FEEDING ALKALINE TREATED AND PROCESSED CROP RESIDUE TO FEEDLOT CATTLE

Chemical treatment and decreased particle size are methods used to improve digestibility and utilization of the available nutrients in low quality forages. Previous research has indicated that chemically treated corn residue can take the place of corn when included in finishing rations containing distillers grains. Also, decreasing particle size utilizing methods such as pelleting has been shown to improve DMI and ADG. However, limited research has been completed on use of chemical treatment and pelleting in growing and receiving rations. Also, an ideal distillers inclusion has not yet been identified when including alkaline treated stalks in finishing rations. Therefore, a finishing study, a receiving study, two growing studies, and a digestion study were completed to evaluate the effects of alkaline treatment and pelleting on cattle performance, carcass characteristics, and diet digestibility. For the finishing study, data suggest that feeding 10 or 20% treated corn residue with 40% modified distillers grains plus solubles (MDGS) gives comparable performance and carcass traits compared to a corn based control diet. However, if 20% MDGS is fed no more than 10% treated residue should be included. Growing studies indicated that chemical treatment improved DMI, ADG, and G:F when compared to untreated equivalents. However a greater G:F improvement (8%) was noted with treated wheat straw, while a 2% improvement was observed for treated corn residue. For the digestion study, chemical treatment was not shown to improve residue digestibility in growing calves. Pelleting was shown to improve DMI and ADG, however better G:F was noted with unpelleted diets fed to growing calves. When a pelleted complete feed was tested as a receiving ration, DMI was improved due to pelleting however ADG and G:F did not surpass observed performance paired with the unpelleted control. Advisors: Jim C. MacDonald and Galen E. Erickso

Personality and Learning Predictors of Adolescent Alcohol Consumption Trajectories

In a sample of 1897 youth studied across the last year of elementary school to the second year of high school, we (a) characterized different developmental trajectories of drinking frequency and drinking-related problems and (b) tested an a priori risk model that predicted variation in trajectory group membership. Analyses revealed five separate trajectories for both drinking frequency and drinking problems. Wave 1 scores on impulsigenic traits, expectancies for the reinforcing and stimulating effects of alcohol, and early pubertal onset differentiated among the trajectory groups, in some cases before the groups differed in drinking behavior. We also found substantial covariation between membership in high drinking frequency groups and membership in groups experiencing problems from alcohol consumption. The findings suggest that (a) youth vary considerably in the development of drinking behavior, and (b) trajectory groups can be distinguished by specific biological, personality, and learning risk factors

Early Maturing Out of Problematic Alcohol Use

Most research suggests that alcohol use peaks in the college years then declines into the mid-thirties (Jochman & Fromme, 2010). However, there is evidence that some individuals mature out earlier: downward trends for some individuals begin in college, with as many as one third of students decreasing their drinking (Baer et al., 2001). It is crucial to identify factors that differentiate those who decrease their drinking early from those who persist in high levels of consumption; doing so would clarify risk for college-related alcohol problems and perhaps subsequent alcohol use disorder, and aid in earlier targeted prevention and intervention. This study emphasizes two possibilities: 1) perhaps those who mature out early have adult-like responsibilities such as paying for their educations (i.e. financial burden) and/or 2) perhaps those who persist have higher levels of personality (i.e. urgency or sensation seeking) and learning-based (i.e. alcohol expectancies) risk factors. A sample of 591 college students were assessed four times across two years. Five trajectories of drinking frequency were identified. Three displayed stable drinking patterns across the two year period at low/infrequent, moderate and high levels. A fourth group displayed an increase at wave 4, and a fifth group decreased their drinking at wave 4. The latter two groups could be differentiated by sensation seeking and positive social expectancies, but not urgency or financial burden, before their patterns diverged. These results emphasize heterogeneity in alcohol use development across emerging adulthood, as well as the integration of contextual and individual difference risk factors

Image Segmentation using Human Visual System Properties with Applications in Image Compression

In order to represent a digital image, a very large number of bits is required. For example, a 512 X 512 pixel, 256 gray level image requires over two million bits. This large number of bits is a substantial drawback when it is necessary to store or transmit a digital image. Image compression, often referred to as image coding, attempts to reduce the number of bits used to represent an image, while keeping the degradation in the decoded image to a minimum. One approach to image compression is segmentation-based image compression. The image to be compressed is segmented, i.e. the pixels in the image are divided into mutually exclusive spatial regions based on some criteria. Once the image has been segmented, information is extracted describing the shapes and interiors of the image segments. Compression is achieved by efficiently representing the image segments. In this thesis we propose an image segmentation technique which is based on centroid-linkage region growing, and takes advantage of human visual system (HVS) properties. We systematically determine through subjective experiments the parameters for our segmentation algorithm which produce the most visually pleasing segmented images, and demonstrate the effectiveness of our method. We also propose a method for the quantization of segmented images based on HVS contrast sensitivity, arid investigate the effect of quantization on segmented images

