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36 research outputs found

Angiotensin-Neprilysin inhibition in heart failure with preserved ejection fraction

Author: Anand Inder S.
Boytsov Sergey A.
Claggett Brian
Cleland John
Comín Colet Josep
Desai Akshay S.
Düngen Hans-Dirk
Ge Junbo
Goncalvesova Eva
Gong Jianjian
gorzata
Jhund Pardeep S.
Katova Tzvetana
Kerr Saraiva Jose F.
Lam Carolyn S. P.
Lefkowitz Martin P.
Lelonek Mał
Maggioni Aldo P.
Martinez Felipe
McMurray John J.V.
Merkely Béla
Packer Milton
Pfeffer Marc A.
Pieske Burkert
Redfield Margaret M.
Rizkala Adel R.
Rouleau Jean L.
Senni Michele
Shah Sanjiv J.
Shi Victor C.
Solomon Scott D.
van Veldhuisen Dirk J.
Zannad Faiez
Zhou Jingmin
Zile Michael R.
Publication venue: 'Massachusetts Medical Society'
Publication date: 31/03/2021
Field of study

Background: the angiotensin receptor-neprilysin inhibitor sacubitril-valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure and reduced ejection fraction. The effect of angiotensin receptor-neprilysin inhibition in patients with heart failure with preserved ejection fraction is unclear. Methods: we randomly assigned 4822 patients with New York Heart Association (NYHA) class II to IV heart failure, ejection fraction of 45% or higher, elevated level of natriuretic peptides, and structural heart disease to receive sacubitril-valsartan (target dose, 97 mg of sacubitril with 103 mg of valsartan twice daily) or valsartan (target dose, 160 mg twice daily). The primary outcome was a composite of total hospitalizations for heart failure and death from cardiovascular causes. Primary outcome components, secondary outcomes (including NYHA class change, worsening renal function, and change in Kansas City Cardiomyopathy Questionnaire [KCCQ] clinical summary score [scale, 0 to 100, with higher scores indicating fewer symptoms and physical limitations]), and safety were also assessed. Results: there were 894 primary events in 526 patients in the sacubitril-valsartan group and 1009 primary events in 557 patients in the valsartan group (rate ratio, 0.87; 95% confidence interval [CI], 0.75 to 1.01; P = 0.06). The incidence of death from cardiovascular causes was 8.5% in the sacubitril-valsartan group and 8.9% in the valsartan group (hazard ratio, 0.95; 95% CI, 0.79 to 1.16); there were 690 and 797 total hospitalizations for heart failure, respectively (rate ratio, 0.85; 95% CI, 0.72 to 1.00). NYHA class improved in 15.0% of the patients in the sacubitril-valsartan group and in 12.6% of those in the valsartan group (odds ratio, 1.45; 95% CI, 1.13 to 1.86); renal function worsened in 1.4% and 2.7%, respectively (hazard ratio, 0.50; 95% CI, 0.33 to 0.77). The mean change in the KCCQ clinical summary score at 8 months was 1.0 point (95% CI, 0.0 to 2.1) higher in the sacubitril-valsartan group. Patients in the sacubitril-valsartan group had a higher incidence of hypotension and angioedema and a lower incidence of hyperkalemia. Among 12 prespecified subgroups, there was suggestion of heterogeneity with possible benefit with sacubitril-valsartan in patients with lower ejection fraction and in women. Conclusions: sacubitril-valsartan did not result in a significantly lower rate of total hospitalizations for heart failure and death from cardiovascular causes among patients with heart failure and an ejection fraction of 45% or higher. (Funded by Novartis; PARAGON-HF ClinicalTrials.gov number, NCT01920711.)

Diposit Digital de la Universitat de Barcelona

Efficacy and safety of dapagliflozin according to frailty in patients with heart failure: a prespecified analysis of the DELIVER trial

Author: Bachus Erasmus
Belohlávek Jan
Butt Jawad H.
Chiang Chern-En
Claggett Brian L.
de Boer Rudolf A.
Desai Akshai S.
Drożdzż Jaroslaw
Hernandez Adrian F.
Inzucchi Silvio E.
Jhund Pardeep S.
Katova Tzvetana
Kitakaze Masafumi
Kosiborod Mikhail N.
Lam Carolyn S.P.
Langkilde Anna Maria
Lindholm Daniel
Martinez Felipe
McMurray John J.V.
Merkely Béla
Petersson Magnus
Saraiva Jose F. Kerr
Shah Sanjiv J.
Solomon Scott D.
Vaduganathan Muthiah
Vardeny Orly
Wilderäng Ulrica
Publication venue: 'Ovid Technologies (Wolters Kluwer Health)'
Publication date: 27/08/2022
Field of study

