Solitary fibrous tumor arising in the mesentery: a case report

<p>Abstract</p> <p>Background</p> <p>Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm usually found in the pleura, soft tissues and visceral organs. We describe one case arising in the mesentery, which is an exceptional localization.</p> <p>Case presentation</p> <p>A 71-year-old man was referred to our establishment for a painless hypogastric mass. Further investigation revealed a vascular tumor, which was resected <it>en bloc</it>. Pathological findings confirmed solitary fibrous tumor of the mesentery.</p> <p>Conclusion</p> <p>This is the second case of solitary fibrous tumor of the small intestine mesentery ever reported. It was managed by <it>en bloc </it>resection and close follow up considering the high risk of recurrence. Investigation should be made regarding the use of adjuvant systemic therapy to improve long-term survival for these patients.</p

TRPC1 AS THE MISSING LINK BETWEEN THE BMP AND Ca2+ SIGNALLING PATHWAYS DURING NEURAL SPECIFICATION IN AMPHIBIANS

International audienceIn amphibians, the inhibition of bone morphogenetic protein (BMP) in the dorsal ectoderm has been proposed to be responsible for the first step of neural specification, called neural induction. We previously demonstrated that in Xenopus laevis embryos, the BMP signalling antagonist, noggin, triggers an influx of Ca 2+ through voltage-dependent L-type Ca 2+ channels (LTCCs), mainly via Ca V 1.2, and we showed that this influx constitutes a necessary and sufficient signal for triggering the expression of neural genes. However, the mechanism linking the inhibition of BMP signalling with the activation of LTCCs remained unknown. Here, we demonstrate that the transient receptor potential canonical subfamily member 1, (Trpc1), is an intermediate between BMP receptor type II (BMPRII) and the Ca V 1.2 channel. We show that noggin induces a physical interaction between BMPRII and Trpc1 channels

Considerations in the Use of Podcasts for Teaching and Learning in Occupational Therapy: A Scoping Study

Evidence-based practice integrates and supports the best interventions in clinical practice. However, a gap of about ten years may elapse between the production of evidence and integration of best practices in clinical settings. Some technologies, such as podcasting, have become increasingly popular and are emerging as an innovative teaching modality that can support knowledge acquisition and integration. This scoping study gathered and synthesized the information in the literature regarding the use of podcasts by occupational therapy clinicians and students as a means for teaching and learning evidence-based knowledge. A scoping study approach was used following the five stages defined by Arksey and O\u27Malley. In four databases and using 40 keywords, two team members selected and cross-checked articles. Two team members also extracted data and analyzed them in the form of descriptive statistics and salience (recurrence and importance). Of the 46 articles selected, seven broad categories of 20 important themes related to the use of podcasting were identified: facilitators and obstacles to podcast use, advantages and disadvantages of podcasts, effects of podcasts, potential utility of podcasts, and elements to consider for podcast creation. Podcasting is an innovative and appropriate modality for the retention of knowledge and the optimization of practical skills. It differs from traditional methods in its ease of access and portability. Many positive effects have been associated with its use. However, podcasts should not replace class attendance or other active learning opportunities

Exciton Formation, Relaxation, and Decay in PCDTBT

The nature and time evolution of the primary excitations in the pristine conjugated polymer, PCDTBT, are investigated by femtosecond-resolved fluorescence up-conversion spectroscopy. The extensive study includes data from PCDTBT thin film and from PCDTBT in chlorobenzene solution, compares the fluorescence dynamics for several excitation and emission wavelengths, and is complemented by polarization-sensitive measurements. The results are consistent with the photogeneration of mobile electrons and holes by interband π−π* transitions, which then self-localize within about 100 fs and evolve to a bound singlet exciton state in less than 1 ps. The excitons subsequently undergo successive migrations to lower energy localized states, which exist as a result of disorder. In parallel, there is also slow conformational relaxation of the polymer backbone. While the initial self-localization occurs faster than the time resolution of our experiment, the exciton formation, exciton migration, and conformational changes lead to a progressive relaxation of the inhomogeneously broadened emission spectrum with time constants ranging from about 500 fs to tens of picoseconds. The time scales found here for the relaxation processes in pristine PCDTBT are compared to the time scale (<0.2 ps) previously reported for photoinduced charge transfer in phase-separated PCDTBT:fullerene blends (Phys. Rev. B 2010, 81, 125210). We point out that exciton formation and migration in PCDTBT occur at times much longer than the ultrafast photoinduced electron transfer time in PCDTBT:fullerene blends. This disparity in time scales is not consistent with the commonly proposed idea that photoinduced charge separation occurs after diffusion of the polymer exciton to a fullerene interface. We therefore discuss alternative mechanisms that are consistent with ultrafast charge separation before localization of the primary excitation to form a bound exciton

NeuroCOPE: A novel intervention to increase professional fulfillment and reduce burnout by connecting Neuro-ICU healthcare workers to their post-recovery patients

