The Resilience Vaccine

Healthcare workers have been working in unprecedented circumstances since the declaration of the COVID-19 pandemic. Caregivers have been taxed with burnout. A large healthcare organization’s 26-bed, medical-surgical, telemetry, COVID-19 overflow unit was significantly impacted. Many healthcare organizations have adopted advocacy for attaining joy in work as an extra dimension of the Institute for Health Improvement’s Triple Aim. Adding this fourth aim supports averting caregiver burnout (CBO) while promoting joy in work. This quality improvement project examined nurse leaders’ interventions that address CBO, promote healthy work environments, and promote joy in work. From June through August 2021, an 8-week resilience program was implemented during huddles to support decreasing CBO for frontline nursing staff. Interventions were evidence-based and changed weekly. Education, connection, humor, self-care, gratitude, music, spirituality, and fun were facilitated. A survey was performed pre- and post-program. CBO, employee turnover, absenteeism, management support, and the burden of joy at work were measured for effectiveness. The aim of this project was to gain 75% staff attendance and reduce CBO 10% in the unit over 3 months. Results demonstrated that CBO and absenteeism significantly decreased, while attendance, employee turnover, management support, and joy at work did not meet their targeted goals. Implications of these findings include cultivating resilience modalities to foster employee well-being and joy in work results in decreasing CBO while improving productivity. Nurse leader support towards desired restorative efforts for staff can make a valuable difference. The World Health Organization (2020) recommends that protecting healthcare staff from chronic stress and poor mental health development is crucial

Corporatisation and financialisation of social reproduction: Care homes and childcare in the United Kingdom

The ownership and financial strategies of companies providing care for children or older people have become an increasingly salient concern, in both research and policy, because of their implications for the quality and availability of care services, as well as working conditions. However, analysis has tended to be sector specific. This article provides the first comparison of ownership, business models and workforces across childcare and adult social care in the United Kingdom. It reveals growing convergence in terms of the dominance of large companies and their financial strategies, which can reward investors while undermining access to care and worsening working conditions for large, low-paid workforces. We conceptualise these developments in terms of corporatisation and the related process of financialisation. They are, we argue, underpinned by the political economy of low wages for care work, which we explain using feminist social reproduction theory – highlighting the devaluation of feminised and racialised caring labour. The article identifies the need for further research to account for differences between the sectors, to map the geographies and political economies of care, and to compare these processes internationally

Media Review: Mindful Leadership: A Guide for the Health of Care Professions

Sara Horton-Deutsch reviews Mindful Leadership: A Guide for the Health of Care Professions, by Christopher Johns

The COS-AGN survey: Revealing the nature of circum-galactic gas around hosts of active galactic nuclei

Active galactic nuclei (AGN) are thought to play a critical role in shaping galaxies, but their effect on the circumgalactic medium (CGM) is not well studied. We present results from the COS-AGN survey: 19 quasar sightlines that probe the CGM of 20 optically-selected AGN host galaxies with impact parameters $80 < \rho_{imp} < 300$ kpc. Absorption lines from a variety of species are measured and compared to a stellar mass and impact parameter matched sample of sightlines through non-AGN galaxies. Amongst the observed species in the COS-AGN sample (HI, CII, SiII, SiIII, CIV, SiIV, NV), only Ly$\alpha$ shows a high covering fraction ($94^{+6}_{-23}$% for rest-frame equivalent widths EW $> 124$ m\AA) whilst many of the metal ions are not detected in individual sightlines. A sightline-by-sightline comparison between COS-AGN and the control sample yields no significant difference in EW distribution. However, stacked spectra of the COS-AGN and control samples show significant (> 3 sigma) enhancements in the EW of both Ly$\alpha$ and SiIII at impact parameters $> 164$ kpc by a factor of $+0.45\pm0.05$ dex and $> +0.75$ dex respectively. The lack of detections of both high-ionization species near the AGN and strong kinematic offsets between the absorption systemic galaxy redshifts indicates that neither the AGN's ionization nor its outflows are the origin of these differences. Instead, we suggest the observed differences could result from either AGN hosts residing in haloes with intrinsically distinct gas properties, or that their CGM has been affected by a previous event, such as a starburst, which may also have fuelled the nuclear activity.Comment: Accepted for publication in MNRA

A Program Aimed toward Inclusive Excellence for Underrepresented Undergraduate Women in the Sciences