Background: Frailty is increasing in prevalence and because frail patients are often perceived to have a less favorable benefit/risk profile, they may be less likely to receive new pharmacological treatments. We investigated the efficacy and tolerability of dapagliflozin according to frailty status in patients with heart failure and mildly reduced and preserved ejection fraction randomized in DELIVER. Methods: Frailty was measured using the Rockwood cumulative deficit approach. The primary endpoint was time to a first worsening heart failure event or cardiovascular death. Results: Of the 6263 patients randomized, a Frailty Index (FI) was calculable in 6258. In total, 2,354 (37.6%) patients had class 1 frailty (FI <0.210, i.e., not frail), 2,413 (38.6%) were in class 2 (FI 0.211-0.310, i.e., more frail), and 1,491 (23.8%) had class 3 frailty (FI >0.311, i.e., most frail). Greater frailty was associated with a higher rate of the primary endpoint (per 100 person years): FI class 1, 6.3 (95% CI 5.7-7.1); class 2, 8.3 (7.5-9.1); and class 3, 13.4 (12.1-14.7), P<0.001. The effect of dapagliflozin (as a hazard ratio) on the primary endpoint from FI class 1 to 3 was: 0.85 (95% CI, 0.68-1.06); 0.89 (0.74-1.08); and 0.74 (0.61-0.91), respectively (Pinteraction=0.40). Although frailer patients had worse KCCQ scores at baseline, the improvement with dapagliflozin was greater than in less frail patients: placebo-corrected improvement in KCCQ-OSS at 4 months FI class 1, 0.3 (95% CI -0.9 to 1.4); class 2, 1.5 (0.3-2.7); and class 3, 3.4 (1.7-5.1) [Pinteraction=0.021]. Adverse reactions and treatment discontinuation, while more frequent in frailer patients, were not more common with dapagliflozin than placebo, irrespective of frailty class. Conclusions: In DELIVER, frailty was common and associated with worse outcomes. The benefit of dapagliflozin was consistent across the range of frailty studied. The improvement in health-related quality of life with dapagliflozin occurred early and was greater in patients with greater frailty

PubMed Central

EUR Research Repository

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Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Author: Abban D. W.
Abdul N.
Abud A. M.
Adams F.
Addala S.
Adragao P.
Ageno W.
Aggarwal R.
Agosti S.
Agostoni P.
Aguilar F.
Aguinaga L.
Ahmed J.
Aiello A.
Ainsworth P.
Aiub J. R.
Al-Dallow R.
Alderson L.
Aldrete Velasco J. A.
Alexopoulos D.
Aliyar P.
Almeida L. F.
Alonso D.
Alves da Costa F. A.
Amado J.
Amara W.
Amelot M.
Amjadi N.
Ammirati F.
Andrade M.
Andrawis N.
Angela Koh S. M.
Anna omaszuk-Kazberuk
Annoni G.
Ansalone G.
Ariani M. K.
Arias J. C.
Armero S.
Arora C.
Asensi J. O.
Aslam M. S.
Asselman M.
Audouin P.
Augenbraun C.
Aydin S.
Ayryanova I.
Aziz E.
Backes L. M.
Badings E.
Bagni E.
Baker S. H.
Bala R.
Baldi A.
Bando S.
Banerjee S.
Bank A.
Barr C.
Bartlett M.
Baula G.
Behrens S.
Bell A.
Benedetti R.
Benhalima B.
Berg J. M. T.
Bergler-Klein J.
Berneau J. -B.
Bernstein R. A.
Berrospi P.
Berti S.
Berz A.
Best E.
Bettencourt P.
Betzu R.
Bhagwat R.
Bhatta L.
Biscione F.
BISIGNANI G.
Black T.
Bloch M. J.
Bloom S.
Blumberg E.
Bo M.
Bodes R. S.
Bohmer E.
Bollmann A.
Bongiorni M. G.
Boriani G.
Boswijk D. J.
Bott J.
Bottacchi E.
Bradman D.
Brautigam D.
Breton N.
Briones I. R.
Brkljacic D. D.
Brouwers P. J. A. M.
Browne K.
Bruni A.
Brunschwig C.
Bryan Yan P. Y.
Buathier H.
Buenostro G. C.
Buhl A.
Bullinga J.
Cabrera J. W.
Caccavo A.
Cai S.
Caine S.
Calo L.
Calvi V.
Campos R. N.
Candeias R.
Capuano V.
Capucci A.
Caputo R.
Cardona F.
Carlos da Costa Darrieux F.
Carolei A.
Carreno S.
Carvalho P.
Cary S.
Casu G.
Cavallini C.
Cayla G.
Celentano A.
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Chartier L.
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Choi D. J.
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Chouinard G.
Chreih R. M.
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Cislowski D. J.
Clay A.
Clifford P.
Cohen A.
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Cohen S.
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Compton S.
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Coodley G.
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Wang N.
Wang T.
Wang X.
Warner A. L.
Watanabe K.
Wei J.
Weimar C.
Weiner S.
Weinrich R.
Wen M. -S.
Wiemer M.
Wiggers P.
Wilke A.
Williams D.
Williams M. L.
Witzenbichler B.
Wong B.
Wozakowska-Kaplon B.
Wu R. C.
Wu S.
Wunderlich S.
Wyatt N.
Wylie J. J.
Xu X.
Xu Y.
Yamanoue H.
Yamashita T.
Yang T.
Yao J.
Yeh K. -H.
Yin W. H.
Yotov Y.
Zahn R.
Zanetti F. L.
Zarich S.
Zenin S.
Zeuthen E. L.
Zhang D.
Zhang H.
Zhang J.
Zhang P.
Zhang X.
Zhao S. P.
Zhao Y.
Zhao Z.
Zheng Y.
Zhou J.
Zimmermann S.
Zini A.
Zizzo S.
Zong W.
Zukerman L. S.
Publication venue: Hellenic Society of Cardiology. Publishing services by Elsevier B.V.
Publication date: 01/01/2021
Field of study

