Instructional planning and new technologies in teacher education: the initial phase of a research project

The purpose of this work is to present the initial phase of a research project focused on the integration of technologies in the education of kindergarten and primary school student teachers through instructional planning. Firstly, we illustrate a tool designed for planning integrated learning units and describe the training path in which it was used. Secondly, we report the results of a preliminary study conducted with 96 students attending a university course that investigates two personal traits considered as prerequisites for using the tool: perceived proficiency in technology use, and opinions on the importance of each constituent element of the tool. With regard to both traits, some statistically significant variations emerged. The results obtained are an encouragement to continue the research project to verify whether the tool could be suitable to help student teachers develop an integrated planning procedure

A quantum particle in a box with moving walls

We analyze the non-relativistic problem of a quantum particle that bounces back and forth between two moving walls. We recast this problem into the equivalent one of a quantum particle in a fixed box whose dynamics is governed by an appropriate time-dependent Schroedinger operator.Comment: 12 pages, 0 figure

Oral erythema multiforme after Pfizer-BioNTech COVID-19 vaccination: a report of four cases.

BACKGROUND The 2019 Coronavirus disease (Covid-19) has affected thousands of people worldwide. To date, vaccines appear to be the only method to prevent and reduce mortality. Four vaccinations have been outwardly approved by European Medicine Agency (EMA) in Europe: BNT162b2 (Comirnaty-BioNTech/Pfizer), mRNA-1273 (Spikevax-Moderna), ChAdOx1 (VaxzevriaAstrazeneca), and Ad26.COV2-S (Janssen-Johnson&Johnson). After vaccination, local and systemic adverse effects can occur. Cutaneous reactions like urticaria, local injection site pain, morbilliform rash have been documented after vaccination. CASES PRESENTATION We report four cases of oral erythema multiforme flare arising after BNT162b2 vaccination administration. All the patients denied previous erythema-like and herpetic manifestations history. Two of the reported cases (number 1 and 2) presented with both oral and cutaneous lesions, while cases 3 and 4 showed only oral manifestations. Three of the cases presented the erythema after the first vaccination dosage administration, only one case reported lesions after the second vaccination dosage administration. All the cases were treated with prednisone via oral administration and topical 0.05% clobetasol ointment. CONCLUSIONS The present reports represent some of the few cases of erythema multiforme occurring as a side effect of the BNT162b2 COVID-19 vaccination. The causal role of the vaccine for the erythema multiforme has not been proven yet; nevertheless, it is not uncommon for medications to trigger this disease. The vaccine could surface a silent herpes virus infection, which would induce the erythema multiforme instead

Training kindergarten and primary education student teachers to plan learning units combining TPACK, LAT and multimodality

[EN] This contribution presents an educational proposal, which will be the prelude to an action research project aimed at the operative integration of technologies in the education and training of future kindergarten and primary school teachers. The contribution proposes, in particular, an instrument for planning learning units that has been developed according to specific theoretical models – TPACKTechnological Pedagogical And Content Knowledge (Mishra & Koehler, 2006), LAT-Learning Activity Types (Harris & Hofer, 2009), multimodality (Cope & Kalantzis, 2000) – and can be used in a learning path for the above-mentioned future teachers both as part of courses on educational technology as well as those for specific disciplines. This contribution illustrates and justifies the structure of such an instrument, the use of which could help enable future teachers to develop an integrated planning procedure that should be dynamic and open to refinements and improvements as they meet with different knowledge domains during their trainingMessina, L.; Tabone, S. (2015). Training kindergarten and primary education student teachers to plan learning units combining TPACK, LAT and multimodality. En 1ST INTERNATIONAL CONFERENCE ON HIGHER EDUCATION ADVANCES (HEAD' 15). Editorial Universitat Politècnica de València. 349-356. https://doi.org/10.4995/HEAd15.2015.295OCS34935

Effects of protein supplementation in fitness world: A 12-week cross-over studio

The aim of this project was to evaluate the effect of isolated protein supplementation in young amateur athletes. Sixteen subjects aged between 20 and 30 were recruited for this study. Before to start sports performance was assessed at T0, in all subjects, using physical performance test and evaluated body composition. Therefore, the subjects were randomly assigned in two groups (group A and B) of 8 subjects each. The group A start to intake 30 g of protein powder diluted in water after each training session (3 times a week) for six weeks (T0) whilst the group B was the placebo. After 6 weeks (T1), the measurement were repeated for all subjects and the group A became placebo and the group B started with the supplementation. At the end of 6 weeks (T2) we carried out all the tests were performed again. Results showed a significant improvement in almost all tests between T0 and T2 within the same group (p < .05), but not significant difference was found between the start and the end of protein’s intake period in both groups. In conclusion, supplementation did not have affect the performance and body composition significantly. Instead, training seems to influence the performance more the supplementation

MicroRNAs in T Cell-Immunotherapy.

MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.This manuscript was funded by grants AEI/10.13039/501100011033, PID-2020-120412RBI100 and PDC2021-121797-I00 (F.S.-M.) from the Spanish Ministry of Economy and Competitiveness; CAM (S2017/BMD-3671-INFLAMUNE-CM) from the Comunidad de Madrid (F.S.-M.), CIBERCV (CB16/11/00272) and BIOIMID PIE13/041 from the Instituto de Salud Carlos “la Caixa” Foundation under the project code HR17-00016. The current research is supported by AECC-Coordinated Grant 2022 (PRYCO223002PEIN). The CNIC is supported by the Ministerio de Ciencia, Innovacion y Universidades and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015- 0505). IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, CEX2020-001039-S). S.G.D. is supported by a grant from the Spanish Ministry of Universities.S

Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer's Disease

Alzheimer's disease (AD) is an aging-related multi-factorial disorder to which metabolic factors contribute at what has canonically been considered a centrally mediated process. Although the exact underlying mechanisms are still unknown, obesity is recognized as a risk factor for AD and the condition of insulin resistance seems to be the link between the two pathologies. Using mice with high fat diet (HFD) obesity we dissected the molecular mechanisms shared by the two disorders. Brains of HFD fed mice showed elevated levels of APP and Aβ40/Aβ42 together with BACE, GSK3β and Tau proteins involved in APP processing and Aβ accumulation. Immunofluorescence, Thioflavin T staining experiments, confirmed increased Aβ generation, deposition in insoluble fraction and plaques formation in both the hippocampus and the cerebral cortex of HFD mice. Presence of Aβ40/Aβ42 in the insoluble fraction was also shown by ELISA assay. Brain insulin resistance was demonstrated by reduced presence of insulin receptor (IRs) and defects in Akt-Foxo3a insulin signaling. We found reduced levels of phospho-Akt and increased levels of Foxo3a in the nuclei of neurons where proapototic genes were activated. Dysregulation of different genes related to insulin resistance, especially those involved in inflammation and adipocytokines synthesis were analyzed by Profiler PCR array. Further, HFD induced oxidative stress, mitochondrial dysfunction and dynamics as demonstrated by expression of biomarkers involved in these processes. Here, we provide evidence that obesity and AD markers besides insulin resistance are associated with inflammation, adipokine dyshomeostasis, oxidative stress and mitochondrial dysfunction, all mechanisms leading to neurodegeneration

Biparametric prostate MRI: impact of a deep learning-based software and of quantitative ADC values on the inter-reader agreement of experienced and inexperienced readers

Objective To investigate the impact of an artificial intelligence (AI) software and quantitative ADC (qADC) on the inter-reader agreement, diagnostic performance, and reporting times of prostate biparametric MRI (bpMRI) for experienced and inexperienced readers. Materials and methods A total of 170 multiparametric MRI (mpMRI) of patients with suspicion of prostate cancer (PCa) were retrospectively reviewed by one experienced and one inexperienced reader three times, following a wash-out period. First, only the bpMRI sequences, including T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) sequences, and apparent diffusion coefficient (ADC) maps, were used. Then, bpMRI and quantitative ADC values were used. Lastly, bpMRI and the AI software were used. Inter-reader agreement between the two readers and between each reader and the mpMRI original reports was calculated. Detection rates and reporting times were calculated for each group. Results Inter-reader agreement with respect to mpMRI was moderate for bpMRI, Quantib, and qADC for both the inexperienced (weighted k of 0.42, 0.45, and 0.41, respectively) and the experienced radiologists (weighted k of 0.44, 0.46, and 0.42, respectively). Detection rate of PCa was similar between the inexperienced (0.24, 0.26, and 0.23) and the experienced reader (0.26, 0.27 and 0.27), for bpMRI, Quantib, and qADC, respectively. Reporting times were lower for Quantib (8.23, 7.11, and 9.87 min for the inexperienced reader and 5.62, 5.07, and 6.21 min for the experienced reader, for bpMRI, Quantib, and qADC, respectively). Conclusions AI and qADC did not have a significant impact on the diagnostic performance of both readers. The use of Quantib was associated with lower reporting times

Análisis de una actividad de comprensión lectora sobre un texto de álgebra con alumnos de la carrera de ingeniería

En este trabajo contamos una actividad de comprensión lectora realizada por estudiantes de álgebra y Geometría Analítica. Para ello elegimos un texto universitario que trata el trinomio de segundo grado. Caracterizamos la comprensión lectora y el marco de alfabetización académica que la contiene. Describimos el contexto en que fue realizada. Utilizamos como instrumento de evaluación un cuestionario. Diseñamos y aplicamos un procedimiento para clasificar las respuestas al cuestionario y evaluamos el instrumento. Presentamos los resultados. El desarrollo de la actividad estuvo mediado por el aula virtual. Describimos el trabajo de los alumnos y le otorgamos valor acreditativo. Sostenemos que la práctica de la lectura académica aporta a una mejor formación de los ingenieros