The relevance of individualization in the choice of methods of testing of physical abilities of students in special medical groups

Alternative methods of testing of students of special medical group.Альтернативные методы тестирования студентов специальной медицинской группы

Correction of myopia of primary school pupils at lessons of physical culture

In this paper, methods of myopia correction in primary school pupils by means of adapted games and physical exercises in physical education classes are disclosed.В данной работе раскрываются методы коррекции миопии у младших школьников средствами адаптированных игр и физических упражнений на уроках физической культуры

Azoloazines as Perspective Antiglycating Agents for Therapy of Diabetes Complications

This work was supported by Russian Federation Ministry of education and science (grant № 4.6351.2017/8.9) and Russian Foundation for Basic Research (grant № 18-03-00787)

Therapy of Schizoaffective Disorder and Paranoid Schizophrenia with Episodic Course

Background. The use of atypical antipsychotics in schizophrenia contributes to the reduction of psychotic, affective, negative and cognitive disorders.Aims. To evaluate the effectiveness of ziprasidone therapy in patients with schizoaffective disorder and paranoid schizophrenia with episodic course.Materials and methods. In accordance with ICD-10 there were 14 (63.6 %) people with schizoaffective disorder (F25), 8 (36.4 %) people with paranoid schizophrenia, episodic course (F20.x1). Treatment with ziprasidone lasted 42 days. The dose of ziprasidone in 6 patients (27.3 %) was 80 mg, in 10 patients (45.5 %) – 120 mg, in 6 patients (27.3 %) – 160 mg. Evaluation of the effectiveness of ziprasidone therapy was carried out using psychometric scales (PANSS, General clinical impression scale to assess the effectiveness of therapy – CGI-S, CGI-I), adverse events were registered with the UKU scale.Results. The number of respondents was 19 (86.3 %) (reduction of the total score on the PANSS scale > 20 % of the pre-treatment level). Ziprasidone was effective in patients with schizoaffective disorder with a significant decrease in total score on PANSS subscales to the 14 th day of therapy (p < 0.05), with paranoid schizophrenia with episodic course – by the 21st day (p < 0.01). According to the CGI-S scale at the end of therapy, “borderline condition” was observed in 10 patients (52.6 %), mild severity – in 3 (15.8 %), normal condition – in 6 (31.6 %). CGI-I scale showed a significant improvement in 10 patients (52.6 %), marked improvement – in 9 patients (47.4 %). Among the mild adverse events that do not require discontinuation of the drug, we noted: weakness – in 3 patients (15.8 %), drowsiness – in 3 (15.8 %), impaired concentration – in 2 (10.5 %), orthostatic dizziness – in 2 (10.5 %), galactorrhea – in 1 (5.3 %).Conclusions. Ziprasidone is an effective antipsychotic drug that has a safe tolerability profile. It can be used in patients with schizoaffective disorders and paranoid schizophrenia with episodic course

Health status of students in the special medical group

To assess the health level of first-year students studying in a special medical group, we researched such indicators as physical development, morbidity, physical training, biological age using the method of V. Sukhov and the health level according to G. L. Apanasenko. The leading positions in the structure of morbidity take diseases of the musculoskeletal system, the nervous system, the eye and its appendage occupy take. 63% of students have a low level of health, more than half of students have a biological age in the range of 31-40 years. Therefore, the training session must be adapted to the state of health.Для оценки уровня здоровья студентов 1 курса, занимающихся в специальной медицинской группе, изучены показатели физического развития, заболеваемости, физической подготовки, биологический возраст по методике В.Сухова, уровень здоровья по Г.Л.Апанасенко. В структуре заболеваемости ведущие позиции занимают болезни костно-мышечной системы, нервной системы, глаза и его придаточного аппарата. Низкий уровень здоровья имеют 63% студентов, более половины студентов имеют биологический возраст в диапазоне 31-40 лет. Поэтому тренировочное занятие должно быть адаптировано с учетом состояния здоровья

Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins

[Figure not available: see fulltext.] The nucleophilic susbstitution of nitro group in [1,2,4]triazolo[5,1-c][1,2,4]triazinones upon treatment with cysteine and glutathione was studied as a model for the interaction with thiol groups of virus proteins, which mimics the metabolic transformations of antiviral drug Triazavirin® and its derivatives. © 2015 Springer Science+Business Media New York.Russian Science Foundation, RSF: 14-13-01301The study was performed with the financial support from the Russian Science Foundation (grant 14-13-01301)

Injuries in physical education classes

In foreign and domestic literature, the problems of combating various types of injuries are widely considered, and there are absolutely insufficient issues on the organization of trauma care and prevention of injuries in physical education classes. In physical education classes, most students are at risk of people who are prone to injury, because the class differs from other subjects by high motor activty, the use of various equipment and sports equipmentВ зарубежной и отечественной литературе довольно широко рассматриваются проблемы борьбы с различными видами травматизма и совершенно недостаточно вопросы по организации травматологической помощи и профилактики травматизма на занятиях физической культурой. На занятиях физической культурой большинство студентов входят в группу риска людей, которые подвержены травматизму, потому что занятие отличается от других предметов высокой двигательной активностью, использованием различного инвентаря и спортивного оборудовани