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007

PubliCatt

Archivio istituzionale della ricerca - Università dell'Insubria

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Archivio della ricerca- Università di Roma La Sapienza

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

Institutional Research Information System University of Turin

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Author: Abban Dzifa
Abdul Nasser
Abelson Mark
Ackermann Alan
Adams Fran
Adams Luthando
Adrag\ue3o Pedro
Ageno Walter
Aggarwal Rajesh
Agosti Sergio
Aguilar Linares Julio Alberto
Aguilar Francisco
Aguinaga Luis
Ahmad Zia
Ainsworth Paul
Al Dallow Raed
Al Ghalayini Kamal
Al Ismail Saad
Al Joundi Tammam
Al Mahameed Soufian
Al Obaidi Mohamed
Al Zoebi Ayham
Alasfar Abdelfatah
Alawwa Abdul
Alderson Lisa
Alexopoulos Dimitrios
Ali Abdullah
Ali Malik
Aliyar Pareed
Almassi Hossein
Almuti Khalid
Alshehri Mohamed
Altmann Ute
Alves Alvaro Rabelo
Amara Walid
Amelot Mathieu
Amjadi Nima
Ammirati Fabrizio
Andrawis Nabil
Angela Koh Su Mei
Angoulvant Denis
Annoni Giorgio
Ansalone Gerardo
Antonescu Sorin Alexandru
Ariani Mehrdad
Arias Juan Carlos
Armero S\ue9bastien
Arora Chander
Arora Rohit
Ashcraft William
Aslam M. Shakil
Astesiano Alfredo
Audouin Philippe
Augenbraun Charles
Aydin S.
Azar Rabih
Azim Abul
Aziz Shahid
B\uf8hmer Ellen
Backes Luciano Marcelo
Baig Mirza
Bains Suchdeep
Bakbak Asaad
Baker Seth
Bakhtiar Karim
Bala Richard
Banayan Jonathan
Bandh Stellan
Bando Shigenobu
Banerjee Subhash
Bank Alan
Bar\uf3n Gonzalo
Barbarash Olga
Barr Craig
Barrera Carlos
Bartels Dorothee B.
Barton John
Baula Giovanni
Bayeh Hamid
Bazargani Nooshin
Behrens Steffen
Bell Alan
Benezet Mazuecos Juan
Benhalima Bouziane
Berdagu\ue9 Philippe
Berg van den B. J.
Bergen van P. F. M. M.
Berngard Edvard
Bernstein Richard
Berrospi Percy
Berti Sergio
Bertomeu Vicente
Berz Andrea
Bettencourt Paulo
Betzu Robert
Beyer Westendorf Jan
Bhagwat Ravi
Black Toby
Blanco Ibaceta Jorge Hugo
Bloom Stephen
Blumberg Edwin
Bo Mario
Bockisch Valerie
Bongiorni Maria Grazia
Boriani Giuseppe
Borret Mariano Ruiz
Bosch Ralph
Boswijk D. J.
Bott Jochen
Bottacchi Edo
Brandes Axel
Bratland Bj\uf8rn
Brautigam Donald
Breton Nicolas
Briones Ignacio Rodriguez
Brkljacic Diana Delic
Brouwers P. J. A. M.
Browne Kevin
Bruguera Jordi
Brunehaut Myriam
Brunschwig Claude
Bryan Yan Ping Yen
Buathier Herv\ue9
Buenostro Gabriel Contreras
Buhl Aur\ue9lie
Bullinga John
Butcher Kenneth
Cabrera Honorio Jose Walter
Caccavo Alberto
Cadinot Didier
Cai Shanglang
Caiedo Carolina Guevara
Calin Podoleanu Cristian Gheorghe
Calvi Valeria
Camm John
Candeias Rui
Cao Phai G\ue9rald Phan
Capo James
Capucci Alessandro
Cardoso Juliano Novaes
Carlson Brian
Carvalho Paula
Cary Susanna
Casanova Rene
Casu Gavino
Cattan Simon
Cavallini Claudio
Cayla Guillaume
