Urban socioeconomic inequality and biodiversity often converge, but not always: A global meta-analysis

It is through urban biodiversity that the majority of humans experience nature on a daily basis. As cities expand globally, it is increasingly important to understand how biodiversity is shaped by human decisions, institutions, and environments. In some cities, research has documented convergence between high socioeconomic status (SES) and high species diversity. Yet, other studies show that residents with low SES live amid high biodiversity or that SES and biodiversity appear unrelated. This study examines the conditions linked to varying types of relationships between SES and biodiversity. We identified and coded 84 case studies from 34 cities in which researchers assessed SES-biodiversity relationships. We used fuzzy-set Qualitative Comparative Analysis (fsQCA) to evaluate combinations of study design and city-level conditions that explain why SES-biodiversity relationships vary city to city and between plants and animals. While the majority of cases demonstrated increased biodiversity in higher SES neighborhoods, we identified circumstances in which inequality in biodiversity distribution was ameliorated or negated by disturbance, urban form, social policy, or collective human preference. Overall, our meta-analysis highlights the contributions of residential and municipal decisions in differentially promoting biodiversity along socioeconomic lines, situated within each city’s environmental and political context. Through identifying conditions under which access to biodiversity is more or less unequal, we call attention to outstanding research questions and raise prospects for better promoting equitable access to biodiversity

Quantifying Long-Term Urban Grassland Dynamics: Biotic Homogenization and Extinction Debts

Sustainable urban nature conservation calls for a rethinking of conventional approaches. Traditionally, conservationists have not incorporated the history of the landscape in management strategies. This study shows that extant vegetation patterns are correlated to past landscapes indicating potential extinction debts. We calculated urban landscape measures for seven time periods (1938–2019) and correlated it to three vegetation sampling events (1995, 2012, 2019) using GLM models. We also tested whether urban vegetation was homogenizing. Our results indicated that urban vegetation in our study area is not currently homogenizing but that indigenous forb species richness is declining significantly. Furthermore, long-term studies are essential as the time lags identified for different vegetation sampling periods changed as well as the drivers best predicting these changes. Understanding these dynamics are critical to ensuring sustainable conservation of urban vegetation for future citizens

Design, synthesis and biological evaluation of edaravone derivatives bearing theN-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents

A series of multi-target directed edaravone derivatives bearingN-benzyl pyridinium moieties weredesigned and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects andN-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, peripheralanionic site (PAS) and catalytic anionic site (CAS), acetylcholinesterase (AChE) inhibitor. The designed edar-avone-N-benzyl pyridinium hybrid compounds were docked within the AChE active site. The results indi-cated interactions with conserved amino acids (Trp279 in PAS and Trp84 in CAS), suggesting good dual-site inhibitory activity. Significantin vitroAChE inhibitory activities were observed for selected compounds(IC50:1.2–4.6mM) with limited butyrylcholinesterase inhibitory activity (IC50’s>160mM), indicating excellentselectivity towards AChE (SI: 46–>278). The compounds also showed considerable antioxidant ability,similar to edaravone.In silicostudies indicated that these compounds should cross the blood–brain bar-rier, making them promising lead molecules in the development of anti-Alzheimer’s agents

Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents

A series of multi-target directed edaravone derivatives bearing N-benzyl pyridinium moieties were designed and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, peripheral anionic site (PAS) and catalytic anionic site (CAS), acetylcholinesterase (AChE) inhibitor. The designed edaravone-N-benzyl pyridinium hybrid compounds were docked within the AChE active site. The results indicated interactions with conserved amino acids (Trp279 in PAS and Trp84 in CAS), suggesting good dual-site inhibitory activity. Significant in vitro AChE inhibitory activities were observed for selected compounds (IC50: 1.2–4.6 µM) with limited butyrylcholinesterase inhibitory activity (IC50’s >160 µM), indicating excellent selectivity towards AChE (SI: 46–>278). The compounds also showed considerable antioxidant ability, similar to edaravone

The emergence of insecticide resistance in central Mozambique and potential threat to the successful indoor residual spraying malaria control programme.

