New reference ranges for interpreting forced expiratory manoeuvres in infants and implications for clinical interpretation: a multicentre collaboration

The raised volume rapid thoracoabdominal compression (RVRTC) technique is commonly used to obtain full forced expiratory manoeuvres from infants, but reference equations derived from 'in-house' equipment have been shown to be inappropriate for current commercially available devices

Synthesis, morphology and crystallization kinetics of Polyheptalactone (PHL)

Aliphatic polyesters are widely studied due to their excellent properties and low-cost production and also because, in many cases, they are biodegradable and/or recyclable. Therefore, expanding the range of available aliphatic polyesters is highly desirable. This paper reports the synthesis, morphology, and crystallization kinetics of a scarcely studied polyester, polyheptalactone (PHL). First, we synthesized the η-heptalactone monomer by the Baeyer–Villiger oxidation of cycloheptanone before several polyheptalactones of different molecular weights (in the range between 2 and 12 kDa), and low dispersities were prepared by ring-opening polymerization (ROP). The influence of molecular weight on primary nucleation rate, spherulitic growth rate, and overall crystallization rate was studied for the first time. All of these rates increased with PHL molecular weight, and they approached a plateau for the highest molecular weight samples employed here. Single crystals of PHLs were prepared for the first time, and hexagonal-shaped flat single crystals were obtained. The study of the crystallization and morphology of PHL revealed strong similarities with PCL, making PHLs very promising materials, considering their potential biodegradable character.This work has received funding from the Basque Government through grant IT1503-22. The authors would also like to acknowledge the financial support from the BIODEST project; this project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 778092

S-system theory applied to array-based GNSS ionospheric sensing

The GPS carrier-phase and code data have proven to be valuable sources of measuring the Earth’s ionospheric total electron content (TEC). With the development of new GNSSs with multi frequency data, many more ionosphere-sensing combinations of different precision can be formed as input of ionospheric modelling. We present the general way of interpreting such combinations through an application of S-system theory and address how their precision propagates into that of the unbiased TEC solution. Presenting the data relevant to TEC determination, we propose the usage of an array of GNSS antennas to improve the TEC precision and to expedite the rather long observational time-span required for high-precision TEC determination

Enhanced and reusable poly(hydroxy urethane)-based low temperature hot-melt adhesives

peer reviewedPoly(hydroxy urethane)s (PHUs) based on 5- membered cyclic carbonates have emerged as sustainable alternatives to conventional isocyanate-based polyurethanes. However, while from the point of view of sustainability they represent an improvement, their properties are still not competitive with conventional polyurethanes. In this work, the potential of PHUs as reversible hot-melt adhesives is discussed. We found that with a judicious choice of reagents (i.e., the dicyclic carbonate and diamine), the detrimental hydrogen bonding between the soft segment of the chains and the pendant hydroxyl groups was partially avoided, thus imparting PHUs with hot-melt adhesion properties (i.e., adhesion at elevated temperatures and cohesive- ness at a temperature lower than Tg/Tm). The importance of a balanced hard to soft segment ratio, along with the relevance of the chain extender in the final properties, is highlighted. Addition of aliphatic diamines (HMDA, 1,12-DAD) resulted in rubbery materials, while the employment of cycloaliphatic (CBMA) or aromatic ones (MXDA, PXDA) led to materials with hot-melt adhesive properties. The thermoreversibility of all compositions was assessed by rebonding specimens after lap-shear tests. Lap-shear strength values that were comparable to the virgin adhesives were observed. The breaking and reformation of hydrogen bonding interactions was demonstrated by FTIR measurements at different temperatures, as well as by rheological frequency sweep experiments. In order to mitigate the negative impact of the low molar mass PHUs and to enhance the service temperature of the adhesives, a hybrid PHU was prepared by adding a small amount of an epoxy resin, which acts as a cross-linker. These hybrid PHUs maintain the thermoreversibility displayed by thermoplastic PHUs while providing better adhesion at elevated temperatures. We believe that this work provides some important insights into the design of PHU-based hot-melt adhesives

Review of code and phase biases in multi-GNSS positioning

A review of the research conducted until present on the subject of Global Navigation Satellite System (GNSS) hardware-induced phase and code biases is here provided. Biases in GNSS positioning occur because of imperfections and/or physical limitations in the GNSS hardware. The biases are a result of small delays between events that ideally should be simultaneous in the transmission of the signal from a satellite or in the reception of the signal in a GNSS receiver. Consequently, these biases will also be present in the GNSS code and phase measurements and may there affect the accuracy of positions and other quantities derived from the observations. For instance, biases affect the ability to resolve the integer ambiguities in Precise Point Positioning (PPP), and in relative carrier phase positioning when measurements from multiple GNSSs are used. In addition, code biases affect ionospheric modeling when the Total Electron Content is estimated from GNSS measurements. The paper illustrates how satellite phase biases inhibit the resolution of the phase ambiguity to an integer in PPP, while receiver phase biases affect multi-GNSS positioning. It is also discussed how biases in the receiver channels affect relative GLONASS positioning with baselines of mixed receiver types. In addition, the importance of code biases between signals modulated onto different carriers as is required for modeling the ionosphere from GNSS measurements is discussed. The origin of biases is discussed along with their effect on GNSS positioning, and descriptions of how biases can be estimated or in other ways handled in the positioning process are provided.QC 20170922</p

