"We Have Never Allowed Such A Thing Here...": Social Responses to Saskatchewan's Early Sex Trade, 1880 to 1920

Despite what the title suggests, Saskatchewan had a booming sex trade in its early years. The area attracted hundreds of women sex workers before Saskatchewan had even become a province in 1905. They were drawn to the area by the demands of bachelors who dominated Canada's prairie west. According to Saskatchewan's moral reformers, however, the sex trade was a hindrance to the province's Christian potential. They called for its abolishment and headed white slavery campaigns that characterized prostitution as a form of slavery. Their approach stood in contrast with law enforcement's stance on the trade. The police took a tolerant approach, allowing its operation as long as sex workers and their clients remained circumspect. Law enforcement's approach reflected their own propensity to use the services of sex workers as well as community attitudes toward the trade. Some communities were more welcoming of sex workers, while others demanded that police suppress the trade. Saskatchewan's newspapers also reflected differing attitudes toward the trade. While Regina's Leader purveyed a no tolerance view of the sex trade, Saskatoon's Phoenix and Star held more tolerant views. Saskatchewan's newspapers reveal that as the province's population increased and notions of moral reform gained popularity, police were challenged to take a less tolerant approach. However, reformers' efforts to end the sex trade dwindled with the onset of the First World War and attitudes toward sex workers shifted drastically as responsibility for venereal disease was placed largely on women who sold sex. Using government and police records, moral reform and public health documents, and media sources such as newspapers, as well as intersectional analysis of gender, race, class, and ethnicity, this examination of Saskatchewan’s sex trade investigates the histories and social responses to the buying and selling of sex, revealing the complex and, at times, contradictory place of sex workers and the sex trade in Saskatchewan’s early history

The experience of diagnostic radiography students during the early stages of the COVID‐19 pandemic – a cross‐sectional study

Abstract: Introduction: The rationale for this study was to ascertain the impact of the COVID‐19 pandemic on Undergraduate B.Sc (Hons) Diagnostic Radiography students at the University of Hertfordshire in the UK. This would provide an ideal opportunity for students to reflect on their experience and indicate if they required additional support from the University. Methods: An online anonymous cross‐sectional survey was deployed to all year groups (n = 283) during the first nationwide lockdown in May 2020, eliciting qualitative responses on questions about the effect of the pandemic; emotions experienced; support required and consideration of their choice of a career in the health sector. Results: Two hundred and one students responded to the survey, with many having experienced the illness or loss of a loved one. Trying to balance family commitments and study was a concern to some students, as well as struggling with the financial burden of job losses or furlough. Many students commented that educational support was a requirement with the move to online teaching and assessment. The main focus of student responses was the emotions that they had experienced, many of which were negative. Anxiety and fear were commonly expressed feelings, along with sadness and feelings of isolation. A small number of students reported feeling grateful, happy and relieved. An overwhelming majority of respondents commented that they were proud to be healthcare students and they were resolute in wanting to continue the course and join the frontline of the NHS workforce. Conclusion: Some students have been deeply affected by their experiences of the pandemic, and University support mechanisms should be refined to better assist with their ongoing challenges.Peer reviewe

Blood conservation : cultural change in pediatric intensive care nursing

While monitoring of pediatric intensive care unit (PICU) patients requires repeated blood sampling, excessive sampling can lead to anemia. Upon PICU admission, 33% of patients are anemic and 41% develop anemia. Anemia increases the PICU length of stay and days of mechanical ventilation. Anemia is often treated with red blood cell (RBC) transfusion, but RBC transfusion is associated with increased healthcare costs and morbidity. Blood conservation strategies are needed in the PICU; these changes in turn require changes in PICU practice and culture to reduce the amount of blood overdraw

Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV

BACKGROUND: Jaagsiekte sheep retrovirus (JSRV) causes a lethal lung cancer in sheep and goats. Expression of the JSRV envelope (Env) protein in mouse lung, by using a replication-defective adeno-associated virus type 6 (AAV6) vector, induces tumors resembling those seen in sheep. However, the mouse and sheep tumors have not been carefully compared to determine if Env expression alone in mice can account for the disease features observed in sheep, or whether additional aspects of virus replication in sheep are important, such as oncogene activation following retrovirus integration into the host cell genome. RESULTS: We have generated mouse monoclonal antibodies (Mab) against JSRV Env and have used these to study mouse and sheep lung tumor histology. These Mab detect Env expression in tumors in sheep infected with JSRV from around the world with high sensitivity and specificity. Mouse and sheep tumors consisted mainly of well-differentiated adenomatous foci with little histological evidence of anaplasia, but at long times after vector exposure some mouse tumors did have a more malignant appearance typical of adenocarcinoma. In addition to epithelial cell tumors, lungs of three of 29 sheep examined contained fibroblastic cell masses that expressed Env and appeared to be separate neoplasms. The Mab also stained nasal adenocarcinoma tissue from one United States sheep, which we show was due to expression of Env from ovine enzootic nasal tumor virus (ENTV), a virus closely related to JSRV. Systemic administration of the AAV6 vector encoding JSRV Env to mice produced numerous hepatocellular tumors, and some hemangiomas and hemangiosarcomas, showing that the Env protein can induce tumors in multiple cell types. CONCLUSION: Lung cancers induced by JSRV infection in sheep and by JSRV Env expression in mice have similar histologic features and are primarily characterized by adenomatous proliferation of peripheral lung epithelial cells. Thus it is unnecessary to invoke a role for insertional mutagenesis, gene activation, viral replication, or expression of other viral gene products in sheep lung tumorigenesis, although these processes may play a role in other clinically less important sequelae of JSRV infection such as metastasis observed with variable frequency in sheep

4D In-Situ Microscopy of Aerosol Filtration in a Wall Flow Filter

The transient nature of the internal pore structure of particulate wall flow filters, caused by the continuous deposition of particulate matter, makes studying their flow and filtration characteristics challenging. In this article we present a new methodology and first experimental demonstration of time resolved in-situ synchrotron micro X-ray computed tomography (micro-CT) to study aerosol filtration. We directly imaged in 4D (3D plus time) pore scale deposits of TiO2 nanoparticles (nominal mean primary diameter of 25 nm) with a pixel resolution of 1.6 μm. We obtained 3D tomograms at a rate of ∼1 per minute. The combined spatial and temporal resolution allows us to observe pore blocking and filling phenomena as they occur in the filter’s pore space. We quantified the reduction in filter porosity over time, from an initial porosity of 0.60 to a final porosity of 0.56 after 20 min. Furthermore, the penetration depth of particulate deposits and filtration rate was quantified. This novel image-based method offers valuable and statistically relevant insights into how the pore structure and function evolves during particulate filtration. Our data set will allow validation of simulations of automotive wall flow filters. Evolutions of this experimental design have potential for the study of a wide range of dry aerosol filters and could be directly applied to catalysed automotive wall flow filters

The Impact of Intrinsic Alignments: Cosmological Constraints from a Joint Analysis of Cosmic Shear and Galaxy Survey Data

Constraints on cosmology from recent cosmic shear observations are becoming increasingly sophisticated in their treatment of potential systematic effects. Here we present cosmological constraints which include modelling of intrinsic alignments. We demonstrate how the results are changed for three different intrinsic alignment models, and for two different models of the cosmic shear galaxy population. We find that intrinsic alignments can either reduce or increase measurements of the fluctuation amplitude parameter sigma_8 depending on these decisions, and depending on the cosmic shear survey properties. This is due to the interplay between the two types of intrinsic alignment, II and GI. It has been shown that future surveys must make a careful treatment of intrinsic alignments to avoid significant biases, and that simultaneous constraints from shear-shear and shear-position correlation functions can mitigate the effects. For the first time we here combine constraints from cosmic shear surveys (shear-shear correlations) with those from "GI" intrinsic alignment data sets (shear-position correlations). We produce updated constraints on cosmology marginalised over two free parameters in the halo model for intrinsic alignments. We find that the additional freedom is well compensated by the additional information, in that the constraints are very similar indeed to those obtained when intrinsic alignments are ignored, both in terms of best fit values and uncertainties.Comment: 16 pages, 11 figure