BACKGROUND: Malaria vector control by indoor residual spraying was reinitiated in 2006 with DDT in Zambézia province, Mozambique. In 2007, these efforts were strengthened by the President's Malaria Initiative. This manuscript reports on the monitoring and evaluation of this programme as carried out by the Malaria Decision Support Project. METHODS: Mosquitoes were captured daily through a series of 114 window exit traps located at 19 sentinel sites, identified to species and analysed for sporozoites. Anopheles mosquitoes were collected resting indoors and tested for insecticide resistance following the standard WHO protocol. Annual cross sectional household parasite surveys were carried out to monitor the impact of the control programme on prevalence of Plasmodium falciparum in children aged 1 to 15 years. RESULTS: A total of 3,769 and 2,853 Anopheles gambiae s.l. and Anopheles funestus, respectively, were captured from window exit traps throughout the period. In 2010 resistance to the pyrethroids lambda-cyhalothrin and permethrin and the carbamate, bendiocarb was detected in An. funestus. In 2006, the sporozoite rate in An. gambiae s.s. was 4% and this reduced to 1% over 4 rounds of spraying. The sporozoite rate for An. funestus was also reduced from 2% to 0 by 2008. Of the 437 Anopheles arabiensis identified, none were infectious. Overall prevalence of P. falciparum in the sentinel sites fell from 60% to 32% between October 2006 and October 2008. CONCLUSION: Both An. gambiae s.s. and An. funestus were controlled effectively with the DDT-based IRS programme in Zambézia, reducing disease transmission and burden. However, the discovery of pyrethroid resistance in the province and Mozambique's policy change away from DDT to pyrethroids for IRS threatens the gains made here

International nonproprietary names for monoclonal antibodies: an evolving nomenclature system

Appropriate nomenclature for all pharmaceutical substances is important for clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique and globally recognized for all pharmaceutical substances are assigned by the International Nonproprietary Names (INN) Programme of the World Health Organization (WHO). In 1991, the INN Programme implemented the first nomenclature scheme for monoclonal antibodies. To accompany biotechnological development, this nomenclature scheme has evolved over the years; however, since the scheme was introduced, all pharmacological substances that contained an immunoglobulin variable domain were coined with the stem -mab. To date, there are 879 INN with the stem -mab. Owing to this high number of names ending in -mab, devising new and distinguishable INN has become a challenge. The WHO INN Expert Group therefore decided to revise the system to ease this situation. The revised system was approved and adopted by the WHO at the 73rd INN Consultation held in October 2021, and the radical decision was made to discontinue the use of the well-known stem -mab in naming new antibody-based drugs and going forward, to replace it with four new stems: -tug, -bart, -mig, and -ment. Keywords: International Nonproprietary Name (INN); antibodies; antibody-based drugs; antibody-drug conjugates; biological drugs; biologics; nomenclature scheme; pharmaceuticals; safety; therapeutic antibodies

International nonproprietary names for monoclonal antibodies: an evolving nomenclature system

Appropriate nomenclature for all pharmaceutical substances is important for clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique and globally recognized for all pharmaceutical substances are assigned by the International Nonproprietary Names (INN) Programme of the World Health Organization (WHO). In 1991, the INN Programme implemented the first nomenclature scheme for monoclonal antibodies. To accompany biotechnological development, this nomenclature scheme has evolved over the years; however, since the scheme was introduced, all pharmacological substances that contained an immunoglobulin variable domain were coined with the stem -mab. To date, there are 879 INN with the stem -mab. Owing to this high number of names ending in -mab, devising new and distinguishable INN has become a challenge. The WHO INN Expert Group therefore decided to revise the system to ease this situation. The revised system was approved and adopted by the WHO at the 73rd INN Consultation held in October 2021, and the radical decision was made to discontinue the use of the well-known stem -mab in naming new antibody-based drugs and going forward, to replace it with four new stems: -tug, -bart, -mig, and -ment

Adrenocorticotrophic hormone-stimulated cortisol release by the head kidney inter-renal tissue from sea bream (Sparus aurata) fed with linseed oil and soyabean oil

