6 research outputs found
Recommended from our members
Diabetes, Obesity, and Hypertension May Enhance Associations between Air Pollution and Markers of Systemic Inflammation
Airborne particulate matter (PM) may lead to increased cardiac risk through
an inflammatory pathway. Therefore, we investigated associations
between ambient PM and markers of systemic inflammation among repeated
measures from 44 senior citizens (ā„ 60 years of age) and examined
susceptibility by conditions linked to chronic inflammation. Mixed
models were used to identify associations between concentrations of
fine PM [aerodynamic diameter ā¤ 2.5 Ī¼m (PM2.5)] averaged over 1ā7 days and measures of C-reactive protein (CRP), interleukin-6 (IL-6), and white blood cells (WBCs). Effect
modification was investigated for diabetes, obesity, hypertension, and
elevated mean inflammatory markers. We found positive associations
between longer moving averages of PM2.5 and WBCs across all participants, with a 5.5% [95% confidence
interval (CI), 0.10 to 11%] increase per
interquartile increase (5.4 Ī¼g/m3) of PM2.5 averaged over the previous week. PM2.5 and CRP also exhibited positive associations among all individuals for
averages longer than 1 day, with the largest associations for persons
with diabetes, obesity, and hypertension. For example, an interquartile
increase in the 5-day mean PM2.5 (6.1 Ī¼g/m3) was associated with a 14% increase in CRP (95% CI, ā5.4 to 37%) for all individuals and an 81% (95% CI, 21 to 172%) increase for persons with diabetes, obesity, and
hypertension. Persons with diabetes, obesity, and hypertension
also exhibited positive associations between PM2.5 and IL-6. Individuals with elevated mean inflammatory markers exhibited
enhanced associations with CRP, IL-6, and WBCs. We found modest positive
associations between PM2.5 and indicators of systemic inflammation, with larger associations suggested
for individuals with diabetes, obesity, hypertension, and elevated
mean inflammatory markers
Diabetes, Obesity, and Hypertension May Enhance Associations between Air Pollution and Markers of Systemic Inflammation
Airborne particulate matter (PM) may lead to increased cardiac risk through an inflammatory pathway. Therefore, we investigated associations between ambient PM and markers of systemic inflammation among repeated measures from 44 senior citizens (ā„ 60 years of age) and examined susceptibility by conditions linked to chronic inflammation. Mixed models were used to identify associations between concentrations of fine PM [aerodynamic diameter ā¤ 2.5 Ī¼m (PM(2.5))] averaged over 1ā7 days and measures of C-reactive protein (CRP), interleukin-6 (IL-6), and white blood cells (WBCs). Effect modification was investigated for diabetes, obesity, hypertension, and elevated mean inflammatory markers. We found positive associations between longer moving averages of PM(2.5) and WBCs across all participants, with a 5.5% [95% confidence interval (CI), 0.10 to 11%] increase per interquartile increase (5.4 Ī¼g/m(3)) of PM(2.5) averaged over the previous week. PM(2.5) and CRP also exhibited positive associations among all individuals for averages longer than 1 day, with the largest associations for persons with diabetes, obesity, and hypertension. For example, an interquartile increase in the 5-day mean PM(2.5) (6.1 Ī¼g/m(3)) was associated with a 14% increase in CRP (95% CI, ā5.4 to 37%) for all individuals and an 81% (95% CI, 21 to 172%) increase for persons with diabetes, obesity, and hypertension. Persons with diabetes, obesity, and hypertension also exhibited positive associations between PM(2.5) and IL-6. Individuals with elevated mean inflammatory markers exhibited enhanced associations with CRP, IL-6, and WBCs. We found modest positive associations between PM(2.5) and indicators of systemic inflammation, with larger associations suggested for individuals with diabetes, obesity, hypertension, and elevated mean inflammatory markers