Cha Kwang Soo
Cha Tae Joon
Chaaban Said
Chae Jei Keon
Challappa Krishnan
Chand Sunil
Chandrashekar Harinath
Chang Mark
Charbel Paul
Chartier Ludovic
Chatterjee Kausik
Cheema Aamir
Chen Shih Ann
Chevallereau Pierre
Chiang Fu Tien
Chiarella Francesco
Chih Chan Lin
Cho Yong Keun
Choi Dong Ju
Chouinard Guy
Chow Hoi Fan
Chreih Rami Mihail
Chrysos Dimitrios
Chumakova Galina
Cieza Lara Tomas
Ciobotaru Vlad
Cislowski David
Citerne Olivier
Claus Matthias
Clay Anthony
Clifford Piers
Cocina Emilio Gonzalez
Cohen Andrew
Cohen Serge
Colivicchi Furio
Collins R\uf3n\ue1n
Compton Steve
Connors Sean
Conti Alberto
Coodley Gregg
Cooper Martin
Corbett Lynn
Corey Oran
Coronel Juli\ue1n
Corrigan John
Cotrina Pereyra Rosa Ysabel
Cottin Yves
Coutu Benoit
Cracan Aurel
Crean Peter
Crenshaw James
Crijns H. J. G. M.
Crump Charles
Cucher Fred
Cudmore David
Cui Lianqun
Culp John
D'Souza Anthony
Daniel Oh Chia Theng
Danny Null
Darius Harald
Dary Patrick
Dascotte Olivier
Dauber Ira
Davee Thomas
Davies Ruth
Davis Gershan
Davy Jean Marc
Dayer Mark
De La Briolle Axel
de Los Rios Ibarra Manuel Odin
de Mora Manuel
de Souza Olga Ferreira
De Teresa Eduardo
De Wolf Luc
Decoulx Eric
Deepak Sasalu
Defaye Pascal
Del Carpio Munoz Freddy
Deluche Laurent
Destrac Sylvain
Deumite N. Joseph
Di Legge Silvia
Dibon Olivier
Diemberger Igor
Diener Hans Christoph
Dillinger Jean
Dion\uedsio Pedro
Dotani Imran
Dotcheva Elena
Duarte Vera Yan Carlos
Dubner Sergio J.
Dubrey Simon
Ducrocq Xavier
Dupljakov Dmitry
Duthinh Vuong
Dutra Oscar Pereira
Dutta Dipankar
Duvilla Nathalie
Dy Johnny
Dziewas Rainer
Eaton Charles
Eaves William
Ebinger Matthew
Eck van J. W. M.
Edwards Tim
Egocheaga Isabel
Ehrlich Clifford
Eisenberg Steven
El Hallak Abdel
El Hamdani Mehiar
El Jabali Adnan
El Mahmoud Rami
El Sayed Hassan
El Shahawy Mahfouz
Eldadah Zayd
Elghelbazouri Fouad
Elhag Omar
Elias Darlene
Ellery Adam
Elsaesser Amelie
Elvan A.
Erickson Bernard
Espaliat Eric
Essandoh Louis
Everington Tamara
Evonich Rudolph
Ezhov Andrey
F\ue1cila Lorenzo
Farsad Ramin
Fayard Maxime
Fedele Francesco
Ferreira Daniel
Ferrier Anna
Finsen Alexandra
First Brian
Fisher Raymond
Floyd John
Folk Thomas
Fonseca Catarina
Fonseca Luisa
Fonteles Ritt Luiz Eduardo
Forman Steven
Forsgren Magnus
Foster Malcolm
Foster Nathan
Frais Michael
Frandsen Brad
Frapp\ue9 Thierry
Freixa Ramon
French William
Freydlin Marina
Frickel Siegfried
Fruntelata Ana Gabriela
Fujii Shigeru
Fujino Yusuke
Fukunaga Hiroshi
Furukawa Yutaka
G\uf6tte Andreas
Gabelmann Matthias
Gabris Michael
Gadsb\uf8ll Niels
Galin Pavel
Galinier Michel
Ganim Ricky
Garcia Ronnie
Gartenlaub Olivier
Genz Conrad
Georger Fr\ue9d\ue9ric
Georges Jean Louis
Georgeson Steven
Ghanbasha Ali
Giedrimas Evaldas
Gierba Mariusz
Gillespie Eve
Giniger Alberto
Gkotsis Alexandros
Gmehling Joachim
Gniot Jacek
Goethals Peter
