Alcohol slows interhemispheric transmission, increases the flash-lag effect, and prolongs masking: evidence for a slowing of neural processing and transmission.

While the alcohol literature is extensive, relatively little addresses the relationship between physiological effects and behavioural changes. Using the visual system as a model, we examined alcohol\u27s influence on neural temporal processing as a potential means for alcohol\u27s effects. We did this by using tasks that provided a measure of processing speed: Poffenberger paradigm, flash-lag, and backward masking. After moderate alcohol, participants showed longer interhemispheric transmission times, larger flash-lags, and prolonged masking. Our data are consistent with the view that alcohol slows neural processing, and provide support for a reduction in processing efficiency underlying alcohol-induced changes in temporal visual processing

Feasibility and acceptability of a future‐oriented empowerment program to prevent substance use and school dropout among school‐disengaged youth

ObjectiveTo evaluate the feasibility and acceptability of a health promotion program to prevent school dropout and substance use among middle school‐aged youth who display early warning signs of school disengagement.InterventionYouth Empowerment Solutions for Positive Futures (YES‐PF), an intensive, theoretically driven, 5‐week summer enrichment program, aims to prevent school dropout and substance use by promoting youth empowerment, school engagement, and future orientation.Design and SampleUsing a pre–post‐intervention design, we test feasibility and acceptability with 6th and 7th grade students (n = 43) who exhibited early warning signs for school disengagement (e.g., chronic absenteeism) in two school districts.MeasuresProgram evaluation components included: (a) program session forms completed by facilitators; (b) post‐program interviews with facilitators; (c) post‐intervention program evaluation surveys with youth; (d) attendance; and (e) baseline and post‐intervention surveys with youth to assess behavioral and psychosocial outcomes.ResultsFacilitators routinely delivered core component lesson activities. Acceptability and program satisfaction were evidenced in strong program attendance by youth. Youth participants reported higher levels of leadership efficacy (p < .05) and a greater sense of control over their lives and potential problems (p < .01).ConclusionsYES‐PF was feasible and acceptable to school personnel and youth. Program refinement, based on implementation findings, is discussed.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154506/1/phn12706.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154506/2/phn12706_am.pd

Review of biphasic insulin aspart in the treatment of type 1 and 2 diabetes

Nazia Raja-Khan, Sarah S Warehime, Robert A GabbayDivision of Endocrinology, Diabetes, and Metabolism, Penn State Institute for Diabetes and Obesity, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USABackground: Insulin is an effective treatment for achieving glycemic control and preventing complications in patients with diabetes. In order to make insulin therapy more acceptable to patients, newer formulations of insulin have been developed, such as biphasic insulins. Biphasic insulins conveniently provide both prandial and basal insulin in a single injection. One of the most well-studied biphasic insulins is biphasic insulin aspart 70/30.Objective: Our goal was to review the current literature on the safety and efficacy of biphasic insulin aspart in type 1 and type 2 diabetes.Methods: A MEDLINE search was conducted using the terms &ldquo;biphasic insulin aspart&rdquo; to identify clinical studies and reviews.Results: Biphasic insulin aspart more effectively reduces post-prandial glucose compared to other biphasic insulins and basal insulins. Compared to biphasic insulin aspart, fasting glucose levels are lower with NPH, similar with glargine, and similar or lower with biphasic human insulin. Treat-to-target trials have shown that a goal HbA1c below 6.5 or 7% can be achieved with biphasic insulin aspart. The risk of hypoglycemia is similar to or less than that seen with other biphasic insulins or NPH insulin.Conclusion: Biphasic insulin aspart 70/30 is a safe and effective treatment option for patients with diabetes.Keywords: biphasic insulin aspart, insulin, diabete

Effects of ethanol on anti-saccade task performance.

It has been shown that saccade-related neurons in the superior colliculus (SC) display an increased level of prestimulus activity and a higher stimulus-related burst in action potentials preceding direction errors in the anti-saccade task compared with correct anti-saccades. From this, it has been hypothesized that errors occur when the incoming visual signal in the SC passes a threshold and triggers a reflexive saccade. This hypothesis predicts that an attenuated visual signal will reduce the number of direction errors. Since ethanol has been shown to have a suppressive effect on cortical visual event-related potentials (ERPs), the purpose of the present study was to investigate the effects of moderate ethanol consumption on anti-saccade performance. Under both placebo and ethanol conditions, we recorded ERPs and measured eye movements in male subjects during the performance of an anti-saccade task in which the fixation point disappeared 200 ms prior to stimulus presentation. Compared with the placebo condition, we found in the ethanol condition: (1). a decrease in ERP amplitudes during the gap period and after stimulus presentation, (2). an increase in the latencies of anti-saccades, and (3). a decrease in the percentage of direction errors. These data demonstrate the effects of ethanol on anti-saccade task performance and provide further support for the hypothesis that errors in the anti-saccade task are triggered by the incoming visual signal