Background: Healthcare workers (HCWs) caring for patients with acute neurologic injury in the ICU rarely receive detailed information on the recovery of their patients. The missing connection between the period of acute neurologic injury and long-term outcomes is a psychological burden that contributes to moral fatigue and burnout. We hypothesize that attending an Interprofessional conference series through which patients describe their acute brain injury and recovery to Neuro-ICU HCWs may ease moral fatigue, increasing professional fulfillment and reducing burnout.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2023/1014/thumbnail.jp

Impacto da pandemia COVID-19 nas notificações de eventos adversos de medicamentos às autoridades de saúde: protocolo de revisão sistemática

The aim was to outline the protocol for carrying out the systematic review, which will have the objective of evaluating the impact of the COVID-19 pandemic on notifications of adverse drug events to health authorities worldwide. This is a systematic review protocol consistent with PRISMA 2020 regulations and checklist, will be conducted in accordance with the recommendations of the Cochrane Manual, will include original observational studies, letters to editors and editorials containing summary information on adverse drug events before and during the COVID-19 pandemic. The search strategy was developed for the MEDLINE, Embase, CINALH, SciELO and gray literature databases, using the Health Sciences Descriptors (DECs) and the Medical Subject Heading (MeSH). Two independent reviewers will investigate the eligibility of the articles, extract the data and assess the risk of bias. The results of this review will contribute to identifying the impact of COVID-19 on adverse drug event reporting, this will be a significant step in informing and preventing such events and will provide an essential evidence base for the development of strategies and improvements that will contribute to patient safety worldwide.Objetivou-se delinear o protocolo da realização da revisão sistemática que terá o objetivo de avaliar o impacto da pandemia COVID-19 nas notificações de eventos adversos a medicamentos às autoridades sanitárias em todo o mundo.  Trata-se de um protocolo de revisão sistemática consistente com as normativas e checklist PRISMA 2020, será conduzido de acordo com as recomendações do Manual Cochrane, incluirá estudos observacionais originais, cartas aos editores e editoriais contendo informações resumidas sobre os eventos adversos a medicamentos antes e durante a pandemia COVID-19. A estratégia de busca foi desenvolvida para as bases de dados MEDLINE, Embase, CINALH, SciELO e literatura cinzenta, utilizando os Descritores em Ciências da Saúde (DECs) e no Medical Subject Heading (MeSH). Dois revisores independentes investigarão a elegibilidade dos artigos, extrairão os dados e avaliarão o risco de viés. Os resultados desta revisão contribuirão para identificar o impacto da COVID-19 nas notificações de eventos adversos a medicamentos, este será um passo significativo para informar e prevenir tais eventos e fornecerá uma base de evidências essenciais para o desenvolvimento de estratégias e melhorias que contribuirão para a segurança do paciente em nível mundial

Impacto da pandemia COVID-19 nas notificações de eventos adversos de medicamentos às autoridades de saúde: protocolo de revisão sistemática

The aim was to outline the protocol for carrying out the systematic review, which will have the objective of evaluating the impact of the COVID-19 pandemic on notifications of adverse drug events to health authorities worldwide. This is a systematic review protocol consistent with PRISMA 2020 regulations and checklist, will be conducted in accordance with the recommendations of the Cochrane Manual, will include original observational studies, letters to editors and editorials containing summary information on adverse drug events before and during the COVID-19 pandemic. The search strategy was developed for the MEDLINE, Embase, CINALH, SciELO and gray literature databases, using the Health Sciences Descriptors (DECs) and the Medical Subject Heading (MeSH). Two independent reviewers will investigate the eligibility of the articles, extract the data and assess the risk of bias. The results of this review will contribute to identifying the impact of COVID-19 on adverse drug event reporting, this will be a significant step in informing and preventing such events and will provide an essential evidence base for the development of strategies and improvements that will contribute to patient safety worldwide.Objetivou-se delinear o protocolo da realização da revisão sistemática que terá o objetivo de avaliar o impacto da pandemia COVID-19 nas notificações de eventos adversos a medicamentos às autoridades sanitárias em todo o mundo.  Trata-se de um protocolo de revisão sistemática consistente com as normativas e checklist PRISMA 2020, será conduzido de acordo com as recomendações do Manual Cochrane, incluirá estudos observacionais originais, cartas aos editores e editoriais contendo informações resumidas sobre os eventos adversos a medicamentos antes e durante a pandemia COVID-19. A estratégia de busca foi desenvolvida para as bases de dados MEDLINE, Embase, CINALH, SciELO e literatura cinzenta, utilizando os Descritores em Ciências da Saúde (DECs) e no Medical Subject Heading (MeSH). Dois revisores independentes investigarão a elegibilidade dos artigos, extrairão os dados e avaliarão o risco de viés. Os resultados desta revisão contribuirão para identificar o impacto da COVID-19 nas notificações de eventos adversos a medicamentos, este será um passo significativo para informar e prevenir tais eventos e fornecerá uma base de evidências essenciais para o desenvolvimento de estratégias e melhorias que contribuirão para a segurança do paciente em nível mundial

The carbon footprint of diagnostic delays in asthma

« Asthma is a prevalent chronic disease worldwide [1], yet its diagnosis remains a challenge [2]. The difficulty partly stems from bronchial provocation testing (BPT) diagnostic delays, a highly sensitive yet specialised procedure [3–6]. [...]