Biometrics of the primary dentition in a Nigerian sample

Objective: The purpose of this study was to determine normative values of crown dimensions, arch dimensions, and amount of interdental space in the primary dentition of Nigerian children. Method: Dental casts from alginate impressions obtained from 125 randomly selected nursery school children (65 boys, 60 girls) aged 3 to 5 years, were measured with electronic caliper. Independent tests were used to analyze sample differences between sexes. Result: There were significant gender differences in arch width, depth and length dimensions, with the exception of the left mandibular anterior length. The boys showed significantly larger mesiodistal crown dimensions, except in the maxillary and mandibular primary lateral incisors. Gender differences in buccolingual crown diameters were statistically significant for maxillary second primary molars. There was no significant gender difference in amount of interdental spaces. Conclusion: It can be concluded that males had larger tooth/arch dimensions than females in the primary dentition stage

Knowledge and behavior of Nigerian dentists concerning the treatment of children with special needs

BACKGROUND: Children with special needs (CSN) are reported to receive less adequate dental care due to various behavioral problems and barriers created by dental professionals. This study was carried out to determine the knowledge and behaviour of Nigerian dentists concerning the treatment of CSN. METHODS: Questionnaires consisting of open and closed ended questions requesting socio-demographic information, type of practice, undergraduate and postgraduate training, self-rated knowledge and behaviour concerning care of CSN, were hand delivered to 359 dentists in the 3 geographical zones of Nigeria over a period of 8 weeks. Responses were compared across age groups, gender, type of practice and training received. RESULT: Two hundred and eighty questionnaires were returned completed, constituting 79.9% response rate. Most of the respondents were aged 30 – 39 years (44.3%). There were more males (56.1%) and more recent graduates of 10 years and below (78.5%). Over 80% of respondents had treated children with disabilities, those with physical disabilities being most encountered. Only 19.3% of respondents rated their knowledge of management of CSN as adequate, with no significant difference across age groups and gender, but with a significantly higher number of older graduates reporting to have adequate knowledge (p < 0.05). Those who had undergraduate training in care of CSN were 69.5% compared with only 12.8% who had post graduate training. Only 11.8% rated their undergraduate training as adequate. Thirty seven percent of respondents rated the CSN they had treated as very challenging. A higher proportion of older graduates (of more than 10 years post graduation) and those who rated their undergraduate training as inadequate used sedation and general anaesthesia. Seventy one percent of respondents were willing to treat CSN, with no significant difference across age groups, gender and training, but with a significantly higher percentage among those who had rated their knowledge as adequate. Most of those who were unwilling to treat CSN felt their management was tedious and challenging. CONCLUSION: From this study, very few dentists reported to have adequate knowledge of management of CSN, irrespective of age, gender and place of practice. A significant number of those with more experience rated their knowledge as adequate. Although most dentists rated the children's behaviour as challenging, they indicated their willingness to treat them in their practices

Mutagenesis of Puccinia graminis f. sp. tritici and selection of gain-of-virulence mutants

Wheat stem rust caused by the fungus Puccinia graminis f. sp. tritici (Pgt), is regaining prominence due to the recent emergence of virulent isolates and epidemics in Africa, Europe and Central Asia. The development and deployment of wheat cultivars with multiple stem rust resistance (Sr) genes stacked together will provide durable resistance. However, certain disease resistance genes can suppress each other or fail in particular genetic backgrounds. Therefore, the function of each Sr gene must be confirmed after incorporation into an Sr-gene stack. This is difficult when using pathogen disease assays due to epistasis from recognition of multiple avirulence (Avr) effectors. Heterologous delivery of single Avr effectors can circumvent this limitation, but this strategy is currently limited by the paucity of cloned Pgt Avrs. To accelerate Avr gene cloning, we outline a procedure to develop a mutant population of Pgt spores and select for gain-of-virulence mutants. We used ethyl methanesulphonate (EMS) to mutagenize urediniospores and create a library of > 10,000 independent mutant isolates that were combined into 16 bulks of ~658 pustules each. We sequenced random mutants and determined the average mutation density to be 1 single nucleotide variant (SNV) per 258 kb. From this, we calculated that a minimum of three independently derived gain-of-virulence mutants is required to identify a given Avr gene. We inoculated the mutant library onto plants containing Sr43, Sr44, or Sr45 and obtained 9, 4, and 14 mutants with virulence toward Sr43, Sr44, or Sr45, respectively. However, only mutants identified on Sr43 and Sr45 maintained their virulence when reinolculated onto the lines from which they were identified. We further characterized 8 mutants with virulence toward Sr43. These also maintained their virulence profile on the stem rust international differential set containing 20 Sr genes, indicating that they were most likely not accidental contaminants. In conclusion, our method allows selecting for virulent mutants toward targeted resistance (R) genes. The development of a mutant library from as little as 320 mg spores creates a resource that enables screening against several R genes without the need for multiple rounds of spore multiplication and mutagenesis

Everything Matters: The ReproNim Perspective on Reproducible Neuroimaging

There has been a recent major upsurge in the concerns about reproducibility in many areas of science. Within the neuroimaging domain, one approach is to promote reproducibility is to target the re-executability of the publication. The information supporting such re-executability can enable the detailed examination of how an initial finding generalizes across changes in the processing approach, and sampled population, in a controlled scientific fashion. ReproNim: A Center for Reproducible Neuroimaging Computation is a recently funded initiative that seeks to facilitate the “last mile” implementations of core re-executability tools in order to reduce the accessibility barrier and increase adoption of standards and best practices at the neuroimaging research laboratory level. In this report, we summarize the overall approach and tools we have developed in this domain