Goldberg Ronald
Goldmann Britta
Goldscher David
Golitsyn Sergey
Gomes Ferreira Luis Gustavo
Gomez Lopez Efrain Alonso
Gomez Mesa Juan Esteban
Gonzalez Efrain
Gorbunov Vladimir
Gordon Brian
Gorka Herv\ue9
Gornick Charles
Gorog Diana
Goss Franz
Goube Pascal
Goudevenos Ioannis
Goulden Dudley
Gr\uf6nefeld Gerian
Graham Brett
Grande Angel
Greco Cesare
Green Martin
Greer Gerald
Gremmler Uwe
Grena Paul
Grinshstein Yuriy
Grond Martin
Gronda Edoardo
Grondin Francois
Groot de J. R.
Guardigli Gabriele
Guarnieri Thomas
Guignier Alexandre
Gulizia Michele
Gumbley Michael
Gupta Dhiraj
Hack Terrence
Haerer Winfried
Hakas Joseph
Hall Christian
Halperin Jonathan L.
Hampsey James
Hananis Georgios
Hanbali Basel
Handel Franklin
Hargrove Joe
Hargroves David
Harris Kenneth
Hartley David
Haruna Tetsuya
Hata Yoshiki
Hayek Emil
Healey Jeff
Hearne Steven
Heggelund Geir
Hemels M. E. W.
Hemery Yann
Henein Sam
Henz Benhur
Her Sung Ho
Hermany Paul
Hern\ue1ndez Norberto Matadamas
Hernandes Mauro Esteves
Higashino Yorihiko
Hill Michael
Hisadome Tetsuo
Hishida Eiji
Hitchcock James
Hoffer Etienne
Hoghton Matthew
Holmes Clare
Hong Suk Keun
Houppe Nousse Marie Paule
Howard Victor
Hsu Li Fern
Huang Chi Hung
Huckins David
Huehnergarth Kier
Huisman Menno V
Huizenga A.
Huntley Richard
Hussein Gamal
Hwang Gyo Seung
Igbokidi Oyidie
Iglesias Ignacio
Ikpoh Margaret
Imberti Davide
Ince H\ufcseyin
Indolfi Ciro
Ionova Tatiana
Ip John
Irles Didier
Iseki Harukazu
Ismail Younus
Israel Noah
Isserman Steven
Iteld Bruce
Ivanchura Galina
Iyer Ramakrishnan
Iyer Venkat
Iza Villanueva Ruben Omar
J\ue4ger Frank
Jackson Voyzey Ewart
Jaffrani Naseem
Jain Manish
James Martin
Jamon Yann
Jang Sung Won
Jarmukli Nabil
Jeanfreau Robert
Jenkins Ronald
Jiang Heng
Jiang Nan
Jiang Tiemin
Jiang Xianyan
Jimenez Javier
Jobe Robert
Joffe Ian
Johansson Bengt
Jones Nick
Jos\ue9 Roberto Chuquiure Valenzuela Eduardo Juli\ue1n
Jouve Bernard
Juanatey Carlos Gonzalez
Jundi Mayar
Jung Byung Chun
Jung Kyung Tae
Jung Werner
K\uf6hrmann Martin
K\ufcmler Thomas
K\ufcppers Achim
Kabbani Samer
Kabour Ameer
Kafkala Chrystalenia
Kajiwara Koji
Kalan Marica Bracic
Kalinina Larisa
Kampus Priit
Kanda Junji
Kapadia Shaival
Karim Amin
Karolyi Laszlo
Kashou Hisham
Kastrup Andreas
Katsivas Apostolos
Kaufman Elizabeth
Kawai Kazuya
Kawajiri Kenji
Kazmierski John
Keeling Phil
Kerfes Galal Ali
Kerr Saraiva Jos\ue9 Francisco
Kes Vanja Basic
Ketova Galina
Khaira Ajit
Khalid Muhammad
Khludeeva Elena
Khripun Aleksey
Kim Dae Kyeong
Kim Doo Il
Kim Jeong Su
Kim Jin bae
Kim June Soo
Kim Ki Seok
Kim Nam Ho
Kim Young Hoon
Kinova Elena
Klein Alexander
Kleinschnitz Christoph
Kmetzo James
Kneller G. Larsen
Knezevic Aleksandar
Koch Stanley
Koenig Kai
Koons Jay
Korabathina Ravikiran
Korennova Olga
Koschutnik Martin
Kosinski Edward
Kovacic Dragan
Kowalczyk Jacek
