15 research outputs found
Original Article - A study of histopathological features of medullary carcinoma of the thyroid: Cases from a single institute in India
BACKGROUND: The microscopic features of medullary carcinoma have been
described in world literature, together with its behavior and molecular
biology. However, no large study has been reported from India. AIMS:
This study aims to analyse the clinical, and especially the
pathological features of medullary carcinoma of the thyroid, and the
surrounding thyroid. MATERIALS AND METHODS: In this study a total of
234 cases of medullary thyroid carcinoma (MTC) were gathered over a
period of 3 decades. The clinical presentation, the microscopic
features and the clinical outcome were analyzed. RESULTS: MTC was
found to be twice as common in men as in women and for some reason it
occurred 10 years earlier in women. The histology revealed certain
interesting features like the presence of apoptosis in over half of the
tumors, in addition to the other common and not so common histological
findings (encapsulated variant, small cell variants, follicular
pattern, rosettes, oncocytic change, osteosarcoma-like pattern, and
cribriform pattern). The adjacent thyroid in about 19% of the cases
showed optically clear nuclei in the follicles that were close to the
tumor cells. These features were similar to those seen in papillary
thyroid carcinoma. CONCLUSIONS: The thyroid adjacent to MTC showed
nuclear changes, which are also found in papillary carcinoma of the
thyroid. The occasional concurrent occurrence of these two tumors and
the involvement of the RET gene in both medullary and papillary
carcinomas, makes this observation worth discussing and studying
further
A study of histopathological features of medullary carcinoma of the thyroid: Cases from a single institute in India
BACKGROUND: The microscopic features of medullary carcinoma have been
described in world literature, together with its behavior and molecular
biology. However, no large study has been reported from India. AIMS:
This study aims to analyse the clinical, and especially the
pathological features of medullary carcinoma of the thyroid, and the
surrounding thyroid. MATERIALS AND METHODS: In this study a total of
234 cases of medullary thyroid carcinoma (MTC) were gathered over a
period of 3 decades. The clinical presentation, the microscopic
features and the clinical outcome were analyzed. RESULTS: MTC was
found to be twice as common in men as in women and for some reason it
occurred 10 years earlier in women. The histology revealed certain
interesting features like the presence of apoptosis in over half of the
tumors, in addition to the other common and not so common histological
findings (encapsulated variant, small cell variants, follicular
pattern, rosettes, oncocytic change, osteosarcoma-like pattern, and
cribriform pattern). The adjacent thyroid in about 19% of the cases
showed optically clear nuclei in the follicles that were close to the
tumor cells. These features were similar to those seen in papillary
thyroid carcinoma. CONCLUSIONS: The thyroid adjacent to MTC showed
nuclear changes, which are also found in papillary carcinoma of the
thyroid. The occasional concurrent occurrence of these two tumors and
the involvement of the RET gene in both medullary and papillary
carcinomas, makes this observation worth discussing and studying
further