Pathways to care for people for dementia: an international multi-centre study

Objective: the aim of the present study was to characterize the clinical pathways that people with dementia (PwD) in different countries follow to reach specialized dementia care. Methods: we recruited 548 consecutive clinical attendees with a standardized diagnosis of dementia, in 19 specialized public centers for dementia care in 15 countries. The WHO “Encounter Form”, a standardized schedule that enables data concerning basic socio-demographic, clinical and pathways data to be gathered, was completed for each participant. Results: the median time from the appearance of the first symptoms to the first contact with specialist dementia care was 56 weeks. The primary point of access to care was the general practitioners (55.8%). Psychiatrists, geriatricians and neurologists represented the most important second point of access. In about a third of cases, PwD were prescribed psychotropic drugs (mostly antidepressants and tranquillizers). Psychosocial interventions (such as psychological counselling, psychotherapy and practical advice) were delivered in less than 3% of situations. The analyses of the ‘pathways diagram’ revealed that the path of PwD to receiving care is complex, diverse across countries, and that there are important barriers to clinical care. Conclusions: the study of pathways followed by PwD to reach specialized care has implications for the subsequent course and the outcome of dementia. Insights into local differences in the clinical presentations and the implementation of currently available dementia care are essential to develop more tailored strategies for these patients, locally, nationally and internationally

Beliefs and Perceptions about HIV Infection/AIDS among Adults Attending a Dental Clinic At The Lagos University Teaching Hospital

One hundred and thirty eights adults were interviewed by means of semi-structured questionnaires in the Oral Diagnosis Clinic of the Lagos University Teaching Hospital [LUTH], Lagos, Nigeria, about their perceptions and beliefs about HIV infections and AIDS. Emphasis was laid on how the infection could be acquired in situations related to the oral environment and during dental procedures. The findings revealed that 92.8% of the respondents believe that HIV infection does exist in Nigeria but only 55.0% claimed they have seen AIDS patients. Some admitted that they have seen them on the television. Over 90% of the respondents knew an individual can get infected through blood and blood products and through injections [94.9% and 94.2% respectively]. About one-third [31.9%] erroneously believed saliva could be a means by which one can be get infected, 57.2% of the respondents believed infection could be by using the same toothbrush or chewing stick and 19.6% believed that the infection could be contacted by using the same cutlery or cup. Ninety seven percent believed that people can protect themselves from having the infection by various means including avoiding sharing of needles [93.5%], mutual fidelity with a single sexual partner [89.1%], and use of condoms [89.9%]. Those with higher level of education showed better knowledge generally than those with lower level of education. However, in spite of the higher correlation with formal education, some misconceptions still existed in all groups. The differences for those with higher and lower levels of education were however not statistically significant. It was concluded that awareness of HIV infection and AIDS is a high among adults attending the Oral Diagnosis Clinic, LUTH, Lagos. However, knowledge of the modes of transmission of HIV infection and AIDS should be improved and should be targeted at those with none or minimal level of formal education. NQJHM Vol. 14 (1) 2004: pp. 11-1

Management of Malocclusions: Report of Two Cases Treated Using Begg Technique at the Lagos University Teaching Hospital, Lagos, Nigeria

Two young Nigerians, one male and the other female who reported with crowding and proclamation of the incisors were successfully treated with Begg Light Technique at the Orthodontic Unit of the Lagos University Teaching Hospital. The active treatment times were 23 and 27 months respectively and Hawley Retainers were used to achieve stability of the occlusion for a duration of six months. At the end of treatment, patients' aesthetics and the occlusal relationship of the dentition were dramatically improved. NQJHM Vol. 14 (1) 2004: pp. 39-4

Talon cusp: clinical features, diagnosis and orthodontic consideration in management

Talon cusp is a rare odontogenic anomaly of tooth shape comprising of accessory cusp-like structure often present on the palatal surface of maxillary or mandibular incisor. This developmental anomaly causes clinical problems including unsightly dental appearance, occlusal interference, and displacement of the affected tooth, irritation of the tongue, caries and malocclusion. Few cases have been reported in this environment. Management of the talon cusp varies according to the circumstances of the individual case and should be as conservative as possible. This report presents a case of a 15-year -old Nigerian girl with talon cusp on the maxillary left central incisor. The talon cusp was managed conservatively and orthodontic treatment was concurrently carried out. It is concluded that when talon cusp occur in association with an occlusal anomaly, careful evaluation of the patient is crucial for successful talon cusp occur in association with an occlusal anomaly, careful evaluation of the patient is crucial for successful orthodontic treatment

Everything Matters: The ReproNim Perspective on Reproducible Neuroimaging

There has been a recent major upsurge in the concerns about reproducibility in many areas of science. Within the neuroimaging domain, one approach is to promote reproducibility is to target the re-executability of the publication. The information supporting such re-executability can enable the detailed examination of how an initial finding generalizes across changes in the processing approach, and sampled population, in a controlled scientific fashion. ReproNim: A Center for Reproducible Neuroimaging Computation is a recently funded initiative that seeks to facilitate the ‘last mile’ implementations of core re-executability tools in order to reduce the accessibility barrier and increase adoption of standards and best practices at the neuroimaging research laboratory level. In this report, we summarize the overall approach and tools we have developed in this domain