Koziolova Natalya
Kragten J. A.
Krause Lars Udo
Kreidieh Imad
Krenning B. J.
Krishnaswamy Kannappan
Krysiak Waldemar
Kuck Karl Heinz
Kumar Somnath
Kuniss Malte
Kuo Jen Yuan
Kurrelmeyer Karla
Kwan Tak
Kyo Eisho
L\uf3pez Send\uf3n Jos\ue9
Labovitz Arthur
Lacroix Alain
Lam Andy
Lanas Zanetti Fernando Tomas
Landau Charles
Landini Giancarlo
Lang Wilfried
Larsen Torben Bjerregaard
Laske Volker
Lavandier Karine
Law Nicki
Lawrence Wong Ka Sing
Lee Daniel
Lee Moon Hyoung
Leit\ue3o Ana
Lejay Dominique
Lelonek Malgorzata
Lenarczyk Radoslaw
Leprince Patrick
Lequeux Benoit
Leschke Matthias
Ley Nicolas
Li Weihua
Li Xiaodong
Li Yansheng
Li Zhanquan
Li Zicheng
Liang Jianqiu
Lieber Ira
Lillestol Michael
Limon Rodriguez Ramon Horacio
Lin Hailong
Lip Gregory
Lip Gregory Y. H.
Litchfield Jennifer
Liu Feng
Liu Wenhui
Liu Xuebo
Liu Yalin
Liu Zhitao
Llamas Esperon Guillermo Antonio
Llisterri Jose Luis
Lo Eric
Lo Ted
Lobos Jose Maria
Lodde Bernhard Paul
Loiselet Philippe
Lorga Filho Adalberto Menezes
Lori Ido
Luo Ming
Lupovitch Steven
Lyrer Philippe
M\ufcgge Andreas
Ma Chang Sheng
Ma Changsheng
Ma Genshan
Ma Hong
Madariaga Irene
Maeno Koji
Magnin Dominique
Mahmood Shahid
Mahood Karen
Maid Gustavo
Mainigi Sumeet
Makaritsis Konstantinos
Maldonado Villalon Jos\ue9 Arturo
Malhotra Rohit
Malik Amir
Mallecourt Catherine
Mallik Rajiv
Manning Rickey
Manolis Athanasios
Mantas Ioannis
Manzur Jattin Fernando Gabriel
Mar\uedn Francisco
Marcionni Niccolo'
Marin Javier Aguila
Martinez Jorge
Martinez Luis
Maskova Petra
Matskeplishvili Simon
Matsuda Katsuhiro
Mavri Alenka
May Erik
Mayer Nolan
Mazon Pilar
Mcclure John
Mccormack Terry
Mcgarity William
Mcguire Michael
Mcintyre Hugh
Mclaughlin Paul
Mclaurin Brent
Medina Palomino Feliz Alvaro
Mehta Paresh
Mehzad Reza
Meinel Andreas
Melandri Francesco
Mena Amparo
Meno Hirosi
Menzies Dhananjai
Metcalf Kneale
Meyer Beat
Miarka Jacek
Mibach Frank
Michalski Dominik
Michel Patrik
Mikdadi Ghiath
Mikhail Magdy
Mikus Milan
Milicic Davor
Militaru Constantin
Miller Gary
Milonas Christos
Minescu Bogdan
Mintale Iveta
Miralles Aur\ue9lien
Mirault Tristan
Mistry Dinesh
Mitchell George
Miu Nicoleta Violeta
Miyamoto Naomasa
Moccetti Tiziano
Mohammed Akber
Molina de Salazar Dora Ines
Molon Giulio
Molony David
Mondillo Sergio
Mont Lluis
Moodley Rajendra
Moore Roger
Morales Oscar Saenz
Mori Kiyoo
Moriarty Andrew
Morka Jacek
Moschos Nikitas
Mota Gomes Marco Ant\uf4nio
Moura Jorge Jose Carlos
Mousallem Nicolas
Moya Angel
Mulhearn Thomas
Muller Jean Joseph
Muresan Carmen Manuela
Muse Derek
Musial Wlodzimierz
Musumeci Francesco
Nadar Venkatesh
Nageh Thuraia
Nair Priya
Nakagawa Hidemitsu
Nakamura Yuichiro
Nakayama Toru
Nam Ki Byeong
Napalkov Dmitry
Natarajan Indira
Nayak Hemal
Naydenov Stefan
Nechvatal Libor
Neiman James
Nerheim Pamela
Neuenschwander Fernando Carvalho
Nica Violeta Cindea