Antioxidants and Cognitive-Behavioral Therapy in Patients with Functional Dyspepsia

Аim: development of an algorithm for the use of antioxidant cognitive-behavioral therapy in adult patients with functional dyspepsia.Material and methods. The study included 112 adult patients with functional dyspepsia receiving the antioxidant drug Cytoflavin containing succinic acid, inosine, nicotinamide and riboflavin, and cognitive behavioral therapy according to the method of Beck and Jacobson in addition to the main therapy (prokinetics, proton pump inhibitors, psychotropic drugs).Results. Of the total group, 74 patients had an optimal response to the inclusion of an antioxidant and psychotherapy in the treatment regimen (increased quality of life and reduced anxiety) and 38 patients had the insignificant response. It has been established that the main predictors of the successful use of an extended treatment regimen are the patient's disadaptation in relation to the disease, a recent stress factor, the duration of functional dyspepsia, the presence of an overlap syndrome (combination with other functional gastrointestinal disorders).Conclusions. Based on the collection of a small amount of anamnestic information (the duration of functional dyspepsia, the presence of an acute stress factor in the anamnesis), the assessment of the presence of an overlap syndrome and disadaptation in relation to the patient to his illness, the value of the discriminant function is calculated. After comparing it with a threshold, the probability of a positive response to a combination of antioxidant and cognitive-behavioral therapy is estimated. The developed prediction algorithm is valid (sensitivity — 91 %, specificity — 73 %, accuracy — 84.8 %) and allows to optimize the definition of treatment tactics for a patient with functional dyspepsia

Определение пирогенных примесей в гормональных имплантатах с помощью ЛАЛ-теста

The State Pharmacopoeia of the Russian Federation, 14th edition states that implants are a sterile dosage form, and have to be tested for pyrogens. However, it does not provide details on how the test should be performed for this dosage form.The aim of the study was to develop a LAL test procedure for detection of bacterial endotoxins (BE) in implants, using the example of a goserelin product.Materials and methods: BE extraction from the implant surface into an aqueous medium was performed with subsequent BE detection in the extract by turbidimetric kinetic test. The implant was then dissolved in dimethyl sulfoxide, and the obtained goserelin solution was tested for BEs using the gel-clot test.Results: the analysis of the Russian and foreign pharmacopoeial approaches to pyrogenic substance detection in hormonal implants helped to develop two sample preparation procedures for determination of BE content (in the extract and the implant solution). It was demonstrated that the BE content in the water extract did not exceed 0.01 EU/mL and was less than 0.07 EU per implant. The BE content in the implant solution was less than 8.3 EU per 1 mg of goserelin, which is almost eleven-fold lower than the theoretically-derived limit.Conclusions: the authors developed two test procedures for BE detection in hormonal implants using the LAL test, which could be included in manufacturers’ product files. The first procedure involves testing of the water extract from the implant surface and establishes the BE limit of no more than 20 EU/product. The second procedure involves complete dissolution of the implant in dimethyl sulfoxide and establishes the limit of not more than 97.22 EU per 1 mg of goserelin.Согласно Государственной фармакопее Российской Федерации XIV изд. имплантаты являются стерильной лекарственной формой, для которой обязательным является контроль пирогенности. Однако особенности выполнения анализа для данной лекарственной формы в отечественной фармакопее не описаны.Цель работы: разработать методику определения содержания бактериальных эндотоксинов (БЭ) с помощью ЛАЛ-теста в имплантатах на примере гормонального препарата с активным веществом гозерелин.Материалы и методы: выполняли процесс экстракции БЭ с поверхности имплантата в водную среду и определяли содержание БЭ в смыве турбидиметрическим кинетическим методом. Затем имплантат растворяли в диметилсульфоксиде и оценивали наличие БЭ в полученном растворе гозерелина с помощью гель-тромб теста.Результаты: на основании существующих в отечественной и зарубежной фармакопейной практике подходов к определению пирогенных примесей в гормональных имплантатах предложено два способа предварительной подготовки образцов для последующего определения содержания БЭ (в смыве и в растворе имплантата). Установлено, что содержание БЭ в водном смыве не превышает 0,01 ЕЭ/мл и составляет менее 0,07 ЕЭ на имплантат. Содержание БЭ в растворе имплантата составило менее 8,3 ЕЭ на 1 мг гозерелина, что почти в 11 раз меньше теоретически рассчитанной нормы.Выводы: разработаны две методики определения БЭ в имплантатах гормональных препаратов с помощью ЛАЛ-теста, пригодные для включения в нормативную документацию. Первая методика предусматривает испытание водного смыва с поверхности имплантата с нормой предельного содержания БЭ «не более 20 ЕЭ/изделие». Вторая методика основана на полном растворении имплантата в диметилсульфоксиде с нормой «не более 97,22 ЕЭ на 1 мг гозерелина»

New antiglycating agents for diabetes therapy

It was shown that azoloazines (1) demonstrated higher antiglycation activity than reference compound, aminoguanidine, and have some potential as dipeptidylpeptidase-4 inhibitors. By given results this class of heterocycles can be considered as candidate for extended studies to develop drugs against complications of T2DM [1-4].The work was supported by the Ministry of Education and Science of Russia (grant №0836-2020-0058)