The impact of heat waves on mortality in 9 European cities: results from the EuroHEAT project

BACKGROUND: The present study aimed at developing a standardized heat wave definition to estimate and compare the impact on mortality by gender, age and death causes in Europe during summers 1990-2004 and 2003, separately, accounting for heat wave duration and intensity. METHODS: Heat waves were defined considering both maximum apparent temperature and minimum temperature and classified by intensity, duration and timing during summer. The effect was estimated as percent increase in daily mortality during heat wave days compared to non heat wave days in people over 65 years. City specific and pooled estimates by gender, age and cause of death were calculated. RESULTS: The effect of heat waves showed great geographical heterogeneity among cities. Considering all years, except 2003, the increase in mortality during heat wave days ranged from + 7.6% in Munich to + 33.6% in Milan. The increase was up to 3-times greater during episodes of long duration and high intensity. Pooled results showed a greater impact in Mediterranean (+ 21.8% for total mortality) than in North Continental (+ 12.4%) cities. The highest effect was observed for respiratory diseases and among women aged 75-84 years. In 2003 the highest impact was observed in cities where heat wave episode was characterized by unusual meteorological conditions. CONCLUSIONS: Climate change scenarios indicate that extreme events are expected to increase in the future even in regions where heat waves are not frequent. Considering our results prevention programs should specifically target the elderly, women and those suffering from chronic respiratory disorders, thus reducing the impact on mortality

Ionospheric modelling using GPS to calibrate the MWA. 1 : Comparison of first order ionospheric effects between GPS models and MWA observations

This document is the Accepted Manuscript version of the following article: B. S. Arora, et al, ‘Ionospheric Modelling using GPS to Calibrate the MWA. I: Comparison of First Order Ionospheric Effects between GPS Models and MWA Observations’, Publications of the Astronomical Society of Australia, Vol. 32, e029, August 2015. The final, published version is available online at doi: https://doi.org/10.1017/pasa.2015.29. COPYRIGHT: © Astronomical Society of Australia 2015.We compare first order (refractive) ionospheric effects seen by the Murchison Widefield Array (MWA) with the ionosphere as inferred from Global Positioning System (GPS) data. The first order ionosphere manifests itself as a bulk position shift of the observed sources across an MWA field of view. These effects can be computed from global ionosphere maps provided by GPS analysis centres, namely the Center for Orbit Determination in Europe (CODE), using data from globally distributed GPS receivers. However, for the more accurate local ionosphere estimates required for precision radio astronomy applications, data from local GPS networks needs to be incorporated into ionospheric modelling. For GPS observations, the ionospheric parameters are biased by GPS receiver instrument delays, among other effects, also known as receiver Differential Code Biases (DCBs). The receiver DCBs need to be estimated for any non-CODE GPS station used for ionosphere modelling, a requirement for establishing dense GPS networks in arbitrary locations in the vicinity of the MWA. In this work, single GPS station-based ionospheric modelling is performed at a time resolution of 10 minutes. Also the receiver DCBs are estimated for selected Geoscience Australia (GA) GPS receivers, located at Murchison Radio Observatory (MRO1), Yarragadee (YAR3), Mount Magnet (MTMA) and Wiluna (WILU). The ionospheric gradients estimated from GPS are compared with the ionospheric gradients inferred from radio source position shifts observed with the MWA. The ionospheric gradients at all the GPS stations show a correlation with the gradients observed with the MWA. The ionosphere estimates obtained using GPS measurements show promise in terms of providing calibration information for the MWA.Peer reviewe

Meiotic Regulation of TPX2 Protein Levels Governs Cell Cycle Progression in Mouse Oocytes

Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and via local activation of the RanGTPase on chromosomes. Vertebrate oocytes present a RanGTP gradient centred on chromatin at all stages of meiotic maturation. However, this gradient is dispensable for assembly of the first meiotic spindle. To understand this meiosis I peculiarity, we studied TPX2, a Ran target, in mouse oocytes. Strikingly, TPX2 activity is controlled at the protein level through its accumulation from meiosis I to II. By RNAi depletion and live imaging, we show that TPX2 is required for spindle assembly via two distinct functions. It controls microtubule assembly and spindle pole integrity via the phosphorylation of TACC3, a regulator of MTOCs activity. We show that meiotic spindle formation in vivo depends on the regulation of at least a target of Ran, TPX2, rather than on the regulation of the RanGTP gradient itself