Nishida Kunihiro
Nizov Alexey
Nor Azlisham Mohd
Novikova Tatiana
Novo Salvatore
Nowalany Kozielska Ewa
Nsah Emmanuel
Nunez Fragoso Juan Carlos
Nyvad Ole
O'Donnell Martin
O'Donnell Philip
O'Hara Gilles
Oh Dong Jin
Oh Yong Seog
Oikonomou Kostas
Olalla Juan Jose
Olivari Zoran
Oliver Richard
Olympios Christoforos
Osborne John
Osca Joaquin
Osman Raed
Osunkoya Abayomi
Padanilam Benzy
Panchenko Elizaveta
Pandey A. Shekhar
Paquette Miney
Paraschos Alexander
Pardell Herbert
Park Hyung Wook
Park Jong Sung
Parkash Ratika
Parker Ian
Parrens Eric
Parris Robert
Pascual Carlos Rodr\uedguez
Passamonti Enrico
Patel Jaydutt
Patel Rajesh
Pentz William H.
Pereira Jardim Cesar Augusto
Persic Viktor
Perticone Francesco
Peters Patrick
Petkar Sanjiv
Pezo Luis Felipe
Pham David
Phlaum Stephen
Pineau Julien
Pineda Velez Armando
Pini Riccardo
Pinter Arnold
Pinto Fausto
Pirelli Salvatore
Pivac Nediljko
Pizzini Attilia Maria
Pocanic Darko
Polanczyk Carisi Anne
Polasek Petr
Poljakovic Zdravka
Pollock Stewart
Polo Jose
Poock James
Poppert Holger
Porro Yamile
Pose Antonio
Poulain Fran\ue7ois
Poulard Jean Ernst
Pouzar Joe
Povolny Petr
Pozzer Domingo
Pras Athanasios
Prasad Neeraj
Prevot S\ue9bastien
Protasov Konstantin
Prunier Laurent
Puleo John
Pye Maurice
Qaddoura Fatma
Quedillac Jean Michel
Quintana Antonio Garcia
Raev Dimitar
Rahimi Sidiqullah
Raisaro Arturo
Rama Bhola
Ranadive Nandkishore
Randall Katie
Ranjith Naresh
Raposo Nuno
Rashid Haroon
Raters Christa
Rauch Kroehnert Ursula
Rebane Thomas
Regner Stefan
Renzi Michael
Reyes Rocha Miguel Agustin
Reyes Humberto Rodriguez
Reza Shabbir
Ria Luigi
Ribeiro Moreira Dalmo Antonio
Richter Dimitrios
Rickli Hans
Rickner Kyle
Rieker Werner
Rigo Fausto
Ripoll Tomas
Roberts Douglas
Roelke Marc
Roman Mark
Romeo Francesco
Ronner E.
Ronziere Thomas
Rooyer F. A.
Rosenbaum David
Roth Sherryn
Rothman Kenneth J.
Rozkova Nadezda
Rubacek Miroslav
Rubalcava Frank
Rubanenko Olesya
Rubin Andrew
Rybak Karin
Sabbour Hani
Sakai Tetsuo
Salacata Abraham
Salecker Ilsbe
Salem Adrien
Salfity Marwan
Salguero Rafael
Salvioni Alessandro
Samson Mercedes
Sanchez Gregorio
Sandesara Chirag
Santana Antonio Mart\uedn
Santos Jos\ue9 Ferreira
Saporito Wladmir Faustino
Sasaoka Taishi
Sattar Payman
Savard Daniel
Scala Pierre Jean
Scemama Jacques
Sch\uf6n Norbert
Schaupp Thierry
Schellinger Peter
Scherr Carlos
Schmitz Bettina
Schmitz Karl Heinz
Schmitz Lisa
Schnitzler Robert
Schnupp Steffen
Schoeniger Peter
Schuster Stefan
Schwimmbeck Peter
Seamark Clare
Seebass Ruediger
Seidl Karl Heinz
Seidman Barry
Sek Jaroslaw
Sekaran Lakshmanan
Seko Yoshinori
Sepulveda Varela Pablo Andres
Sevilla Bego\uf1a
Shah Aman
Shah Anil
Shah Neerav
Shah Vinay
Shanes Jeffrey
Sharareh Ali
Sharma Vijay Kumar
Shaw Louise
Shimizu Yutaka
Shimomura Hideki
Shin Dong Gu
Shin Eun Seok
Shite Junya
