introduced in the system, this permits observation of relatively large time intervals with respect to the trigger pulse with an appropriately lower accuracy

Elliptic flow studies using the CMS detector

The azimuthal anisotropy of charged particles in heavy ion collisions is an important probe of quark-gluon plasma evolution at early stages. The nuclear reaction plane can be determined independently by different detector subsystems and using different analysis methods. This paper reports the capability of the CMS detector at the LHC to reconstruct the reaction plane of the collision and to me asure elliptic flow with calorimetry and a tracking system. The analysis is based on a full CMS detector simulation of \rm{Pb+Pb} events with the HYDJET event generator

Study of the anti-inflammatory and immunotropic activity of the secretome from multipotent mesenchymal stromal cells induced by erythropoietin, valproic acid or dexamethasone in vitro

The aim of this study was to evaluate the effect of treatment with valproic acid, erythropoietin, and dexamethasone on the anti-inflammatory and immunosuppressive activity of the secretome of adipose-derived multipotent mesenchymal stromal cells (MMSCs) in an in vitro experimen

Azimuthal anisotropy of jet quenching at LHC

We analyze the azimuthal anisotropy of jet spectra due to energy loss of hard partons in quark-gluon plasma, created initially in nuclear overlap zone in collisions with non-zero impact parameter. The calculations are performed for semi-central Pb-Pb collisions at LHC energy.Comment: Talk given at Fourth International Conference "Physics and Astrophysics of Quark-Gluon Plasma", November 26-30, 2001; 4 pages including 4 eps-figure

Two-dimensional discrete wavelet analysis of multiparticle event topology in heavy ion collisions

The event-by-event analysis of multiparticle production in high energy hadron and nuclei collisions can be performed using the discrete wavelet transformation. The ring-like and jet-like structures in two-dimensional angular histograms are well extracted by wavelet analysis. For the first time the method is applied to the jet-like events with background simulated by event generators, which are developed to describe nucleus-nucleus collisions at LHC energies. The jet positions are located quite well by the discrete wavelet transformation of angular particle distribution even in presence of strong background.Comment: 6 pages, 6 figure

Изучение противовоспалительной и иммунотропной активности секретома мультипотентных мезенхимальных стромальных клеток, индуцированных эритропоэтином, вальпроевой кислотой или дексаметазоном in vitro

The aim of this study was to evaluate the effect of treatment with valproic acid, erythropoietin, and dexamethasone on the anti-inflammatory and immunosuppressive activity of the secretome of adipose-derived multipotent mesenchymal stromal cells (MMSCs) in an in vitro experiment.Materials and methods. MMSCs were isolated from the fat of 6 healthy donors. The cells were grown in the culture up to passage 4. Then they were treated with valproic acid, erythropoietin or dexamethasone for 3 hours, washed from preparations, and incubated in a serum-free medium for 48 hours. Some of the cells were not treated with preparations. Supernatants from the cell cultures were concentrated by ultrafiltration, and protein standardization was performed using a nanophotometer. Then the supernatants were sterilized and added to mononuclear cells from peripheral blood of 8 healthy donors. The mononuclear cells were isolated by Ficoll density gradient centrifugation according to the standard protocol. Concentrations of TNFα, IL-2, IL-4, IL-6, IL-10, and IFNγ cytokines in 24-hour cultures and IL-9, IL-10, IL-17A, and IL-21 cytokines in 48-hour cultures were determined using multiplex analysis.Results. The production of IL-2, IL-6, TNFα, and IL-10 was reduced by the secretome of MMSCs treated with valproic acid. The production of IL-2, IL-6, and TNFα decreased during incubation of the mononuclear cells with the secretome of MMSCs treated with erythropoietin. The secretome of dexamethasone-treated MMSCs suppressed the production of IFNγ, IL-1β, IL-1ra, IL-2, IL-6, IL-9, IL-10, and IL-17A. No statistically significant differences were revealed in the production of IL-4, IL-5, IL-9, and IL-21.Conclusion. Among the studied inducers, dexamethasone enhanced the anti-inflammatory and immunosuppressive activity of MMSCs the most, which was manifested through the effect of their supernatants on peripheral blood mononuclear cells.Цель. Исследовать влияние обработки вальпроевой кислотой, эритропоэтином и дексаметазоном на противовоспалительную и иммуносупрессивную активность секретома мультипотентных мезенхимальных стромальных клеток (ММСК) жировой ткани в эксперименте in vitro.Материалы и методы. ММСК выделяли из жира шести здоровых доноров. Клетки растили в культуре до четвертого пассажа, затем обрабатывали вальпроевой кислотой, эритропоэтином или дексаметазоном в течение 3 ч, отмывали от препаратов и инкубировали в бессывороточной среде в течение 48 ч. Часть клеток не обрабатывали препаратами. Супернатанты от культур клеток сконцентрировали ультрафильтрацией, стандартизировали по содержанию белка с помощью нанофотометра, стерилизовали и добавляли к мононуклеарам из периферической крови восьми здоровых доноров. Мононуклеары выделяли в градиенте плотности фиколла по стандартному протоколу. Концентрации цитокинов фактора некроза опухоли альфа (TNFα), интерлейкина (IL) 2, IL-4, IL-6, IL-10, интерферона гамма (IFNγ) в суточных культурах и IL-9, IL-10, IL-17A, IL-21 в 48-часовых культурах определяли с помощью мультиплексного анализа.Результаты. Продукция IL-2, IL-6, TNFα, IL-10 снижается под действием секретома от обработанных вальпроевой кислотой ММСК. Продукция IL-2, IL-6, TNFα уменьшается при инкубации мононуклеаров с секретомом клеток, обработанных эритпропоэтином. Секретом обработанных дексаметазоном ММСК подавляет продукцию IFNγ, IL-1β, IL-1ra, IL-2, IL-6, IL-9, IL-10, IL-17A. Статистически значимых различий по изменению продукции IL-4, IL-5, IL-9, IL-21 не выявлено.Заключение. Среди изученных индукторов дексаметазон показал себя более активным в усилении противовоспалительной и иммуносупрессивной активности ММСК, выраженной через влияние их супернатантов на мононуклеары периферической крови