Created to foster inclusive excellence, Smith College’s Achieving Excellence in Mathematics, Engineering, and Science (AEMES) Scholars program provides early faculty-mentored research opportunities and other programming as a way to foster success in academic outcomes for underrepresented women in science. Using academic record data, we compared Scholars’ outcomes over time with those of underrepresented students before program launch and to relevant peer comparison groups. Since its launch, AEMES Scholars have achieved significantly higher gateway life sciences course grade point averages (GPAs), rates of persistence in life and natural sciences, and participation in natural sciences advanced research relative to baseline. Gains for Scholars in gateway course GPA eliminated the significant gap that previously existed between science, technology, engineering, and mathematics (STEM)-underrepresented and other students, whereas gains in natural sciences persistence now has Scholars continuing in STEM at significantly higher rates than all other students. Many of the gains for AEMES Scholars were echoed in findings of improved outcomes for our STEM students overall since AEMES’ launch. Underrepresented students who were not part of the Scholars program also evidenced increased gateway course GPA over this same period. We discuss potential explanations for these outcomes and ongoing work aimed at achieving further inclusive excellence for women in the sciences

Improving outcomes for underrepresented women in science: The Achieving Excellence in Mathematics, Engineering, and Science (AEMES) programs at Smith College

Created to support diverse students interested in the sciences, Smith College’s Achieving Excellence in Mathematics, Engineering, and Science (AEMES) programs have improved life science academic outcomes for women of color. Elements of Smith’s AEMES programs include leadership development, peer mentoring, and faculty-mentored research opportunities, all sharing the goals of building community, increasing academic engagement, and encouraging persistence for underrepresented students. Since launching AEMES, our students of color in the life sciences have shown significant gains in positive outcomes (introductory biology and chemistry course GPA; retention in life sciences majors), dissolving a previously observed gap in gateway course performance relative to majority students. We discuss potential explanations for these outcomes as well as our ongoing work to evaluate and foster programming efforts aimed at achieving further inclusive excellence in the sciences, especially given the lack of change in advanced life sciences research participation for students of color over time. With greater investments in programs that encourage access in undergraduate programs across the United States, such as Smith’s AEMES program, the next generation of scientists will become increasingly diverse, broadening the approaches and perspectives of our STEM talent and workforce

Infant pain-regulation as an early predictor of childhood temperament

BACKGROUND: There is considerable variability in infants’ responses to painful stimuli, including facial and vocal expressions. This variability in pain-related distress response may be an indicator of temperament styles in childhood. OBJECTIVE: To examine the relationships among immunization pain outcomes (pain reactivity, pain regulation and parent ratings of infant pain) over the first year of life and parent report of early temperament. METHODS: A subset of parent-infant dyads in an ongoing Canadian longitudinal cohort was studied. Infant pain behaviours were coded using the Modified Behavior Pain Scale. Parental judgments of infant pain were recorded using the Numeric Rating Scale. Infant temperament was measured using the Infant Behaviour Questionnaire-Revised. Correlational analyses and multiple regressions were conducted. RESULTS: Multiple regressions revealed that the 12-month regulatory pain scores predicted parent ratings of the Negative Affectivity temperament dimension at 14 months of age. Parent ratings of infant pain at 12 months of age predicted parent ratings of the Orienting/Affiliation temperament dimension, with sex differences observed in this substrate. CONCLUSION: Pain-related distress regulation at one year of age appears to be a novel indicator of parent report of temperament ratings. Pain outcomes in the first six months of life were not related to parent temperament ratings

The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

Neurolysin (NLN) is a zinc metallopeptidase whose mitochondrial function is unclear. We found that NLN was overexpressed in almost half of patients with acute myeloid leukemia (AML), and inhibition of NLN was selectively cytotoxic to AML cells and stem cells while sparing normal hematopoietic cells. Mechanistically, NLN interacted with the mitochondrial respiratory chain. Genetic and chemical inhibition of NLN impaired oxidative metabolism and disrupted the formation of respiratory chain supercomplexes (RCS). Furthermore, NLN interacted with the known RCS regulator, LETM1, and inhibition of NLN disrupted LETM1 complex formation. RCS were increased in patients with AML and positively correlated with NLN expression. These findings demonstrate that inhibiting RCS formation selectively targets AML cells and stem cells and highlights the therapeutic potential of pharmacologically targeting NLN in AML

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.

BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their molecular organization. For example, the pathway of energy metabolism that power motility, a feature that facilitates gamete encounter and fertilization, is unknown. METHODS: Plasmodium berghei microgametes were purified and analysed by whole-cell proteomic analysis for the first time. Data are available via ProteomeXchange with identifier PXD001163. RESULTS: 615 proteins were recovered, they included all male gamete proteins described thus far. Amongst them were the 11 enzymes of the glycolytic pathway. The hexose transporter was localized to the gamete plasma membrane and it was shown that microgamete motility can be suppressed effectively by inhibitors of this transporter and of the glycolytic pathway. CONCLUSIONS: This study describes the first whole-cell proteomic analysis of the malaria male gamete. It identifies glycolysis as the likely exclusive source of energy for flagellar beat, and provides new insights in original features of Plasmodium flagellar organization