Shoukfeh Mohammad
Shoultz Charles
Silver Frank
Sime Iveta
Simmers T. A.
Singal Dinesh
Singh Narendra
Siostrzonek Peter
Sirajuddin Mohiburrahman
Skeppholm Mika
Smadja Didier
Smith David
Smith Richard
Soda Hassan
Sofley C. Wilson
Sokal Adam
Sotolongo Rodolfo
Sparby Jon Arne
Spinar Jindrich
Sprigings David
Spyropoulos Alex
Stakos Dimitrios
Steinberg Alon
Steinwender Clemens
Stergiou Georgios
Stites H. William
Stoikov Anastas
Strasser Ruth
Streb Witold
Styliadis Ioannis
Su Guohai
Su Xi
Suarez Rafael Martin
Sudnik Wanda
Sueyoshi Atsushi
Sukles Kai
Sun Li
Suneja Randeep
Svensson Peter
Szavits Nossan Janko
Taggeselle Jens
Takagi Yuichiro
Takhar Amrit
Tallet Julio
Tamm Angelika
Tanaka Katsumi
Tanaka Shozo
Tang Aylmer
Tang Sherman
Tassinari Tiziana
Tayama Shinji
Tayebjee Muzahir
Tebbe Ulrich
Teixeira Jose
Tesloianu Dan Nicolae
Tessier Pascal
Teutsch Christine
The S. H. K.
Thevenin J\ue9rome
Thomas Harold
Timsit Serge
Topkis Robert
Torosoff Mikhail
Touze Emmanuel
Traissac Thalie
Trendafilova Elina
Troyan Barry
Tsai Wenchi Kevin
Tse Hung Fat
Tsutsui Hiroshi
Tsutsui Takashi
Tuininga Y. S.
Turakhia Minang
Turk Samir
Turner Wayne
Tveit Arnljot
Twiddy Shannon
Tytus Richard
Ukrainski Gerald
Valdovinos Chavez Salvador Bruno
Van De Graaff Eric
Vanacker Peter
Vardas Panagiotis
Vargas Michael
Vassilikos Vassilios
Vazquez Juan
Venkataraman Asok
Verdecchia Paolo
Vester Ernst G\ufcnter
Vial Hubert
Vicenzo de Paola Angelo Amato
Vinereanu Dragos
Vlastaris Anthony
Vogel Craig
vom Dahl J\ufcrgen
von Mering Matthias
Vora Kishor
Wakefield Paul
Walia Jasjit
Walter Thomas
Wang Feng
Wang Kuo Yang
Wang Mingsheng
Wang Ningfu
Wang Xinhua
Wang Zulu
Watanabe Kouki
Wei Jeanne
Weimar Christian
Weinrich Renate
Wen Ming Shien
Wheelan Kevin
Wicke Jens
Wiemer Marcus
Wild Beate
Wilke Andreas
Willems Stephan
Williams David
Williams Marcus
Winkler Andreas
Wirtz Jost Henner
Witzenbichler Bernhard
Wong Brian
Wong Danny H. K.
Wozakowska Kaplon Beata
Wu Shulin
Wu Zhaohui
Wyatt Nell
Xu Xiangdong
Xu Yong
Yamada Akira
Yamamoto Kazuya
Yamanoue Hiroki
Yamashita Takeshi
Yang Tianlun
Yang Yanmin
Yao Jing
Yarlagadda Chakri
Yeh Kuo Ho
Yotov Yoto
Yvorra Serge
Zahn Ralf
Zamorano Jos\ue9
Zanini Roberto
Zarich Stuart
Zebrack James
Zenin Sergei
Zeuthen Elisabeth Louise
Zhang Dadong
Zhang Donghui
Zhang Huanyi
Zhang Quansan
Zhang Xingwei
Zhao Shuiping
Zhao Xinwen
Zheng Qiangsun
Zheng Yang
Zhou Jian
Zhou Jing
Ziekenhuis Antonius
Zimmermann Rainer
Zimmermann Sergio Luiz
Zint Kristina
Zuhairy Hamed M.
Zukerman L. Steven
Zwaan van der C.
Publication venue: 'Elsevier BV'
Publication date: 01/01/2017
Field of study

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

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Archivio della ricerca- Università di Roma La Sapienza

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia