Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?

The aims of the present work were to study the effects of chronic NO inhibition on liver cirrhosis and to analyze its relationship with liver and kidney damage markers. Two inhibitors of NO synthesis (inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG), and nonselective NOS inhibitor, L-nitroarginine methyl ester (L-NAME)) were administered for 6 weeks to bile duct ligated (BDL) rats 3 days after surgery. The present study showed that BDL was associated with liver injury and renal impairment. BDL increased liver NO content and myeloperoxidase (MPO) activity. This was corroborated by increased oxidative stress, TNF-α, TGF-1β, and MMP-13 genes overexpression. Although both drugs reduced NO synthesis and TNF-α gene overexpression, only AG improved renal dysfunction and liver damage and reduced liver oxidative stress. However, L-NAME exacerbated liver and renal dysfunction. Both drugs failed to modulate TGF-1β and MMP-13 genes overexpression. In conclusion, inhibition of NO production by constitutive nitric oxide synthase (cNOS) plays a crucial role in liver injury and renal dysfunction while inhibition of iNOS by AG has beneficial effect. TNF-α is not the main cytokine responsible for liver injury in BDL model. Nitric oxide inhibition did not stop the progression of cholestatic liver damage

The Effect of Ownership Structure on Share Price Volatility of Listed Companies in Amman Stock Exchange

This dissertation investigates the effect of different ownership structure (The largest, Five Greatest, Institutional and Individual Shareholder Structure) on a share price volatility of listed companies in Amman Stock Exchange. The research has four hypotheses. To test each hypothesis; a model was defined based on dependent variables employed to measure share price volatility. A panel data procedure is applied to the dataset that includes 51 Jordanians companies from 2005 to 2009. Two empirical models are used OLS (Ordinary Least Square) and SUR (Seemingly Unrelated Regression), and we found that SUR shows better and accurate result than OLS. The results provide evidence of positive statistically significant relationship between the largest shareholder and share price volatility .Also; the results reveal a positive and significant relationship between the five greatest shareholder and share price volatility. The study, however, could not provide a significant relationship between the individual and institutional shareholder in one hand and share price volatility on the other. These results are consistent with prior empirical studies. This dissertation helps managers and investors to have insight into the nature of ownership structure and is it possible for companies’ ownership structures to influence firms’ risk and the stocks’ return

Unemployment of University Graduates: Reasons, Results and Solutions Available -Case Study of Biskra State-

الهدف من هذا المقال هو التعرف على ظاهرة بطالة خريجي الجامعات من خلال التعرض لأسبابها وخصائصها ونتائجها والأجهزة المتوفرة لمواجهة هذه الظاهرة، كما تم عرض واقع هذه الظاهرة بسوق العمل بولاية بسكرة، وقد خلص هذا البحث إلى عدة نتائج منها أن بطالة خريجي الجامعات بسوق العمل بولاية بسكرة يرجع لارتفاع النمو السكاني والطلب المتزايد على التعليم العالي الذي ينتج عنه العدد الهائل من الخريجين سنويا بالإضافة إلى عدم ملائمة مخرجات التعليم العالي مع احتياجات سوق العمل بولاية بسكرة، وتراجع تدخل الدولة في توفير فرص عمل في القطاع العام، أما القطاع الخاص فيفرض شروط ومؤهلات لا تتوفر في خريجي الجامعات مثل الخبرة المهنية والتي في المتوسط تكون خمس سنوات، مما ينتج عن هذه الأسباب وغيرها عجز في تزويد سوق العمل بالكفاءات اللازمة لدعم النمو الاقتصادي بما يتلاءم مع متطلبات سوق العمل. تصنيف جال: J64 ، J40، I20، I23.The aim of this article is to identify the phenomenon of unemployment of university graduates through exposure to its causes, characteristics, and results and the available mechanisms to confront this phenomenon, and the reality of this phenomenon was presented in the labor market in the state of Biskra. This research concluded that the unemployment of university graduates in the labor market In the state of Biskra is due to the high population growth and the increasing demand for higher education, which results in a large number of graduates annually, in addition to the inappropriate outputs of higher education with the needs of the labor market in the state of Biskra, and the decline of the state intervention in providing employment in the public sector, Imposing conditions and qualifications are not available in university graduates, such as professional experience, which on average are five years, resulting from these and other reasons, the inability to provide the labor market needed to support economic growth in line with the requirements of the labor market competencies

E-services computer system for UiTM student in Shah Alam / Siti Sara Zakaria @ Mustafa

E-Services Computer system (ESC) is an online service of renting computer and providing computer maintenance information. ESC has been set up to give companies that provide computer services an easy of putting their renting computer information and view computer maintenance status. TWs ESC was there to put companies that provide computer services and student can make computer services like computer renting by company selected. This project aims to create a system where any company can adding their computer rent information and student can choose company to make services. The company also can put computer maintenance status to the student and student can view the maintenance status either under maintenance or done. The E-Services Computer System is an alternative ^proach that allowed company can put their computer services and student can make their services within this system. This project is using the behavior of common computer services as an approach, which is allowed user to list, select, view the renting computer and computer maintenance information through online. A user interface for E-Service Computer System was developed using Macromedia Dreamweaver and the interfaces of the system were designed using Adobe Photoshop, SwishMAX and Macromedia Flash MX. PHP: Hypertext Preprocessor is being used as a programming language platform for designing and developing this system. MySQL is the database programs that been used in this system and it was create for developing and support complete management database. As the conclusion, E-Services Computer System will take advantage of new content and delivery technology to enable E-Services Computer system provide renting computer listing and information service

Implant Site Preparation Using Conventional Drilling Technique Versus Magnetic Malleting Technique (Randomized Clinical Study).

Background The purpose of our current study is to determine whether using a Magnetic Mallet during oral and implant surgical procedures is more effective than using traditional instruments with regard to complication rate, tissue healing, and surgical results (primary stability and crestal bone loss). According to a number of writers, a Magnetic Mallet can be utilized for implant insertion, ridge expansion, sinus lifts, tooth extractions, and implant site preparation. So, this study was conducted to ascertain whether using a Magnetic Mallet Throughout the process of oral and surgical implant operations is effective and to assume on whether it might help prevent failures and implications. Material and Methods: In the current investigation, nine patients had twenty implants placed bilaterally in the posterior maxilla to compare the advanced osteotome technique (Magnetic Mallet) with the conventional drilling approach clinically and radiographically after loading. They were chosen from the Department of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Medicine, Future University in Egypt\u27s outpatient clinics. On one side, eight patients were recruited as study subjects, while on the other side, then they were recruited as control subjects. They were given one implant on the control side and one on the study side. The last patient had two implants on the control side and two on the research side. Results: It was noticed that Stability at baseline was significantly higher in the Magnetic Mallet (Study group) (71.77±2.71) than in the Conventional (Control group) (68.67±2.36) in our study. When the amount of difference from baseline to 6 months was compared between groups, it was shown that the Magnetic Mallet (Study group) showed an increased gain in stability (6.21±1.78) than the Conventional (Control group) (4.49±0.9). Regarding marginal bone loss, there was no statistically significant difference between the two groups in the current investigation. Conclusion: From the current study it was concluded that the usage of Magnetic Mallets is reported to offer better clinical benefits than the traditional instruments. Due to its safety, predictability, speed, and simplicity of use, it can be useful during dental and implant surgery procedures. The Magnetic Mallet improves implant stability compared to conventional drilling technique, but it doesn\u27t reduce the amount of marginal bone loss around dental implants. The Magnetic Mallet is quick, precise, and effective in bone condensing and an appropriate tool for preparing implant bed in softer maxillary bone

Green nanocomposites from rosin-limonene copolymer and algerian clay

Green nanocomposites from rosin-limonene (Ros-Lim) copolymers based on Algerian organophilic-clay named Maghnite-CTA+ (Mag-CTA+) were prepared by in-situ polymerization using di erent amounts (1, 5 and 10% by weight) of Mag-CTA+ and azobisisobutyronitrile as a catalyst. The Mag-CTA+ is an organophilic montmorillonite silicate clay prepared through a direct exchange process; the clay was modified by ultrasonic-assisted method using cetyltrimethylammonuim bromide in which it used as green nano-filler.The preparation method of nanocomposites was studied in order to determine and improve structural, morphological, mechanical and thermal properties ofsin.The structure and morphology of the obtained nanocomposites(Ros-Lim/Mag-CTA+) were determined using Fourier transform infrared spectroscopy, X-ray di raction, scanning electronic microscopy and transmission electronic microscopy. The analyses confirmed the chemical modification of clay layers and the intercalation of rosin-limonene copolymer within the organophilic-clay sheets. An exfoliated structure was obtained for the lower amount of clay (1% wt of Mag-CTA+), while intercalated structures were detected for high amounts of clay (5 and 10% wt of Mag-CTA+). The thermal properties of the nanocomposites were studied by thermogravimetric analysis (TGA) and show a significant improvement inthe thermal stability of the obtained nanocomposites compared to the purerosin-limonene copolymer (a degradation temperature up to 280ºC).info:eu-repo/semantics/publishedVersio

Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model

Cancer is the second leading cause of death worldwide, and triple-negative breast cancer (TNBC) patients show the poorest prognosis and survival and the highest metastasis prevalence among all breast cancer subtypes. Matcha has recently been associated with multiple health benefits, and in vitro studies showed the potential effect of matcha in inhibiting cancer development and metastasis. We aimed to determine the safe, non-toxic dose of matcha suitable for zebrafish and to investigate the anticancer effect of matcha on the metastasis and growth of human TBNC cells using a zebrafish xenograft model. Wild-type AB zebrafish were used to conduct multiple general toxicity assessments, including developmental, neuromuscular, and cardiovascular toxicities. The safe, non-toxic concentration of matcha was determined to be 50 µg/mL and 100 µg/mL. Afterward, the zebrafish xenograft model was successfully established for MDA-MB-468 and MDA-MB-231 TNBC cells. The tumor size and metastasis of the injected cancer cells were traced through CM-Dil red fluorescent dye. Upon exposure to matcha at the safe doses, MDA-MB-231 and MDA-MB-468 showed a trend toward reduction in tumor size in a dose-dependent manner, indicated by quantified fluorescence. Matcha also visibly suppressed metastasis of cancer cells in the zebrafish body. Our results point to a potential dose-dependent anticancer effect of matcha on TNBC cells; however, more extended observation periods after xenotransplantation are required to confirm the long-term anticancer effect of matcha on tumor growth and metastasis.This research was funded by Qatar University-internal grants (QUCP-CHS-2022-483) and QUST-1-CHS-2023-790 for M.A.-A.Scopu

Water in the Green Economy: Capacity Development Aspects

This book discusses needs related to capacity development for water resources management, including water supply and sanitation, in the context of the green economy. It showcases theoretical and practical approaches with proven success. Most contributions come from members and partners within the interagency mechanism, UN-Water. The 11 case studies in this book range from innovative design and delivery of capacity development programs related to water in the green economy, market mechanisms, and quality control procedures supporting capacity development success towards the practical implementation of programs to enhance individual and institutional capacity