Statin Discontinuation among Nursing Home Residents with Advanced Dementia

Background: Statin use in elderly individuals with life-limiting illness such as advanced dementia is controversial. Objective: To describe factors associated with statin discontinuation and estimate impact of discontinuation on 28-day hospitalizations in nursing home (NH) residents with advanced dementia. Methods: Retrospective cohort study of NH residents ≥ 65 years with recent progression to advanced dementia from 5 large U.S. states drawn from the 2007-2008 Minimum Data Set 2.0. We identified residents using statins. Clinical characteristics and 28-day hospitalization risk were compared for residents discontinuing and continuing statins. Multivariable Cox proportional hazard models identified factors associated with time to statin discontinuation and time to hospitalization. Sensitivity analysis using self-controlled case series examined the role of confounding-by-indication on risk estimation from the cohort approach. Results: Of 10,212 residents with decline to advanced dementia, 16.6% were prescribed statins (n=1,699). Statin users had mean age of 83.1 yrs, 68.9% were female, and mean medication burden was 10.3 (SD 4.8, range 1-31). Over one-third (n=632) discontinued in follow-up. Median time to discontinuation was 36 days after decline to advanced dementia (IQR [25%, 75%]: 12 days, 110 days). After adjustment, factors independently associated with increased hazard of discontinuation included residence in a NH in Florida relative to California, hospitalization in the 30 days prior to decline to advanced dementia, greater medication burden, and having cancer. The 28-day hospitalization risk was higher for residents discontinuing statins compared to continuing (adjusted hazard ratio = 1.78, CI 1.61,2.58). The SCCS estimate for 28-day hospitalization risk following statin discontinuation compared to a 28-day pre-discontinuation control period was lower than the cohort estimate (IRR= 0.79, CI 0.76, 0.83). Conclusion: A significant proportion of nursing home residents with dementia who use statins when they progress to advanced stage disease discontinue use. Hospitalization outcomes following discontinuation differ depending on method of estimation

Effects of Shambhavi Mahamudra Kriya, a Multicomponent Breath-Based Yogic Practice ( Pranayama), on Perceived Stress and General Well-Being

Stress-induced disorders such as anxiety represent the leading causes of adult disability worldwide. Previous studies indicate that yoga and other contemplative practices such as pranayama, or controlled yogic breathing techniques, may be effective in the treatment of mood disorders and stress. In this study, 142 individuals (mean age = 43 years; SD = 13.90) participated in a 3-day retreat program during which they learned Shambhavi Mahamudra kriya, which is a yogic practice that includes both deep breathing and meditation techniques. Participants were instructed to practice the kriya each day for 21 minutes. After 6 weeks of daily practice, participants reported subjectively lower levels of perceived stress (Perceived Stress Scale) and higher levels of general well-being (General Well-Being Scale) compared to baseline. These results support the notion that Shambhavi Mahamudra kriya may represent a natural treatment for stress reduction

Cutaneous microvascular reactivity in Charcot neuroarthropathy : a systematic review and meta-analysis

Background: To systematically evaluate the literature investigating the relationship between cutaneous microvascular reactivity in the foot of adults with diabetes-related Charcot neuroarthropathy compared to a non-Charcot adult control group. Methods: A systematic search was conducted to June 2021 using the biomedical databases EBSCO Megafile Ultimate, Cochrane Library and EMBASE. Original research conducting comparative investigation of cutaneous microvascular reactivity in the foot of adults with diabetes and any pattern of acute or chronic Charcot neuroarthropathy and any non-Charcot adult control groups were included. A modified Critical Appraisal Skills Programme tool was used for quality appraisal. Cutaneous microvascular reactivity in diabetes-related Charcot neuroarthropathy data were synthesised and meta-analysis conducted where possible. Results: The search strategy identified 1,684 articles, with seven eligible for inclusion. Included studies used various methodologies and equipment to assess cutaneous microvascular reactivity in 553 participants (162 with Charcot neuroarthropathy). Cutaneous microvascular reactivity in Charcot neuroarthropathy groups was impaired compared to uncomplicated diabetes groups. Meta-analysis investigating the difference in response to thermal hyperaemia demonstrated a significant difference in cutaneous microvascular reactivity between Charcot neuroarthropathy and peripheral neuropathy with a large, pooled effect size (SMD 1.46 95% CI: 0.89– 2.02) and low heterogeneity (I 2 = 4%, T 2 = 0.01) indicating that the cutaneous microvascular response is more impaired in peripheral neuropathy than in Charcot neuroarthropathy. Conclusions: Charcot neuroarthropathy is associated with greater cutaneous microvascular reactivity in the periphery relative to diabetes cohorts with diabetes-related peripheral neuropathy alone. It is unknown if this occurs prior to, or as a result of, Charcot neuroarthropathy

Innate Immunity in the C. elegans Intestine Is Programmed by a Neuronal Regulator of AWC Olfactory Neuron Development

Olfactory neurons allow animals to discriminate nutritious food sources from potential pathogens. From a forward genetic screen, we uncovered a surprising requirement for the olfactory neuron gene olrn-1 in the regulation of intestinal epithelial immunity in Caenorhabditis elegans. During nematode development, olrn-1 is required to program the expression of odorant receptors in the AWC olfactory neuron pair. Here, we show that olrn-1 also functions in AWC neurons in the cell non-autonomous suppression of the canonical p38 MAPK PMK-1 immune pathway in the intestine. Low activity of OLRN-1, which activates the p38 MAPK signaling cassette in AWC neurons during larval development, also de-represses the p38 MAPK PMK-1 pathway in the intestine to promote immune effector transcription, increased clearance of an intestinal pathogen, and resistance to bacterial infection. These data reveal an unexpected connection between olfactory receptor development and innate immunity and show that anti-pathogen defenses in the intestine are developmentally programmed