The mode of action of highly unsaturated fatty acids (HUFA) in regulating gilthead sea bream (Sparus aurata) head kidney (HK) cortisol production was studied through in vitro trials using a dynamic superfusion system. Fish were previously fed with different diets containing several inclusion levels of linseed oil (LO) or soyabean oil (SO) for 26 weeks. Five diets were tested; anchovy oil was the only lipid source for the control diet (fish oil, FO) and two different substitution levels (70 and 100 %) were tested using either LO or SO (70LO, 70SO, 100LO and 100SO). Fatty acid compositions of the HK reflected the dietary input, thus EPA, DHA, arachidonic acid and n-3 HUFA were significantly (P,0·05) reduced in fish fed vegetable oils compared with fish fed the FO diet. Feeding 70 or 100% LO increased significantly (P,0·05) cortisol release in HK after stimulation with adrenocorticotrophic hormone (ACTH), while feeding SO had no effect on this response. Cortisol stimulation factor (SF) was increased in fish fed the 70LO and 100LO diets compared with fish fed the control diet. Moreover, eicosanoid inhibition by incubating the HK tissue with indomethacin (INDO) as a cyclo-oxygenase (COX) inhibitor, or nordihydroguaiaretic acid (NDGA) as a lipoxygenase (LOX) inhibitor, significantly reduced (P,0·05) the cortisol release after ACTH stimulation in the 70LO and 100LO diets. Cortisol SF was reduced in the FO, 70LO and 100LO diets when incubating the HK with INDO or NDGA, while it was increased in the 70SO diet. The present results indicate that changing the fatty acid profile of gilthead sea bream HK by including LO and/or SO in the fish diet affected the in vitro cortisol release, and this effect is partly mediated by COX and/or LOX metabolites

Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents

Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease (AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of monoamine oxidase (MAO) and cholinesterase enzymes, which are complicit in AD’s complex pathophysiology. A preliminary series of 3,7-substituted coumarin derivatives were synthesised and evaluated for enzyme inhibitory activity, cytotoxicity as well as neuroprotective ability. The results indicated that the compounds are weak cholinesterase inhibitors with five compounds demonstrating relatively potent inhibition and selectivity towards MAO-B with IC50 values between 0.014 and 0.498 hx00B5;mM. Significant neuroprotective effects towards MPPþ-compromised SH-SY5Y neuroblastoma cells were also observed, with no inherent cytotoxicity at 10 mM for all compounds. The overall results demonstrated that substitution of the phenylethyloxy moiety at the 7-position imparted superior general activity to the derivatives, with the propargylamine substitution at the 3-position, in particular, displaying the best MAO-B selectivity and neuroprotection

Could purposefully engineered native grassland gardens enhance urban insect biodiversity?

Progress is required in response to how cities can support greater biodiversity. This calls for more research on how landscape designers can actively shape urban ecologies to deliver contextspecific empirical bases for green space intervention decisions. Design experiments offer opportunities for implemented projects within real-world settings to serve as learning sites. This paper explores preliminary ecological outcomes from a multidisciplinary team on whether purposefully engineered native grassland gardens provide more habitat functions for insects than mainstream gardens in the City of Tshwane, South Africa. Six different sites were sampled: two recently installed native grassland garden interventions (young native), two contemporary non-native control gardens (young non-native) on the same premises and of the same ages as the interventions, one remnant of a more pristine native grassland reference area (old native), and one long-established, non-native reference garden (old non-native). Plant and insect diversity were sampled over one year. The short-term findings suggest that higher plant beta diversity (species turnover indicating heterogeneity in a site) supports greater insect richness and evenness in richness. Garden size, age, and connectivity were not clear factors mediating urban habitat enhancement. Based on the preliminary results, the researchers recommend high native grassland species composition and diversity, avoiding individual species dominance, but increasing beta diversity and functional types when selecting garden plants for urban insect biodiversity conservation in grassland biomes.National Research Foundation: Incentive funding; University of Pretoria: University Capacity Development Program; Research Development Program.https://www.mdpi.com/journal/landam2023ArchitectureZoology and Entomolog