A Dispersive Force Model of Caribbean Island Biogeography

Framework-based models serve as an important tool to describe, predict and manage ecological systems. In this paper I construct one such model, a dispersive force model based on MacArthur and Wilson’s (1963) theory of island biogeography, in order to assess island species richness with varying climatic patterns. Specifically, I use island–mainland distance (d), insular area (A), a climatic dispersal parameter (f), and a climatic disturbance parameter (h) to calculate the insular species richness ratio at equilibrium. To test this model through hurricane impact on marine islands, it was executed with data from islands of the Dutch Caribbean. Future climatic conditions were based on the UN IPCC report’s 2100 predictions with a mean global temperature rise of 2°C. Although the model was implemented with conservative estimates, all the islands tested show a significant decline in species diversity in future climatic conditions. The windward islands show a ~9% to 13% decrease in insular species richness, compared to ~2% decline on the leeward islands

Achievable Rate Regions for Two-Way Relay Channel using Nested Lattice Coding

This paper studies Gaussian Two-Way Relay Channel where two communication nodes exchange messages with each other via a relay. It is assumed that all nodes operate in half duplex mode without any direct link between the communication nodes. A compress-and-forward relaying strategy using nested lattice codes is first proposed. Then, the proposed scheme is improved by performing a layered coding : a common layer is decoded by both receivers and a refinement layer is recovered only by the receiver which has the best channel conditions. The achievable rates of the new scheme are characterized and are shown to be higher than those provided by the decode-and-forward strategy in some regions.Comment: 27 pages, 13 figures, Submitted to IEEE Transactions on Wireless Communications (October 2013

Energy minimization based Resource Scheduling for Strict Delay Constrained Wireless Communications

This paper investigates the energy consumption minimization for resource scheduling in a wireless communication. We propose to take into account a strict delay constraint for each queued packet rather than an average delay constraint, in addition to a buffer overflow constraint. The associated optimization problem can be modeled as Constraint Markov Decision Problem where the actions are the number of packets sent on the known channel at each slot. The optimal random policy is exhibited through the resolution of standard linear programming. We show the gain in energy is substantial compared to naive policy

Testing Against Independence with an Eavesdropper

We study a distributed binary hypothesis testing (HT) problem with communication and security constraints, involving three parties: a remote sensor called Alice, a legitimate decision centre called Bob, and an eavesdropper called Eve, all having their own source observations. In this system, Alice conveys a rate R description of her observation to Bob, and Bob performs a binary hypothesis test on the joint distribution underlying his and Alice's observations. The goal of Alice and Bob is to maximise the exponential decay of Bob's miss-detection (type II-error) probability under two constraints: Bob's false alarm-probability (type-I error) probability has to stay below a given threshold and Eve's uncertainty (equivocation) about Alice's observations should stay above a given security threshold even when Eve learns Alice's message. For the special case of testing against independence, we characterise the largest possible type-II error exponent under the described type-I error probability and security constraints.Comment: submitted to ITW 202

Diagnosis of invasive aspergillus tracheobronchitis facilitated by endobronchial ultrasound-guided transbronchial needle aspiration: a case report

<p>Abstract</p> <p>Introduction</p> <p>Invasive pulmonary aspergillosis is the most common form of infection by <it>Aspergillus species </it>among immunocompromised patients. Although this infection frequently involves the lung parenchyma, it is unusual to find it limited to the tracheobronchial tree, a condition known as invasive aspergillus tracheobronchitis.</p> <p>Case presentation</p> <p>A 65 year-old Hispanic man from Bolivia with a history of chronic lymphocytic leukemia developed cough and malaise eight months after having an allogenic stem cell transplant. A computed tomography of the chest revealed an area of diffuse soft tissue thickening around the left main stem bronchus, which was intensely fluorodeoxyglucose-avid on positron emission tomography scanning. An initial bronchoscopic exam revealed circumferential narrowing of the entire left main stem bronchus with necrotic and friable material on the medial wall. Neither aspirates from this necrotic area nor bronchial washing were diagnostic. A second bronchoscopy with endobronchial ultrasound evidenced a soft tissue thickening on the medial aspect of the left main stem bronchus underlying the area of necrosis visible endoluminally. Endobronchial ultrasound-guided transbronchial needle aspiration performed in this area revealed multiple fungal elements suggestive of <it>Aspergillus species</it>.</p> <p>Conclusion</p> <p>We describe the first case of invasive aspergillus tracheobronchitis in which the diagnosis was facilitated by the use of endobronchial ultrasound guided trans-bronchial needle aspiration. To the best of our knowledge, we are also presenting the first positron emission tomography scan images of this condition in the literature. We cautiously suggest that endobronchial ultrasound imaging may be a useful tool to evaluate the degree of invasion and the involvement of vascular structures in these patients prior to bronchoscopic manipulation of the affected areas in an effort to avoid potentially fatal hemorrhage.</p

Does pleural fluid appearance really matter? The relationship between fluid appearance and cytology, cell counts, and chemical laboratory measurements in pleural effusions of patients with cancer

<p>Abstract</p> <p>Background</p> <p>Previous reports have suggested that the appearance of pleural effusions (i.e., the presence or absence of blood) might help to establish the etiology of the effusions. This study explores the relationship between pleural fluid appearance and the results of chemical and cytological analyses in a group of patients with recurrent symptomatic pleural effusions and a diagnosis of cancer.</p> <p>Methods</p> <p>Medical records were reviewed from all 390 patients who were diagnosed with cancer, who underwent thoracentesis before placement of an intrapleural catheter (IPC) between April 2000 and January 2006. Adequate information for data analysis was available in 365 patients. The appearance of their pleural fluid was obtained from procedure notes dictated by the pulmonologists who had performed the thoracenteses. The patients were separated into 2 groups based on fluid appearance: non-bloody and bloody. Group differences in cytology interpretation were compared by using the chi square test. Cellular counts, chemical laboratory results, and survival after index procedure were compared by using the student's t test.</p> <p>Results</p> <p>Pleural fluid cytology was positive on 82.5% of the non-bloody effusions and on 82.4% of the bloody ones. The number of red blood cells (220.5 × 10³/μL vs. 12.3 × 10³/μL) and LDH values (1914 IU/dl vs. 863 IU/dl) were statistically higher in bloody pleural effusions.</p> <p>Conclusion</p> <p>The presence or absence of blood in pleural effusions cannot predict their etiology in patients with cancer and recurrent symptomatic pleural effusions.</p

Modulation of BCL-X(L) is a critical determinant of C-myc induced apoptosis

The fine balance between proliferation and apoptosis plays a primary role in carcinogenesis. Proto-oncogenes that induce both proliferation and apoptosis provide a powerful inbuilt system to inhibit clonal expansion of cells with high proliferation rates. This provides a restraint to the development of neoplasms. C-myc expressing cells undergo apoptosis in low serum by an unknown mechanism. Several lines of evidence suggested that c-myc induces apoptosis by a transcriptional mechanism. However, the target genes of this program have not been fully defined. Protein synthesis inhibitors induce apoptosis in c-myc over-expressing cells at high serum levels suggesting that inhibition of synthesis of a survival factor may induce apoptosis. We show that the expression of c-myc directly correlates with an increase in the level of a survival protein, bcl-\rm x\sb{L}, and a decrease in the pro-apoptotic protein, bax, at both the protein and mRNA level. Furthermore, a significant decrease of the bcl-\rm x\sb{L} protein levels is observed under low serum conditions. In order to investigate the mechanism of regulation of bcl-\rm x\sb{L} and bax by c-myc, the bcl-x and bax promoters were cloned, sequenced and shown to contain c-myc binding sites. The chloramephenicol acetyl transferase (CAT) reporter assay was used to demonstrate activation of the bcl-x promoter by increasing levels of c-myc when co-transfected in COS cells. The bax promoter was also shown to be transrepressed in c-myc expressing cells. The role of bcl-\rm x\sb{L} in apoptosis regulation in c-myc cell lines in normal and low serum was then investigated. Cells lines expressing c-myc and bcl-\rm x\sb{L} were generated and were shown to be resistant to apoptosis induction in low serum. Furthermore, cell lines expressing c-myc, anti-sense bcl-\rm x\sb{L} and $\beta$-galactosidase demonstrated significantly enhanced rates of apoptosis in high serum compared to c-myc Rat 1a cells. These findings suggest that c-myc activates a survival program involving bcl-\rm x\sb{L} upregulation and bax downregulation. However, this survival signal is reduced under low serum conditions by the relative downregulation of bcl-\rm x\sb{L} allowing for apoptosis to proceed. These data also directly demonstrates that downregulation in the level of bcl-\rm x\sb{L} associated with low serum conditions is a critical determinant of c-myc induced apoptosis