Pandangan Tentang Kecemburuan Allah dalam Hukum Kedua Dihubungkan dengan Ikatan Keluarga

This article is a literature study that describes the concept of jealousy towards family, especially spouses and jealousy of God which is written in the Book of Exodus. To be understood, the author presents various information through related sources related to the topic and then explained descriptively. From the research that has been made, the concept of jealousy of a partner is different from the concept of jealousy of God based on general and Biblical views. Human jealousy can make it possible to sin and have some form of jealousy, whether at a young or old age, you will not be separated from this type of emotion. God's law helps human to reflect and breaking the law means not loving God. The Creator of mankind wanted His creation not to turn its back on the idols of the world. He cares about human; therefore, the law helps human not to sin, in this case helping human to obey so that there is no jealousy that will result in evil deeds against others and sins against God

A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture

<p>Abstract</p> <p>Background</p> <p><it>Clostridium acetobutylicum </it>is an anaerobic bacterium which is known for its solvent-producing capabilities, namely regarding the bulk chemicals acetone and butanol, the latter being a highly efficient biofuel. For butanol production by <it>C. acetobutylicum </it>to be optimized and exploited on an industrial scale, the effect of pH-induced gene regulation on solvent production by <it>C. acetobutylicum </it>in continuous culture must be understood as fully as possible.</p> <p>Results</p> <p>We present an ordinary differential equation model combining the metabolic network governing solvent production with regulation at the genetic level of the enzymes required for this process. Parameterizing the model with experimental data from continuous culture, we demonstrate the influence of pH upon fermentation products: at high pH (pH 5.7) acids are the dominant product while at low pH (pH 4.5) this switches to solvents. Through steady-state analyses of the model we focus our investigations on how alteration in gene expression of <it>C. acetobutylicum </it>could be exploited to increase butanol yield in a continuous culture fermentation.</p> <p>Conclusions</p> <p>Incorporating gene regulation into the model of solvent production by <it>C. acetobutylicum </it>enables an accurate representation of the pH-induced switch to solvent production to be obtained and theoretical investigations of possible synthetic-biology approaches to be pursued. Steady-state analyses suggest that, to increase butanol yield, alterations in the expression of single solvent-associated genes are insufficient; a more complex approach targeting two or more genes is required.</p

Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma

Natural killer (NK) cells are innate lymphocytes with a strong antitumor ability. In tumor patients, such as multiple myeloma (MM) patients, an elevated number of NK cells after stem cell transplantation (SCT) has been reported to be correlated with a higher overall survival rate. With the aim of improving NK cell use for adoptive cell therapy, we also addressed the cytotoxicity of patient-derived, cytokine-stimulated NK cells against MM cells at specific time points: at diagnosis and before and after autologous stem cell transplantation. Remarkably, after cytokine stimulation, the patients' NK cells did not significantly differ from those of healthy donors. In a small cohort of MM patients, we were able to isolate autologous tumor cells, and we could demonstrate that IL-2/15 stimulated autologous NK cells were able to significantly improve their killing capacity of autologous tumor cells. With the aim to further improve the NK cell killing capacity against MM cells, we investigated the potential use of NK specific check point inhibitors with focus on NKG2A because this inhibitory NK cell receptor was upregulated following ex vivo cytokine stimulation and MM cells showed HLA-E expression that could even be increased by exposure to IFN-γ. Importantly, blocking of NKG2A resulted in a significant increase in the NK cell-mediated lysis of different MM target cells. Finally, these results let suggest that combining cytokine induced NK cell activation and the specific check point inhibition of the NKG2A-mediated pathways can be an effective strategy to optimize NK cell therapeutic approaches for treatment of multiple myeloma

The Lantern Vol. 1, No. 1, May 1933

• Remember: Translation of Rappelle-toi by Alfred de Musset • Lighting the Lantern • Footfalls • To a Lovely Lady • The Sons of Martha • Strategy • Lumine Lunae • Poetry in Retrospect • Nirvana • A Domestic Episode • At Night • Haman and Hitler • This is What He Said • Bookocracy • Four Loves • Cities and Personalitieshttps://digitalcommons.ursinus.edu/lantern/1000/thumbnail.jp

Dirección de proyecto en la construcción del edificio Municipal de Oyón

Busca demostrar de manera aplicada el impacto en costo y lograr el éxito de los proyectos implementando los estándares de la Guía del PMBOK®. La aplicación se realiza en el ámbito de la construcción del Edificio Municipal “Ingeniero Alberto Benavides de la Quintana” del distrito y provincia de Oyón. El proyecto consiste en la demolición de la estructura existente donde actualmente viene funcionando la sede provincial y la construcción de una edificación nueva compuesta por un sótano y 4 pisos; 2 escaleras y un ascensor, así como la instalación de servicios básicos de agua, desagüe, instalación eléctrica, teléfono e internet. Los principales interesados son: Autoridades de la Municipalidad Provincial de Oyón, Supervisión Técnica del proyecto, Supervisión Financiera del proyecto - FIDUCIARIA S.A, Consorcio San Nicolás, Pobladores de Oyón y Autoridades del Gobierno Regional.TesisEn proceso de revisió

Parascapular Flap for Severe Hidradenitis Suppurativa

Hidradenitis suppurativa is a chronic inflammatory disease which affects apocrine glands and hair follicles of the skin, primarily in the axillary and groin regions. This condition can be highly debilitating, causing painful lesions and a negative psychological impact on patients. While medical and minimally invasive treatments are available, surgical intervention may be necessary for severe cases. In cases involving axillary defects, the use of local flaps such as the parascapular flap is a viable option. In this case report, we present a 34-year-old woman who presented to our clinic with a history of recurrent abscesses and cutaneous infections in the axillary region. After thorough evaluation, we chose to use the parascapular flap for reconstruction. The parascapular flap is a one-stage procedure that allows for extensive resection of the axillary area without resulting in contractions or retractions over the long term. Additionally, this technique allows for preservation of the axilla’s original shape with minimal donor site morbidity

Mechanical Regulation of Epithelial Tissue Homeostasis

Despite recent efforts to understand homeostasis in epithelial tissues, there are many unknowns surrounding this steady state. It is considered to be regulated by mechanoresponse, but unlike for single cells, this remains heavily debated for tissues. Here, we show that changes in matrix stiffness induce a non-equilibrium transition from tubular to squamous Madin-Darby Canine Kidney II tissues. Nonetheless, despite different cell morphologies and densities, all homeostatic tissues display equivalent topologies, which, hence, must be actively targeted and regulated. On the contrary, the mechanoresponse induces dramatic changes in the large-scale organization of the colonies. On stiff gels, this yields an unreported cooperative state of motile cells displaying higher densities than in the arrested homeostatic state. This suggests a more complex relation between cell density and motility than previously anticipated. Our results unequivocally relate the mechanosensitive properties of individual cells to the evolving macroscopic structures, an effect that could be important for understanding the emergent pathologies of living tissues