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production

IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells. Although IL-2 is produced by all polarized Th subsets to some level, how it impacts cytokine production when effector T cells are restimulated is unknown. We show in this article that Golgi transport inhibitors (GTIs) blocked IL-9 production. Mechanistically, GTIs blocked secretion of IL-2 that normally feeds back in a paracrine manner to promote STAT5 activation and IL-9 production. IL-2 feedback had no effect on Th1- or Th17-signature cytokine production, but it promoted Th2- and Th9-associated cytokine expression. These data suggest that the use of GTIs results in an underestimation of the presence of type 2 cytokine-secreting cells and highlight IL-2 as a critical component in optimal cytokine production by Th2 and Th9 cells in vitro and in vivo

Cystic Fibrosis - An Ever Evolving Challenge

Cystic fibrosis (CF) is a genetic disease that results from mutations in a large single gene located on chromosome 7. More than 2000 different mutations in the gene have been identified to have caused the disease. Most of these mutations are exceedingly rare and therefore not a part of CF screening or all testing panels. This case discusses an adult female with a history of asthma, bronchiectasis, pseudomonas colonization, and respiratory failure on chronic oxygen who presented to the ED with sudden onset shortness of breath, fever, chills, body aches, nonproductive cough, and headache. The patient\u27s condition clinically improved with treatment and was discharged on day three. The patient had previously undergone a laboratory evaluation of bronchiectasis. Due to the patient\u27s history of bronchiectasis and pseudomonas colonization, there was a decision to reconsider the possibility of CF. The patient underwent a routine cystic fibrosis genetic testing panel which subsequently confirmed a CFTR mutation. The discussion highlights the importance of remaining vigilant for signs of CF, to remain open to the possibility of CF or CFTR related disorders, when patients have had evaluations for such that predate current testing standards or capabilities

Heterogeneity in progression of prodromal features in Parkinson’s disease

Background: In the pre-diagnostic phase of Parkinson’s disease (PD), a range of motor and non-motor symptoms can occur. However, there is considerable variability in their onset and currently little information exists on the pattern of progression of clinical features before diagnosis. Methods: We analysed data from a survey amongst patients with PD from 11 European countries by the European Parkinson’s Disease Association. They completed questions on first occurrence of 21 pre-diagnostic features. A principal component analysis (PCA) with varimax rotation was performed to determine the co-occurrence of these features. Findings: 1,467 patients were included. Changes in movement were the most commonly reported features up to 4 years before diagnosis. However, at five or more years before diagnosis loss of sense of smell, sleep problems, fatigue and other non-motor features had been experienced most frequently. PCA of pre-diagnostic features’ duration revealed three factors with eigenvalues over Kaiser’s criterion of 1: a) a neuropsychiatric factor comprised of anxiety, depression, apathy, stress, and sleep problems; b) an axial factor defined by difficulty eating and/or swallowing problems, freezing, and falls/balance problems; and c) a motor factor with additional non-motor features. Bladder/bowel problems and tremor had low factor loadings on all components. However, in those with disease duration less than 5 years the autonomic features were associated with the axial factor and tremor loaded on both the motor and psychiatric symptom factors. Interpretation: The identified symptom complexes in the pre-diagnostic stage of PD may be reflective of a shared pattern of pathological disease progression

The Role of Social Media Platforms in Confronting Intellectual Extremism from Majmaah University Students Perspective

The present study aims to investigate the role of social media platforms in confronting intellectual extremism among Majmaah University students. The researchers conducted the descriptive analytical approach and applied a 20- item questionnaire to a randomly selected sample of (213) students. The results showed that Tik Tok and Snapchat were ranked first among the study sample. Also, there was a moderate negative impact of social media on intellectual security, with a mean of (2.99). This is due to the nature of the content published on networks and its impact on the subscribers. It indicated the importance of social media, more specifically Tik Tok and Snapchat, among the sample of the study. It can be attributed to gender since females are more interested in social networks to publish and share photos. Moreover, the results revealed that social media platforms played a moderate role in resisting intellectual deviation among the participants, with an average mean of (2.96). There were no statistical differences in the impact of social media platforms on young peoples intellectual security and their role in resisting intellectual extremism due to responses to the study questions. The findings of the study call for the necessity of activating the positive role of social media by exploring new approaches to evolve effective alternatives in dealing with social networks by enhancing young peoples media literacy. Contribution/Originality: This study contributed to the existing literature by identifying the role of social media in combating intellectual extremism from the perspective of students at Majmaah University, Saudi Arabia. It also explored the most popular social media platforms among university students and their impact on students intellectual security