Constraining the Scatter in the Mass-Richness Relation of maxBCG Clusters With Weak Lensing and X-ray Data

We measure the logarithmic scatter in mass at fixed richness for clusters in the maxBCG cluster catalog, an optically selected cluster sample drawn from SDSS imaging data. Our measurement is achieved by demanding consistency between available weak lensing and X-ray measurements of the maxBCG clusters, and the X-ray luminosity--mass relation inferred from the 400d X-ray cluster survey, a flux limited X-ray cluster survey. We find \sigma_{\ln M|N_{200}}=0.45^{+0.20}_{-0.18} (95% CL) at N_{200} ~ 40, where N_{200} is the number of red sequence galaxies in a cluster. As a byproduct of our analysis, we also obtain a constraint on the correlation coefficient between \ln Lx and \ln M at fixed richness, which is best expressed as a lower limit, r_{L,M|N} >= 0.85 (95% CL). This is the first observational constraint placed on a correlation coefficient involving two different cluster mass tracers. We use our results to produce a state of the art estimate of the halo mass function at z=0.23 -- the median redshift of the maxBCG cluster sample -- and find that it is consistent with the WMAP5 cosmology. Both the mass function data and its covariance matrix are presented.Comment: 14 pages, 6 figures, submitted to Ap

A Survey of CN and CH Variations in Galactic Globular Clusters from SDSS Spectroscopy

We present a homogeneous survey of the CN and CH bandstrengths in eight Galactic globular clusters observed during the course of the Sloan Extension for Galactic Understanding and Exploration (SEGUE) sub-survey of the SDSS. We confirm the existence of a bimodal CN distribution among RGB stars in all of the clusters with metallicity greater than [Fe/H] = -1.7; the lowest metallicity cluster with an observed CN bimodality is M53, with [Fe/H] ~ -2.1. There is also some evidence for individual CN groups on the subgiant branches of M92, M2, and M13, and on the red giant branches of M92 and NGC 5053. Finally, we quantify the correlation between overall cluster metallicity and the slope of the CN bandstrength-luminosity plot as a means of further demonstrating the level of CN-enrichment in cluster giants. Our results agree well with previous studies reported in the literature.Comment: AJ submitted; 80 pages, 22 figure

The Cluster Mass Function from Early SDSS Data: Cosmological Implications

The mass function of clusters of galaxies is determined from 400 deg^2 of early commissioning imaging data of the Sloan Digital Sky Survey; ~300 clusters in the redshift range z = 0.1 - 0.2 are used. Clusters are selected using two independent selection methods: a Matched Filter and a red-sequence color magnitude technique. The two methods yield consistent results. The cluster mass function is compared with large-scale cosmological simulations. We find a best-fit cluster normalization relation of sigma_8*omega_m^0.6 = 0.33 +- 0.03 (for 0.1 ~< omega_m ~< 0.4), or equivalently sigma_8 = (0.16/omega_m)^0.6. The amplitude of this relation is significantly lower than the previous canonical value, implying that either omega_m is lower than previously expected (omega_m = 0.16 if sigma_8 = 1) or sigma_8 is lower than expected (sigma_8 = 0.7 if omega_m = 0.3). The best-fit mass function parameters are omega_m = 0.19 (+0.08,-0.07) and sigma_8 = 0.9 (+0.3,-0.2). High values of omega_m (>= 0.4) and low sigma_8 (=~ 2 sigma.Comment: AASTeX, 25 pages, including 7 figures, accepted for publication in ApJ, vol.585, March 200